Aliases for EDN2 Gene
External Ids for EDN2 Gene
Previous GeneCards Identifiers for EDN2 Gene
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
GeneCards Summary for EDN2 Gene
EDN2 (Endothelin 2) is a Protein Coding gene. Diseases associated with EDN2 include aortic disease and patent ductus arteriosus. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity. An important paralog of this gene is EDN3.
UniProtKB/Swiss-Prot for EDN2 Gene
Endothelins are endothelium-derived vasoconstrictor peptides
The endothelin family consists of highly potent vasoconstrictive peptides. Three endogenous isoforms are known to exist, ET-1, ET-2 and ET-3, and two distinct endothelin receptors have so far been cloned in mammals, classified as ETA and ETB receptors. Endothelin receptors are widely expressed in all tissues, which is consistent with their physiological role as vasoactive peptides. They are also localized to non-vascular structures including epithelial cells, glia and neurons. The principle physiological role of endothelin receptors is the maintenance of vascular tone. They also have co-mitogenic activity, potentiating the effects of other growth factors such as PDGF.