Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DTYMK Gene

Aliases for DTYMK Gene

  • Deoxythymidylate Kinase 2 3 5
  • DTMP Kinase 2 3 4
  • Deoxythymidylate Kinase (Thymidylate Kinase) 2 3
  • CDC8 3 4
  • TMPK 3 4
  • TYMK 3 4
  • Thymidylate (DTMP) Kinase 2
  • Thymidylate Kinase 3
  • EC 4
  • PP3731 3

External Ids for DTYMK Gene

Previous GeneCards Identifiers for DTYMK Gene

  • GC02U990022
  • GC02P239574
  • GC02M242634
  • GC02M242935
  • GC02M242335
  • GC02M242263
  • GC02M234370
  • GC02M242615

Summaries for DTYMK Gene

GeneCards Summary for DTYMK Gene

DTYMK (Deoxythymidylate Kinase) is a Protein Coding gene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Purine metabolism (KEGG). GO annotations related to this gene include kinase activity and thymidylate kinase activity.

UniProtKB/Swiss-Prot for DTYMK Gene

  • Catalyzes the conversion of dTMP to dTDP.

Gene Wiki entry for DTYMK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTYMK Gene

Genomics for DTYMK Gene

Regulatory Elements for DTYMK Gene

Enhancers for DTYMK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G240920 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +763.2 763204 6.6 HDGF PKNOX1 ARNT YBX1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 ZNF207 CAPN10-AS1 ENSG00000235351 LOC100422094 SNED1 FARP2 ENSG00000223374 DTYMK LOC200772 C2orf54 GPC1
GH02G241616 1.2 ENCODE dbSUPER 11.3 +68.0 67985 4.1 HDGF PKNOX1 GLI4 YY1 ETS1 ZNF143 FOS SP3 YY2 TSHZ1 SNED1 ENSG00000223374 ENSG00000235351 BOK ING5 DTYMK LOC100422094 PASK PPP1R7 FARP2
GH02G241664 1.1 Ensembl ENCODE 9.5 +21.3 21276 2.1 PKNOX1 ARID4B SIN3A RAD21 ZEB1 GLIS2 ZNF366 SCRT2 FOS KDM4B ING5 ATG4B D2HGDH ENSG00000234793 DTYMK GC02M241661
GH02G241678 0.9 Ensembl ENCODE 0.4 +6.0 5970 4.3 JUN BHLHE40 SIN3A ZNF121 ZFHX2 JUND POLR2A ZNF341 FOS MAFK ING5 ATG4B STK25 ENSG00000235351 BOK LINC01238 D2HGDH DTYMK GC02M241661
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DTYMK on UCSC Golden Path with GeneCards custom track

Genomic Location for DTYMK Gene

241,675,742 bp from pter
241,686,991 bp from pter
11,250 bases
Minus strand

Genomic View for DTYMK Gene

Genes around DTYMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTYMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTYMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTYMK Gene

Proteins for DTYMK Gene

  • Protein details for DTYMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymidylate kinase
    Protein Accession:
    Secondary Accessions:
    • B7ZW70
    • Q6FGX1
    • Q9BUX4

    Protein attributes for DTYMK Gene

    212 amino acids
    Molecular mass:
    23819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DTYMK Gene

    Alternative splice isoforms for DTYMK Gene


neXtProt entry for DTYMK Gene

Post-translational modifications for DTYMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for DTYMK
  • Santa Cruz Biotechnology (SCBT) Antibodies for DTYMK

No data available for DME Specific Peptides for DTYMK Gene

Domains & Families for DTYMK Gene

Protein Domains for DTYMK Gene

Suggested Antigen Peptide Sequences for DTYMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thymidylate kinase family.
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with DTYMK: view

No data available for Gene Families for DTYMK Gene

Function for DTYMK Gene

Molecular function for DTYMK Gene

GENATLAS Biochemistry:
deoxythymidylate kinase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + dTMP = ADP + dTDP.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of dTMP to dTDP.

Enzyme Numbers (IUBMB) for DTYMK Gene

Gene Ontology (GO) - Molecular Function for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004798 thymidylate kinase activity IDA,IEA 8845311
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IBA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DTYMK: view
genes like me logo Genes that share phenotypes with DTYMK: view

Animal Model Products

CRISPR Products

miRNA for DTYMK Gene

miRTarBase miRNAs that target DTYMK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DTYMK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTYMK Gene

Localization for DTYMK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTYMK gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DTYMK Gene

Pathways & Interactions for DTYMK Gene

genes like me logo Genes that share pathways with DTYMK: view

UniProtKB/Swiss-Prot P23919-KTHY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis.

