Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUSP3 Gene

Aliases for DUSP3 Gene

  • Dual Specificity Phosphatase 3 2 3
  • VHR 3 4 6
  • Dual Specificity Protein Phosphatase VHR 3 4
  • Vaccinia Virus Phosphatase VH1-Related 2 3
  • Vaccinia H1-Related Phosphatase 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 3 3
  • EC 4
  • EC 4

External Ids for DUSP3 Gene

Previous HGNC Symbols for DUSP3 Gene

  • VHR

Previous GeneCards Identifiers for DUSP3 Gene

  • GC17M041587
  • GC17M044020
  • GC17M041856
  • GC17M042320
  • GC17M042318
  • GC17M039199
  • GC17M037607
  • GC17M041843

Summaries for DUSP3 Gene

Entrez Gene Summary for DUSP3 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP3 Gene

DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include byssinosis and vaccinia. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot for DUSP3 Gene

  • Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Gene Wiki entry for DUSP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP3 Gene

Genomics for DUSP3 Gene

Regulatory Elements for DUSP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP3 Gene

43,766,121 bp from pter
43,779,000 bp from pter
12,880 bases
Minus strand

Genomic View for DUSP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP3 Gene

Proteins for DUSP3 Gene

  • Protein details for DUSP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 3
    Protein Accession:
    Secondary Accessions:
    • D3DX45
    • Q5U0J1
    • Q8IYJ9

    Protein attributes for DUSP3 Gene

    185 amino acids
    Molecular mass:
    20478 Da
    Quaternary structure:
    • Interacts with VRK3, which seems to activate its phosphatase activity.

    Three dimensional structures from OCA and Proteopedia for DUSP3 Gene

    Alternative splice isoforms for DUSP3 Gene


neXtProt entry for DUSP3 Gene

Proteomics data for DUSP3 Gene at MOPED

Post-translational modifications for DUSP3 Gene

  • Ubiquitination at Lys53 and Lys116
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP3 (DUSP3)

Protein Products

No data available for DME Specific Peptides for DUSP3 Gene

Domains for DUSP3 Gene

Gene Families for DUSP3 Gene

  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for DUSP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • P51452
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP3: view

Function for DUSP3 Gene

Molecular function for DUSP3 Gene

GENATLAS Biochemistry: dual specificity (tyr/thr) phosphatase 3,vaccinia virus phosphatase VH1 related,expressed in breast and ovary,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Enzyme Numbers (IUBMB) for DUSP3 Gene

Gene Ontology (GO) - Molecular Function for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004725 protein tyrosine phosphatase activity IDA 11863439
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IMP 7961745
GO:0016791 phosphatase activity --
GO:0019901 protein kinase binding IDA 22572157
genes like me logo Genes that share ontologies with DUSP3: view
genes like me logo Genes that share phenotypes with DUSP3: view

Animal Model Products

CRISPR Products

miRNA for DUSP3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP3 Gene

Localization for DUSP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP3 Gene

Subcellular locations from

Jensen Localization Image for DUSP3 Gene COMPARTMENTS Subcellular localization image for DUSP3 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 12447358
GO:0005634 nucleus IDA 16604064
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 12447358
genes like me logo Genes that share ontologies with DUSP3: view

Pathways for DUSP3 Gene

genes like me logo Genes that share pathways with DUSP3: view

Pathways by source for DUSP3 Gene

1 KEGG pathway for DUSP3 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IMP 16604064
GO:0001701 in utero embryonic development IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with DUSP3: view

Compounds for DUSP3 Gene

(3) HMDB Compounds for DUSP3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • NFB Orthophosphate
  • Dihydrogen oxide

(9) Novoseek inferred chemical compound relationships for DUSP3 Gene

Compound -log(P) Hits PubMed IDs
cl 100 81 1
phosphothreonine 77.7 1
phosphotyrosine 77 4
phosphoserine 72.4 2
tyrosine 58.5 8
genes like me logo Genes that share compounds with DUSP3: view

