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Aliases for DTYMK Gene

Aliases for DTYMK Gene

  • Deoxythymidylate Kinase (Thymidylate Kinase) 2 3
  • DTMP Kinase 2 3 4
  • CDC8 3 4 6
  • TYMK 3 4 6
  • TMPK 3 4
  • Thymidylate (DTMP) Kinase 2
  • Thymidylate Kinase 3
  • EC 4
  • PP3731 3

External Ids for DTYMK Gene

Previous GeneCards Identifiers for DTYMK Gene

  • GC02U990022
  • GC02P239574
  • GC02M242634
  • GC02M242935
  • GC02M242335
  • GC02M242263
  • GC02M234370
  • GC02M242615

Summaries for DTYMK Gene

GeneCards Summary for DTYMK Gene

DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include thymidylate kinase activity.

UniProtKB/Swiss-Prot for DTYMK Gene

  • Catalyzes the conversion of dTMP to dTDP

Gene Wiki entry for DTYMK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTYMK Gene

Genomics for DTYMK Gene

Regulatory Elements for DTYMK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DTYMK Gene

241,675,742 bp from pter
241,686,991 bp from pter
11,250 bases
Minus strand

Genomic View for DTYMK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTYMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTYMK Gene

Proteins for DTYMK Gene

  • Protein details for DTYMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymidylate kinase
    Protein Accession:
    Secondary Accessions:
    • B7ZW70
    • Q6FGX1
    • Q9BUX4

    Protein attributes for DTYMK Gene

    212 amino acids
    Molecular mass:
    23819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DTYMK Gene

    Alternative splice isoforms for DTYMK Gene


neXtProt entry for DTYMK Gene

Proteomics data for DTYMK Gene at MOPED

Post-translational modifications for DTYMK Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for DTYMK Gene

Antibody Products

No data available for DME Specific Peptides for DTYMK Gene

Domains for DTYMK Gene

Protein Domains for DTYMK Gene

Suggested Antigen Peptide Sequences for DTYMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thymidylate kinase family.
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with DTYMK: view

No data available for Gene Families for DTYMK Gene

Function for DTYMK Gene

Molecular function for DTYMK Gene

GENATLAS Biochemistry:
deoxythymidylate kinase
UniProtKB/Swiss-Prot CatalyticActivity:
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of dTMP to dTDP

Enzyme Numbers (IUBMB) for DTYMK Gene

Gene Ontology (GO) - Molecular Function for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004798 thymidylate kinase activity IDA 8845311
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IBA --
GO:0016301 kinase activity --
GO:0050145 nucleoside phosphate kinase activity EXP --
genes like me logo Genes that share ontologies with DTYMK: view

Phenotypes for DTYMK Gene

genes like me logo Genes that share phenotypes with DTYMK: view

Animal Model Products

miRNA for DTYMK Gene

miRTarBase miRNAs that target DTYMK

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTYMK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DTYMK Gene

Localization for DTYMK Gene

Subcellular locations from

Jensen Localization Image for DTYMK Gene COMPARTMENTS Subcellular localization image for DTYMK gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IBA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DTYMK Gene

Pathways for DTYMK Gene

genes like me logo Genes that share pathways with DTYMK: view

UniProtKB/Swiss-Prot P23919-KTHY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis

Gene Ontology (GO) - Biological Process for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IBA --
GO:0006235 dTTP biosynthetic process IEA --
GO:0007049 cell cycle TAS 8024690
GO:0008283 cell proliferation TAS 8024690
genes like me logo Genes that share ontologies with DTYMK: view

Drugs for DTYMK Gene

(8) Drugbank Compounds for DTYMK Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
165151 Target experimental
46936750 Target experimental
46936803 Target experimental
46936628 Target experimental
Phosphoaminophosphonic Acid-Adenylate Ester
44462678 Target experimental

(7) HMDB Compounds for DTYMK Gene

Compound Synonyms Cas Number PubMed IDs
5-Thymidylic acid
  • 2'-Deoxythymidine 5'-monophosphate
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
  • Deoxy-TDP
  • 2'-Deoxyuridine-5'-diphosphate

(22) Novoseek inferred chemical compound relationships for DTYMK Gene

Compound -log(P) Hits PubMed IDs
thymidylate 94.7 122
aztmp 94.2 11
aztdp 89.9 2
nucleoside monophosphate 87.6 3
triphosphate 82.7 3
genes like me logo Genes that share compounds with DTYMK: view

Transcripts for DTYMK Gene

Unigene Clusters for DTYMK Gene

Deoxythymidylate kinase (thymidylate kinase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTYMK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -

Relevant External Links for DTYMK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DTYMK Gene

mRNA expression in normal human tissues for DTYMK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DTYMK Gene

This gene is overexpressed in Bone (14.2) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTYMK Gene

SOURCE GeneReport for Unigene cluster for DTYMK Gene Hs.471873

genes like me logo Genes that share expressions with DTYMK: view

Expression partners for DTYMK Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DTYMK Gene

Orthologs for DTYMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTYMK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DTYMK 35
  • 82.15 (n)
  • 82.94 (a)
  • 83 (a)
(Mus musculus)
Mammalia Dtymk 35
  • 82.55 (n)
  • 81.13 (a)
Dtymk 16
Dtymk 36
  • 81 (a)
(Pan troglodytes)
Mammalia DTYMK 35
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dtymk 35
  • 82.23 (n)
  • 81.13 (a)
(Canis familiaris)
Mammalia DTYMK 36
  • 78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia DTYMK 36
  • 72 (a)
(Gallus gallus)
Aves DTYMK 36
  • 29 (a)
(Anolis carolinensis)
Reptilia DTYMK 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dtymk 35
  • 64.94 (n)
  • 65.57 (a)
Str.7637 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19382 35
(Danio rerio)
Actinopterygii dtymk 35
  • 62.74 (n)
  • 64.15 (a)
dtymk 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5757 37
  • 41 (a)
CG5757 35
  • 49.68 (n)
  • 45.19 (a)
CG5757 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005260 35
  • 54.84 (n)
  • 46.8 (a)
(Caenorhabditis elegans)
Secernentea R53.2 37
  • 39 (a)
R53.2 35
  • 47.29 (n)
  • 42.36 (a)
R53.2 36
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR369W 35
  • 52.9 (n)
  • 45.65 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06556g 35
  • 50.6 (n)
  • 47.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC8 35
  • 51.76 (n)
  • 52.8 (a)
CDC8 36
  • 44 (a)
CDC8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ZEU1 35
  • 50.9 (n)
  • 51.23 (a)
(Oryza sativa)
Liliopsida Os07g0639900 35
  • 53.78 (n)
  • 54.67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07773 35
  • 52.92 (n)
  • 50.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tmp1 35
  • 52.33 (n)
  • 50.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for DTYMK:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTYMK Gene

Gene Tree for DTYMK (if available)
Gene Tree for DTYMK (if available)

Paralogs for DTYMK Gene

(11) SIMAP similar genes for DTYMK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DTYMK: view

No data available for Paralogs for DTYMK Gene

Variants for DTYMK Gene

Sequence variations from dbSNP and Humsavar for DTYMK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs5860 -- 241,676,047(+) GACTC(C/T)GCTGG utr-variant-3-prime, nc-transcript-variant
rs1131195 -- 241,678,635(-) CTAGA(C/T)TGGTG intron-variant, synonymous-codon, reference, nc-transcript-variant
rs1131266 -- 241,675,983(-) CTCTT(C/T)TGCCC utr-variant-3-prime, nc-transcript-variant
rs1803265 -- 241,676,066(-) CTCGC(A/G)GAAGG utr-variant-3-prime, nc-transcript-variant
rs1803266 -- 241,678,599(-) AAACC(C/T)GACCT intron-variant, reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DTYMK Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv4493n71 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
dgv4496n71 CNV Loss 21882294
nsv508901 CNV Insertion 20534489
nsv876242 CNV Loss 21882294
dgv4497n71 CNV Loss 21882294

Relevant External Links for DTYMK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTYMK Gene

Disorders for DTYMK Gene

(1) University of Copenhagen DISEASES for DTYMK Gene

(5) Novoseek inferred disease relationships for DTYMK Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 52.3 22
immunodeficiency 30.7 3
herpes simplex 29.3 1
infectious disease 23.4 1
cancer 0 1
genes like me logo Genes that share disorders with DTYMK: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for DTYMK Gene

Publications for DTYMK Gene

  1. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PMID: 2017365) Su J.Y. … Sclafani R.A. (Nucleic Acids Res. 1991) 2 3 4 23
  2. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PMID: 8024690) Huang S.H. … Jong A. (DNA Cell Biol. 1994) 2 3 4 23
  3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PMID: 12614151) Ostermann N. … Lavie A. (Biochemistry 2003) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PMID: 18413751) Hu C.M. … Chang Z.F. (Cancer Res. 2008) 3 23

Products for DTYMK Gene

  • Addgene plasmids for DTYMK

Sources for DTYMK Gene

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