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Aliases for ARID3A Gene

Aliases for ARID3A Gene

  • AT Rich Interactive Domain 3A (BRIGHT-Like) 2 3
  • DRIL1 3 4 6
  • B-Cell Regulator Of IgH Transcription 3 4
  • ARID Domain-Containing Protein 3A 3 4
  • Dead Ringer-Like Protein 1 3 4
  • E2F-Binding Protein 1 3 4
  • BRIGHT 3 4
  • E2FBP1 3 4
  • DRIL3 3 4
  • AT Rich Interactive Domain 3A (BRIGHT- Like) Protein 3
  • AT-Rich Interactive Domain-Containing Protein 3A 3
  • AT Rich Interactive Domain 3A (BRIGHT- Like) 2
  • Dead Ringer-Like 1 (Drosophila) 2
  • ARID Domain-Containing 3A 3
  • Dead Ringer-Like 1 3
  • DRX 4

External Ids for ARID3A Gene

Previous HGNC Symbols for ARID3A Gene

  • DRIL1

Previous GeneCards Identifiers for ARID3A Gene

  • GC19P000880
  • GC19P000877
  • GC19P000699

Summaries for ARID3A Gene

Entrez Gene Summary for ARID3A Gene

  • This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3A Gene

ARID3A (AT Rich Interactive Domain 3A (BRIGHT-Like)) is a Protein Coding gene. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ARID3B.

UniProtKB/Swiss-Prot for ARID3A Gene

  • Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.

Gene Wiki entry for ARID3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3A Gene

Genomics for ARID3A Gene

Regulatory Elements for ARID3A Gene

Genomic Location for ARID3A Gene

Start:
925,733 bp from pter
End:
975,934 bp from pter
Size:
50,202 bases
Orientation:
Plus strand

Genomic View for ARID3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3A Gene

Proteins for ARID3A Gene

  • Protein details for ARID3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99856-ARI3A_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 3A
    Protein Accession:
    Q99856
    Secondary Accessions:
    • Q5I858
    • Q6P9C6
    • Q8IZA7
    • Q8N4Z3

    Protein attributes for ARID3A Gene

    Size:
    593 amino acids
    Molecular mass:
    62889 Da
    Quaternary structure:
    • Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.
    SequenceCaution:
    • Sequence=AAW30734.1; Type=Frameshift; Positions=498; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARID3A Gene

neXtProt entry for ARID3A Gene

Proteomics data for ARID3A Gene at MOPED

Post-translational modifications for ARID3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID3A Gene

Domains for ARID3A Gene

Protein Domains for ARID3A Gene

Suggested Antigen Peptide Sequences for ARID3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99856

UniProtKB/Swiss-Prot:

ARI3A_HUMAN :
  • Q99856
Domain:
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3A: view

No data available for Gene Families for ARID3A Gene

Function for ARID3A Gene

Molecular function for ARID3A Gene

UniProtKB/Swiss-Prot Function: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
UniProtKB/Swiss-Prot Induction: By p53/TP53 following DNA damage.

Gene Ontology (GO) - Molecular Function for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with ARID3A: view
genes like me logo Genes that share phenotypes with ARID3A: view

Animal Models for ARID3A Gene

MGI Knock Outs for ARID3A:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARID3A Gene

Localization for ARID3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3A Gene

Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID3A Gene COMPARTMENTS Subcellular localization image for ARID3A gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ARID3A: view

Pathways for ARID3A Gene

SuperPathways for ARID3A Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with ARID3A: view

Pathways by source for ARID3A Gene

1 BioSystems pathway for ARID3A Gene

Gene Ontology (GO) - Biological Process for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARID3A: view

Transcripts for ARID3A Gene

Unigene Clusters for ARID3A Gene

AT rich interactive domain 3A (BRIGHT-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3A Gene

No ASD Table

Relevant External Links for ARID3A Gene

GeneLoc Exon Structure for
ARID3A
ECgene alternative splicing isoforms for
ARID3A

Expression for ARID3A Gene

mRNA expression in normal human tissues for ARID3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID3A Gene

This gene is overexpressed in Whole Blood (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARID3A Gene

