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Aliases for EBF1 Gene

Aliases for EBF1 Gene

  • Early B-Cell Factor 1 2 3
  • EBF 3 4 6
  • Early B-Cell Factor 2 4
  • O/E-1 3 4
  • OLF1 3 6
  • COE1 3 4
  • OE-1 3 4
  • Collier, Olf And EBF Transcription Factor 1 3
  • Olfactory Neuronal Transcription Factor 1 3
  • Transcription Factor COE1 3

External Ids for EBF1 Gene

Previous Symbols for EBF1 Gene

  • EBF

Summaries for EBF1 Gene

GeneCards Summary for EBF1 Gene

EBF1 (Early B-Cell Factor 1) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Adipogenesis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is EBF2.

UniProtKB/Swiss-Prot for EBF1 Gene

  • Transcriptional activator which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

Gene Wiki entry for EBF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBF1 Gene

Genomics for EBF1 Gene

Genomic Location for EBF1 Gene

158,695,908 bp from pter
159,099,780 bp from pter
403,873 bases
Minus strand

Genomic View for EBF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EBF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBF1 Gene

Regulatory Elements for EBF1 Gene

Proteins for EBF1 Gene

  • Protein details for EBF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor COE1
    Protein Accession:
    Secondary Accessions:
    • Q8IW11

    Protein attributes for EBF1 Gene

    591 amino acids
    Molecular mass:
    64464 Da
    Quaternary structure:
    • Forms either a homodimer or a heterodimer with a related family member (By similarity). Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes.

    Three dimensional structures from OCA and Proteopedia for EBF1 Gene

    Alternative splice isoforms for EBF1 Gene


neXtProt entry for EBF1 Gene

Proteomics data for EBF1 Gene at MOPED

Post-translational modifications for EBF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EBF1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EBF1 Gene

Domains for EBF1 Gene

Suggested Antigen Peptide Sequences for EBF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IPT/TIG domain.:
    • Q9UH73
  • Belongs to the COE family.:
    • Q9UH73
genes like me logo Genes that share domains with EBF1: view

No data available for Gene Families for EBF1 Gene

Function for EBF1 Gene

Molecular function for EBF1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

Gene Ontology (GO) - Molecular Function for EBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with EBF1: view
genes like me logo Genes that share phenotypes with EBF1: view

Animal Models for EBF1 Gene

MGI Knock Outs for EBF1:

miRNA for EBF1 Gene

miRTarBase miRNAs that target EBF1
Targeting motifs for EBF1 Gene
HOMER Transcription Factor Regulatory Elements motif EBF1
  • Consensus sequence: GGTCCCTAGGGA Submotif: canonical Cell Type: proBcell GeoId: GSE21978

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for EBF1 Gene

Localization for EBF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBF1 Gene

Subcellular locations from

Jensen Localization Image for EBF1 Gene COMPARTMENTS Subcellular localization image for EBF1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for EBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EBF1: view

Pathways for EBF1 Gene

genes like me logo Genes that share pathways with EBF1: view

Pathways by source for EBF1 Gene

1 BioSystems pathway for EBF1 Gene

Gene Ontology (GO) - Biological Process for EBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007275 multicellular organismal development IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with EBF1: view

Transcripts for EBF1 Gene

Unigene Clusters for EBF1 Gene

Early B-cell factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EBF1 Gene

No ASD Table

Relevant External Links for EBF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EBF1 Gene

mRNA expression in normal human tissues for EBF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EBF1 Gene

This gene is overexpressed in Adipose - Subcutaneous (4.7) and Artery - Tibial (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EBF1 Gene

SOURCE GeneReport for Unigene cluster for EBF1 Gene Hs.573143

genes like me logo Genes that share expressions with EBF1: view

No data available for mRNA Expression by UniProt/SwissProt for EBF1 Gene

Orthologs for EBF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EBF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EBF1 35
  • 99.77 (n)
  • 100 (a)
EBF1 36
  • 100 (a)
(Bos Taurus)
Mammalia EBF1 35
  • 95.43 (n)
  • 99.49 (a)
EBF1 36
  • 99 (a)
(Canis familiaris)
Mammalia EBF1 35
  • 95.94 (n)
  • 99.32 (a)
EBF1 36
  • 98 (a)
(Mus musculus)
Mammalia Ebf1 35
  • 94.08 (n)
  • 100 (a)
Ebf1 16
Ebf1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia EBF1 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia EBF1 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Ebf1 35
  • 94.29 (n)
  • 99.83 (a)
(Gallus gallus)
Aves EBF1 35
  • 86.63 (n)
  • 98.48 (a)
EBF1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
-- 36
  • 78 (a)
-- 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ebf1 35
  • 81.44 (n)
  • 94.59 (a)
(Danio rerio)
Actinopterygii coe2 35
EBF1 (3 of 3) 36
  • 88 (a)
ebf1a 35
  • 79.08 (n)
  • 93.57 (a)
ebf1a 36
  • 94 (a)
ebf1b 36
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta kn 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea unc-3 35
  • 64.11 (n)
  • 70.14 (a)
unc-3 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for EBF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EBF1 Gene

Gene Tree for EBF1 (if available)
Gene Tree for EBF1 (if available)

Paralogs for EBF1 Gene

Paralogs for EBF1 Gene

Selected SIMAP similar genes for EBF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EBF1: view

Variants for EBF1 Gene

Sequence variations from dbSNP and Humsavar for EBF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs891903 -- 158,852,630(-) TGGAT(C/T)GTCTA intron-variant
rs891904 -- 158,840,465(-) TTAAA(C/T)TGCAT intron-variant
rs891905 -- 158,840,415(-) ATCCA(A/G)TTGGA intron-variant
rs929626 -- 158,883,623(-) GGAGA(C/T)GGTAA intron-variant
rs929779 -- 159,061,190(-) TGTTT(G/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EBF1 Gene

Variant ID Type Subtype PubMed ID
nsv5093 CNV Insertion 18451855
nsv830528 CNV Gain 17160897
esv999938 CNV Deletion 20482838
dgv153e180 CNV Loss 20482838
esv6691 CNV Gain 19470904
nsv5094 CNV Insertion 18451855
esv2730966 CNV Deletion 23290073
esv2730967 CNV Deletion 23290073
esv2730968 CNV Deletion 23290073
nsv524803 CNV Loss 19592680
nsv526407 CNV Loss 19592680

Relevant External Links for EBF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBF1 Gene

Disorders for EBF1 Gene

(2) Novoseek inferred disease relationships for EBF1 Gene

Disease -log(P) Hits PubMed IDs
plasmacytoma 65 1
tumors 0 1

Relevant External Links for EBF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with EBF1: view

No data available for UniProtKB/Swiss-Prot for EBF1 Gene

Publications for EBF1 Gene

  1. Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11. (PMID: 8012110) Milatovich A. … Francke U. (Mamm. Genome 1994) 2 3 23
  2. Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse. (PMID: 10942392) Gisler R. … Sigvardsson M. (Blood 2000) 3 4 23
  3. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. (PMID: 14630787) Bond H.M. … Venuta S. (Blood 2004) 3 4 23
  4. The human V-preB promoter is a target for coordinated activation by early B cell factor and E47. (PMID: 11994467) Gisler R. … Sigvardsson M. (J. Immunol. 2002) 3 23
  5. Inhibition of p300/CBP by early B-cell factor. (PMID: 12748286) Zhao F. … Kadesch T. (Mol. Cell. Biol. 2003) 3 23

Products for EBF1 Gene

Sources for EBF1 Gene

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