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Aliases for TSC22D3 Gene

Aliases for TSC22D3 Gene

  • TSC22 Domain Family Member 3 2 3 5
  • Glucocorticoid-Induced Leucine Zipper Protein 3 4
  • Delta Sleep Inducing Peptide, Immunoreactor 2 3
  • Delta Sleep-Inducing Peptide Immunoreactor 3 4
  • TSC22 Domain Family, Member 3 2 3
  • DSIP-Immunoreactive Peptide 3 4
  • TSC-22-Related Protein 3 4
  • TSC-22-Like Protein 3 4
  • TSC-22R 3 4
  • DSIPI 3 4
  • GILZ 3 4
  • DSIP-Immunoreactive Leucine Zipper Protein 3
  • Glucocorticoid-Induced Leucine Zipper 2
  • TSC-22 Related Protein 3
  • Protein DIP 4
  • HDIP 4
  • DIP 3

External Ids for TSC22D3 Gene

Previous HGNC Symbols for TSC22D3 Gene

  • DSIPI

Previous GeneCards Identifiers for TSC22D3 Gene

  • GC0XM106763
  • GC0XM106956
  • GC0XM096580

Summaries for TSC22D3 Gene

Entrez Gene Summary for TSC22D3 Gene

  • This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TSC22D3 Gene

TSC22D3 (TSC22 Domain Family Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and MRF binding. An important paralog of this gene is TSC22D2.

UniProtKB/Swiss-Prot for TSC22D3 Gene

  • Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

Gene Wiki entry for TSC22D3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D3 Gene

Genomics for TSC22D3 Gene

Regulatory Elements for TSC22D3 Gene

Promoters for TSC22D3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSC22D3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TSC22D3 gene promoter:

Genomic Location for TSC22D3 Gene

Chromosome:
X
Start:
107,713,221 bp from pter
End:
107,777,342 bp from pter
Size:
64,122 bases
Orientation:
Minus strand

Genomic View for TSC22D3 Gene

Genes around TSC22D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSC22D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSC22D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D3 Gene

Proteins for TSC22D3 Gene

  • Protein details for TSC22D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99576-T22D3_HUMAN
    Recommended name:
    TSC22 domain family protein 3
    Protein Accession:
    Q99576
    Secondary Accessions:
    • Q5H9S3
    • Q5JRI9
    • Q6FIH6
    • Q8NAI1
    • Q8WVB9
    • Q9UBN5
    • Q9UG13

    Protein attributes for TSC22D3 Gene

    Size:
    134 amino acids
    Molecular mass:
    14810 Da
    Quaternary structure:
    • Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1. Isoform 1 interacts with MYOD1 (By similarity). Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).
    SequenceCaution:
    • Sequence=AAH18148.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA90644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB53669.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for TSC22D3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSC22D3 Gene

Proteomics data for TSC22D3 Gene at MOPED

Post-translational modifications for TSC22D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TSC22D3 Gene

Domains & Families for TSC22D3 Gene

Protein Domains for TSC22D3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99576

UniProtKB/Swiss-Prot:

T22D3_HUMAN :
  • The leucine-zipper is involved in homodimerization.
  • Belongs to the TSC-22/Dip/Bun family.
Domain:
  • The leucine-zipper is involved in homodimerization.
Family:
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D3: view

No data available for Gene Families for TSC22D3 Gene

Function for TSC22D3 Gene

Molecular function for TSC22D3 Gene

UniProtKB/Swiss-Prot Function:
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
UniProtKB/Swiss-Prot Induction:
By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Isoform 1 expression is up-regulated by synthetic glucocorticoid dexamethasone in differentiating myoblasts (By similarity).
genes like me logo Genes that share phenotypes with TSC22D3: view

Animal Models for TSC22D3 Gene

MGI Knock Outs for TSC22D3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSC22D3 Gene

Localization for TSC22D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSC22D3 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSC22D3 Gene COMPARTMENTS Subcellular localization image for TSC22D3 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
golgi apparatus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TSC22D3 Gene

Pathways & Interactions for TSC22D3 Gene

genes like me logo Genes that share pathways with TSC22D3: view

Pathways by source for TSC22D3 Gene

Gene Ontology (GO) - Biological Process for TSC22D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0048642 negative regulation of skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with TSC22D3: view

