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Aliases for DNM1 Gene

Aliases for DNM1 Gene

  • Dynamin 1 2 3 5
  • EC 4 58
  • DNM 3 4
  • Dynamin-1 3
  • EIEE31 3

External Ids for DNM1 Gene

Previous HGNC Symbols for DNM1 Gene

  • DNM

Previous GeneCards Identifiers for DNM1 Gene

  • GC09P122080
  • GC09P122612
  • GC09P124419
  • GC09P126342
  • GC09P126343
  • GC09P128045
  • GC09P130005
  • GC09P130965
  • GC09P100579

Summaries for DNM1 Gene

Entrez Gene Summary for DNM1 Gene

  • This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNM1 Gene

DNM1 (Dynamin 1) is a Protein Coding gene. Diseases associated with DNM1 include Epileptic Encephalopathy, Early Infantile, 31 and Lennox-Gastaut Syndrome. Among its related pathways are Gap junction trafficking and Primary Focal Segmental Glomerulosclerosis FSGS. GO annotations related to this gene include poly(A) RNA binding and GTP binding. An important paralog of this gene is DNM3.

UniProtKB/Swiss-Prot for DNM1 Gene

  • Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Tocris Summary for DNM1 Gene

  • GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ ions are essential for catalytic activity. GTPases, often coupled to G proteins, are essential in signal transduction.

Gene Wiki entry for DNM1 Gene

Additional gene information for DNM1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNM1 Gene

Genomics for DNM1 Gene

Regulatory Elements for DNM1 Gene

Enhancers for DNM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H128203 1.3 ENCODE dbSUPER 17.4 +12.3 12269 2.3 HDGF ARNT SIN3A ZNF2 ZNF207 ZNF143 SP3 REST SMARCB1 ZNF592 DNM1 URM1 CIZ1 LOC105376285
GH09H128097 1.6 Ensembl ENCODE dbSUPER 11 -90.8 -90782 9 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 NAIF1 PTGES2 CIZ1 ZNF79 PTGES2-AS1 NUP188 SLC25A25-AS1 SLC25A25 LCN2 C9orf16
GH09H128090 1.3 ENCODE dbSUPER 10.9 -98.4 -98418 5.3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A YY1 TCF12 GATA2 ELK1 SLC25A25-AS1 PTGES2-AS1 PTGES2 SLC25A25 NAIF1 ENSG00000230848 LCN2 C9orf16 CIZ1 ENSG00000230536
GH09H128770 1.2 ENCODE 11 +580.0 579961 2.7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CIZ1 CDK9 ENSG00000272696 SPOUT1 NUP188 SPTAN1 LOC101929314 CERCAM LOC101929270 DNM1
GH09H128254 0.8 ENCODE 11.3 +63.6 63608 1.3 HNRNPUL1 CTCF BACH1 RAD21 RELA CC2D1A ZFHX2 ZBTB48 POLR2A EED CIZ1 SLC27A4 ZNF79 NUP188 RPL12 TMSB4XP4 DNM1 GLE1 NAIF1 GC09M128254
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNM1 on UCSC Golden Path with GeneCards custom track

Promoters for DNM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for DNM1 Gene

Genomic Locations for DNM1 Gene
63,595 bases
Plus strand

Genomic View for DNM1 Gene

Genes around DNM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNM1 Gene

Proteins for DNM1 Gene

  • Protein details for DNM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NLM6
    • Q5SYX0
    • Q5SYX2
    • Q6P3T6
    • Q86VD2

    Protein attributes for DNM1 Gene

    864 amino acids
    Molecular mass:
    97408 Da
    Quaternary structure:
    • Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1 (PubMed:23325789).
    • Sequence=AAA02805.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNM1 Gene

    Alternative splice isoforms for DNM1 Gene


neXtProt entry for DNM1 Gene

Selected DME Specific Peptides for DNM1 Gene


Post-translational modifications for DNM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DNM1 Gene

Gene Families for DNM1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DNM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
genes like me logo Genes that share domains with DNM1: view

Function for DNM1 Gene

Molecular function for DNM1 Gene

GENATLAS Biochemistry:
dynamin 1,100kDa,GTP binding protein,expressed in the brain,involved in early stage of clathrin-mediated endocytosis and formation of synaptic vesicles
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Enzyme Numbers (IUBMB) for DNM1 Gene

Phenotypes From GWAS Catalog for DNM1 Gene

Gene Ontology (GO) - Molecular Function for DNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0003924 GTPase activity IBA,IEA --
GO:0005515 protein binding IPI 9148966
GO:0005525 GTP binding IEA --
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with DNM1: view
genes like me logo Genes that share phenotypes with DNM1: view

Human Phenotype Ontology for DNM1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DNM1 Gene

MGI Knock Outs for DNM1:

Animal Model Products

miRNA for DNM1 Gene

miRTarBase miRNAs that target DNM1

Clone Products

  • Addgene plasmids for DNM1

No data available for Transcription Factor Targets and HOMER Transcription for DNM1 Gene

Localization for DNM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNM1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNM1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 4
mitochondrion 4
cytosol 3
peroxisome 2
endosome 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001917 photoreceptor inner segment IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with DNM1: view

