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Aliases for AGER Gene

Aliases for AGER Gene

  • Advanced Glycosylation End Product-Specific Receptor 2 3
  • RAGE 3 4 6
  • Receptor For Advanced Glycation End-Products Variant 20 3
  • Receptor For Advanced Glycosylation End Products 4
  • RAGE Isoform NtRAGE-Delta 3
  • RAGE Isoform SRAGE-Delta 3

External Ids for AGER Gene

Summaries for AGER Gene

Entrez Gene Summary for AGER Gene

  • The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

GeneCards Summary for AGER Gene

AGER (Advanced Glycosylation End Product-Specific Receptor) is a Protein Coding gene. Diseases associated with AGER include diabetic angiopathy and noma. Among its related pathways are amb2 Integrin signaling and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include receptor activity and S100 protein binding.

UniProtKB/Swiss-Prot for AGER Gene

  • Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

Gene Wiki entry for AGER Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGER Gene

Genomics for AGER Gene

Genomic Location for AGER Gene

Start:
32,180,968 bp from pter
End:
32,184,324 bp from pter
Size:
3,357 bases
Orientation:
Minus strand

Genomic View for AGER Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for AGER Gene

Proteins for AGER Gene

  • Protein details for AGER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15109-RAGE_HUMAN
    Recommended name:
    Advanced glycosylation end product-specific receptor
    Protein Accession:
    Q15109
    Secondary Accessions:
    • A2BFI7
    • A6NKF0
    • A7Y2U9
    • B0V176
    • Q15279
    • Q3L1R4
    • Q3L1R5
    • Q3L1R6
    • Q3L1R7
    • Q3L1R8
    • Q3L1S0
    • Q86SN1
    • Q9H2X7
    • Q9Y3R3
    • V5R6A3

    Protein attributes for AGER Gene

    Size:
    404 amino acids
    Molecular mass:
    42803 Da
    Quaternary structure:
    • Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for AGER Gene

    Alternative splice isoforms for AGER Gene

neXtProt entry for AGER Gene

Proteomics data for AGER Gene at MOPED

Post-translational modifications for AGER Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn25 and Asn81

No data available for DME Specific Peptides for AGER Gene

Domains for AGER Gene

Gene Families for AGER Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

UniProtKB/Swiss-Prot:

RAGE_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q15109
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q15109
genes like me logo Genes that share domains with AGER: view

Function for AGER Gene

Molecular function for AGER Gene

GENATLAS Biochemistry: receptor of advanced glycosylation end products of proteins,mediating amyloid beta peptide effect on neurons and microglia
UniProtKB/Swiss-Prot Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

Gene Ontology (GO) - Molecular Function for AGER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8751438
GO:0004888 transmembrane signaling receptor activity TAS 1378843
GO:0005515 protein binding IPI 16061848
GO:0042802 identical protein binding IPI 24119142
GO:0044548 S100 protein binding IPI 15033494
genes like me logo Genes that share ontologies with AGER: view
genes like me logo Genes that share phenotypes with AGER: view

Animal Models for AGER Gene

MGI Knock Outs for AGER:

miRNA for AGER Gene

miRTarBase miRNAs that target AGER

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AGER Gene

Localization for AGER Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGER Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 10: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGER Gene COMPARTMENTS Subcellular localization image for AGER gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AGER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1378843
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with AGER: view

Pathways for AGER Gene

genes like me logo Genes that share pathways with AGER: view

Pathways by source for AGER Gene

1 R&D Systems pathway for AGER Gene
1 Qiagen pathway for AGER Gene
1 Cell Signaling Technology pathway for AGER Gene

Gene Ontology (GO) - Biological Process for AGER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007166 cell surface receptor signaling pathway TAS 10835680
GO:0009611 response to wounding TAS 10399917
GO:0031175 neuron projection development IGI 10391939
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with AGER: view

Compounds for AGER Gene

(31) Novoseek inferred chemical compound relationships for AGER Gene

Compound -log(P) Hits PubMed IDs
n(epsilon)-(carboxymethyl)lysine 79.1 11
pentosidine 68.5 5
3-deoxyglucosone 62.3 1
gw9662 59.7 2
telmisartan 44.1 12
genes like me logo Genes that share compounds with AGER: view

