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Aliases for AGRP Gene

Aliases for AGRP Gene

  • Agouti Related Neuropeptide 2 3
  • AGRT 3 4 6
  • ART 3 4 6
  • Agouti Related Protein Homolog (Mouse) 2
  • Agouti (Mouse) Related Protein 2
  • Agouti Related Protein Homolog 3
  • Agouti-Related Protein 3
  • ASIP2 3

External Ids for AGRP Gene

Previous GeneCards Identifiers for AGRP Gene

  • GC16M058210
  • GC16M067894
  • GC16M067251
  • GC16M067292
  • GC16M066073
  • GC16M067516
  • GC16M053389

Summaries for AGRP Gene

Entrez Gene Summary for AGRP Gene

  • This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

GeneCards Summary for AGRP Gene

AGRP (Agouti Related Neuropeptide) is a Protein Coding gene. Diseases associated with AGRP include overnutrition and obesity. Among its related pathways are Adipocytokine signaling pathway and Syndecan-3-mediated signaling events. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for AGRP Gene

  • Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

Gene Wiki entry for AGRP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGRP Gene

Genomics for AGRP Gene

Regulatory Elements for AGRP Gene

Transcription factor binding sites by QIAGEN in the AGRP gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGRP Gene

Start:
67,482,571 bp from pter
End:
67,483,813 bp from pter
Size:
1,243 bases
Orientation:
Minus strand

Genomic View for AGRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGRP Gene

Proteins for AGRP Gene

  • Protein details for AGRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00253-AGRP_HUMAN
    Recommended name:
    Agouti-related protein
    Protein Accession:
    O00253
    Secondary Accessions:
    • O15459
    • Q2TBD9

    Protein attributes for AGRP Gene

    Size:
    132 amino acids
    Molecular mass:
    14440 Da
    Quaternary structure:
    • Interacts with melanocortin receptors MC3R, MC4R and MC5R.

    Three dimensional structures from OCA and Proteopedia for AGRP Gene

neXtProt entry for AGRP Gene

Proteomics data for AGRP Gene at MOPED

Post-translational modifications for AGRP Gene

No Post-translational modifications

Other Protein References for AGRP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AGRP Gene

Domains for AGRP Gene

Gene Families for AGRP Gene

HGNC:

Protein Domains for AGRP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AGRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00253

UniProtKB/Swiss-Prot:

AGRP_HUMAN :
  • O00253
Domain:
  • The presence of a disulfide through disulfide knot structurally defines this protein as a knottin.
  • Contains 1 agouti domain.
genes like me logo Genes that share domains with AGRP: view

Function for AGRP Gene

Molecular function for AGRP Gene

GENATLAS Biochemistry:
mouse agouti related protein,primarily expressed in adrenal gland,subthalamic mucleus,hypothalamus,potent antagonist of melanocortin receptor MICR3,MICR4, implicated in body weight regulation
UniProtKB/Swiss-Prot Function:
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

Gene Ontology (GO) - Molecular Function for AGRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10318826
GO:0005184 neuropeptide hormone activity IDA 15927146
genes like me logo Genes that share ontologies with AGRP: view
genes like me logo Genes that share phenotypes with AGRP: view

Animal Models for AGRP Gene

MGI Knock Outs for AGRP:

Animal Model Products

miRNA for AGRP Gene

miRTarBase miRNAs that target AGRP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGRP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AGRP Gene

Localization for AGRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGRP Gene

Secreted. Golgi apparatus lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGRP Gene COMPARTMENTS Subcellular localization image for AGRP gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 3

Gene Ontology (GO) - Cellular Components for AGRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 15927146
GO:0005796 Golgi lumen IDA 15927146
GO:0043025 neuronal cell body IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AGRP: view

Pathways for AGRP Gene

genes like me logo Genes that share pathways with AGRP: view

Pathways by source for AGRP Gene

1 BioSystems pathway for AGRP Gene
1 KEGG pathway for AGRP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for AGRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IDA 15927146
GO:0007631 feeding behavior TAS 9751529
GO:0008343 adult feeding behavior IEA --
GO:0009648 photoperiodism IEA --
GO:0009755 hormone-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with AGRP: view

