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Aliases for DNM1 Gene

Aliases for DNM1 Gene

  • Dynamin 1 2 3
  • EC 4 63
  • DNM 3 4
  • Dynamin-1 3

External Ids for DNM1 Gene

Previous HGNC Symbols for DNM1 Gene

  • DNM

Previous GeneCards Identifiers for DNM1 Gene

  • GC09P122080
  • GC09P122612
  • GC09P124419
  • GC09P126342
  • GC09P126343
  • GC09P128045
  • GC09P130005
  • GC09P130965
  • GC09P100579

Summaries for DNM1 Gene

Entrez Gene Summary for DNM1 Gene

  • This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNM1 Gene

DNM1 (Dynamin 1) is a Protein Coding gene. Diseases associated with DNM1 include neuronal intranuclear inclusion disease. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include identical protein binding and phospholipid binding. An important paralog of this gene is MX1.

UniProtKB/Swiss-Prot for DNM1 Gene

  • Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis

Tocris Summary for DNM1 Gene

  • Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation

Gene Wiki entry for DNM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNM1 Gene

Genomics for DNM1 Gene

Regulatory Elements for DNM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNM1 Gene

128,203,355 bp from pter
128,255,249 bp from pter
51,895 bases
Plus strand

Genomic View for DNM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNM1 Gene

Proteins for DNM1 Gene

  • Protein details for DNM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NLM6
    • Q5SYX0
    • Q5SYX2
    • Q6P3T6
    • Q86VD2

    Protein attributes for DNM1 Gene

    864 amino acids
    Molecular mass:
    97408 Da
    Quaternary structure:
    • Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity).
    • Sequence=AAA02805.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNM1 Gene

    Alternative splice isoforms for DNM1 Gene


neXtProt entry for DNM1 Gene

Proteomics data for DNM1 Gene at MOPED

Post-translational modifications for DNM1 Gene

  • Ubiquitination at Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for DNM1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DNM1 (DYN1)

Domains for DNM1 Gene

Gene Families for DNM1 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for DNM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q05193
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Contains 1 GED domain.
  • Contains 1 PH domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
genes like me logo Genes that share domains with DNM1: view

Function for DNM1 Gene

Molecular function for DNM1 Gene

GENATLAS Biochemistry:
dynamin 1,100kDa,GTP binding protein,expressed in the brain,involved in early stage of clathrin-mediated endocytosis and formation of synaptic vesicles
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate
UniProtKB/Swiss-Prot Function:
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis

Enzyme Numbers (IUBMB) for DNM1 Gene

Gene Ontology (GO) - Molecular Function for DNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 10206341
GO:0005525 GTP binding IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0019901 protein kinase binding ISS --
genes like me logo Genes that share ontologies with DNM1: view
genes like me logo Genes that share phenotypes with DNM1: view

Animal Models for DNM1 Gene

MGI Knock Outs for DNM1:

Animal Model Products

miRNA for DNM1 Gene

miRTarBase miRNAs that target DNM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNM1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DNM1 Gene

Localization for DNM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNM1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.

Subcellular locations from

Jensen Localization Image for DNM1 Gene COMPARTMENTS Subcellular localization image for DNM1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
endosome 2
mitochondrion 2
plasma membrane 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane TAS --
GO:0030117 membrane coat IEA --
GO:0043234 protein complex --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with DNM1: view

Pathways for DNM1 Gene

genes like me logo Genes that share pathways with DNM1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006897 endocytosis TAS 16648839
GO:0006898 receptor-mediated endocytosis IMP 10521508
GO:0007032 endosome organization IMP 19706678
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with DNM1: view

Compounds for DNM1 Gene

Compound Products

(5) Tocris Compounds for DNM1 Gene

Compound Action Cas Number
8-CPT-2Me-cAMP, sodium salt Selective Epac activator [634207-53-7]
8-pCPT-2-O-Me-cAMP-AM Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645) [1152197-23-3]
Dynasore Non-competitive dynamin inhibitor [304448-55-3]
ML 141 Selective inhibitor of Cdc42 Rho family GTPase [71203-35-5]
Salirasib Ras inhibitor; also induces autophagy [162520-00-5]

(1) ApexBio Compounds for DNM1 Gene

Compound Action Cas Number
Mdivi 1 "Selective DRP1/Dnm1 inhibitor, cell-permeable" [338967-87-6]

(4) HMDB Compounds for DNM1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine triphosphate
  • 5'-GTP
  • NFB Orthophosphate
  • Dihydrogen oxide

(5) Novoseek inferred chemical compound relationships for DNM1 Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 46.8 2
gtp 35.8 3
phosphatidylinositol 15.8 1
lipid 0 1
calcium 0 3
genes like me logo Genes that share compounds with DNM1: view

Transcripts for DNM1 Gene

Unigene Clusters for DNM1 Gene

Dynamin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNM1 Gene

No ASD Table

Relevant External Links for DNM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNM1 Gene

mRNA expression in normal human tissues for DNM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNM1 Gene

This gene is overexpressed in Brain - Cortex (7.9), Brain - Frontal Cortex (BA9) (6.9), Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Cerebellar Hemisphere (4.9), and Brain - Cerebellum (4.9).

