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Aliases for E2F3 Gene

Aliases for E2F3 Gene

  • E2F Transcription Factor 3 2 3 5
  • E2F-3 3 4
  • KIAA0075 4

External Ids for E2F3 Gene

Previous GeneCards Identifiers for E2F3 Gene

  • GC06P020459
  • GC06P020510

Summaries for E2F3 Gene

Entrez Gene Summary for E2F3 Gene

  • This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for E2F3 Gene

E2F3 (E2F Transcription Factor 3) is a Protein Coding gene. Diseases associated with E2F3 include retinoblastoma and urinary bladder cancer. Among its related pathways are Signaling by GPCR and Cellular Senescence. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter binding. An important paralog of this gene is E2F1.

UniProtKB/Swiss-Prot for E2F3 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

Gene Wiki entry for E2F3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F3 Gene

Genomics for E2F3 Gene

Regulatory Elements for E2F3 Gene

Promoters for E2F3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around E2F3 on UCSC Golden Path with GeneCards custom track

Genomic Location for E2F3 Gene

Chromosome:
6
Start:
20,401,906 bp from pter
End:
20,493,715 bp from pter
Size:
91,810 bases
Orientation:
Plus strand

Genomic View for E2F3 Gene

Genes around E2F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F3 Gene

Proteins for E2F3 Gene

  • Protein details for E2F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00716-E2F3_HUMAN
    Recommended name:
    Transcription factor E2F3
    Protein Accession:
    O00716
    Secondary Accessions:
    • Q15000
    • Q68DT0
    • Q9BZ44

    Protein attributes for E2F3 Gene

    Size:
    465 amino acids
    Molecular mass:
    49162 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP.

    Alternative splice isoforms for E2F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for E2F3 Gene

Proteomics data for E2F3 Gene at MOPED

Post-translational modifications for E2F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for E2F3 Gene

No data available for DME Specific Peptides for E2F3 Gene

Domains & Families for E2F3 Gene

Gene Families for E2F3 Gene

Suggested Antigen Peptide Sequences for E2F3 Gene

Graphical View of Domain Structure for InterPro Entry

O00716

UniProtKB/Swiss-Prot:

E2F3_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F3: view

Function for E2F3 Gene

Molecular function for E2F3 Gene

GENATLAS Biochemistry:
transcription factor E2F-like 3,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis,involved in transcription repression in quiescent cell by interaction with histone deacetylase
UniProtKB/Swiss-Prot Function:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

Gene Ontology (GO) - Molecular Function for E2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with E2F3: view
genes like me logo Genes that share phenotypes with E2F3: view

Animal Models for E2F3 Gene

MGI Knock Outs for E2F3:

Animal Model Products

miRNA for E2F3 Gene

miRTarBase miRNAs that target E2F3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for E2F3 Gene

Localization for E2F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F3 Gene COMPARTMENTS Subcellular localization image for E2F3 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for E2F3 Gene

Pathways & Interactions for E2F3 Gene

genes like me logo Genes that share pathways with E2F3: view

SIGNOR curated interactions for E2F3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for E2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS 8246996
GO:0007219 Notch signaling pathway TAS --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with E2F3: view

Drugs & Compounds for E2F3 Gene

(1) Drugs for E2F3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for E2F3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with E2F3: view

Transcripts for E2F3 Gene

Unigene Clusters for E2F3 Gene

E2F transcription factor 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - -
SP2:
SP3:
SP4: - - - - - - - -

Relevant External Links for E2F3 Gene

GeneLoc Exon Structure for
E2F3
ECgene alternative splicing isoforms for
E2F3

Expression for E2F3 Gene

mRNA expression in normal human tissues for E2F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F3 Gene

This gene is overexpressed in Heart (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for E2F3 Gene



SOURCE GeneReport for Unigene cluster for E2F3 Gene Hs.269408

genes like me logo Genes that share expression patterns with E2F3: view

Protein tissue co-expression partners for E2F3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for E2F3 Gene

