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Aliases for EBF1 Gene

Aliases for EBF1 Gene

  • Early B-Cell Factor 1 2 3 5
  • Early B-Cell Factor 2 4
  • O/E-1 3 4
  • COE1 3 4
  • EBF 3 4
  • Collier, Olf And EBF Transcription Factor 1 3
  • Olfactory Neuronal Transcription Factor 1 3
  • OLF1 3
  • OE-1 4

External Ids for EBF1 Gene

Previous HGNC Symbols for EBF1 Gene

  • EBF

Previous GeneCards Identifiers for EBF1 Gene

  • GC05M158059
  • GC05M153220
  • GC05M158123
  • GC05M158126

Summaries for EBF1 Gene

GeneCards Summary for EBF1 Gene

EBF1 (Early B-Cell Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include Plasmacytoma and Fetal Erythroblastosis. Among its related pathways are Developmental Biology and Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and C2H2 zinc finger domain binding. An important paralog of this gene is EBF2.

UniProtKB/Swiss-Prot for EBF1 Gene

  • Transcriptional activator which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

Gene Wiki entry for EBF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBF1 Gene

Genomics for EBF1 Gene

Regulatory Elements for EBF1 Gene

Enhancers for EBF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EBF1 on UCSC Golden Path with GeneCards custom track

Promoters for EBF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EBF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EBF1 Gene

158,695,908 bp from pter
159,099,780 bp from pter
403,873 bases
Minus strand

Genomic View for EBF1 Gene

Genes around EBF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBF1 Gene

Proteins for EBF1 Gene

  • Protein details for EBF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor COE1
    Protein Accession:
    Secondary Accessions:
    • Q8IW11

    Protein attributes for EBF1 Gene

    591 amino acids
    Molecular mass:
    64464 Da
    Quaternary structure:
    • Forms either a homodimer or a heterodimer with a related family member (By similarity). Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes.

    Three dimensional structures from OCA and Proteopedia for EBF1 Gene

    Alternative splice isoforms for EBF1 Gene


neXtProt entry for EBF1 Gene

Proteomics data for EBF1 Gene at MOPED

Post-translational modifications for EBF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for EBF1 Gene

Domains & Families for EBF1 Gene

Suggested Antigen Peptide Sequences for EBF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IPT/TIG domain.
  • Belongs to the COE family.
  • Contains 1 IPT/TIG domain.
  • Belongs to the COE family.
genes like me logo Genes that share domains with EBF1: view

No data available for Gene Families for EBF1 Gene

Function for EBF1 Gene

Molecular function for EBF1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which recognizes variations of the palindromic sequence 5-ATTCCCNNGGGAATT-3.

Gene Ontology (GO) - Molecular Function for EBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0046983 protein dimerization activity IEA --
GO:0070742 C2H2 zinc finger domain binding IEA --
genes like me logo Genes that share ontologies with EBF1: view
genes like me logo Genes that share phenotypes with EBF1: view

Animal Models for EBF1 Gene

MGI Knock Outs for EBF1:

Animal Model Products

Targeted motifs for EBF1 Gene
HOMER Transcription Factor Regulatory Elements motif EBF1
  • Consensus sequence: GGTCCCTAGGGA Submotif: canonical Cell Type: proBcell GEO ID: GSE21978

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for EBF1 Gene

Localization for EBF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBF1 Gene

Subcellular locations from

Jensen Localization Image for EBF1 Gene COMPARTMENTS Subcellular localization image for EBF1 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for EBF1 Gene

Pathways & Interactions for EBF1 Gene

genes like me logo Genes that share pathways with EBF1: view

Pathways by source for EBF1 Gene

1 BioSystems pathway for EBF1 Gene

SIGNOR curated interactions for EBF1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with EBF1: view

Drugs & Compounds for EBF1 Gene

No Compound Related Data Available

Transcripts for EBF1 Gene

Unigene Clusters for EBF1 Gene

Early B-cell factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EBF1 Gene

No ASD Table

Relevant External Links for EBF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EBF1 Gene

mRNA expression in normal human tissues for EBF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EBF1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.7) and Artery - Tibial (x4.4).

