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Aliases for ECM2 Gene

Aliases for ECM2 Gene

  • Extracellular Matrix Protein 2, Female Organ And Adipocyte Specific 2 3
  • Matrix Glycoprotein SC1/ECM2 2 4

External Ids for ECM2 Gene

Previous GeneCards Identifiers for ECM2 Gene

  • GC09M086084
  • GC09M086985
  • GC09M088556
  • GC09M090599
  • GC09M090597
  • GC09M092335
  • GC09M094297
  • GC09M095257
  • GC09M064935

Summaries for ECM2 Gene

Entrez Gene Summary for ECM2 Gene

  • ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for ECM2 Gene

ECM2 (Extracellular Matrix Protein 2, Female Organ And Adipocyte Specific) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is FMOD.

UniProtKB/Swiss-Prot for ECM2 Gene

  • Promotes matrix assembly and cell adhesiveness.

Gene Wiki entry for ECM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ECM2 Gene

Genomics for ECM2 Gene

Regulatory Elements for ECM2 Gene

Genomic Location for ECM2 Gene

92,493,547 bp from pter
92,536,655 bp from pter
43,109 bases
Minus strand

Genomic View for ECM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ECM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ECM2 Gene

Proteins for ECM2 Gene

  • Protein details for ECM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Extracellular matrix protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R730
    • E2PU11
    • Q5T9F2
    • Q7Z3D0

    Protein attributes for ECM2 Gene

    699 amino acids
    Molecular mass:
    79789 Da
    Quaternary structure:
    • Interacts with numerous extracellular matrix proteins.
    • Sequence=CAD97940.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ECM2 Gene


neXtProt entry for ECM2 Gene

Proteomics data for ECM2 Gene at MOPED

Post-translational modifications for ECM2 Gene

  • Glycosylation at Asn378, Asn449, and Asn506
  • Modification sites at PhosphoSitePlus

Other Protein References for ECM2 Gene

No data available for DME Specific Peptides for ECM2 Gene

Domains for ECM2 Gene

Protein Domains for ECM2 Gene

Suggested Antigen Peptide Sequences for ECM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRNT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
  • Contains 13 LRR (leucine-rich) repeats.
  • Contains 1 LRRNT domain.
  • Contains 1 VWFC domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
  • Contains 13 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ECM2: view

No data available for Gene Families for ECM2 Gene

Function for ECM2 Gene

Molecular function for ECM2 Gene

GENATLAS Biochemistry:
extracellular matrix 2,predominantly expressed in adipose tissue,mammary gland,ovary and uterus
UniProtKB/Swiss-Prot Function:
Promotes matrix assembly and cell adhesiveness.

Gene Ontology (GO) - Molecular Function for ECM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 9790758
GO:0005515 protein binding --
GO:0005518 collagen binding --
GO:0008201 heparin binding IEA --
GO:0070052 collagen V binding IEA --
genes like me logo Genes that share ontologies with ECM2: view

Animal Model Products

miRNA for ECM2 Gene

miRTarBase miRNAs that target ECM2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ECM2 Gene

Localization for ECM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ECM2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for ECM2 Gene COMPARTMENTS Subcellular localization image for ECM2 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ECM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix TAS 9790758
GO:0005614 interstitial matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ECM2: view

Pathways for ECM2 Gene

genes like me logo Genes that share pathways with ECM2: view

Pathways by source for ECM2 Gene

Interacting Proteins for ECM2 Gene

Gene Ontology (GO) - Biological Process for ECM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion TAS 9790758
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with ECM2: view

Transcripts for ECM2 Gene

Unigene Clusters for ECM2 Gene

Extracellular matrix protein 2, female organ and adipocyte specific:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ECM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ECM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12
SP1: - - - -
SP2: - - -
SP3: - - -
SP5: -

Relevant External Links for ECM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ECM2 Gene

mRNA expression in normal human tissues for ECM2 Gene

mRNA differential expression in normal tissues according to GTEx for ECM2 Gene

This gene is overexpressed in Artery - Coronary (5.4), Artery - Tibial (4.9), and Artery - Aorta (4.8).

Protein differential expression in normal tissues for ECM2 Gene

This gene is overexpressed in Ovary (21.3), Breast (18.4), Heart (12.9), and Adipocyte (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ECM2 Gene

SOURCE GeneReport for Unigene cluster for ECM2 Gene Hs.117060

mRNA Expression by UniProt/SwissProt for ECM2 Gene

Tissue specificity: Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus
genes like me logo Genes that share expressions with ECM2: view

Expression partners for ECM2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for ECM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ECM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ECM2 35
  • 85.33 (n)
  • 80.44 (a)
ECM2 36
  • 79 (a)
(Canis familiaris)
Mammalia ECM2 35
  • 82.06 (n)
  • 77.51 (a)
ECM2 36
  • 77 (a)
(Mus musculus)
Mammalia Ecm2 35
  • 81.05 (n)
  • 76.24 (a)
Ecm2 16
Ecm2 36
  • 75 (a)
(Pan troglodytes)
Mammalia ECM2 35
  • 99.14 (n)
  • 99 (a)
ECM2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100361383 35
  • 82.02 (n)
  • 80 (a)
(Monodelphis domestica)
Mammalia ECM2 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia ECM2 36
  • 68 (a)
(Gallus gallus)
Aves ECM2 35
  • 65.98 (n)
  • 59.8 (a)
ECM2 36
  • 57 (a)
(Anolis carolinensis)
Reptilia ECM2 36
  • 55 (a)
(Danio rerio)
Actinopterygii ecm2 35
  • 56.5 (n)
  • 53.31 (a)
ecm2 36
  • 45 (a)
Species with no ortholog for ECM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ECM2 Gene

Gene Tree for ECM2 (if available)
Gene Tree for ECM2 (if available)

Paralogs for ECM2 Gene

Paralogs for ECM2 Gene

(7) SIMAP similar genes for ECM2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ECM2: view

Variants for ECM2 Gene

Sequence variations from dbSNP and Humsavar for ECM2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_052011 -
VAR_052010 -
VAR_024646 -

Structural Variations from Database of Genomic Variants (DGV) for ECM2 Gene

Variant ID Type Subtype PubMed ID
nsv893573 CNV Gain 21882294
esv1019101 CNV Insertion 17803354
nsv527206 CNV Loss 19592680

Relevant External Links for ECM2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ECM2 Gene

Disorders for ECM2 Gene

Relevant External Links for ECM2

Genetic Association Database (GAD)

No disorders were found for ECM2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ECM2 Gene

Publications for ECM2 Gene

  1. Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3. (PMID: 9790758) Nishiu J. … Nakamura Y. (Genomics 1998) 2 3 4 23
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. (PMID: 9345023) Oritani K. … Kincade P.W. (Blood 1997) 3 23
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for ECM2 Gene

Sources for ECM2 Gene

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