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Aliases for E4F1 Gene

Aliases for E4F1 Gene

  • E4F Transcription Factor 1 2 3 4
  • E4F 3 4 6
  • Putative E3 Ubiquitin-Protein Ligase E4F1 3 4
  • Transcription Factor E4F 3 4
  • P120E4F 3 4
  • P50E4F 3 4
  • Transcription Factor E4F1 3
  • EC 6.3.2.- 4

External Ids for E4F1 Gene

Previous GeneCards Identifiers for E4F1 Gene

  • GC16M002500
  • GC16P002299
  • GC16P002213
  • GC16P002274
  • GC16P002199
  • GC16P002275
  • GC16P002276

Summaries for E4F1 Gene

Entrez Gene Summary for E4F1 Gene

  • The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]

GeneCards Summary for E4F1 Gene

E4F1 (E4F Transcription Factor 1) is a Protein Coding gene. Among its related pathways are p53 pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity.

UniProtKB/Swiss-Prot for E4F1 Gene

  • May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription

  • Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes

Gene Wiki entry for E4F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E4F1 Gene

Genomics for E4F1 Gene

Regulatory Elements for E4F1 Gene

Genomic Location for E4F1 Gene

Start:
2,223,488 bp from pter
End:
2,235,742 bp from pter
Size:
12,255 bases
Orientation:
Plus strand

Genomic View for E4F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for E4F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E4F1 Gene

Proteins for E4F1 Gene

  • Protein details for E4F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K89-E4F1_HUMAN
    Recommended name:
    Transcription factor E4F1
    Protein Accession:
    Q66K89
    Secondary Accessions:
    • A8K2R4
    • O00146

    Protein attributes for E4F1 Gene

    Size:
    784 amino acids
    Molecular mass:
    83496 Da
    Quaternary structure:
    • Homodimer; binds DNA as a dimer. Forms a complex with CDKN2A and TP53. Interactions with TP53, RB1, ANP32A, BMI1 and FHL2 regulate E4F1 activity. Interacts with HDAC1, HMGA2 and RASSF1. Interacts with HBV protein X.

neXtProt entry for E4F1 Gene

Proteomics data for E4F1 Gene at MOPED

Post-translational modifications for E4F1 Gene

  • May be sumoylated by UBE2I upon interaction with CDKN2A.
  • Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent and differentially regulates DNA-binding activity and function of both forms.
  • Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity and activates transcription in presence of the adenoviral E1A protein. The major full length protein (p120E4F) functions as a repressor of transcription.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for E4F1 Gene

No data available for DME Specific Peptides for E4F1 Gene

Domains for E4F1 Gene

Gene Families for E4F1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for E4F1 Gene

Suggested Antigen Peptide Sequences for E4F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q66K89

UniProtKB/Swiss-Prot:

E4F1_HUMAN :
  • Q66K89
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with E4F1: view

Function for E4F1 Gene

Molecular function for E4F1 Gene

GENATLAS Biochemistry: transcription factor E4F1,adenovirus EIA regulated,with low spliced isoforms,one 120kDa) upregulated,50kDa,down-regulated
UniProtKB/Swiss-Prot Function: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription
UniProtKB/Swiss-Prot Function: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes
UniProtKB/Swiss-Prot Induction: Up-regulated by estrogen.

Enzyme Numbers (IUBMB) for E4F1 Gene

Gene Ontology (GO) - Molecular Function for E4F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 2169022
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IC --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding TAS 10869426
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10869426
genes like me logo Genes that share ontologies with E4F1: view
genes like me logo Genes that share phenotypes with E4F1: view

Animal Models for E4F1 Gene

MGI Knock Outs for E4F1:

miRNA for E4F1 Gene

miRTarBase miRNAs that target E4F1

No data available for Transcription Factor Targeting and HOMER Transcription for E4F1 Gene

Localization for E4F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E4F1 Gene

Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E4F1 Gene COMPARTMENTS Subcellular localization image for E4F1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for E4F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with E4F1: view

Pathways for E4F1 Gene

SuperPathways for E4F1 Gene

Superpath Contained pathways
1 p53 pathway
genes like me logo Genes that share pathways with E4F1: view

