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Aliases for AGER Gene

Aliases for AGER Gene

  • Advanced Glycosylation End Product-Specific Receptor 2 3 5
  • RAGE 3 4
  • Receptor For Advanced Glycation End-Products Variant 20 3
  • Receptor For Advanced Glycosylation End Products 4
  • RAGE Isoform NtRAGE-Delta 3
  • RAGE Isoform SRAGE-Delta 3

External Ids for AGER Gene

Previous GeneCards Identifiers for AGER Gene

  • GC06M032175
  • GC06M031920
  • GC06M032220
  • GC06M032256
  • GC06M031903
  • GC06M032148

Summaries for AGER Gene

Entrez Gene Summary for AGER Gene

  • The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

GeneCards Summary for AGER Gene

AGER (Advanced Glycosylation End Product-Specific Receptor) is a Protein Coding gene. Diseases associated with AGER include diabetic angiopathy and leukostasis. Among its related pathways are A-beta Pathways: Uptake and Degradation and Immune System. GO annotations related to this gene include identical protein binding and transmembrane signaling receptor activity. An important paralog of this gene is ALCAM.

UniProtKB/Swiss-Prot for AGER Gene

  • Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

Gene Wiki entry for AGER Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGER Gene

Genomics for AGER Gene

Regulatory Elements for AGER Gene

Genomic Location for AGER Gene

Chromosome:
6
Start:
32,180,968 bp from pter
End:
32,184,324 bp from pter
Size:
3,357 bases
Orientation:
Minus strand

Genomic View for AGER Gene

Genes around AGER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for AGER Gene

  • Protein details for AGER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15109-RAGE_HUMAN
    Recommended name:
    Advanced glycosylation end product-specific receptor
    Protein Accession:
    Q15109
    Secondary Accessions:
    • A2BFI7
    • A6NKF0
    • A7Y2U9
    • B0V176
    • Q15279
    • Q3L1R4
    • Q3L1R5
    • Q3L1R6
    • Q3L1R7
    • Q3L1R8
    • Q3L1S0
    • Q86SN1
    • Q9H2X7
    • Q9Y3R3
    • V5R6A3

    Protein attributes for AGER Gene

    Size:
    404 amino acids
    Molecular mass:
    42803 Da
    Quaternary structure:
    • Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for AGER Gene

    Alternative splice isoforms for AGER Gene

neXtProt entry for AGER Gene

Proteomics data for AGER Gene at MOPED

Post-translational modifications for AGER Gene

  • Glycosylation at Asn 25 and Asn 81
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AGER (RAGE)

No data available for DME Specific Peptides for AGER Gene

Domains & Families for AGER Gene

Graphical View of Domain Structure for InterPro Entry

Q15109

UniProtKB/Swiss-Prot:

RAGE_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with AGER: view

Function for AGER Gene

Molecular function for AGER Gene

GENATLAS Biochemistry:
receptor of advanced glycosylation end products of proteins,mediating amyloid beta peptide effect on neurons and microglia
UniProtKB/Swiss-Prot Function:
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

Gene Ontology (GO) - Molecular Function for AGER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16061848
genes like me logo Genes that share ontologies with AGER: view
genes like me logo Genes that share phenotypes with AGER: view

Animal Models for AGER Gene

MGI Knock Outs for AGER:

miRNA for AGER Gene

miRTarBase miRNAs that target AGER

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGER Gene

Localization for AGER Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGER Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 10: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGER Gene COMPARTMENTS Subcellular localization image for AGER gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AGER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0009925 basal plasma membrane IEA --
genes like me logo Genes that share ontologies with AGER: view

Pathways & Interactions for AGER Gene

SuperPathways for AGER Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Cytosolic sensors of pathogen-associated DNA
3 Immune System
4 Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
5 A-beta Pathways: Uptake and Degradation
genes like me logo Genes that share pathways with AGER: view

Gene Ontology (GO) - Biological Process for AGER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001914 regulation of T cell mediated cytotoxicity IDA 22473704
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006954 inflammatory response IEA --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway TAS 10835680
genes like me logo Genes that share ontologies with AGER: view

No data available for SIGNOR curated interactions for AGER Gene

Drugs & Compounds for AGER Gene

(15) Drugs for AGER Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for AGER Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AGER: view

Transcripts for AGER Gene

Unigene Clusters for AGER Gene

Advanced glycosylation end product-specific receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGER Gene

No ASD Table

Relevant External Links for AGER Gene

GeneLoc Exon Structure for
AGER
ECgene alternative splicing isoforms for
AGER

Expression for AGER Gene

mRNA expression in normal human tissues for AGER Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGER Gene

This gene is overexpressed in Lung (x26.6).

Protein differential expression in normal tissues from HIPED for AGER Gene

This gene is overexpressed in Lung (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGER Gene



SOURCE GeneReport for Unigene cluster for AGER Gene Hs.534342

mRNA Expression by UniProt/SwissProt for AGER Gene

Q15109-RAGE_HUMAN
Tissue specificity: Endothelial cells.
genes like me logo Genes that share expression patterns with AGER: view

Protein tissue co-expression partners for AGER Gene

Primer Products

In Situ Assay Products

Orthologs for AGER Gene

This gene was present in the common ancestor of mammals.

Orthologs for AGER Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGER 35
  • 86.6 (n)
  • 82.88 (a)
AGER 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGER 35
  • 83.72 (n)
  • 78.26 (a)
AGER 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ager 35
  • 81.09 (n)
  • 78.61 (a)
Ager 16
Ager 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGER 35
  • 99.59 (n)
  • 98.76 (a)
AGER 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ager 35
  • 81.18 (n)
  • 78.61 (a)
oppossum
(Monodelphis domestica)
Mammalia AGER 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGER 36
  • 48 (a)
OneToOne
Species with no ortholog for AGER:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AGER Gene

ENSEMBL:
Gene Tree for AGER (if available)
TreeFam:
Gene Tree for AGER (if available)

Paralogs for AGER Gene

Paralogs for AGER Gene

genes like me logo Genes that share paralogs with AGER: view

Variants for AGER Gene

Sequence variations from dbSNP and Humsavar for AGER Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_011338 -
rs2070600 - 32,183,666(-) CCAAC(A/G)GCTCC nc-transcript-variant, reference, missense
rs184003 -- 32,182,519(-) AACTA(G/T)CAACA intron-variant
rs204996 -- 32,182,106(-) CCCCT(A/G)CCCCA intron-variant
rs1035798 -- 32,183,445(-) CCACA(C/T)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGER Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv462877 CNV Loss 19166990

Variation tolerance for AGER Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGER Gene

HapMap Linkage Disequilibrium report
AGER
Human Gene Mutation Database (HGMD)
AGER

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGER Gene

Disorders for AGER Gene

MalaCards: The human disease database

(14) MalaCards diseases for AGER Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetic angiopathy
  • diabetic vascular disorder
leukostasis
atherosclerosis
  • arteriosclerosis
diabetic neuropathy
  • diabetic neuropathies
microvascular complications of diabetes 5
  • diabetic nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search AGER in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGER

Genetic Association Database (GAD)
AGER
Human Genome Epidemiology (HuGE) Navigator
AGER
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGER
genes like me logo Genes that share disorders with AGER: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGER Gene

Publications for AGER Gene

  1. Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. (PMID: 11375354) Hudson B.I. … Grant P.J. (Diabetes 2001) 3 4 48 67
  2. Irbesartan inhibits advanced glycation end product (AGE)-induced proximal tubular cell injury in vitro by suppressing receptor for AGEs (RAGE) expression. (PMID: 19635564) Matsui T. … Okuda S. (Pharmacol. Res. 2010) 3 23
  3. The association between the -374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies. (PMID: 20051912) Engelen L. … Schalkwijk C.G. (J. Hypertens. 2010) 3 23
  4. Resveratrol prevents the impairment of advanced glycosylation end products (AGE) on macrophage lipid homeostasis by suppressing the receptor for AGE via peroxisome proliferator-activated receptor gamma activation. (PMID: 20372816) Zhang Y. … Si L. (Int. J. Mol. Med. 2010) 3 23
  5. Angiotensin II upregulates RAGE expression on podocytes: role of AT2 receptors. (PMID: 19129693) RA1ster C. … Wolf G. (Am. J. Nephrol. 2009) 3 23

Products for AGER Gene

Sources for AGER Gene

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