Protein differential expression in normal tissues for DNM1 Gene

This gene is overexpressed in Brain (37.6) and Frontal cortex (21.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNM1 Gene

SOURCE GeneReport for Unigene cluster for DNM1 Gene Hs.522413

genes like me logo Genes that share expressions with DNM1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for DNM1 Gene

Orthologs for DNM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNM1 35
  • 93.43 (n)
  • 99.3 (a)
DNM1 36
  • 97 (a)
(Canis familiaris)
Mammalia DNM1 35
  • 92.25 (n)
  • 97.79 (a)
DNM1 36
  • 99 (a)
(Mus musculus)
Mammalia Dnm1 35
  • 90.94 (n)
  • 97.64 (a)
Dnm1 16
Dnm1 36
  • 98 (a)
(Pan troglodytes)
Mammalia DNM1 35
  • 98.07 (n)
  • 98.26 (a)
DNM1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dnm1 35
  • 92.5 (n)
  • 99.53 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia DNM1 36
  • 84 (a)
(Gallus gallus)
Aves DNM1 35
  • 82.45 (n)
  • 93.63 (a)
-- 36
  • 96 (a)
(Danio rerio)
Actinopterygii dnm1b 35
  • 76.64 (n)
  • 87.38 (a)
dnm1a 36
  • 90 (a)
fruit fly
(Drosophila melanogaster)
Insecta shi 37
  • 68 (a)
shi 35
  • 65.89 (n)
  • 71.43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003018 35
  • 66.06 (n)
  • 70.91 (a)
(Caenorhabditis elegans)
Secernentea dyn-1 37
  • 67 (a)
dyn-1 35
  • 62.44 (n)
  • 66.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGM1 38
(Hordeum vulgare)
Liliopsida Hv.13156 35
(Oryza sativa)
Liliopsida Os.19079 35
Species with no ortholog for DNM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DNM1 Gene

Gene Tree for DNM1 (if available)
Gene Tree for DNM1 (if available)

Paralogs for DNM1 Gene

Paralogs for DNM1 Gene

Selected SIMAP similar genes for DNM1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNM1: view

Variants for DNM1 Gene

Sequence variations from dbSNP and Humsavar for DNM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs740943 -- 128,240,188(+) TGCAC(A/G)AGCCA intron-variant
rs1004464 -- 128,241,398(-) TTTCA(C/T)GGCAG intron-variant
rs1042007 - 128,250,268(+) TCGGC(A/G)ACATC missense, reference, nc-transcript-variant
rs1077931 -- 128,240,964(-) ACCAG(A/C/T)AGATC intron-variant
rs1134203 -- 128,229,274(+) cctgc(A/G)gtcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNM1 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv893896 CNV Loss 21882294
nsv831728 CNV Loss 17160897

Relevant External Links for DNM1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNM1 Gene

Disorders for DNM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DNM1 Gene in MalaCards »

(1) Diseases for DNM1 Gene including...

(2) Novoseek inferred disease relationships for DNM1 Gene

Disease -log(P) Hits PubMed IDs
neurodegeneration 28.2 1
senile plaques 19.7 1

Relevant External Links for DNM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DNM1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for DNM1 Gene

Publications for DNM1 Gene

  1. Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PMID: 9143509) Newman-Smith E.D. … van der Bliek A.M. (Genomics 1997) 2 3 23
  2. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. (PMID: 15703209) Soulet F. … Schmid S.L. (Mol. Biol. Cell 2005) 3 4 23
  3. Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans. (PMID: 18987626) Xu Q. … Li M.D. (Neuropsychopharmacology 2009) 3 23 48
  4. NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture. (PMID: 18836734) Pountney D.L. … Gai W.P. (Acta Neuropathol. 2008) 3 23
  5. A possible effector role for the pleckstrin homology (PH) domain of dynamin. (PMID: 19666604) Bethoney K.A. … Lemmon M.A. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for DNM1 Gene

  • Addgene plasmids for DNM1

Sources for DNM1 Gene

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