Compounds for AGRP Gene

(14) Novoseek inferred chemical compound relationships for AGRP Gene

Compound -log(P) Hits PubMed IDs
alpha msh 82.9 7
oxyntomodulin 69.6 1
cocaine 57.5 19
tcep 53.3 1
cystine 50.7 2
genes like me logo Genes that share compounds with AGRP: view

Transcripts for AGRP Gene

mRNA/cDNA for AGRP Gene

(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGRP Gene

Agouti related protein homolog (mouse):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGRP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGRP Gene

No ASD Table

Relevant External Links for AGRP Gene

GeneLoc Exon Structure for
AGRP
ECgene alternative splicing isoforms for
AGRP

Expression for AGRP Gene

mRNA expression in normal human tissues for AGRP Gene

mRNA differential expression in normal tissues according to GTEx for AGRP Gene

This gene is overexpressed in Brain - Hypothalamus (27.3) and Adrenal Gland (13.0).

Protein differential expression in normal tissues for AGRP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AGRP Gene

SOURCE GeneReport for Unigene cluster for AGRP Gene Hs.104633

mRNA Expression by UniProt/SwissProt for AGRP Gene

O00253-AGRP_HUMAN
Tissue specificity: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney
genes like me logo Genes that share expressions with AGRP: view

Expression partners for AGRP Gene

In Situ Assay Products

Orthologs for AGRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGRP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGRP 35
  • 82.07 (n)
  • 76.52 (a)
AGRP 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGRP 35
  • 86.32 (n)
  • 82.05 (a)
AGRP 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agrp 35
  • 82.44 (n)
  • 80.92 (a)
Agrp 16
Agrp 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGRP 35
  • 99.75 (n)
  • 100 (a)
AGRP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agrp 35
  • 82.68 (n)
  • 75.59 (a)
oppossum
(Monodelphis domestica)
Mammalia AGRP 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGRP 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859622 35
  • 59.54 (n)
  • 50.38 (a)
AGRP 36
  • 27 (a)
OneToMany
AGRP 36
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii agrp 36
  • 33 (a)
OneToOne
Species with no ortholog for AGRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGRP Gene

ENSEMBL:
Gene Tree for AGRP (if available)
TreeFam:
Gene Tree for AGRP (if available)

Paralogs for AGRP Gene

Selected SIMAP similar genes for AGRP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AGRP: view

No data available for Paralogs for AGRP Gene

Variants for AGRP Gene

Sequence variations from dbSNP and Humsavar for AGRP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_015385 -

Structural Variations from Database of Genomic Variants (DGV) for AGRP Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv471092 CNV Gain 18288195
nsv833266 CNV Loss 17160897

Relevant External Links for AGRP Gene

HapMap Linkage Disequilibrium report
AGRP
Human Gene Mutation Database (HGMD)
AGRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGRP Gene

Disorders for AGRP Gene

(1) OMIM Diseases for AGRP Gene (602311)

UniProtKB/Swiss-Prot

AGRP_HUMAN
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(8) Novoseek inferred disease relationships for AGRP Gene

Disease -log(P) Hits PubMed IDs
obesity 68 26
anorexia nervosa 55.1 6
prader-willi syndrome 37 1
eating disorders 27.8 1
chronic disease 5.26 1

Relevant External Links for AGRP

Genetic Association Database (GAD)
AGRP
Human Genome Epidemiology (HuGE) Navigator
AGRP
genes like me logo Genes that share disorders with AGRP: view

No data available for University of Copenhagen DISEASES and Genatlas for AGRP Gene

Publications for AGRP Gene

  1. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. (PMID: 9311920) Ollmann M.M. … Barsh G.S. (Science 1997) 2 3 4 23
  2. Association between an agouti-related protein gene polymorphism and anorexia nervosa. (PMID: 11326303) Vink T. … Adan R.A. (Mol. Psychiatry 2001) 3 4 23 48
  3. Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. (PMID: 11487744) Dubern B. … Tounian P. (J. Pediatr. 2001) 3 23 48
  4. A polymorphism in the human agouti-related protein is associated with late-onset obesity. (PMID: 12213871) Argyropoulos G. … Bouchard C. (J. Clin. Endocrinol. Metab. 2002) 3 4 23
  5. Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation. (PMID: 9724530) Bures E.J. … Haniu M. (Biochemistry 1998) 3 4 23

Products for AGRP Gene

Sources for AGRP Gene

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