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Aliases for DUSP3 Gene

Aliases for DUSP3 Gene

  • Dual Specificity Phosphatase 3 2 3 5
  • Dual Specificity Protein Phosphatase VHR 3 4
  • Vaccinia Virus Phosphatase VH1-Related 2 3
  • Vaccinia H1-Related Phosphatase 3 4
  • VHR 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP3 Gene

Previous HGNC Symbols for DUSP3 Gene

  • VHR

Previous GeneCards Identifiers for DUSP3 Gene

  • GC17M041587
  • GC17M044020
  • GC17M041856
  • GC17M042320
  • GC17M042318
  • GC17M039199
  • GC17M037607
  • GC17M041843

Summaries for DUSP3 Gene

Entrez Gene Summary for DUSP3 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP3 Gene

DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include vaccinia and cervix carcinoma. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP15.

UniProtKB/Swiss-Prot for DUSP3 Gene

  • Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Gene Wiki entry for DUSP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP3 Gene

Genomics for DUSP3 Gene

Regulatory Elements for DUSP3 Gene

Promoters for DUSP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP3 Gene

Chromosome:
17
Start:
43,766,121 bp from pter
End:
43,779,000 bp from pter
Size:
12,880 bases
Orientation:
Minus strand

Genomic View for DUSP3 Gene

Genes around DUSP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP3 Gene

Proteins for DUSP3 Gene

  • Protein details for DUSP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51452-DUS3_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 3
    Protein Accession:
    P51452
    Secondary Accessions:
    • D3DX45
    • Q5U0J1
    • Q8IYJ9

    Protein attributes for DUSP3 Gene

    Size:
    185 amino acids
    Molecular mass:
    20478 Da
    Quaternary structure:
    • Interacts with VRK3, which seems to activate its phosphatase activity.

    Three dimensional structures from OCA and Proteopedia for DUSP3 Gene

    Alternative splice isoforms for DUSP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP3 Gene

Proteomics data for DUSP3 Gene at MOPED

Post-translational modifications for DUSP3 Gene

  • Ubiquitination at Lys 53 and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP3 (DUSP3)

Protein Products

No data available for DME Specific Peptides for DUSP3 Gene

Domains & Families for DUSP3 Gene

Gene Families for DUSP3 Gene

Suggested Antigen Peptide Sequences for DUSP3 Gene

Graphical View of Domain Structure for InterPro Entry

P51452

UniProtKB/Swiss-Prot:

DUS3_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP3: view

Function for DUSP3 Gene

Molecular function for DUSP3 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 3,vaccinia virus phosphatase VH1 related,expressed in breast and ovary,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Enzyme Numbers (IUBMB) for DUSP3 Gene

genes like me logo Genes that share phenotypes with DUSP3: view

Animal Models for DUSP3 Gene

MGI Knock Outs for DUSP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP3 Gene

Localization for DUSP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP3 Gene COMPARTMENTS Subcellular localization image for DUSP3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DUSP3: view

Pathways & Interactions for DUSP3 Gene

genes like me logo Genes that share pathways with DUSP3: view

Pathways by source for DUSP3 Gene

1 GeneGo (Thomson Reuters) pathway for DUSP3 Gene
2 Qiagen pathways for DUSP3 Gene

SIGNOR curated interactions for DUSP3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IMP 16604064
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0034134 toll-like receptor 2 signaling pathway TAS --
genes like me logo Genes that share ontologies with DUSP3: view

Drugs & Compounds for DUSP3 Gene

(5) Drugs for DUSP3 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(8) Additional Compounds for DUSP3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP3: view

Transcripts for DUSP3 Gene

Unigene Clusters for DUSP3 Gene

Dual specificity phosphatase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - - - - - -
SP7: - - - - - - - -

Relevant External Links for DUSP3 Gene

GeneLoc Exon Structure for
DUSP3
ECgene alternative splicing isoforms for
DUSP3

Expression for DUSP3 Gene

mRNA expression in normal human tissues for DUSP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for DUSP3 Gene

This gene is overexpressed in Cardia (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP3 Gene



SOURCE GeneReport for Unigene cluster for DUSP3 Gene Hs.181046

genes like me logo Genes that share expression patterns with DUSP3: view

Protein tissue co-expression partners for DUSP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DUSP3 Gene

Orthologs for DUSP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP3 35
  • 92.21 (n)
  • 98.37 (a)
DUSP3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP3 35
  • 93.96 (n)
  • 97.8 (a)
DUSP3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp3 35
  • 90.4 (n)
  • 93.48 (a)
Dusp3 16
Dusp3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP3 35
  • 99.82 (n)
  • 100 (a)
DUSP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp3 35
  • 89.86 (n)
  • 92.39 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP3 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP3 35
  • 72.55 (n)
  • 81.62 (a)
DUSP3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP3 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498529 35
  • 65.39 (n)
  • 67.21 (a)
zebrafish
(Danio rerio)
Actinopterygii dusp3a 35
  • 70.39 (n)
  • 71.51 (a)
dusp3a 36
  • 65 (a)
OneToMany
dusp3b 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7378 36
  • 31 (a)
OneToMany
Species with no ortholog for DUSP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP3 Gene

ENSEMBL:
Gene Tree for DUSP3 (if available)
TreeFam:
Gene Tree for DUSP3 (if available)

Paralogs for DUSP3 Gene

Pseudogenes.org Pseudogenes for DUSP3 Gene

genes like me logo Genes that share paralogs with DUSP3: view

Variants for DUSP3 Gene

Sequence variations from dbSNP and Humsavar for DUSP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11713 -- 43,768,456(-) CATGG(C/T)GGAGT utr-variant-3-prime
rs15359 -- 43,766,611(+) TGCTG(C/G)CCATC utr-variant-3-prime
rs1059602 -- 43,769,246(-) ACCTC(A/C)CTTCC utr-variant-3-prime
rs1230396 -- 43,765,661(+) AGGCA(A/C)CTACT downstream-variant-500B
rs1230397 -- 43,767,321(+) TACTT(C/T)GGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP3 Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294
nsv908267 CNV Gain 21882294
esv2660851 CNV Deletion 23128226

Variation tolerance for DUSP3 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP3 Gene

HapMap Linkage Disequilibrium report
DUSP3
Human Gene Mutation Database (HGMD)
DUSP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP3 Gene

Disorders for DUSP3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DUSP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vaccinia
cervix carcinoma
  • cancer of cervix
byssinosis
  • cotton mill fever
- elite association - COSMIC cancer census association via MalaCards
Search DUSP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUSP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP3
genes like me logo Genes that share disorders with DUSP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP3 Gene

Publications for DUSP3 Gene

  1. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd J.L. … Denu J.M. (J. Biol. Chem. 1999) 3 4 23 67
  2. High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. (PMID: 18311544) Wong P.F. … Abubakar S. (Cell. Mol. Biol. Lett. 2008) 3 23
  3. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. (PMID: 18505570) Henkens R. … Rahmouni S. (BMC Cancer 2008) 3 23
  4. Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. (PMID: 11863439) Schumacher M.A. … Denu J.M. (Biochemistry 2002) 3 23
  5. Crystal structure of the dual specificity protein phosphatase VHR. (PMID: 8650541) Yuvaniyama J. … Saper M.A. (Science 1996) 3 23

Products for DUSP3 Gene

Sources for DUSP3 Gene

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