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Aliases for E2F5 Gene

Aliases for E2F5 Gene

  • E2F Transcription Factor 5, P130-Binding 2 3
  • E2F-5 3 4

External Ids for E2F5 Gene

Previous GeneCards Identifiers for E2F5 Gene

  • GC08P084913
  • GC08P086046
  • GC08P085869
  • GC08P086164
  • GC08P086276
  • GC08P081583
  • GC08P086089

Summaries for E2F5 Gene

Entrez Gene Summary for E2F5 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F5 Gene

E2F5 (E2F Transcription Factor 5, P130-Binding) is a Protein Coding gene. Diseases associated with E2F5 include retinal cancer and retinoblastoma. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is E2F1.

UniProtKB/Swiss-Prot for E2F5 Gene

  • Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Wiki entry for E2F5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F5 Gene

Genomics for E2F5 Gene

Regulatory Elements for E2F5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for E2F5 Gene

Chromosome:
8
Start:
85,177,056 bp from pter
End:
85,217,158 bp from pter
Size:
40,103 bases
Orientation:
Plus strand

Genomic View for E2F5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for E2F5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F5 Gene

Proteins for E2F5 Gene

  • Protein details for E2F5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15329-E2F5_HUMAN
    Recommended name:
    Transcription factor E2F5
    Protein Accession:
    Q15329
    Secondary Accessions:
    • E9PBN9
    • Q16601
    • Q92756

    Protein attributes for E2F5 Gene

    Size:
    346 amino acids
    Molecular mass:
    37610 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Alternative splice isoforms for E2F5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for E2F5 Gene

Proteomics data for E2F5 Gene at MOPED

Post-translational modifications for E2F5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for E2F5 Gene

Domains & Families for E2F5 Gene

Gene Families for E2F5 Gene

Suggested Antigen Peptide Sequences for E2F5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15329

UniProtKB/Swiss-Prot:

E2F5_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F5: view

Function for E2F5 Gene

Molecular function for E2F5 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Ontology (GO) - Molecular Function for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16360038
GO:0008134 transcription factor binding IPI 16360038
genes like me logo Genes that share ontologies with E2F5: view
genes like me logo Genes that share phenotypes with E2F5: view

Animal Models for E2F5 Gene

MGI Knock Outs for E2F5:

Animal Model Products

Transcription Factor Targets for E2F5 Gene

Selected GeneGlobe predicted Target genes for E2F5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for E2F5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for E2F5 Gene

Localization for E2F5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F5 Gene COMPARTMENTS Subcellular localization image for E2F5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with E2F5: view

Pathways & Interactions for E2F5 Gene

genes like me logo Genes that share pathways with E2F5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Stem Cell Signaling in human,mouse,rat
    • TGFB Signaling Targets in human,mouse,rat

Gene Ontology (GO) - Biological Process for E2F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with E2F5: view

No data available for SIGNOR curated interactions for E2F5 Gene

Drugs & Compounds for E2F5 Gene

(1) Additional Compounds for E2F5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dihydrofolate
genes like me logo Genes that share compounds with E2F5: view

Transcripts for E2F5 Gene

Unigene Clusters for E2F5 Gene

E2F transcription factor 5, p130-binding:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for E2F5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1:
SP2:
SP3:

Relevant External Links for E2F5 Gene

GeneLoc Exon Structure for
E2F5
ECgene alternative splicing isoforms for
E2F5

Expression for E2F5 Gene

mRNA expression in normal human tissues for E2F5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for E2F5 Gene



SOURCE GeneReport for Unigene cluster for E2F5 Gene Hs.445758

genes like me logo Genes that share expression patterns with E2F5: view

Protein tissue co-expression partners for E2F5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for E2F5 Gene

Orthologs for E2F5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for E2F5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia E2F5 35
  • 90.68 (n)
  • 91.96 (a)
E2F5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia E2F5 35
  • 94.05 (n)
  • 96.65 (a)
E2F5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E2f5 35
  • 88.56 (n)
  • 88.96 (a)
E2f5 16
E2f5 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia E2F5 35
  • 99.9 (n)
  • 100 (a)
E2F5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f5 35
  • 88.46 (n)
  • 89.05 (a)
oppossum
(Monodelphis domestica)
Mammalia E2F5 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F5 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F5 35
  • 75 (n)
  • 80.3 (a)
E2F5 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F5 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f5 35
  • 72.48 (n)
  • 81.21 (a)
zebrafish
(Danio rerio)
Actinopterygii e2f5 35
  • 64.99 (n)
  • 66.89 (a)
e2f5 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta E2f2 35
  • 46.48 (n)
  • 35.13 (a)
E2f2 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-1 37
  • 41 (a)
efl-1 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons E2F1 35
  • 51.85 (n)
  • 43.25 (a)
Species with no ortholog for E2F5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F5 Gene

ENSEMBL:
Gene Tree for E2F5 (if available)
TreeFam:
Gene Tree for E2F5 (if available)

Paralogs for E2F5 Gene

Paralogs for E2F5 Gene

(3) SIMAP similar genes for E2F5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with E2F5: view

Variants for E2F5 Gene

Sequence variations from dbSNP and Humsavar for E2F5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1137517 -- 85,210,602(+) cttga(A/C)cccag intron-variant
rs2278459 -- 85,202,443(-) CCCAA(C/T)ATCCA intron-variant
rs2283745 -- 85,181,074(-) atggc(A/G)aaatc intron-variant
rs2403083 -- 85,195,914(+) AATAT(A/C)TTTTT intron-variant
rs2403084 -- 85,199,247(+) acctt(C/T)gtgct intron-variant

Variation tolerance for E2F5 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for E2F5 Gene

HapMap Linkage Disequilibrium report
E2F5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for E2F5 Gene

Disorders for E2F5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for E2F5 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
retinal cancer
  • neoplasm of retina
retinoblastoma
  • retinoblastoma, trilateral
- elite association
Search E2F5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for E2F5

Genetic Association Database (GAD)
E2F5
Human Genome Epidemiology (HuGE) Navigator
E2F5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
E2F5
genes like me logo Genes that share disorders with E2F5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F5 Gene

Publications for E2F5 Gene

  1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PMID: 7892279) Sardet C. … Weinberg R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 23 67
  2. Functional analysis of LOXL2 in pancreatic carcinoma. (PMID: 20012301) RA1ckert F. … Pilarsky C. (Int J Colorectal Dis 2010) 23 67
  3. E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. (PMID: 20181230) Kothandaraman N. … Choolani M. (BMC Cancer 2010) 23 67
  4. Wild-type p53 and p73 negatively regulate expression of proliferation related genes. (PMID: 17982488) Scian M.J. … Deb S. (Oncogene 2008) 23 67
  5. Human papillomavirus type 16 E7 oncoprotein associates with E2F6. (PMID: 18579589) McLaughlin-Drubin M.E. … MA1nger K. (J. Virol. 2008) 23 67

Products for E2F5 Gene

Sources for E2F5 Gene

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