Protein differential expression in normal tissues from HIPED for EBF1 Gene

This gene is overexpressed in Blymphocyte (48.0) and Heart (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EBF1 Gene

SOURCE GeneReport for Unigene cluster for EBF1 Gene Hs.573143

genes like me logo Genes that share expression patterns with EBF1: view

Protein tissue co-expression partners for EBF1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for EBF1 Gene

Orthologs for EBF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EBF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EBF1 35
  • 95.43 (n)
  • 99.49 (a)
EBF1 36
  • 99 (a)
(Canis familiaris)
Mammalia EBF1 35
  • 95.94 (n)
  • 99.32 (a)
EBF1 36
  • 98 (a)
(Mus musculus)
Mammalia Ebf1 35
  • 94.08 (n)
  • 100 (a)
Ebf1 16
Ebf1 36
  • 100 (a)
(Pan troglodytes)
Mammalia EBF1 35
  • 99.77 (n)
  • 100 (a)
EBF1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ebf1 35
  • 94.29 (n)
  • 99.83 (a)
(Monodelphis domestica)
Mammalia EBF1 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia EBF1 36
  • 96 (a)
(Gallus gallus)
Aves EBF1 35
  • 86.63 (n)
  • 98.48 (a)
EBF1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
-- 36
  • 78 (a)
-- 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ebf1 35
  • 81.44 (n)
  • 94.59 (a)
(Danio rerio)
Actinopterygii coe2 35
ebf1a 35
  • 79.08 (n)
  • 93.57 (a)
EBF1 (3 of 3) 36
  • 88 (a)
ebf1a 36
  • 94 (a)
ebf1b 36
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta kn 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea unc-3 35
  • 64.11 (n)
  • 70.14 (a)
unc-3 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for EBF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EBF1 Gene

Gene Tree for EBF1 (if available)
Gene Tree for EBF1 (if available)

Paralogs for EBF1 Gene

Paralogs for EBF1 Gene

(4) SIMAP similar genes for EBF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EBF1: view

Variants for EBF1 Gene

Sequence variations from dbSNP and Humsavar for EBF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs717563 -- 158,897,528(-) ATATA(A/G)GTAAA intron-variant
rs717564 -- 158,897,698(-) CTTCT(A/G)TGAAA intron-variant
rs869591 -- 159,003,040(+) ATTTA(C/T)ATATA intron-variant
rs869592 -- 159,003,179(+) TAACT(C/G)TGTTA intron-variant
rs869593 -- 159,003,867(-) TACAC(A/C)ACTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EBF1 Gene

Variant ID Type Subtype PubMed ID
nsv5093 CNV Insertion 18451855
nsv830528 CNV Gain 17160897
esv999938 CNV Deletion 20482838
dgv153e180 CNV Loss 20482838
esv6691 CNV Gain 19470904
nsv5094 CNV Insertion 18451855
esv2730966 CNV Deletion 23290073
esv2730967 CNV Deletion 23290073
esv2730968 CNV Deletion 23290073
nsv524803 CNV Loss 19592680
nsv526407 CNV Loss 19592680

Variation tolerance for EBF1 Gene

Residual Variation Intolerance Score: 7.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EBF1 Gene

Disorders for EBF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EBF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • myeloma - solitary
fetal erythroblastosis
  • ef - erythroblastosis foetalis
- elite association - COSMIC cancer census association via MalaCards
Search EBF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EBF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EBF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EBF1 Gene

Publications for EBF1 Gene

  1. Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11. (PMID: 8012110) Milatovich A. … Francke U. (Mamm. Genome 1994) 2 3 23 67
  2. Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. (PMID: 15920012) Smith E.M. … Sigvardsson M. (Blood 2005) 3 23
  3. Early B-cell Factor gene association with multiple sclerosis in the Spanish population. (PMID: 16255771) MartA-nez A. … Urcelay E. (BMC Neurol 2005) 3 23
  4. CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. (PMID: 14594818) Merluzzi S. … Pucillo C. (J. Biol. Chem. 2004) 3 23
  5. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. (PMID: 14630787) Bond H.M. … Venuta S. (Blood 2004) 3 23

Products for EBF1 Gene

Sources for EBF1 Gene