Transcripts for AGER Gene

Unigene Clusters for AGER Gene

Advanced glycosylation end product-specific receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGER Gene

No ASD Table

Relevant External Links for AGER Gene

GeneLoc Exon Structure for
AGER
ECgene alternative splicing isoforms for
AGER

Expression for AGER Gene

mRNA expression in normal human tissues for AGER Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGER Gene

This gene is overexpressed in Lung (26.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AGER Gene

SOURCE GeneReport for Unigene cluster for AGER Gene Hs.534342

mRNA Expression by UniProt/SwissProt for AGER Gene

Q15109-RAGE_HUMAN
Tissue specificity: Endothelial cells
genes like me logo Genes that share expressions with AGER: view

Orthologs for AGER Gene

This gene was present in the common ancestor of mammals.

Orthologs for AGER Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGER 36
  • 99.59 (n)
  • 98.76 (a)
AGER 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGER 36
  • 86.6 (n)
  • 82.88 (a)
AGER 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGER 36
  • 83.72 (n)
  • 78.26 (a)
AGER 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ager 36
  • 81.09 (n)
  • 78.61 (a)
Ager 16
Ager 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGER 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGER 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ager 36
  • 81.18 (n)
  • 78.61 (a)
Species with no ortholog for AGER:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AGER Gene

ENSEMBL:
Gene Tree for AGER (if available)
TreeFam:
Gene Tree for AGER (if available)

Paralogs for AGER Gene

genes like me logo Genes that share paralogs with AGER: view

No data available for Paralogs for AGER Gene

Variants for AGER Gene

Sequence variations from dbSNP and Humsavar for AGER Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs184003 -- 32,182,519(-) AACTA(G/T)CAACA intron-variant
rs204996 -- 32,182,106(-) CCCCT(A/G)CCCCA intron-variant
rs1035798 -- 32,183,445(-) CCACA(C/T)ACAGA intron-variant
rs2070600 - 32,183,666(-) CCAAC(A/G)GCTCC missense, reference, nc-transcript-variant
rs2071288 -- 32,181,483(-) TCTCC(A/G)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGER Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv462877 CNV Loss 19166990

Relevant External Links for AGER Gene

HapMap Linkage Disequilibrium report
AGER
Human Gene Mutation Database (HGMD)
AGER

Disorders for AGER Gene

(3) University of Copenhagen DISEASES for AGER Gene

(61) Novoseek inferred disease relationships for AGER Gene

Disease -log(P) Hits PubMed IDs
diabetic angiopathies 68.9 1
diabetic nephropathies 65.2 22
hyperglycemia 64.4 8
atherosclerosis 63.9 30
microangiopathy diabetic 58.5 6

Relevant External Links for AGER

Genetic Association Database (GAD)
AGER
Human Genome Epidemiology (HuGE) Navigator
AGER
genes like me logo Genes that share disorders with AGER: view

No data available for UniProtKB/Swiss-Prot for AGER Gene

Publications for AGER Gene

  1. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. (PMID: 1378843) Neeper M. … Shaw A. (J. Biol. Chem. 1992) 3 4 23
  2. Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status. (PMID: 11586486) KankovA! K. … VA!cha J. (Metab. Clin. Exp. 2001) 3 23 49
  3. Association of Gly82Ser polymorphism in the RAGE gene with diabetic retinopathy in type II diabetic Asian Indian patients. (PMID: 12477623) Kumaramanickavel G. … Sharma T. (J. Diabetes Complicat. 2002) 3 23 49
  4. Novel splice variants of the receptor for advanced glycation end- products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. (PMID: 12495433) Yonekura H. … Yamamoto H. (Biochem. J. 2003) 3 4 23
  5. -429T/C and -374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes. (PMID: 12941744) JiXiong X. … ShuQin L. (Diabetes Care 2003) 3 23 49

Products for AGER Gene

Sources for AGER Gene

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