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Aliases for E2F2 Gene

Aliases for E2F2 Gene

  • E2F Transcription Factor 2 2 3
  • E2F-2 3 4
  • Transcription Factor E2F2 3

External Ids for E2F2 Gene

Previous GeneCards Identifiers for E2F2 Gene

  • GC01M023394
  • GC01M022908
  • GC01M023302
  • GC01M023578
  • GC01M023705
  • GC01M023832
  • GC01M022083

Summaries for E2F2 Gene

Entrez Gene Summary for E2F2 Gene

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]

GeneCards Summary for E2F2 Gene

E2F2 (E2F Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Glioma and Pathways in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and core promoter binding. An important paralog of this gene is E2F5.

UniProtKB/Swiss-Prot for E2F2 Gene

  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner

Gene Wiki entry for E2F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for E2F2 Gene

Genomics for E2F2 Gene

Regulatory Elements for E2F2 Gene

Genomic Location for E2F2 Gene

Start:
23,506,428 bp from pter
End:
23,531,220 bp from pter
Size:
24,793 bases
Orientation:
Minus strand

Genomic View for E2F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for E2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for E2F2 Gene

Proteins for E2F2 Gene

  • Protein details for E2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14209-E2F2_HUMAN
    Recommended name:
    Transcription factor E2F2
    Protein Accession:
    Q14209
    Secondary Accessions:
    • B2R9W1
    • Q7Z6H1

    Protein attributes for E2F2 Gene

    Size:
    437 amino acids
    Molecular mass:
    47506 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active complex. Binds EAPP.

    Three dimensional structures from OCA and Proteopedia for E2F2 Gene

neXtProt entry for E2F2 Gene

Proteomics data for E2F2 Gene at MOPED

Post-translational modifications for E2F2 Gene

  • Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for E2F2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for E2F2 Gene

Domains for E2F2 Gene

Protein Domains for E2F2 Gene

Suggested Antigen Peptide Sequences for E2F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14209

UniProtKB/Swiss-Prot:

E2F2_HUMAN :
  • Q14209
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with E2F2: view

No data available for Gene Families for E2F2 Gene

Function for E2F2 Gene

Molecular function for E2F2 Gene

GENATLAS Biochemistry: transcription factor E2F-like 2,involved in cell proliferation,controlling genes regulating S phase entry and DNA synthesis
UniProtKB/Swiss-Prot Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3 found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner

Gene Ontology (GO) - Molecular Function for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 15735762
GO:0003677 DNA binding TAS 8246995
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16360038
GO:0008134 transcription factor binding IPI 16360038
genes like me logo Genes that share ontologies with E2F2: view
genes like me logo Genes that share phenotypes with E2F2: view

Animal Models for E2F2 Gene

MGI Knock Outs for E2F2:

Transcription Factor Targeting for E2F2 Gene

Selected GeneGlobe predicted Target genes for E2F2

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for E2F2 Gene

Localization for E2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for E2F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for E2F2 Gene COMPARTMENTS Subcellular localization image for E2F2 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with E2F2: view

Pathways for E2F2 Gene

genes like me logo Genes that share pathways with E2F2: view

Gene Ontology (GO) - Biological Process for E2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS 8246996
GO:0051726 regulation of cell cycle IEA --
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA --
genes like me logo Genes that share ontologies with E2F2: view

Compounds for E2F2 Gene

(2) Novoseek inferred chemical compound relationships for E2F2 Gene

Compound -log(P) Hits PubMed IDs
dihydrofolate 44.2 1
oligonucleotide 0 1
genes like me logo Genes that share compounds with E2F2: view

Transcripts for E2F2 Gene

Unigene Clusters for E2F2 Gene

E2F transcription factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for E2F2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1:
SP2: -
SP3: -

Relevant External Links for E2F2 Gene

GeneLoc Exon Structure for
E2F2
ECgene alternative splicing isoforms for
E2F2

Expression for E2F2 Gene

mRNA expression in normal human tissues for E2F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for E2F2 Gene

This gene is overexpressed in Whole Blood (14.8), Esophagus - Mucosa (7.1), and Colon - Transverse (4.6).

SOURCE GeneReport for Unigene cluster for E2F2 Gene Hs.194333

mRNA Expression by UniProt/SwissProt for E2F2 Gene

Q14209-E2F2_HUMAN
Tissue specificity: Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples
genes like me logo Genes that share expressions with E2F2: view

No data available for Protein expression for E2F2 Gene

Orthologs for E2F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for E2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia E2F2 35
  • 99.62 (n)
  • 99.54 (a)
E2F2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia E2F2 35
  • 88.01 (n)
  • 88.95 (a)
E2F2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia E2F2 35
  • 88.84 (n)
  • 88.6 (a)
E2F2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E2f2 35
  • 84.21 (n)
  • 83.75 (a)
E2f2 16
E2f2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia E2F2 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia E2f2 35
  • 84.36 (n)
  • 83.07 (a)
chicken
(Gallus gallus)
Aves E2F2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia E2F2 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii E2F2 36
  • 52 (a)
OneToOne
LOC568846 35
  • 59.01 (n)
  • 57.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta E2f 36
  • 16 (a)
OneToMany
E2f 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea efl-2 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for E2F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for E2F2 Gene

ENSEMBL:
Gene Tree for E2F2 (if available)
TreeFam:
Gene Tree for E2F2 (if available)

Paralogs for E2F2 Gene

Paralogs for E2F2 Gene

Selected SIMAP similar genes for E2F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with E2F2: view

Variants for E2F2 Gene

Sequence variations from dbSNP and Humsavar for E2F2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1057480 -- 23,509,560(-) ACCTC(A/C)TTTGA utr-variant-3-prime
rs2075993 -- 23,509,872(+) CAGGC(A/G)GGGCC utr-variant-3-prime
rs2075994 -- 23,516,618(+) GCCAT(C/T)CATGG intron-variant
rs2282720 -- 23,513,277(+) taaga(A/G)gtgag intron-variant
rs2282721 -- 23,513,562(+) GGAAC(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for E2F2 Gene

Variant ID Type Subtype PubMed ID
nsv834435 CNV Loss 17160897

Relevant External Links for E2F2 Gene

HapMap Linkage Disequilibrium report
E2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for E2F2 Gene

Disorders for E2F2 Gene

(2) Novoseek inferred disease relationships for E2F2 Gene

Disease -log(P) Hits PubMed IDs
tumors 26.3 3
ovarian cancer 25.2 2

Relevant External Links for E2F2

Genetic Association Database (GAD)
E2F2
Human Genome Epidemiology (HuGE) Navigator
E2F2
genes like me logo Genes that share disorders with E2F2: view

No data available for UniProtKB/Swiss-Prot for E2F2 Gene

Publications for E2F2 Gene

  1. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. (PMID: 8246995) Ivey-Hoyle M. … Heimbrook D.C. (Mol. Cell. Biol. 1993) 2 3 4
  2. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham J.M. … Goode E.L. (Br. J. Cancer 2009) 3 23 48
  3. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. (PMID: 12411495) Schlisio S. … Nevins J.R. (EMBO J. 2002) 3 23
  4. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. (PMID: 12502741) Lee C. … Cho Y. (Genes Dev. 2002) 3 4
  5. An E2F/miR-20a autoregulatory feedback loop. (PMID: 17135249) Sylvestre Y. … Chartrand P. (J. Biol. Chem. 2007) 3 23

Products for E2F2 Gene

  • Addgene plasmids for E2F2

Sources for E2F2 Gene

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