Pathways by source for E4F1 Gene

1 BioSystems pathway for E4F1 Gene

UniProtKB/Swiss-Prot Q66K89-E4F1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for E4F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14645522
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008283 cell proliferation TAS 10869426
genes like me logo Genes that share ontologies with E4F1: view

Transcripts for E4F1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for E4F1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for E4F1 Gene

GeneLoc Exon Structure for
E4F1
ECgene alternative splicing isoforms for
E4F1

Expression for E4F1 Gene

mRNA expression in normal human tissues for E4F1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for E4F1 Gene

SOURCE GeneReport for Unigene cluster for E4F1 Gene Hs.513268

mRNA Expression by UniProt/SwissProt for E4F1 Gene

Q66K89-E4F1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with E4F1: view

No data available for mRNA differential expression in normal tissues for E4F1 Gene

Orthologs for E4F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for E4F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E4F1 35
  • 98.04 (n)
  • 97.53 (a)
E4F1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia E4F1 35
  • 87.75 (n)
  • 88.86 (a)
E4F1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia E4F1 35
  • 86.72 (n)
  • 88.17 (a)
E4F1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E4f1 35
  • 85.73 (n)
  • 88.46 (a)
E4f1 16
E4f1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia E4F1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E4F1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E4f1 35
  • 84.72 (n)
  • 87.71 (a)
chicken
(Gallus gallus)
Aves E4F1 35
  • 68.82 (n)
  • 71.25 (a)
E4F1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E4F1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e4f1 35
  • 65.69 (n)
  • 63.05 (a)
Str.8417 35
zebrafish
(Danio rerio)
Actinopterygii e4f1 35
  • 58.26 (n)
  • 52.2 (a)
e4f1 36
  • 48 (a)
OneToOne
Species with no ortholog for E4F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for E4F1 Gene

ENSEMBL:
Gene Tree for E4F1 (if available)
TreeFam:
Gene Tree for E4F1 (if available)

Paralogs for E4F1 Gene

genes like me logo Genes that share paralogs with E4F1: view

No data available for Paralogs for E4F1 Gene

Variants for E4F1 Gene

Sequence variations from dbSNP and Humsavar for E4F1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs26837 -- 2,230,317(+) GGGCA(A/G)GCTCT intron-variant
rs26838 -- 2,231,150(+) TGGCA(C/G)AGGGT intron-variant
rs26839 - 2,232,255(+) CCCCC(A/G)CCAGC missense, reference, nc-transcript-variant
rs27382 -- 2,230,276(+) TCCCT(A/G)ATGTG intron-variant
rs27709 -- 2,231,828(+) CGGCT(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E4F1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv471072 CNV Loss 18288195
dgv2557n71 CNV Loss 21882294
dgv2558n71 CNV Loss 21882294
dgv2562n71 CNV Loss 21882294
dgv2563n71 CNV Loss 21882294
nsv457351 CNV Loss 19166990
nsv905132 CNV Loss 21882294
nsv1711 CNV Insertion 18451855
nsv905139 CNV Loss 21882294
esv2673834 CNV Deletion 23128226
dgv2567n71 CNV Loss 21882294
esv2750378 CNV Deletion 23290073
nsv905142 CNV Loss 21882294

Relevant External Links for E4F1 Gene

HapMap Linkage Disequilibrium report
E4F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E4F1 Gene

Disorders for E4F1 Gene

(1) Novoseek inferred disease relationships for E4F1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
genes like me logo Genes that share disorders with E4F1: view

No data available for UniProtKB/Swiss-Prot for E4F1 Gene

Publications for E4F1 Gene

  1. The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. (PMID: 9121437) Fernandes E.R. … Rooney R.J. (Mol. Cell. Biol. 1997) 3 4 23
  2. Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. (PMID: 9763670) Saccone S. … Del Sal G. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. (PMID: 12446718) Rizos H. … Kefford R.F. (J. Biol. Chem. 2003) 3 4 23
  4. Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (PMID: 14729613) Fenton S.L. … Latif F. (Cancer Res. 2004) 3 4 23
  5. E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. (PMID: 15579445) Nakamura Y. … Sasano H. (Am. J. Pathol. 2004) 3 4 23

Products for E4F1 Gene

Sources for E4F1 Gene

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