Aliases for DSG1 Gene
External Ids for DSG1 Gene
Previous Symbols for DSG1 Gene
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
GeneCards Summary for DSG1 Gene
DSG1 (Desmoglein 1) is a Protein Coding gene. Diseases associated with DSG1 include erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper ige and pemphigus vegetans. Among its related pathways are Staphylococcus aureus infection and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include calcium ion binding and toxic substance binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for DSG1 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion