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Aliases for ARID3A Gene

Aliases for ARID3A Gene

  • AT-Rich Interaction Domain 3A 2 3 5
  • AT Rich Interactive Domain 3A (BRIGHT-Like) 2 3
  • B-Cell Regulator Of IgH Transcription 3 4
  • ARID Domain-Containing Protein 3A 3 4
  • Dead Ringer-Like Protein 1 3 4
  • E2F-Binding Protein 1 3 4
  • BRIGHT 3 4
  • E2FBP1 3 4
  • DRIL1 3 4
  • DRIL3 3 4
  • AT Rich Interactive Domain 3A (BRIGHT- Like) Protein 3
  • AT Rich Interactive Domain 3A (BRIGHT- Like) 2
  • Dead Ringer-Like 1 (Drosophila) 2
  • ARID Domain-Containing 3A 3
  • Dead Ringer-Like 1 3
  • DRX 4

External Ids for ARID3A Gene

Previous HGNC Symbols for ARID3A Gene

  • DRIL1

Previous GeneCards Identifiers for ARID3A Gene

  • GC19P000880
  • GC19P000877
  • GC19P000699

Summaries for ARID3A Gene

Entrez Gene Summary for ARID3A Gene

  • This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3A Gene

ARID3A (AT-Rich Interaction Domain 3A) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ARID1A.

UniProtKB/Swiss-Prot for ARID3A Gene

  • Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.

Gene Wiki entry for ARID3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3A Gene

Genomics for ARID3A Gene

Regulatory Elements for ARID3A Gene

Enhancers for ARID3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARID3A on UCSC Golden Path with GeneCards custom track

Promoters for ARID3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARID3A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARID3A Gene

925,781 bp from pter
975,934 bp from pter
50,154 bases
Plus strand

Genomic View for ARID3A Gene

Genes around ARID3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3A Gene

Proteins for ARID3A Gene

  • Protein details for ARID3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AT-rich interactive domain-containing protein 3A
    Protein Accession:
    Secondary Accessions:
    • Q5I858
    • Q6P9C6
    • Q8IZA7
    • Q8N4Z3

    Protein attributes for ARID3A Gene

    593 amino acids
    Molecular mass:
    62889 Da
    Quaternary structure:
    • Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.
    • Sequence=AAW30734.1; Type=Frameshift; Positions=498; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARID3A Gene

neXtProt entry for ARID3A Gene

Proteomics data for ARID3A Gene at MOPED

Post-translational modifications for ARID3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID3A Gene

Domains & Families for ARID3A Gene

Gene Families for ARID3A Gene

Protein Domains for ARID3A Gene

Suggested Antigen Peptide Sequences for ARID3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ARID domain.
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3A: view

Function for ARID3A Gene

Molecular function for ARID3A Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
UniProtKB/Swiss-Prot Induction:
By p53/TP53 following DNA damage.

Gene Ontology (GO) - Molecular Function for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IEA,IPI 19214191
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with ARID3A: view
genes like me logo Genes that share phenotypes with ARID3A: view

Animal Models for ARID3A Gene

MGI Knock Outs for ARID3A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID3A Gene

Localization for ARID3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3A Gene

Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.

Subcellular locations from

Jensen Localization Image for ARID3A Gene COMPARTMENTS Subcellular localization image for ARID3A gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ARID3A: view

Pathways & Interactions for ARID3A Gene

genes like me logo Genes that share pathways with ARID3A: view

Gene Ontology (GO) - Biological Process for ARID3A Gene


No data available for SIGNOR curated interactions for ARID3A Gene

Drugs & Compounds for ARID3A Gene

No Compound Related Data Available

Transcripts for ARID3A Gene

Unigene Clusters for ARID3A Gene

AT rich interactive domain 3A (BRIGHT-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3A Gene

No ASD Table

Relevant External Links for ARID3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARID3A Gene

mRNA expression in normal human tissues for ARID3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID3A Gene

This gene is overexpressed in Whole Blood (x9.8).

