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Aliases for E2F4 Gene

Aliases for E2F4 Gene

  • E2F Transcription Factor 4, P107/P130-Binding 2 3
  • E2F-4 3 4
  • P107/P130-Binding Protein 3
  • Transcription Factor E2F4 3

External Ids for E2F4 Gene

Previous GeneCards Identifiers for E2F4 Gene

  • GC16P057920
  • GC16P067603
  • GC16P066962
  • GC16P067002
  • GC16P065783
  • GC16P053100

Summaries for E2F4 Gene

Entrez Gene Summary for E2F4 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F4 Gene

E2F4 (E2F Transcription Factor 4, P107/P130-Binding) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is E2F5.

UniProtKB/Swiss-Prot for E2F4 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Wiki entry for E2F4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F4 Gene

Genomics for E2F4 Gene

Regulatory Elements for E2F4 Gene

Genomic Location for E2F4 Gene

Start:
67,192,165 bp from pter
End:
67,198,918 bp from pter
Size:
6,754 bases
Orientation:
Plus strand

Genomic View for E2F4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for E2F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F4 Gene

Proteins for E2F4 Gene

  • Protein details for E2F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16254-E2F4_HUMAN
    Recommended name:
    Transcription factor E2F4
    Protein Accession:
    Q16254
    Secondary Accessions:
    • A6NGR8
    • B5BU56
    • Q12991
    • Q15328

    Protein attributes for E2F4 Gene

    Size:
    413 amino acids
    Molecular mass:
    43960 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. The E2F4/TFDP1 dimer interacts preferentially with pocket protein RBL1, which inhibits the E2F transactivation domain. Lower affinity interaction has been found with retinoblastoma protein RB1. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Interacts with HCFC1. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5). Interacts with CEBPA (when phosphorylated) (PubMed:15107404).

    Three dimensional structures from OCA and Proteopedia for E2F4 Gene

neXtProt entry for E2F4 Gene

Proteomics data for E2F4 Gene at MOPED

Post-translational modifications for E2F4 Gene

Other Protein References for E2F4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for E2F4 Gene

Domains for E2F4 Gene

Suggested Antigen Peptide Sequences for E2F4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16254

UniProtKB/Swiss-Prot:

E2F4_HUMAN :
  • Q16254
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F4: view

No data available for Gene Families for E2F4 Gene

Function for E2F4 Gene

Molecular function for E2F4 Gene

GENATLAS Biochemistry: transcription factor E2F4,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis
UniProtKB/Swiss-Prot Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Gene Ontology (GO) - Molecular Function for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10488129
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC --
GO:0003677 DNA binding IMP 11418595
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 11418595
GO:0005515 protein binding IPI 11418595
genes like me logo Genes that share ontologies with E2F4: view
genes like me logo Genes that share phenotypes with E2F4: view

Animal Models for E2F4 Gene

MGI Knock Outs for E2F4:

Transcription Factor Targeting for E2F4 Gene

Selected GeneGlobe predicted Target genes for E2F4
Targeting motifs for E2F4 Gene
HOMER Transcription Factor Regulatory Elements motif E2F4
  • Consensus sequence: GGCGGGAAAH Submotif: canonical Cell Type: K562 GeoId: GSE31477

No data available for Enzyme Numbers (IUBMB) for E2F4 Gene

Localization for E2F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F4 Gene COMPARTMENTS Subcellular localization image for E2F4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with E2F4: view

Pathways for E2F4 Gene

genes like me logo Genes that share pathways with E2F4: view

Gene Ontology (GO) - Biological Process for E2F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA --
GO:0000278 mitotic cell cycle TAS --
GO:0002064 epithelial cell development IEA --
GO:0006351 transcription, DNA-templated TAS --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with E2F4: view

Compounds for E2F4 Gene

(6) Novoseek inferred chemical compound relationships for E2F4 Gene

Compound -log(P) Hits PubMed IDs
flavopiridol 46.3 3
roscovitine 42.7 3
serine 15.8 3
threonine 14 1
benzo(a)pyrene 12 4
genes like me logo Genes that share compounds with E2F4: view

Transcripts for E2F4 Gene

mRNA/cDNA for E2F4 Gene

Unigene Clusters for E2F4 Gene

E2F transcription factor 4, p107/p130-binding:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for E2F4 Gene