Orthologs for E2F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia E2F3 35
  • 94.81 (n)
  • 98.2 (a)
E2F3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f3 35
  • 90.59 (n)
  • 92.12 (a)
mouse
(Mus musculus)
Mammalia E2f3 16
E2f3 36
  • 96 (a)
OneToOne
E2f3 35
  • 92.92 (n)
  • 95.62 (a)
cow
(Bos Taurus)
Mammalia E2F3 36
  • 98 (a)
OneToOne
E2F3 35
  • 96.04 (n)
  • 97.62 (a)
oppossum
(Monodelphis domestica)
Mammalia E2F3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia E2F3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia E2F3 35
  • 98.14 (n)
  • 97.41 (a)
E2F3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F3 36
  • 87 (a)
OneToOne
E2F3 35
  • 81.25 (n)
  • 88.69 (a)
lizard
(Anolis carolinensis)
Reptilia E2F3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f3 35
  • 74.05 (n)
  • 78.67 (a)
Str.5921 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398159 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
e2f3 36
  • 48 (a)
OneToOne
e2f3 35
  • 60.08 (n)
  • 60.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta E2f 37
  • 44 (a)
E2f 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efl-2 36
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2502 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for E2F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F3 Gene

ENSEMBL:
Gene Tree for E2F3 (if available)
TreeFam:
Gene Tree for E2F3 (if available)

Paralogs for E2F3 Gene

Paralogs for E2F3 Gene

(5) SIMAP similar genes for E2F3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for E2F3 Gene

genes like me logo Genes that share paralogs with E2F3: view

Variants for E2F3 Gene

Sequence variations from dbSNP and Humsavar for E2F3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4134973 - 20,488,143(+) CCCAA(A/C/G)GGCCC nc-transcript-variant, reference, missense
rs4134982 - 20,490,197(+) ATAGC(A/G/T)ATTGC nc-transcript-variant, reference, missense
rs744143 -- 20,418,487(-) CTAAT(C/T)CTGCA intron-variant
rs746720 -- 20,417,745(+) AAGGG(G/T)TGTTT intron-variant
rs874447 -- 20,431,423(+) GCTGA(C/T)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E2F3 Gene

Variant ID Type Subtype PubMed ID
nsv883467 CNV Loss 21882294
esv2673142 CNV Deletion 23128226
nsv883468 CNV Loss 21882294

Variation tolerance for E2F3 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for E2F3 Gene

HapMap Linkage Disequilibrium report
E2F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F3 Gene

Disorders for E2F3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for E2F3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
urinary bladder cancer
  • bladder cancer
prostate cancer
  • prostate cancer, hereditary, 5
breast cancer
  • breast cancer, invasive ductal
retinal cancer
  • malignant neoplasm of retina
- elite association - COSMIC cancer census association via MalaCards
Search E2F3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for E2F3

Genetic Association Database (GAD)
E2F3
Human Genome Epidemiology (HuGE) Navigator
E2F3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
E2F3
genes like me logo Genes that share disorders with E2F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F3 Gene

Publications for E2F3 Gene

  1. The retinoblastoma protein binds to a family of E2F transcription factors. (PMID: 8246996) Lees J.A. … Helin K. (Mol. Cell. Biol. 1993) 2 3 4 67
  2. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham J.M. … Goode E.L. (Br. J. Cancer 2009) 3 23
  3. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. (PMID: 17925491) Eiring A.M. … Perrotti D. (Blood 2008) 3 23
  4. Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification. (PMID: 18037967) Hurst C.D. … Knowles M.A. (Oncogene 2008) 3 23
  5. The E2F3-Oncomir-1 axis is activated in Wilms' tumor. (PMID: 18519660) Kort E.J. … Teh B.T. (Cancer Res. 2008) 3 23

Products for E2F3 Gene

Sources for E2F3 Gene

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