Transcripts for DUSP3 Gene

Unigene Clusters for DUSP3 Gene

Dual specificity phosphatase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - - - - - -
SP7: - - - - - - - -

Relevant External Links for DUSP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP3 Gene

mRNA expression in normal human tissues for DUSP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP3 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUSP3 Gene

SOURCE GeneReport for Unigene cluster for DUSP3 Gene Hs.181046

genes like me logo Genes that share expressions with DUSP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DUSP3 Gene

Orthologs for DUSP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP3 35
  • 99.82 (n)
  • 100 (a)
DUSP3 36
  • 100 (a)
(Bos Taurus)
Mammalia DUSP3 35
  • 92.21 (n)
  • 98.37 (a)
DUSP3 36
  • 89 (a)
(Canis familiaris)
Mammalia DUSP3 35
  • 93.96 (n)
  • 97.8 (a)
DUSP3 36
  • 95 (a)
(Mus musculus)
Mammalia Dusp3 35
  • 90.4 (n)
  • 93.48 (a)
Dusp3 16
Dusp3 36
  • 93 (a)
(Monodelphis domestica)
Mammalia DUSP3 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Dusp3 35
  • 89.86 (n)
  • 92.39 (a)
(Gallus gallus)
Aves DUSP3 35
  • 72.55 (n)
  • 81.62 (a)
DUSP3 36
  • 78 (a)
(Anolis carolinensis)
Reptilia DUSP3 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498529 35
  • 65.39 (n)
  • 67.21 (a)
(Danio rerio)
Actinopterygii dusp3a 35
  • 70.39 (n)
  • 71.51 (a)
dusp3a 36
  • 65 (a)
dusp3b 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7378 36
  • 31 (a)
Species with no ortholog for DUSP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP3 Gene

Gene Tree for DUSP3 (if available)
Gene Tree for DUSP3 (if available)

Paralogs for DUSP3 Gene Pseudogenes for DUSP3 Gene

genes like me logo Genes that share paralogs with DUSP3: view

Variants for DUSP3 Gene

Sequence variations from dbSNP and Humsavar for DUSP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11713 -- 43,768,456(-) CATGG(C/T)GGAGT utr-variant-3-prime
rs15359 -- 43,766,611(+) TGCTG(C/G)CCATC utr-variant-3-prime
rs1059602 -- 43,769,246(-) ACCTC(A/C)CTTCC utr-variant-3-prime
rs1230396 -- 43,765,661(+) AGGCA(A/C)CTACT downstream-variant-500B
rs1230397 -- 43,767,321(+) TACTT(C/T)GGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP3 Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294
nsv908267 CNV Gain 21882294
esv2660851 CNV Deletion 23128226

Relevant External Links for DUSP3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP3 Gene

Disorders for DUSP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for DUSP3 Gene including...

Search for DUSP3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DUSP3 Gene

(2) Novoseek inferred disease relationships for DUSP3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
cancer 0 3
genes like me logo Genes that share disorders with DUSP3: view

No data available for UniProtKB/Swiss-Prot for DUSP3 Gene

Publications for DUSP3 Gene

  1. Crystal structure of the dual specificity protein phosphatase VHR. (PMID: 8650541) Yuvaniyama J. … Saper M.A. (Science 1996) 3 4 23
  2. Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. (PMID: 11863439) Schumacher M.A. … Denu J.M. (Biochemistry 2002) 3 4 23
  3. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd J.L. … Denu J.M. (J. Biol. Chem. 1999) 3 4 23
  4. Expression cloning of a human dual-specificity phosphatase. (PMID: 1281549) Ishibashi T. … Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  5. High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. (PMID: 18311544) Wong P.F. … Abubakar S. (Cell. Mol. Biol. Lett. 2008) 3 23

Products for DUSP3 Gene

Sources for DUSP3 Gene

Back to Top