SOURCE GeneReport for Unigene cluster for ARID3A Gene Hs.501296

mRNA Expression by UniProt/SwissProt for ARID3A Gene

Q99856-ARI3A_HUMAN
Tissue specificity: Widely expressed, with highest expression in skeletal muscle, thalamus, and colon
genes like me logo Genes that share expressions with ARID3A: view

Orthologs for ARID3A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID3A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARID3A 35
  • 81.7 (n)
  • 82.68 (a)
ARID3A 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID3A 35
  • 84.58 (n)
  • 84.98 (a)
ARID3A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid3a 35
  • 78.89 (n)
  • 81.49 (a)
Arid3a 16
Arid3a 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARID3A 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID3A 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid3a 35
  • 78.16 (n)
  • 81.3 (a)
chicken
(Gallus gallus)
Aves ARID3A 35
  • 73.54 (n)
  • 69.41 (a)
ARID3A 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26694 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arid3a 35
  • 68.3 (n)
  • 71.89 (a)
Str.11240 35
zebrafish
(Danio rerio)
Actinopterygii ARID3A 36
  • 59 (a)
OneToOne
LOC562799 35
  • 71 (n)
  • 74.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta retn 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfi-1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 36
  • 38 (a)
OneToMany
Species with no ortholog for ARID3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID3A Gene

ENSEMBL:
Gene Tree for ARID3A (if available)
TreeFam:
Gene Tree for ARID3A (if available)

Paralogs for ARID3A Gene

Paralogs for ARID3A Gene

Selected SIMAP similar genes for ARID3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARID3A: view

Variants for ARID3A Gene

Sequence variations from dbSNP and Humsavar for ARID3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs168404 -- 924,795(+) GACTA(C/G)AACCC upstream-variant-2KB
rs187048 -- 929,257(+) TCCCC(C/T)TCAGG intron-variant, upstream-variant-2KB
rs349304 -- 950,264(+) CAGAG(G/T)GAACG intron-variant
rs349305 -- 950,169(+) GCCGT(C/G)CCCAG intron-variant
rs349306 -- 950,694(+) CCTCC(A/G)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID3A Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3551n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3558n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
dgv3561n71 CNV Loss 21882294
dgv3562n71 CNV Loss 21882294
nsv910338 CNV Gain+Loss 21882294
nsv9662 CNV Gain 18304495
nsv910347 CNV Loss 21882294
dgv3563n71 CNV Loss 21882294
nsv910351 CNV Gain 21882294
dgv3564n71 CNV Loss 21882294
esv2665746 CNV Deletion 23128226
dgv3565n71 CNV Loss 21882294
esv2673891 CNV Deletion 23128226
esv2717811 CNV Deletion 23290073
dgv3566n71 CNV Loss 21882294
esv2717812 CNV Deletion 23290073
esv3453 CNV Deletion 18987735
esv1501734 CNV Deletion 17803354
esv2717813 CNV Deletion 23290073
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
nsv910359 CNV Loss 21882294
nsv910361 CNV Gain+Loss 21882294
dgv3567n71 CNV Loss 21882294

Relevant External Links for ARID3A Gene

HapMap Linkage Disequilibrium report
ARID3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID3A Gene

Disorders for ARID3A Gene

Relevant External Links for ARID3A

Genetic Association Database (GAD)
ARID3A
Human Genome Epidemiology (HuGE) Navigator
ARID3A
genes like me logo Genes that share disorders with ARID3A: view

No data available for UniProtKB/Swiss-Prot for ARID3A Gene

Publications for ARID3A Gene

  1. The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome. (PMID: 9722953) Kortschak R.D. … Jenne D.E. (Genomics 1998) 2 3 4
  2. A novel E2F binding protein with Myc-type HLH motif stimulates E2F- dependent transcription by forming a heterodimer. (PMID: 9780002) Suzuki M. … Oda K. (Oncogene 1998) 3 4
  3. E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53. (PMID: 12692263) Ma K. … Ikeda M.-A. (Mol. Cancer Res. 2003) 3 4
  4. A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence. (PMID: 11812999) Peeper D.S. … Bernards R. (Nat. Cell Biol. 2002) 3 4
  5. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. (PMID: 16738337) Rajaiya J. … Webb C.F. (Mol. Cell. Biol. 2006) 3 4

Products for ARID3A Gene

Sources for ARID3A Gene

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