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Aliases for EDN2 Gene

Aliases for EDN2 Gene

  • Endothelin 2 2 3
  • PPET2 3 4
  • ET-2 3 4
  • Preproendothelin 2 3
  • Preproendothelin-2 4
  • Endothelin-2 3
  • ET2 3

External Ids for EDN2 Gene

Previous GeneCards Identifiers for EDN2 Gene

  • GC01M041972
  • GC01M040948
  • GC01M041407
  • GC01M041357
  • GC01M041613
  • GC01M041717
  • GC01M040063
  • GC01M041944

Summaries for EDN2 Gene

Entrez Gene Summary for EDN2 Gene

  • This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for EDN2 Gene

EDN2 (Endothelin 2) is a Protein Coding gene. Diseases associated with EDN2 include aortic disease and patent ductus arteriosus. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity. An important paralog of this gene is EDN3.

UniProtKB/Swiss-Prot for EDN2 Gene

  • Endothelins are endothelium-derived vasoconstrictor peptides

Tocris Summary for EDN2 Gene

  • The endothelin family consists of highly potent vasoconstrictive peptides. Three endogenous isoforms are known to exist, ET-1, ET-2 and ET-3, and two distinct endothelin receptors have so far been cloned in mammals, classified as ETA and ETB receptors. Endothelin receptors are widely expressed in all tissues, which is consistent with their physiological role as vasoactive peptides. They are also localized to non-vascular structures including epithelial cells, glia and neurons. The principle physiological role of endothelin receptors is the maintenance of vascular tone. They also have co-mitogenic activity, potentiating the effects of other growth factors such as PDGF.

Gene Wiki entry for EDN2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDN2 Gene

Genomics for EDN2 Gene

Regulatory Elements for EDN2 Gene

Genomic Location for EDN2 Gene

41,478,775 bp from pter
41,484,673 bp from pter
5,899 bases
Minus strand

Genomic View for EDN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDN2 Gene

Proteins for EDN2 Gene

  • Protein details for EDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5T1R3

    Protein attributes for EDN2 Gene

    178 amino acids
    Molecular mass:
    19960 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EDN2 Gene

Proteomics data for EDN2 Gene at MOPED

Post-translational modifications for EDN2 Gene

  • Glycosylation at Thr116, Ser123, and Thr139
  • Modification sites at PhosphoSitePlus

Other Protein References for EDN2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EDN2 Gene

Domains for EDN2 Gene

Gene Families for EDN2 Gene

Suggested Antigen Peptide Sequences for EDN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the endothelin/sarafotoxin family.
  • Belongs to the endothelin/sarafotoxin family.
genes like me logo Genes that share domains with EDN2: view

Function for EDN2 Gene

Molecular function for EDN2 Gene

GENATLAS Biochemistry:
endothelin 2 (vaso-constrictor/pressor peptide),involved in vascular remodeling,commonly expressed in right atrial tissue,susceptibility gene for essential hypertension
UniProtKB/Swiss-Prot Function:
Endothelins are endothelium-derived vasoconstrictor peptides

Gene Ontology (GO) - Molecular Function for EDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IDA 2649896
genes like me logo Genes that share ontologies with EDN2: view
genes like me logo Genes that share phenotypes with EDN2: view

Animal Models for EDN2 Gene

MGI Knock Outs for EDN2:

Animal Model Products

miRNA for EDN2 Gene

miRTarBase miRNAs that target EDN2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EDN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EDN2 Gene

Localization for EDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDN2 Gene


Subcellular locations from

Jensen Localization Image for EDN2 Gene COMPARTMENTS Subcellular localization image for EDN2 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for EDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 15691296
genes like me logo Genes that share ontologies with EDN2: view

Pathways for EDN2 Gene

genes like me logo Genes that share pathways with EDN2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for EDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 9492062
GO:0001659 temperature homeostasis IEA --
GO:0002690 positive regulation of leukocyte chemotaxis IDA 9696419
GO:0003058 hormonal regulation of the force of heart contraction TAS 1652300
GO:0003099 positive regulation of the force of heart contraction by chemical signal TAS 1652300
genes like me logo Genes that share ontologies with EDN2: view

Drugs for EDN2 Gene

(5) Tocris Compounds for EDN2 Gene

Compound Action Cas Number
Endothelin 1 (human, porcine) Potent vasoconstrictor peptide [117399-94-7]
Endothelin 2 (human) ETA/ETB agonist [122879-69-0]
Endothelin 3 (human, rat) Potent vasoconstrictor [117399-93-6]
Sarafotoxin S6a Endothelin receptor agonist [126738-34-9]
Sarafotoxin S6b Endothelin receptor agonist; non-selective [116303-65-2]