No data available for SIGNOR curated interactions for TSC22D3 Gene

Drugs & Compounds for TSC22D3 Gene

(6) Drugs for TSC22D3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for TSC22D3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSC22D3: view

Transcripts for TSC22D3 Gene

Unigene Clusters for TSC22D3 Gene

TSC22 domain family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - -
SP14: -

Relevant External Links for TSC22D3 Gene

GeneLoc Exon Structure for
TSC22D3
ECgene alternative splicing isoforms for
TSC22D3

Expression for TSC22D3 Gene

mRNA expression in normal human tissues for TSC22D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSC22D3 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for TSC22D3 Gene

This gene is overexpressed in Ovary (18.0), Spleen (11.9), Bone marrow stromal cell (8.7), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSC22D3 Gene



SOURCE GeneReport for Unigene cluster for TSC22D3 Gene Hs.522074

mRNA Expression by UniProt/SwissProt for TSC22D3 Gene

Q99576-T22D3_HUMAN
Tissue specificity: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
genes like me logo Genes that share expression patterns with TSC22D3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for TSC22D3 Gene

Orthologs for TSC22D3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSC22D3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSC22D3 36
  • 96 (a)
OneToOne
TSC22D3 35
  • 92.83 (n)
  • 94.5 (a)
dog
(Canis familiaris)
Mammalia TSC22D3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsc22d3 16
Tsc22d3 35
  • 86.87 (n)
  • 89.39 (a)
Tsc22d3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSC22D3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSC22D3 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSC22D3 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSC22D3 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8142 35
zebrafish
(Danio rerio)
Actinopterygii tsc22d3 36
  • 57 (a)
OneToOne
zgc65831 35
fruit fly
(Drosophila melanogaster)
Insecta bun 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30G4.7 36
  • 30 (a)
ManyToMany
T18D3.7 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for TSC22D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSC22D3 Gene

ENSEMBL:
Gene Tree for TSC22D3 (if available)
TreeFam:
Gene Tree for TSC22D3 (if available)

Paralogs for TSC22D3 Gene

Paralogs for TSC22D3 Gene

Pseudogenes.org Pseudogenes for TSC22D3 Gene

genes like me logo Genes that share paralogs with TSC22D3: view

Variants for TSC22D3 Gene

Sequence variations from dbSNP and Humsavar for TSC22D3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4300127 -- 107,773,635(+) GAGAT(A/G)ATTTG intron-variant
rs4418473 -- 107,717,649(+) GGACC(G/T)GCACA intron-variant, upstream-variant-2KB
rs5903308 -- 107,770,381(+) GACTC(-/ACTT)AGAGA intron-variant
rs5917068 -- 107,753,862(+) AATAA(A/T)TAAGA intron-variant
rs6523973 -- 107,722,979(+) GGCCA(A/G)TTCAG intron-variant

Variation tolerance for TSC22D3 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSC22D3 Gene

HapMap Linkage Disequilibrium report
TSC22D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSC22D3 Gene

Disorders for TSC22D3 Gene

Relevant External Links for TSC22D3

Genetic Association Database (GAD)
TSC22D3
Human Genome Epidemiology (HuGE) Navigator
TSC22D3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSC22D3

No disorders were found for TSC22D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSC22D3 Gene

Publications for TSC22D3 Gene

  1. hDIP -- a potential transcriptional regulator related to murine TSC- 22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues. (PMID: 8982256) Vogel P. … Forssmann W.-G. (Biochim. Biophys. Acta 1996) 2 3 4 23 67
  2. The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis. (PMID: 19875485) Lekva T. … Jemtland R. (J. Clin. Endocrinol. Metab. 2010) 3 23
  3. Glucocorticoid-induced leucine zipper (GILZ) promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner. (PMID: 20018851) LatrAc de LatAc P. … Biola-Vidamment A. (J. Biol. Chem. 2010) 3 23
  4. A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport. (PMID: 16216878) Soundararajan R. … Pearce D. (J. Biol. Chem. 2005) 3 23
  5. FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced leucine zipper expression. (PMID: 15705665) Asselin-Labat M.L. … Pallardy M. (Mol. Endocrinol. 2005) 3 23

Products for TSC22D3 Gene

Sources for TSC22D3 Gene

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