No ASD Table

Relevant External Links for E2F4 Gene

GeneLoc Exon Structure for
E2F4
ECgene alternative splicing isoforms for
E2F4

Expression for E2F4 Gene

mRNA expression in normal human tissues for E2F4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for E2F4 Gene

SOURCE GeneReport for Unigene cluster for E2F4 Gene Hs.108371

mRNA Expression by UniProt/SwissProt for E2F4 Gene

Q16254-E2F4_HUMAN
Tissue specificity: Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with E2F4: view

No data available for mRNA differential expression in normal tissues for E2F4 Gene

Orthologs for E2F4 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F4 35
  • 97.79 (n)
  • 97.05 (a)
E2F4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia E2F4 35
  • 89.5 (n)
  • 93.55 (a)
E2F4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia E2F4 35
  • 90.16 (n)
  • 92.62 (a)
E2F4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E2f4 35
  • 88.1 (n)
  • 92.91 (a)
E2f4 16
E2f4 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia E2F4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f4 35
  • 89.38 (n)
  • 93.19 (a)
chicken
(Gallus gallus)
Aves E2F4 35
  • 73.23 (n)
  • 77.66 (a)
E2F4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F4 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24786 35
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f4 35
  • 68.14 (n)
  • 73.41 (a)
Str.4585 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6688 35
zebrafish
(Danio rerio)
Actinopterygii e2f4 35
  • 65.4 (n)
  • 70.19 (a)
e2f4 36
  • 64 (a)
OneToOne
wufb72f07 35
fruit fly
(Drosophila melanogaster)
Insecta E2f2 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-1 36
  • 30 (a)
OneToMany
efl-1 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1239 36
  • 65 (a)
OneToOne
Species with no ortholog for E2F4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F4 Gene

ENSEMBL:
Gene Tree for E2F4 (if available)
TreeFam:
Gene Tree for E2F4 (if available)

Paralogs for E2F4 Gene

Paralogs for E2F4 Gene

Selected SIMAP similar genes for E2F4 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for E2F4 Gene

genes like me logo Genes that share paralogs with E2F4: view

Variants for E2F4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for E2F4 Gene

Q16254-E2F4_HUMAN
The poly-Ser region of E2F4 is polymorphic and the number of Ser varies in the population (from 8 to 17). The variation might be associated with tumorigenesis

Sequence variations from dbSNP and Humsavar for E2F4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1801013 - 67,195,850(+) CAACA(A/C)CACTG reference, missense
rs2881448 -- 67,193,806(+) AGAGG(A/G)AGAGA intron-variant
rs3730392 -- 67,192,233(+) ATGGC(A/G)GAGGC synonymous-codon, reference
rs3730393 -- 67,192,502(+) CGGGG(A/G)ATGTT intron-variant
rs3730394 -- 67,193,366(+) AGAAC(A/G)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E2F4 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990
dgv2889n71 CNV Loss 21882294

Relevant External Links for E2F4 Gene

HapMap Linkage Disequilibrium report
E2F4

Disorders for E2F4 Gene

(1) University of Copenhagen DISEASES for E2F4 Gene

(14) Novoseek inferred disease relationships for E2F4 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 79.3 4
microsatellite instability 57.7 1
tumors 34.8 17
cancer 24.5 7
colon cancer 23.6 3

Relevant External Links for E2F4

Genetic Association Database (GAD)
E2F4
Human Genome Epidemiology (HuGE) Navigator
E2F4
genes like me logo Genes that share disorders with E2F4: view

No data available for UniProtKB/Swiss-Prot for E2F4 Gene

Publications for E2F4 Gene

  1. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (PMID: 7892279) Sardet C. … Weinberg R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. E2F-4, a new member of the E2F transcription factor family, interacts with p107. (PMID: 7958924) Ginsberg D. … Livingston D.M. (Genes Dev. 1994) 2 3 4 23
  3. Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4. (PMID: 10679953) Zhong X. … Shimatake H. (Hum. Mutat. 2000) 3 4 23
  4. Genomic structure and mutation screening of the E2F4 gene in human tumors. (PMID: 10797289) Schwemmle S. … Pfeifer G.P. (Int. J. Cancer 2000) 3 4 23
  5. E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PMID: 11418595) Lang S.E. … Hearing P. (J. Biol. Chem. 2001) 3 4 23

Products for E2F4 Gene

  • Addgene plasmids for E2F4

Sources for E2F4 Gene

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