Protein differential expression in normal tissues from HIPED for ARID3A Gene

This gene is overexpressed in Fetal gut (28.0), Placenta (19.2), and Monocytes (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARID3A Gene

SOURCE GeneReport for Unigene cluster for ARID3A Gene Hs.501296

mRNA Expression by UniProt/SwissProt for ARID3A Gene

Tissue specificity: Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.
genes like me logo Genes that share expression patterns with ARID3A: view

Primer Products

No data available for Protein tissue co-expression partners for ARID3A Gene

Orthologs for ARID3A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARID3A 35
  • 81.7 (n)
  • 82.68 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ARID3A 35
  • 84.58 (n)
  • 84.98 (a)
  • 84 (a)
(Mus musculus)
Mammalia Arid3a 35
  • 78.89 (n)
  • 81.49 (a)
Arid3a 16
Arid3a 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Arid3a 35
  • 78.16 (n)
  • 81.3 (a)
(Monodelphis domestica)
Mammalia ARID3A 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ARID3A 36
  • 84 (a)
(Pan troglodytes)
Mammalia ARID3A 36
  • 99 (a)
(Gallus gallus)
Aves ARID3A 35
  • 73.54 (n)
  • 69.41 (a)
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arid3a 35
  • 68.3 (n)
  • 71.89 (a)
Str.11240 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.26694 35
(Danio rerio)
Actinopterygii LOC562799 35
  • 71 (n)
  • 74.28 (a)
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta retn 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea cfi-1 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 36
  • 38 (a)
Species with no ortholog for ARID3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID3A Gene

Gene Tree for ARID3A (if available)
Gene Tree for ARID3A (if available)

Paralogs for ARID3A Gene

Paralogs for ARID3A Gene

(3) SIMAP similar genes for ARID3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARID3A: view

Variants for ARID3A Gene

Sequence variations from dbSNP and Humsavar for ARID3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17857499 - 929,635(+) ACCCC(A/C/G)CGGCC reference, missense
rs17857501 - 964,840(+) ACATG(A/G)AGTAC reference, missense
rs1051505 - 971,949(+) gcggc(A/G)gcagc reference, missense
rs758207 -- 939,673(+) TTCGC(A/G)TCGTA intron-variant
rs758218 -- 963,334(+) CACGT(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID3A Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3551n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3558n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
dgv3561n71 CNV Loss 21882294
dgv3562n71 CNV Loss 21882294
nsv910338 CNV Gain+Loss 21882294
nsv9662 CNV Gain 18304495
nsv910347 CNV Loss 21882294
dgv3563n71 CNV Loss 21882294
nsv910351 CNV Gain 21882294
dgv3564n71 CNV Loss 21882294
esv2665746 CNV Deletion 23128226
dgv3565n71 CNV Loss 21882294
esv2673891 CNV Deletion 23128226
esv2717811 CNV Deletion 23290073
dgv3566n71 CNV Loss 21882294
esv2717812 CNV Deletion 23290073
esv3453 CNV Deletion 18987735
esv1501734 CNV Deletion 17803354
esv2717813 CNV Deletion 23290073
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
nsv910359 CNV Loss 21882294
nsv910361 CNV Gain+Loss 21882294
dgv3567n71 CNV Loss 21882294

Variation tolerance for ARID3A Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARID3A Gene

Disorders for ARID3A Gene

Relevant External Links for ARID3A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARID3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARID3A Gene

Publications for ARID3A Gene

  1. The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome. (PMID: 9722953) Kortschak R.D. … Jenne D.E. (Genomics 1998) 2 3 4 67
  2. Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells. (PMID: 25535283) Ratliff M.L. … Webb C.F. (J. Immunol. 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3
  5. Disease activity in systemic lupus erythematosus correlates with expression of the transcription factor AT-rich-interactive domain 3A. (PMID: 25185498) Ward J.M. … Webb C.F. ( 2014) 3

Products for ARID3A Gene

Sources for ARID3A Gene