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Aliases for DVL3 Gene

Aliases for DVL3 Gene

  • Dishevelled Segment Polarity Protein 3 2 3
  • Dishevelled 3 (Homologous To Drosophila Dsh) 2 3
  • DSH Homolog 3 3 4
  • Dishevelled-3 3 4
  • Segment Polarity Protein Dishevelled Homolog DVL-3 3
  • Dishevelled, Dsh Homolog 3 (Drosophila) 2
  • Dishevelled, Dsh Homolog 3 3
  • KIAA0208 4

External Ids for DVL3 Gene

Summaries for DVL3 Gene

Entrez Gene Summary for DVL3 Gene

  • This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for DVL3 Gene

DVL3 (Dishevelled Segment Polarity Protein 3) is a Protein Coding gene. Diseases associated with DVL3 include alk-positive anaplastic large cell lymphoma. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include protein heterodimerization activity and signal transducer activity. An important paralog of this gene is DIXDC1.

UniProtKB/Swiss-Prot for DVL3 Gene

  • May play a role in the signal transduction pathway mediated by multiple Wnt genes

Gene Wiki entry for DVL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DVL3 Gene

Genomics for DVL3 Gene

Genomic Location for DVL3 Gene

Start:
184,155,311 bp from pter
End:
184,173,610 bp from pter
Size:
18,300 bases
Orientation:
Plus strand

Genomic View for DVL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DVL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DVL3 Gene

Regulatory Elements for DVL3 Gene

Proteins for DVL3 Gene

  • Protein details for DVL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92997-DVL3_HUMAN
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-3
    Protein Accession:
    Q92997
    Secondary Accessions:
    • B4E3E5
    • D3DNT0
    • O14642
    • Q13531
    • Q8N5E9
    • Q92607

    Protein attributes for DVL3 Gene

    Size:
    716 amino acids
    Molecular mass:
    78055 Da
    Quaternary structure:
    • Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2.
    SequenceCaution:
    • Sequence=BAA13199.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DVL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DVL3 Gene

Proteomics data for DVL3 Gene at MOPED

Post-translational modifications for DVL3 Gene

  • Arginine methylation may function as a switch in regulation of function in Wnt signaling.
  • Phosphorylated by CSNK1D.
  • Ubiquitinated. Deubiquitinated by CYLD, which acts on Lys-63-linked ubiquitin chains.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys283

Other Protein References for DVL3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DVL3 Gene

Domains for DVL3 Gene

Gene Families for DVL3 Gene

HGNC:
  • DVL :Dishevelled homologs

Suggested Antigen Peptide Sequences for DVL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q92997

UniProtKB/Swiss-Prot:

DVL3_HUMAN
Domain:
  • Contains 1 DEP domain.:
    • Q92997
  • Contains 1 DIX domain.:
    • Q92997
  • Contains 1 PDZ (DHR) domain.:
    • Q92997
Family:
  • Belongs to the DSH family.:
    • Q92997
genes like me logo Genes that share domains with DVL3: view

Function for DVL3 Gene

Molecular function for DVL3 Gene

GENATLAS Biochemistry: Drosophila dishevelled segment polarity gene homolog 3,widely expressed,putatively involved in neural and heart development,activated in WNT signal transduction
UniProtKB/Swiss-Prot Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

Gene Ontology (GO) - Molecular Function for DVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 20227366
GO:0005102 receptor binding IPI 17030191
GO:0005109 frizzled binding IPI 19388021
GO:0005515 protein binding IPI 10330181
GO:0008013 beta-catenin binding IDA 10644691
genes like me logo Genes that share ontologies with DVL3: view
genes like me logo Genes that share phenotypes with DVL3: view

Animal Models for DVL3 Gene

MGI Knock Outs for DVL3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DVL3 Gene

Localization for DVL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DVL3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DVL3 Gene COMPARTMENTS Subcellular localization image for DVL3 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005938 cell cortex --
genes like me logo Genes that share ontologies with DVL3: view

Pathways for DVL3 Gene

genes like me logo Genes that share pathways with DVL3: view

Gene Ontology (GO) - Biological Process for DVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 20137080
GO:0003007 heart morphogenesis --
GO:0003148 outflow tract septum morphogenesis IEA --
GO:0016055 Wnt signaling pathway IDA 10644691
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DVL3: view

Transcripts for DVL3 Gene

Unigene Clusters for DVL3 Gene

Dishevelled, dsh homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DVL3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - -
SP6: -
SP7: - -

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DVL3 Gene

GeneLoc Exon Structure for
DVL3
ECgene alternative splicing isoforms for
DVL3

Expression for DVL3 Gene

mRNA expression in normal human tissues for DVL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DVL3 Gene

SOURCE GeneReport for Unigene cluster for DVL3 Gene Hs.388116

genes like me logo Genes that share expressions with DVL3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DVL3 Gene

Orthologs for DVL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DVL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DVL3 35
  • 99.95 (n)
  • 100 (a)
DVL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DVL3 35
  • 93.16 (n)
  • 99.02 (a)
DVL3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DVL3 35
  • 93.16 (n)
  • 99.3 (a)
DVL3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dvl3 35
  • 90.78 (n)
  • 99.02 (a)
Dvl3 16
Dvl3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DVL3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DVL3 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dvl3 35
  • 90.27 (n)
  • 98.8 (a)
chicken
(Gallus gallus)
Aves DVL3 35
  • 82.46 (n)
  • 91.12 (a)
DVL3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DVL3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dvl3 35
  • 74.8 (n)
  • 86.38 (a)
Str.6892 35
zebrafish
(Danio rerio)
Actinopterygii DVL3 (1 of 2) 36
  • 79 (a)
OneToMany
dvl3a 36
  • 73 (a)
OneToMany
LOC100149082 35
  • 70.65 (n)
  • 76.98 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004448 35
  • 61.35 (n)
  • 60.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta dsh 35
  • 58.84 (n)
  • 56.53 (a)
dsh 36
  • 47 (a)
OneToMany
dsh 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea dsh-1 36
  • 26 (a)
ManyToMany
dsh-2 36
  • 29 (a)
ManyToMany
mig-5 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8546 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11084 36
  • 48 (a)
OneToMany
Species with no ortholog for DVL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DVL3 Gene

ENSEMBL:
Gene Tree for DVL3 (if available)
TreeFam:
Gene Tree for DVL3 (if available)

Paralogs for DVL3 Gene

Paralogs for DVL3 Gene

Selected SIMAP similar genes for DVL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DVL3: view

Variants for DVL3 Gene

Sequence variations from dbSNP and Humsavar for DVL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs843370 -- 184,158,034(-) AAACT(A/G)GAGAT intron-variant
rs864577 -- 184,154,092(-) GTGGC(A/G)CATGC upstream-variant-2KB
rs866856 -- 184,154,617(-) TGAGT(A/C)GAGAT upstream-variant-2KB
rs1687251 -- 184,164,543(+) GAGAC(A/G)GACTC synonymous-codon, reference
rs1687252 -- 184,164,595(+) GCCCA(C/G)AGCAT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for DVL3 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV Loss 17160897
nsv878056 CNV Loss 21882294
nsv878057 CNV Loss 21882294
esv2514927 CNV Deletion 19546169
nsv513096 CNV Loss 21212237
esv1000394 CNV Deletion 20482838
esv2726295 CNV Deletion 23290073
esv2671751 CNV Deletion 23128226
esv1004549 CNV Deletion 20482838
esv8912 CNV Loss 19470904
nsv878058 CNV Gain 21882294

Relevant External Links for DVL3 Gene

HapMap Linkage Disequilibrium report
DVL3
Human Gene Mutation Database (HGMD)
DVL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DVL3 Gene

Disorders for DVL3 Gene

Relevant External Links for DVL3

Genetic Association Database (GAD)
DVL3
genes like me logo Genes that share disorders with DVL3: view

No data available for UniProtKB/Swiss-Prot for DVL3 Gene

Publications for DVL3 Gene

  1. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PMID: 8817329) Pizzuti A. … Dallapiccola B. (Hum. Mol. Genet. 1996) 2 3 4
  2. cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. (PMID: 9344861) Bui T.D. … Harris A.L. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. (PMID: 18093802) Lee Y.N. … Wang H.Y. (Cell. Signal. 2008) 3 23
  4. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3 48
  5. Delicate analysis of post-translational modifications on Dishevelled 3. (PMID: 22612246) Wu C. … Zeng R. (J. Proteome Res. 2012) 3 4

Products for DVL3 Gene

  • Addgene plasmids for DVL3

Sources for DVL3 Gene

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