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Aliases for ECH1 Gene

Aliases for ECH1 Gene

  • Enoyl CoA Hydratase 1, Peroxisomal 2 3
  • Enoyl Coenzyme A Hydratase 1, Peroxisomal 2 3
  • Delta(3,5)-Delta(2,4)-Dienoyl-CoA Isomerase, Mitochondrial 3
  • Delta3,5-Delta2,4-Dienoyl-CoA Isomerase 3
  • Peroxisomal Enoyl-CoA Hydratase 1 3
  • Dienoyl-CoA Isomerase 3
  • EC 5.3.3.- 4
  • HPXEL 3

External Ids for ECH1 Gene

Previous GeneCards Identifiers for ECH1 Gene

  • GC19M039918
  • GC19M039697
  • GC19M043982
  • GC19M043997
  • GC19M039306
  • GC19M035752

Summaries for ECH1 Gene

Entrez Gene Summary for ECH1 Gene

  • This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]

GeneCards Summary for ECH1 Gene

ECH1 (Enoyl CoA Hydratase 1, Peroxisomal) is a Protein Coding gene. Among its related pathways are Peroxisome and Fatty Acid Biosynthesis. GO annotations related to this gene include receptor binding and isomerase activity. An important paralog of this gene is CDY1B.

UniProtKB/Swiss-Prot for ECH1 Gene

  • Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.

Gene Wiki entry for ECH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ECH1 Gene

Genomics for ECH1 Gene

Regulatory Elements for ECH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ECH1 Gene

38,815,422 bp from pter
38,832,005 bp from pter
16,584 bases
Minus strand

Genomic View for ECH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ECH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECH1 Gene

Proteins for ECH1 Gene

  • Protein details for ECH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K745
    • Q8WVX0
    • Q96EZ9

    Protein attributes for ECH1 Gene

    328 amino acids
    Molecular mass:
    35816 Da
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for ECH1 Gene

neXtProt entry for ECH1 Gene

Proteomics data for ECH1 Gene at MOPED

Post-translational modifications for ECH1 Gene

  • Ubiquitination at Lys214, Lys231, and Lys276
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ECH1 Gene

Domains for ECH1 Gene

Suggested Antigen Peptide Sequences for ECH1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q13011
  • Belongs to the enoyl-CoA hydratase/isomerase family.
genes like me logo Genes that share domains with ECH1: view

No data available for Gene Families for ECH1 Gene

Function for ECH1 Gene

Molecular function for ECH1 Gene

GENATLAS Biochemistry:
peroxisomal matrix protein,enoyl-CoA hydratase-like
UniProtKB/Swiss-Prot Function:
Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.

Enzyme Numbers (IUBMB) for ECH1 Gene

Gene Ontology (GO) - Molecular Function for ECH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 15383276
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with ECH1: view

Phenotypes for ECH1 Gene

GenomeRNAi human phenotypes for ECH1:
genes like me logo Genes that share phenotypes with ECH1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ECH1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ECH1 Gene

Localization for ECH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ECH1 Gene

Mitochondrion. Peroxisome.

Subcellular locations from

Jensen Localization Image for ECH1 Gene COMPARTMENTS Subcellular localization image for ECH1 gene
Compartment Confidence
peroxisome 5
mitochondrion 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ECH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome NAS 7558027
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with ECH1: view

Pathways for ECH1 Gene

genes like me logo Genes that share pathways with ECH1: view

Pathways by source for ECH1 Gene

1 BioSystems pathway for ECH1 Gene
1 PharmGKB pathway for ECH1 Gene
1 KEGG pathway for ECH1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q13011-ECH1_HUMAN

  • Pathway: Lipid metabolism; fatty acid beta-oxidation

Gene Ontology (GO) - Biological Process for ECH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006635 fatty acid beta-oxidation IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ECH1: view

Compounds for ECH1 Gene

(1) HMDB Compounds for ECH1 Gene

Compound Synonyms Cas Number PubMed IDs
  • S-[(3E,5Z)-3,5-octadienoate Coenzyme A
genes like me logo Genes that share compounds with ECH1: view

Transcripts for ECH1 Gene

Unigene Clusters for ECH1 Gene

Enoyl CoA hydratase 1, peroxisomal:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ECH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ECH1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - -
SP7: - - - -
SP8: - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: - - -

Relevant External Links for ECH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ECH1 Gene

mRNA expression in normal human tissues for ECH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ECH1 Gene

This gene is overexpressed in Heart - Left Ventricle (4.8).

