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Aliases for E2F3 Gene

Aliases for E2F3 Gene

  • E2F Transcription Factor 3 2 3 5
  • E2F-3 3 4
  • Transcription Factor E2F3 3
  • KIAA0075 4

External Ids for E2F3 Gene

Previous GeneCards Identifiers for E2F3 Gene

  • GC06P020459
  • GC06P020510

Summaries for E2F3 Gene

Entrez Gene Summary for E2F3 Gene

  • This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for E2F3 Gene

E2F3 (E2F Transcription Factor 3) is a Protein Coding gene. Diseases associated with E2F3 include Retinoblastoma and Bladder Cancer. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Chronic myeloid leukemia. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and core promoter binding. An important paralog of this gene is E2F2.

UniProtKB/Swiss-Prot for E2F3 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

Gene Wiki entry for E2F3 Gene

Additional gene information for E2F3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F3 Gene

Genomics for E2F3 Gene

GeneHancer (GH) Regulatory Elements for E2F3 Gene

Promoters and enhancers for E2F3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I020400 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.5 1455 6 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 E2F3 CDKAL1 MBOAT1 RN7SL128P
GH06I020427 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.1 +26.1 26147 1 BATF ZNF644 IRF4 RELA ETV6 BCLAF1 IKZF2 RUNX3 ZNF687 NR2F1 E2F3 E2F3-IT1 RN7SL128P
GH06I020456 Enhancer 1.1 ENCODE dbSUPER 12 +56.6 56592 3.3 HDGF ARNT NCOA2 TCF12 ZNF121 ZNF766 CBX5 GATA2 ATF7 NCOA1 E2F3 RNU6-141P GC06M020495
GH06I020528 Enhancer 0.9 Ensembl ENCODE 12.5 +126.7 126695 0.8 BCOR YBX3 HDGF MEIS2 CTCF PKNOX1 ZNF792 ZNF384 ZBTB40 RAD21 E2F3 CDKAL1 ENSG00000201683
GH06I020455 Enhancer 0.9 ENCODE dbSUPER 12 +53.8 53798 1.2 BRD4 RXRA MAX REST RAD21 ZNF395 ZNF592 YY1 JUND ATF3 E2F3 RNU6-141P GC06M020495
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around E2F3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the E2F3 gene promoter:

Genomic Locations for E2F3 Gene

Genomic Locations for E2F3 Gene
chr6:20,401,906-20,493,715
(GRCh38/hg38)
Size:
91,810 bases
Orientation:
Plus strand
chr6:20,402,137-20,493,945
(GRCh37/hg19)

Genomic View for E2F3 Gene

Genes around E2F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
E2F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for E2F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F3 Gene

Proteins for E2F3 Gene

  • Protein details for E2F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00716-E2F3_HUMAN
    Recommended name:
    Transcription factor E2F3
    Protein Accession:
    O00716
    Secondary Accessions:
    • Q15000
    • Q68DT0
    • Q9BZ44

    Protein attributes for E2F3 Gene

    Size:
    465 amino acids
    Molecular mass:
    49162 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP.

    Alternative splice isoforms for E2F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for E2F3 Gene

Post-translational modifications for E2F3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for E2F3 Gene

Domains & Families for E2F3 Gene

Gene Families for E2F3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for E2F3 Gene

Graphical View of Domain Structure for InterPro Entry

O00716

UniProtKB/Swiss-Prot:

E2F3_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F3: view

Function for E2F3 Gene

Molecular function for E2F3 Gene

GENATLAS Biochemistry:
transcription factor E2F-like 3,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis,involved in transcription repression in quiescent cell by interaction with histone deacetylase
UniProtKB/Swiss-Prot Function:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

Phenotypes From GWAS Catalog for E2F3 Gene

Gene Ontology (GO) - Molecular Function for E2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IDA 7739537
GO:0001047 core promoter binding IDA 15735762
GO:0001228 contributes_to transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 7739537
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA,TAS 8246996
genes like me logo Genes that share ontologies with E2F3: view
genes like me logo Genes that share phenotypes with E2F3: view

Animal Models for E2F3 Gene

MGI Knock Outs for E2F3:

miRNA for E2F3 Gene

miRTarBase miRNAs that target E2F3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for E2F3 Gene

Localization for E2F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for E2F3 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for E2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005829 cytosol IDA --
GO:0090575 RNA polymerase II transcription factor complex IDA 7739537
genes like me logo Genes that share ontologies with E2F3: view

