Aliases for DSG3 Gene
External Ids for DSG3 Gene
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
GeneCards Summary for DSG3 Gene
DSG3 (Desmoglein 3) is a Protein Coding gene. Diseases associated with DSG3 include pemphigus vegetans and pemphigus erythematosus. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for DSG3 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion