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Aliases for DNASE1L3 Gene

Aliases for DNASE1L3 Gene

  • Deoxyribonuclease I-Like 3 2 3 4
  • DNase Gamma 2 3 4
  • DNase I Homolog Protein DHP2 3 4
  • Liver And Spleen DNase 3 4
  • DNase I-Like 3 3 4
  • LS-DNase 3 4
  • DNAS1L3 3 4
  • SLEB16 3 6
  • DHP2 3 4
  • LSD 3 4
  • Deoxyribonuclease I-Like III 3
  • DNase I Homolog Protein 2 3
  • Deoxyribonuclease Gamma 3
  • EC 3.1.21.1 63
  • EC 3.1.21.- 4

External Ids for DNASE1L3 Gene

Previous GeneCards Identifiers for DNASE1L3 Gene

  • GC03P057199
  • GC03M057547
  • GC03M058033
  • GC03M058135

Summaries for DNASE1L3 Gene

Entrez Gene Summary for DNASE1L3 Gene

  • This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for DNASE1L3 Gene

DNASE1L3 (Deoxyribonuclease I-Like 3) is a Protein Coding gene. Diseases associated with DNASE1L3 include systemic lupus erythematosus 16 and hypocomplementemic urticarial vasculitis syndrome. GO annotations related to this gene include calcium ion binding and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is DNASE1.

UniProtKB/Swiss-Prot for DNASE1L3 Gene

  • Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units

Gene Wiki entry for DNASE1L3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNASE1L3 Gene

Genomics for DNASE1L3 Gene

Regulatory Elements for DNASE1L3 Gene

Genomic Location for DNASE1L3 Gene

Start:
58,192,257 bp from pter
End:
58,214,697 bp from pter
Size:
22,441 bases
Orientation:
Minus strand

Genomic View for DNASE1L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNASE1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNASE1L3 Gene

Proteins for DNASE1L3 Gene

  • Protein details for DNASE1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13609-DNSL3_HUMAN
    Recommended name:
    Deoxyribonuclease gamma
    Protein Accession:
    Q13609
    Secondary Accessions:
    • B2R8B1
    • B7Z707
    • O75803

    Protein attributes for DNASE1L3 Gene

    Size:
    305 amino acids
    Molecular mass:
    35504 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNASE1L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNASE1L3 Gene

Proteomics data for DNASE1L3 Gene at MOPED

Selected DME Specific Peptides for DNASE1L3 Gene

Post-translational modifications for DNASE1L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNASE1L3 Gene

Antibody Products

Domains for DNASE1L3 Gene

Protein Domains for DNASE1L3 Gene

Suggested Antigen Peptide Sequences for DNASE1L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13609

UniProtKB/Swiss-Prot:

DNSL3_HUMAN :
  • Q13609
Family:
  • Belongs to the DNase I family.
genes like me logo Genes that share domains with DNASE1L3: view

No data available for Gene Families for DNASE1L3 Gene

Function for DNASE1L3 Gene

Molecular function for DNASE1L3 Gene

GENATLAS Biochemistry: DNase I-like endonuclease,33kDa,expressed in liver and spleen,actin-resistant,specific to macrophage populations
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is about 7.2.;
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by zinc
UniProtKB/Swiss-Prot Function: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units

Enzyme Numbers (IUBMB) for DNASE1L3 Gene

Gene Ontology (GO) - Molecular Function for DNASE1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004519 endonuclease activity --
GO:0004520 endodeoxyribonuclease activity IBA --
GO:0004536 deoxyribonuclease activity TAS 9070308
GO:0005509 calcium ion binding TAS 9205125
genes like me logo Genes that share ontologies with DNASE1L3: view

Animal Model Products

CRISPR Products

miRNA for DNASE1L3 Gene

miRTarBase miRNAs that target DNASE1L3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNASE1L3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNASE1L3 Gene

Localization for DNASE1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNASE1L3 Gene

Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNASE1L3 Gene COMPARTMENTS Subcellular localization image for DNASE1L3 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNASE1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DNASE1L3: view

Pathways for DNASE1L3 Gene

SuperPathways for DNASE1L3 Gene

No Data Available

Interacting Proteins for DNASE1L3 Gene

Selected Interacting proteins: Q13609-DNSL3_HUMAN for DNASE1L3 Gene via I2D

Symbol External ID(s) Details
ADAMTSL4

Gene Ontology (GO) - Biological Process for DNASE1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006259 DNA metabolic process TAS 9070308
GO:0006308 DNA catabolic process --
GO:0006309 apoptotic DNA fragmentation IBA --
GO:0010623 developmental programmed cell death IEA --
genes like me logo Genes that share ontologies with DNASE1L3: view

No data available for Pathways by source for DNASE1L3 Gene

Compounds for DNASE1L3 Gene

(2) HMDB Compounds for DNASE1L3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4

(2) Novoseek inferred chemical compound relationships for DNASE1L3 Gene

Compound -log(P) Hits PubMed IDs
aurintricarboxylic acid 76.6 1
paraffin 24.2 2
genes like me logo Genes that share compounds with DNASE1L3: view

Transcripts for DNASE1L3 Gene

Unigene Clusters for DNASE1L3 Gene

Deoxyribonuclease I-like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNASE1L3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for DNASE1L3 Gene

GeneLoc Exon Structure for
DNASE1L3
ECgene alternative splicing isoforms for
DNASE1L3

Expression for DNASE1L3 Gene

mRNA expression in normal human tissues for DNASE1L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNASE1L3 Gene

This gene is overexpressed in Spleen (15.3) and Liver (9.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DNASE1L3 Gene

SOURCE GeneReport for Unigene cluster for DNASE1L3 Gene Hs.476453

mRNA Expression by UniProt/SwissProt for DNASE1L3 Gene

Q13609-DNSL3_HUMAN
Tissue specificity: Liver and spleen
genes like me logo Genes that share expressions with DNASE1L3: view

In Situ Assay Products

Orthologs for DNASE1L3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNASE1L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNASE1L3 35
  • 99.02 (n)
  • 98.69 (a)
DNASE1L3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNASE1L3 35
  • 88.89 (n)
  • 88.41 (a)
DNASE1L3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNASE1L3 35
  • 88.93 (n)
  • 87.31 (a)
DNASE1L3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnase1l3 35
  • 83.77 (n)
  • 81.58 (a)
Dnase1l3 16
Dnase1l3 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNASE1L3 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dnase1l3 35
  • 85.27 (n)
  • 84.39 (a)
chicken
(Gallus gallus)
Aves DNASE1L3 35
  • 65.98 (n)
  • 58.28 (a)
DNASE1L3 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNASE1L3 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia drng-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnase1l3 35
  • 65.24 (n)
  • 59.79 (a)
MGC76250 35
zebrafish
(Danio rerio)
Actinopterygii dnase1l3 35
  • 55.76 (n)
  • 50.72 (a)
dnase1l3l 36
  • 42 (a)
ManyToMany
zgc:101000 36
  • 44 (a)
ManyToMany
zgc:77816 36
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for DNASE1L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNASE1L3 Gene

ENSEMBL:
Gene Tree for DNASE1L3 (if available)
TreeFam:
Gene Tree for DNASE1L3 (if available)

Paralogs for DNASE1L3 Gene

Paralogs for DNASE1L3 Gene

Selected SIMAP similar genes for DNASE1L3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DNASE1L3: view

Variants for DNASE1L3 Gene

Sequence variations from dbSNP and Humsavar for DNASE1L3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1814849 -- 58,201,464(+) tcaag(C/T)ctcct intron-variant
rs1878014 -- 58,209,647(+) TCATG(A/G)ATACC intron-variant
rs2056118 -- 58,196,886(-) TAAAG(C/T)TTTAG intron-variant
rs2070117 -- 58,205,539(-) ATAAC(A/G)TACAA intron-variant, synonymous-codon, reference
rs2292677 -- 58,210,912(+) CCTGG(C/T)GCTGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DNASE1L3 Gene

Variant ID Type Subtype PubMed ID
nsv528147 CNV Gain 19592680
nsv834703 CNV Gain 17160897

Relevant External Links for DNASE1L3 Gene

HapMap Linkage Disequilibrium report
DNASE1L3
Human Gene Mutation Database (HGMD)
DNASE1L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNASE1L3 Gene

Disorders for DNASE1L3 Gene

(1) OMIM Diseases for DNASE1L3 Gene (602244)

UniProtKB/Swiss-Prot

DNSL3_HUMAN
  • Systemic lupus erythematosus 16 (SLEB16) [MIM:614420]: A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:22019780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for DNASE1L3 Gene

Disease -log(P) Hits PubMed IDs
glioma 29.5 2
necrosis 0 2

Relevant External Links for DNASE1L3

Genetic Association Database (GAD)
DNASE1L3
Human Genome Epidemiology (HuGE) Navigator
DNASE1L3
genes like me logo Genes that share disorders with DNASE1L3: view

Publications for DNASE1L3 Gene

  1. Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. (PMID: 9714828) Baron W.F. … Baker K.P. (Gene 1998) 2 3 4 23
  2. cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein. (PMID: 14646506) Shiokawa D. … Tanuma S. (Apoptosis 1998) 2 3 4 23
  3. Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme. (PMID: 19559017) Ueki M. … Yasuda T. (Clin. Chim. Acta 2009) 3 23 48
  4. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PMID: 9205125) Rodriguez A.M. … Schneider M.C. (Genomics 1997) 2 3 4
  5. DNase gamma-dependent and -independent apoptotic DNA fragmentations in Ramos Burkitt's lymphoma cell line. (PMID: 19574717) Mizuta R. … Kitamura D. (Biomed. Res. 2009) 3 23

Products for DNASE1L3 Gene

Sources for DNASE1L3 Gene

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