Pathways & Interactions for E2F3 Gene

genes like me logo Genes that share pathways with E2F3: view

SIGNOR curated interactions for E2F3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for E2F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS 8246996
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with E2F3: view

Drugs & Compounds for E2F3 Gene

(1) Drugs for E2F3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for E2F3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with E2F3: view

Transcripts for E2F3 Gene

Unigene Clusters for E2F3 Gene

E2F transcription factor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for E2F3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - -
SP2:
SP3:
SP4: - - - - - - - -

Relevant External Links for E2F3 Gene

GeneLoc Exon Structure for
E2F3
ECgene alternative splicing isoforms for
E2F3

Expression for E2F3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for E2F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for E2F3 Gene

This gene is overexpressed in Heart (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for E2F3 Gene



Protein tissue co-expression partners for E2F3 Gene

NURSA nuclear receptor signaling pathways regulating expression of E2F3 Gene:

E2F3

SOURCE GeneReport for Unigene cluster for E2F3 Gene:

Hs.269408

Evidence on tissue expression from TISSUES for E2F3 Gene

  • Blood(4.3)
  • Bone marrow(4.2)
  • Nervous system(4.2)
  • Eye(3.9)
  • Lung(2.5)
  • Intestine(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with E2F3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for E2F3 Gene

Orthologs for E2F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F3 34 33
  • 98.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia E2F3 33 34
  • 96.04 (n)
dog
(Canis familiaris)
Mammalia E2F3 33 34
  • 94.81 (n)
mouse
(Mus musculus)
Mammalia E2f3 16 34 33
  • 92.92 (n)
oppossum
(Monodelphis domestica)
Mammalia E2F3 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia E2f3 33
  • 90.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia E2F3 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves E2F3 33 34
  • 81.25 (n)
lizard
(Anolis carolinensis)
Reptilia E2F3 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia e2f3 33
  • 74.05 (n)
Str.5921 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398159 33
zebrafish
(Danio rerio)
Actinopterygii e2f3 33 34
  • 60.08 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta E2f 35 34
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea efl-2 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2502 33
Species where no ortholog for E2F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for E2F3 Gene

ENSEMBL:
Gene Tree for E2F3 (if available)
TreeFam:
Gene Tree for E2F3 (if available)

Paralogs for E2F3 Gene

Paralogs for E2F3 Gene

(5) SIMAP similar genes for E2F3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for E2F3 Gene

genes like me logo Genes that share paralogs with E2F3: view

Variants for E2F3 Gene

Sequence variations from dbSNP and Humsavar for E2F3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000005443 -- 20,441,713(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000014723 -- 20,354,652(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000018432 -- 20,481,528(+) T/A intron_variant
rs1000094049 -- 20,401,257(+) C/A genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000116751 -- 20,393,826(+) C/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for E2F3 Gene

Variant ID Type Subtype PubMed ID
esv2673142 CNV deletion 23128226
esv3608295 CNV loss 21293372
nsv1024963 CNV gain 25217958
nsv1074383 CNV deletion 25765185
nsv1131948 CNV deletion 24896259
nsv1144135 CNV deletion 24896259
nsv965685 CNV duplication 23825009

Variation tolerance for E2F3 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for E2F3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
E2F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F3 Gene

Disorders for E2F3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for E2F3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
bladder cancer
  • bladder cancer, somatic
hepatocellular carcinoma
  • hcc
prostate cancer
  • prostate cancer, susceptibility to
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search E2F3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for E2F3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with E2F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for E2F3 Gene

Publications for E2F3 Gene

  1. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 22 44 58
  2. The retinoblastoma protein binds to a family of E2F transcription factors. (PMID: 8246996) Lees JA … Helin K (Molecular and cellular biology 1993) 2 3 4 58
  3. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. (PMID: 17925491) Eiring AM … Perrotti D (Blood 2008) 3 22 58
  4. Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification. (PMID: 18037967) Hurst CD … Knowles MA (Oncogene 2008) 3 22 58
  5. The E2F3-Oncomir-1 axis is activated in Wilms' tumor. (PMID: 18519660) Kort EJ … Teh BT (Cancer research 2008) 3 22 58

Products for E2F3 Gene

  • Addgene plasmids for E2F3

Sources for E2F3 Gene

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