Gene Ontology (GO) - Biological Process for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IBA,IEA --
GO:0006235 dTTP biosynthetic process IEA --
GO:0007049 cell cycle TAS 8024690
GO:0008283 cell proliferation TAS 8024690
genes like me logo Genes that share ontologies with DTYMK: view

No data available for SIGNOR curated interactions for DTYMK Gene

Drugs & Compounds for DTYMK Gene

(15) Drugs for DTYMK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
5-Thymidylic acid Experimental Pharma Target 0
2',3'-Dideoxythymidine-5'-Monophosphate Experimental Pharma Target 0
3'-Azido-3'-Deoxythymidine-5'-Monophosphate Experimental Pharma Target 0
P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Experimental Pharma Target 0

(20) Additional Compounds for DTYMK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
  • 2'-Deoxyuridine-5'-diphosphate
  • Deoxyuridine-diphosphate
  • dUDP
  • 2'-Deoxy-5'-uridylate
  • 2'-Deoxy-5'-uridylic acid
  • 2'-Deoxyuridine 5'-monophosphate
  • 2'-Deoxyuridine 5'-phosphate
  • 2'-Deoxyuridylate
Thymidine 3',5'-cyclic monophosphate
  • 3',5'-Cyclic thymidine monophosphate
  • 3',5'-Cyclic TMP
  • 4H-Furo[3,2-D]-1,3,2-dioxaphosphorin thymidine deriv.
  • cTMP
  • Cyclic 3',5'-dTMP
genes like me logo Genes that share compounds with DTYMK: view

Transcripts for DTYMK Gene

Unigene Clusters for DTYMK Gene

Deoxythymidylate kinase (thymidylate kinase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DTYMK

Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -

Relevant External Links for DTYMK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DTYMK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTYMK Gene

Protein differential expression in normal tissues from HIPED for DTYMK Gene

This gene is overexpressed in Bone (14.2) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DTYMK Gene

Protein tissue co-expression partners for DTYMK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTYMK Gene:


SOURCE GeneReport for Unigene cluster for DTYMK Gene:


Evidence on tissue expression from TISSUES for DTYMK Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with DTYMK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTYMK Gene

Orthologs for DTYMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTYMK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DTYMK 34 35
  • 99.84 (n)
(Mus musculus)
Mammalia Dtymk 34 16 35
  • 82.55 (n)
(Rattus norvegicus)
Mammalia Dtymk 34
  • 82.23 (n)
(Bos Taurus)
Mammalia DTYMK 34 35
  • 82.15 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
-- 35
  • 76 (a)
(Canis familiaris)
Mammalia DTYMK 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia DTYMK 35
  • 72 (a)
(Gallus gallus)
Aves DTYMK 35
  • 29 (a)
(Anolis carolinensis)
Reptilia DTYMK 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dtymk 34
  • 64.94 (n)
Str.7637 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19382 34
(Danio rerio)
Actinopterygii dtymk 34 35
  • 62.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005260 34
  • 54.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5757 36 34 35
  • 49.68 (n)
(Caenorhabditis elegans)
Secernentea R53.2 36 34 35
  • 47.29 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR369W 34
  • 52.9 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC8 34 35 37
  • 51.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06556g 34
  • 50.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ZEU1 34
  • 50.9 (n)
(Oryza sativa)
Liliopsida Os07g0639900 34
  • 53.78 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07773 34
  • 52.92 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tmp1 34
  • 52.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
Species where no ortholog for DTYMK was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTYMK Gene

Gene Tree for DTYMK (if available)
Gene Tree for DTYMK (if available)

Paralogs for DTYMK Gene

(11) SIMAP similar genes for DTYMK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DTYMK: view

No data available for Paralogs for DTYMK Gene

Variants for DTYMK Gene

Sequence variations from dbSNP and Humsavar for DTYMK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000242398 -- 241,688,233(+) CACTC(C/T)TACCT intron-variant, upstream-variant-2KB
rs1000405985 -- 241,677,678(+) GCCTG(C/T)GAGTC intron-variant
rs1000472141 -- 241,686,872(+) AGCTA(A/G)TATTT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000588761 -- 241,682,832(+) GGCAG(A/G)AGAAT intron-variant, reference, missense
rs1000672993 -- 241,682,166(+) GAGAC(C/T)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTYMK Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
nsv508901 CNV insertion 20534489
nsv584974 CNV gain 21841781

Variation tolerance for DTYMK Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DTYMK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTYMK Gene

Disorders for DTYMK Gene

Relevant External Links for DTYMK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DTYMK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTYMK Gene

Publications for DTYMK Gene

  1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PMID: 8024690) Huang S.H. … Jong A. (DNA Cell Biol. 1994) 2 3 4 22 64
  2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PMID: 2017365) Su J.Y. … Sclafani R.A. (Nucleic Acids Res. 1991) 2 3 4 22 64
  3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PMID: 12614151) Ostermann N. … Lavie A. (Biochemistry 2003) 3 4 22 64
  4. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PMID: 18413751) Hu C.M. … Chang Z.F. (Cancer Res. 2008) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DTYMK Gene

  • Addgene plasmids for DTYMK

Sources for DTYMK Gene

Loading form....