(38) Novoseek inferred chemical compound relationships for EDN2 Gene

Compound -log(P) Hits PubMed IDs
sarafotoxin 91.8 42
bq123 86.6 2
fr139317 83.5 1
phosphoramidon 82.9 11
thiorphan 75.1 5
genes like me logo Genes that share compounds with EDN2: view

Transcripts for EDN2 Gene

Unigene Clusters for EDN2 Gene

Endothelin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EDN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EDN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6: - - - -
SP7: - - - -

Relevant External Links for EDN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EDN2 Gene

mRNA expression in normal human tissues for EDN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EDN2 Gene

This gene is overexpressed in Cervix - Ectocervix (9.4), Vagina (7.6), Esophagus - Mucosa (6.9), Skin - Not Sun Exposed (Suprapubic) (4.7), and Small Intestine - Terminal Ileum (4.4).

SOURCE GeneReport for Unigene cluster for EDN2 Gene Hs.1407

mRNA Expression by UniProt/SwissProt for EDN2 Gene

Tissue specificity: Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.
genes like me logo Genes that share expressions with EDN2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for EDN2 Gene

Orthologs for EDN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EDN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EDN2 35
  • 84 (n)
  • 76 (a)
EDN2 36
  • 75 (a)
(Canis familiaris)
Mammalia EDN2 35
  • 79.88 (n)
  • 68.05 (a)
EDN2 36
  • 60 (a)
(Mus musculus)
Mammalia Edn2 35
  • 78.23 (n)
  • 68.79 (a)
Edn2 16
Edn2 36
  • 67 (a)
(Pan troglodytes)
Mammalia EDN2 35
  • 99.81 (n)
  • 99.44 (a)
EDN2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Edn2 35
  • 76.95 (n)
  • 68 (a)
(Monodelphis domestica)
Mammalia EDN2 36
  • 51 (a)
(Gallus gallus)
Aves EDN2 35
  • 55.62 (n)
  • 47.59 (a)
EDN2 36
  • 42 (a)
(Anolis carolinensis)
Reptilia EDN2 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia edn2 35
  • 53.7 (n)
  • 51.59 (a)
(Danio rerio)
Actinopterygii edn2 36
  • 37 (a)
Species with no ortholog for EDN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EDN2 Gene

Gene Tree for EDN2 (if available)
Gene Tree for EDN2 (if available)

Paralogs for EDN2 Gene

Paralogs for EDN2 Gene

(1) SIMAP similar genes for EDN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EDN2: view

Variants for EDN2 Gene

Sequence variations from dbSNP and Humsavar for EDN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5798 - 41,481,147(-) ACGTG(C/T)TCCAG missense, reference, intron-variant
rs5799 -- 41,479,439(-) CCTCG(A/G)TCCAC synonymous-codon, reference
rs5800 -- 41,479,019(-) TGGAG(A/G)CTGGA utr-variant-3-prime
rs581588 -- 41,485,274(+) AAATG(C/T)CCCCC upstream-variant-2KB
rs734358 -- 41,480,241(-) GATGG(G/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EDN2 Gene

Variant ID Type Subtype PubMed ID
nsv508171 CNV Loss 20534489
nsv871918 CNV Loss 21882294
nsv870508 CNV Loss 21882294
nsv870806 CNV Loss 21882294
nsv870871 CNV Loss 21882294
nsv633 CNV Loss 18451855
nsv525172 CNV Loss 19592680
nsv461350 CNV Loss 19166990

Relevant External Links for EDN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EDN2 Gene

Disorders for EDN2 Gene

(20) Novoseek inferred disease relationships for EDN2 Gene

Disease -log(P) Hits PubMed IDs
essential hypertension 37.6 1
carcinoma renal cell 26.2 10
cardiovascular diseases 23.8 1
hypertension pulmonary 16.3 1
vascular diseases 8.06 1

Relevant External Links for EDN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with EDN2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for EDN2 Gene

Publications for EDN2 Gene

  1. Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension. (PMID: 10489105) Sharma P. … Brown M.J. (J. Hypertens. 1999) 3 23 48
  2. A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic cardiomyopathy. (PMID: 18037749) Nagai T. … Higaki J. (Circ. J. 2007) 3 23 48
  3. cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. (PMID: 1840558) Bloch K.D. … Quertermous T. (Genomics 1991) 3 4 23
  4. Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2. (PMID: 1725387) Onda H. … Fujino M. (J. Cardiovasc. Pharmacol. 1991) 3 4 23
  5. Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization. (PMID: 1701397) Ohkubo S. … Fujino M. (FEBS Lett. 1990) 3 4 23

Products for EDN2 Gene

Sources for EDN2 Gene

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