Protein differential expression in normal tissues for ECH1 Gene

This gene is overexpressed in Liver, secretome (13.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ECH1 Gene

SOURCE GeneReport for Unigene cluster for ECH1 Gene Hs.196176

genes like me logo Genes that share expressions with ECH1: view

Expression partners for ECH1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ECH1 Gene

Orthologs for ECH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ECH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ECH1 35
  • 83.02 (n)
  • 78.93 (a)
ECH1 36
  • 77 (a)
(Canis familiaris)
Mammalia ECH1 35
  • 84.22 (n)
  • 80.37 (a)
ECH1 36
  • 74 (a)
(Mus musculus)
Mammalia Ech1 35
  • 79.92 (n)
  • 74.31 (a)
Ech1 16
Ech1 36
  • 74 (a)
(Pan troglodytes)
Mammalia ECH1 35
  • 97.56 (n)
  • 96.95 (a)
ECH1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ech1 35
  • 79.92 (n)
  • 75.84 (a)
(Monodelphis domestica)
Mammalia ECH1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia ECH1 36
  • 78 (a)
(Gallus gallus)
Aves ECH1 35
  • 67.91 (n)
  • 64.18 (a)
ECH1 36
  • 55 (a)
(Anolis carolinensis)
Reptilia ECH1 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ech1 35
  • 67.02 (n)
  • 71.89 (a)
Str.16617 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24814 35
(Danio rerio)
Actinopterygii Dr.14998 35
ech1 35
  • 66.67 (n)
  • 70.91 (a)
ech1 36
  • 65 (a)
ECH1 (2 of 2) 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9577 37
  • 49 (a)
CG9577 35
  • 61.15 (n)
  • 53.6 (a)
CG9577 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002661 35
  • 58.21 (n)
  • 50 (a)
(Caenorhabditis elegans)
Secernentea F58A6.1 37
  • 43 (a)
Y25C1A.13 37
  • 42 (a)
F58A6.1 35
  • 51.04 (n)
  • 45.79 (a)
F58A6.1 36
  • 46 (a)
Y25C1A.13 36
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DCI1 35
  • 47.3 (n)
  • 45.22 (a)
(Oryza sativa)
Liliopsida Os01g0925200 35
  • 53.55 (n)
  • 43.75 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06647 35
  • 54.17 (n)
  • 47.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2191 36
  • 63 (a)
Species with no ortholog for ECH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ECH1 Gene

Gene Tree for ECH1 (if available)
Gene Tree for ECH1 (if available)

Paralogs for ECH1 Gene

Paralogs for ECH1 Gene

Selected SIMAP similar genes for ECH1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ECH1: view

Variants for ECH1 Gene

Sequence variations from dbSNP and Humsavar for ECH1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9419 - 38,831,447(-) AGAGG(A/C)GGCTT reference, missense
rs10967 -- 38,815,564(-) CCGCC(G/T)CATCC utr-variant-3-prime
rs15570 -- 38,817,550(-) GCTTC(A/G)GACAT synonymous-codon, reference, utr-variant-5-prime
rs889327 -- 38,819,580(-) CAGCT(C/T)GTGTG intron-variant, utr-variant-5-prime
rs1064972 -- 38,815,927(-) CGTGG(C/T)GGTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ECH1 Gene

Variant ID Type Subtype PubMed ID
nsv7307 OTHER Inversion 18451855
nsv911670 CNV Gain 21882294
dgv3859n71 CNV Loss 21882294
nsv175 OTHER Inversion 15895083
nsv9722 CNV Gain 18304495

Relevant External Links for ECH1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECH1 Gene

Disorders for ECH1 Gene

Relevant External Links for ECH1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ECH1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ECH1 Gene

Publications for ECH1 Gene

  1. Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase. (PMID: 7558027) Fitzpatrick D.R. … Valle D. (Genomics 1995) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PMID: 21081666) Greco T.M. … Cristea I.M. (Mol. Cell Proteomics 2011) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ECH1 Gene

  • Addgene plasmids for ECH1

Sources for ECH1 Gene

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