Aliases for DTNA Gene
External Ids for DTNA Gene
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DTNA Gene
DTNA (Dystrobrevin, Alpha) is a Protein Coding gene. Diseases associated with DTNA include left ventricular noncompaction and left ventricular noncompaction 1, with or without congenital heart defects. Among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DRP2.
UniProtKB/Swiss-Prot for DTNA Gene
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors