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Aliases for DPT Gene

Aliases for DPT Gene

  • Dermatopontin 2 3
  • Tyrosine-Rich Acidic Matrix Protein 3 4
  • TRAMP 3 4

External Ids for DPT Gene

Summaries for DPT Gene

Entrez Gene Summary for DPT Gene

  • Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPT Gene

DPT (Dermatopontin) is a Protein Coding gene. Diseases associated with DPT include aniseikonia and anisometropia. Among its related pathways are TGF-beta Signaling Pathway (sino).

UniProtKB/Swiss-Prot for DPT Gene

  • Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).

Gene Wiki entry for DPT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPT Gene

Genomics for DPT Gene

Genomic Location for DPT Gene

Start:
168,695,457 bp from pter
End:
168,729,264 bp from pter
Size:
33,808 bases
Orientation:
Minus strand

Genomic View for DPT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPT Gene

Regulatory Elements for DPT Gene

Proteins for DPT Gene

  • Protein details for DPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07507-DERM_HUMAN
    Recommended name:
    Dermatopontin
    Protein Accession:
    Q07507
    Secondary Accessions:
    • A8K981
    • Q8N4R2
    • Q9UIX8

    Protein attributes for DPT Gene

    Size:
    201 amino acids
    Molecular mass:
    24005 Da
    Quaternary structure:
    • Interacts with TGFB1, DCN and collagen.

neXtProt entry for DPT Gene

Proteomics data for DPT Gene at MOPED

Post-translational modifications for DPT Gene

Other Protein References for DPT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPT Gene

Domains for DPT Gene

Protein Domains for DPT Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DERM_HUMAN
Family:
  • Belongs to the dermatopontin family.:
    • Q07507
genes like me logo Genes that share domains with DPT: view

No data available for Gene Families for DPT Gene

Function for DPT Gene

Molecular function for DPT Gene

GENATLAS Biochemistry: dermatopontin,human proteoglycan binding cell adhesion protein,22kDa
UniProtKB/Swiss-Prot Function: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
UniProtKB/Swiss-Prot Induction: Induced by TGFB1, repressed by IL4/interleukin-4.
genes like me logo Genes that share phenotypes with DPT: view

Animal Models for DPT Gene

MGI Knock Outs for DPT:

miRNA for DPT Gene

miRTarBase miRNAs that target DPT

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for DPT Gene

Localization for DPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPT Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPT Gene COMPARTMENTS Subcellular localization image for DPT gene
Compartment Confidence
extracellular 4
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DPT: view

Pathways for DPT Gene

SuperPathways for DPT Gene

genes like me logo Genes that share pathways with DPT: view

Pathways by source for DPT Gene

1 Sino Biological pathway for DPT Gene

Gene Ontology (GO) - Biological Process for DPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0030199 collagen fibril organization IEA --
genes like me logo Genes that share ontologies with DPT: view

Transcripts for DPT Gene

mRNA/cDNA for DPT Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(201) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DPT Gene

Dermatopontin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPT Gene

No ASD Table

Relevant External Links for DPT Gene

GeneLoc Exon Structure for
DPT
ECgene alternative splicing isoforms for
DPT

Expression for DPT Gene

mRNA expression in normal human tissues for DPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPT Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.8) and Colon - Sigmoid (4.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DPT Gene

SOURCE GeneReport for Unigene cluster for DPT Gene Hs.80552

mRNA Expression by UniProt/SwissProt for DPT Gene

Q07507-DERM_HUMAN
Tissue specificity: Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
genes like me logo Genes that share expressions with DPT: view

Orthologs for DPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for DPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPT 36
  • 99.67 (n)
  • 100 (a)
DPT 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPT 36
  • 92.04 (n)
  • 95.52 (a)
DPT 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPT 36
  • 90.88 (n)
  • 95.52 (a)
DPT 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpt 36
  • 88.06 (n)
  • 92.04 (a)
Dpt 16
Dpt 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPT 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPT 37
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPT 36
  • 77.89 (n)
  • 82.32 (a)
DPT 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPT 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpt 36
  • 73.01 (n)
  • 78.8 (a)
zebrafish
(Danio rerio)
Actinopterygii dpt 37
  • 61 (a)
OneToOne
si:dkey-98p3.2 36
  • 66.47 (n)
  • 64.16 (a)
Species with no ortholog for DPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPT Gene

ENSEMBL:
Gene Tree for DPT (if available)
TreeFam:
Gene Tree for DPT (if available)

Paralogs for DPT Gene

No data available for Paralogs for DPT Gene

Variants for DPT Gene

Sequence variations from dbSNP and Humsavar for DPT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1433 -- 168,696,510(+) TCCCC(G/T)GCCCC utr-variant-3-prime
rs9067 -- 168,695,744(+) CTTTT(C/T)CCACT utr-variant-3-prime
rs14395 -- 168,714,248(-) TCGCT(A/T)CAGCA reference, missense
rs15440 -- 168,695,588(+) ACACA(A/G)AAGGA utr-variant-3-prime
rs475446 -- 168,708,223(+) atttt(G/T)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPT Gene

Variant ID Type Subtype PubMed ID
nsv831836 CNV Gain+Loss 17160897
nsv831847 CNV Gain 17160897

Relevant External Links for DPT Gene

HapMap Linkage Disequilibrium report
DPT

Disorders for DPT Gene

(4) Novoseek inferred disease relationships for DPT Gene

Disease -log(P) Hits PubMed IDs
leiomyoma 44.4 4
infarct 11.4 3
myocardial infarction 3.52 1
tumors 0 1

Relevant External Links for DPT

Genetic Association Database (GAD)
DPT
Human Genome Epidemiology (HuGE) Navigator
DPT
genes like me logo Genes that share disorders with DPT: view

No data available for UniProtKB/Swiss-Prot for DPT Gene

Publications for DPT Gene

  1. Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin). (PMID: 8104875) Superti-Furga A. … Gitzelmann R. (Genomics 1993) 2 3 4 23
  2. Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. (PMID: 10233760) Kuroda K. … Shinkai H. (J. Invest. Dermatol. 1999) 3 4 23
  3. Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor. (PMID: 17547532) Pochampally R.R. … Prockop D.J. (J. Bone Miner. Res. 2007) 3 23
  4. Dermatopontin is expressed in human liver and is downregulated in hepatocellular carcinoma. (PMID: 19916908) Li X. … Zhang C. (Biochemistry Mosc. 2009) 3 23
  5. Dermatopontin interacts with transforming growth factor beta and enhances its biological activity. (PMID: 9895299) Okamoto O. … Sato Y. (Biochem. J. 1999) 3 23

Products for DPT Gene

Sources for DPT Gene

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