Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DTNB Gene

Aliases for DTNB Gene

  • Dystrobrevin, Beta 2 3
  • Beta-Dystrobrevin 3 4
  • DTN-B 3 4
  • Dystrobrevin Beta 3

External Ids for DTNB Gene

Previous GeneCards Identifiers for DTNB Gene

  • GC02M025521
  • GC02M025692
  • GC02M025557
  • GC02M025574
  • GC02M025511
  • GC02M025453
  • GC02M025600
  • GC02M025337

Summaries for DTNB Gene

Entrez Gene Summary for DTNB Gene

  • This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for DTNB Gene

DTNB (Dystrobrevin, Beta) is a Protein Coding gene. Among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DRP2.

Gene Wiki entry for DTNB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTNB Gene

Genomics for DTNB Gene

Regulatory Elements for DTNB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DTNB Gene

25,377,198 bp from pter
25,673,647 bp from pter
296,450 bases
Minus strand

Genomic View for DTNB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DTNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTNB Gene

Proteins for DTNB Gene

  • Protein details for DTNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dystrobrevin beta
    Protein Accession:
    Secondary Accessions:
    • B7Z733
    • F5GZG4
    • G5E9F6
    • O43782
    • O60881
    • O75538
    • Q86VR4
    • Q96AW0
    • Q9UE14
    • Q9UE15
    • Q9UE16

    Protein attributes for DTNB Gene

    627 amino acids
    Molecular mass:
    71356 Da
    Quaternary structure:
    • Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 (By similarity).

    Alternative splice isoforms for DTNB Gene

neXtProt entry for DTNB Gene

Proteomics data for DTNB Gene at MOPED

Post-translational modifications for DTNB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTNB Gene

Domains for DTNB Gene

Protein Domains for DTNB Gene

Graphical View of Domain Structure for InterPro Entry



  • O60941
  • The coiled coil domain may mediate the interaction with dystrophin
  • Belongs to the dystrophin family. Dystrobrevin subfamily.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with DTNB: view

No data available for Gene Families for DTNB Gene

Function for DTNB Gene

Molecular function for DTNB Gene

GENATLAS Biochemistry:
dystrobrevin beta,71kDa,dystrophin related,copurifying with DP71 and DP140 dystrophins,significantly homologous to DBVA,expressed in brain and other tissues but not in muscle

Gene Ontology (GO) - Molecular Function for DTNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DTNB: view

Phenotypes for DTNB Gene

genes like me logo Genes that share phenotypes with DTNB: view

Animal Model Products

miRNA for DTNB Gene

miRTarBase miRNAs that target DTNB

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTNB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DTNB Gene

Localization for DTNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTNB Gene


Subcellular locations from

Jensen Localization Image for DTNB Gene COMPARTMENTS Subcellular localization image for DTNB gene
Compartment Confidence
plasma membrane 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DTNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with DTNB: view

Compounds for DTNB Gene

(1) Novoseek inferred chemical compound relationships for DTNB Gene

Compound -log(P) Hits PubMed IDs
dapc 94.3 1
genes like me logo Genes that share compounds with DTNB: view

Transcripts for DTNB Gene

Unigene Clusters for DTNB Gene

Dystrobrevin, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DTNB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTNB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: -
SP5: -
SP6: -
SP7: - -

ExUns: 19b ^ 20 ^ 21a · 21b ^ 22
SP1: - -
SP7: -

Relevant External Links for DTNB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DTNB Gene

mRNA expression in normal human tissues for DTNB Gene

mRNA differential expression in normal tissues according to GTEx for DTNB Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.0).

Protein differential expression in normal tissues for DTNB Gene

This gene is overexpressed in Heart (20.1), Colon (11.6), Salivary gland (10.2), and Fetal gut (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DTNB Gene

SOURCE GeneReport for Unigene cluster for DTNB Gene Hs.307720

mRNA Expression by UniProt/SwissProt for DTNB Gene

Tissue specificity: Highly expressed in brain, kidney and pancreas
genes like me logo Genes that share expressions with DTNB: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for DTNB Gene

Orthologs for DTNB Gene

This gene was present in the common ancestor of animals.

Orthologs for DTNB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DTNB 35
  • 94.42 (n)
  • 97.93 (a)
  • 98 (a)
(Canis familiaris)
Mammalia DTNB 35
  • 95.11 (n)
  • 98.09 (a)
  • 94 (a)
(Mus musculus)
Mammalia Dtnb 35
  • 91.57 (n)
  • 95.84 (a)
Dtnb 16
Dtnb 36
  • 88 (a)
(Pan troglodytes)
Mammalia DTNB 35
  • 99.84 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dtnb 35
  • 91.35 (n)
  • 96.17 (a)
(Monodelphis domestica)
Mammalia DTNB 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia DTNB 36
  • 76 (a)
(Gallus gallus)
Aves DTNB 35
  • 82.26 (n)
  • 92.28 (a)
(Anolis carolinensis)
Reptilia DTNB 36
  • 79 (a)
(Danio rerio)
Actinopterygii dtnb 35
dtnbb 35
  • 75.13 (n)
  • 83.13 (a)
dtnbb 36
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dyb 35
  • 55.82 (n)
  • 53.06 (a)
Dyb 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea dyb-1 37
  • 42 (a)
dyb-1 35
  • 52.79 (n)
  • 50.38 (a)
dyb-1 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
Species with no ortholog for DTNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DTNB Gene

Gene Tree for DTNB (if available)
Gene Tree for DTNB (if available)

Paralogs for DTNB Gene

Paralogs for DTNB Gene

genes like me logo Genes that share paralogs with DTNB: view

Variants for DTNB Gene

Sequence variations from dbSNP and Humsavar for DTNB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs476731 -- 25,537,044(+) ccCCA(C/T)ACTGC intron-variant
rs478237 -- 25,553,016(+) CCACC(A/G)CGCCC intron-variant
rs483490 -- 25,533,395(-) TTTCG(C/T)TTTAT intron-variant
rs486217 -- 25,544,692(-) GTTAC(C/T)AGGTG intron-variant
rs498615 -- 25,492,456(-) TAAGT(C/T)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DTNB Gene

Variant ID Type Subtype PubMed ID
esv33372 CNV Loss 17666407
esv2719823 CNV Deletion 23290073
esv4217 CNV Deletion 18987735
nsv512768 CNV Insertion 21212237
esv33756 CNV Gain 17666407
esv33316 CNV Loss 17666407
esv2675591 CNV Deletion 23128226
esv2719824 CNV Deletion 23290073
esv2671046 CNV Deletion 23128226
nsv819351 CNV Gain 19587683
nsv873743 CNV Loss 21882294
esv25482 CNV Loss 19812545

Relevant External Links for DTNB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTNB Gene

Disorders for DTNB Gene

(1) University of Copenhagen DISEASES for DTNB Gene

(1) Novoseek inferred disease relationships for DTNB Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 30 1

Relevant External Links for DTNB

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with DTNB: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for DTNB Gene

Publications for DTNB Gene

  1. Beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations. (PMID: 9395493) Peters M.F. … Froehner S.C. (J. Biol. Chem. 1997) 3 4 23
  2. beta-dystrobrevin, a member of the dystrophin-related protein family. (PMID: 9419360) Blake D.J. … Davies K.E. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 23
  3. Identification and characterization of a novel member of the dystrobrevin gene family. (PMID: 9540997) Puca A.A. … Franco B. (FEBS Lett. 1998) 3 4 23
  4. Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. (PMID: 10747910) Piluso G. … Nigro V. (J. Biol. Chem. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DTNB Gene

Sources for DTNB Gene

Back to Top