Pathways & Interactions for DNM1 Gene

genes like me logo Genes that share pathways with DNM1: view

SIGNOR curated interactions for DNM1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IBA --
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA --
GO:0006897 endocytosis TAS 16648839
GO:0006898 receptor-mediated endocytosis IMP 10521508
genes like me logo Genes that share ontologies with DNM1: view

Drugs & Compounds for DNM1 Gene

(10) Drugs for DNM1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Dynasore Pharma Dynamin and GTPase inhibitor 0

(5) Additional Compounds for DNM1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)

(4) Tocris Compounds for DNM1 Gene

Compound Action Cas Number
8-CPT-2Me-cAMP, sodium salt Selective Epac activator 634207-53-7
8-pCPT-2-O-Me-cAMP-AM Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645) 1152197-23-3
ESI 09 EPAC inhibitor 263707-16-0
Salirasib Ras inhibitor; also induces autophagy 162520-00-5

(2) ApexBio Compounds for DNM1 Gene

Compound Action Cas Number
Dynasore Dynamin and GTPase inhibitor 304448-55-3
Mdivi 1 Selective DRP1/Dnm1 inhibitor, cell-permeable 338967-87-6
genes like me logo Genes that share compounds with DNM1: view

Drug Products

Transcripts for DNM1 Gene

Unigene Clusters for DNM1 Gene

Dynamin 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for DNM1

Alternative Splicing Database (ASD) splice patterns (SP) for DNM1 Gene

No ASD Table

Relevant External Links for DNM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNM1 Gene

This gene is overexpressed in Brain - Cortex (x7.9), Brain - Frontal Cortex (BA9) (x6.9), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Cerebellar Hemisphere (x4.9), and Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for DNM1 Gene

This gene is overexpressed in Brain (37.6) and Frontal cortex (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNM1 Gene:


SOURCE GeneReport for Unigene cluster for DNM1 Gene:


Evidence on tissue expression from TISSUES for DNM1 Gene

  • Nervous system(5)
  • Blood(4.5)
  • Heart(2.6)
  • Kidney(2.5)
  • Muscle(2.5)
  • Eye(2.2)
  • Adrenal gland(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DNM1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • forehead
  • head
  • lip
  • mouth
  • nose
  • pharynx
  • skull
  • chest wall
  • diaphragm
  • esophagus
  • lung
  • rib
  • rib cage
  • abdominal wall
  • intestine
  • large intestine
  • stomach
  • pelvis
  • rectum
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • upper limb
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with DNM1: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DNM1 Gene

Orthologs for DNM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNM1 33 34
  • 98.07 (n)
(Bos Taurus)
Mammalia DNM1 33 34
  • 93.43 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Dnm1 33
  • 92.5 (n)
(Canis familiaris)
Mammalia DNM1 33 34
  • 92.25 (n)
(Mus musculus)
Mammalia Dnm1 33 16 34
  • 90.94 (n)
(Ornithorhynchus anatinus)
Mammalia DNM1 34
  • 84 (a)
(Gallus gallus)
Aves -- 34
  • 96 (a)
DNM1 33
  • 82.45 (n)
(Danio rerio)
Actinopterygii dnm1a 34
  • 90 (a)
dnm1b 33
  • 76.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003018 33
  • 66.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta shi 35 33
  • 65.89 (n)
(Caenorhabditis elegans)
Secernentea dyn-1 35 33
  • 62.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGM1 36
(Hordeum vulgare)
Liliopsida Hv.13156 33
(Oryza sativa)
Liliopsida Os.19079 33
Species where no ortholog for DNM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DNM1 Gene

Gene Tree for DNM1 (if available)
Gene Tree for DNM1 (if available)

Paralogs for DNM1 Gene

Paralogs for DNM1 Gene

(5) SIMAP similar genes for DNM1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNM1: view

Variants for DNM1 Gene

Sequence variations from dbSNP and Humsavar for DNM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs587777860 Pathogenic, Epileptic encephalopathy, early infantile, 31 (EIEE31) [MIM:616346] 128,219,192(+) CCCCC(A/C/G)CCAAC nc-transcript-variant, reference, missense
rs587777861 Pathogenic, Epileptic encephalopathy, early infantile, 31 (EIEE31) [MIM:616346] 128,220,016(+) ACCAA(C/G)CTGGA nc-transcript-variant, reference, missense
rs587777862 Pathogenic, Epileptic encephalopathy, early infantile, 31 (EIEE31) [MIM:616346] 128,222,544(+) AGGGG(C/G)AGCCC nc-transcript-variant, reference, missense
rs760270633 Pathogenic, Epileptic encephalopathy, early infantile, 31 (EIEE31) [MIM:616346] 128,220,201(+) TGAAC(C/T)GGAGC nc-transcript-variant, reference, missense
rs869312702 Pathogenic 128,203,609(+) GCTCG(A/G)TGCTC intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DNM1 Gene

Variant ID Type Subtype PubMed ID
nsv972807 CNV duplication 23825009
nsv951772 CNV deletion 24416366
nsv831728 CNV loss 17160897

Variation tolerance for DNM1 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNM1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNM1 Gene

Disorders for DNM1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for DNM1 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DNM1 in MalaCards View complete list of genes associated with diseases


  • Epileptic encephalopathy, early infantile, 31 (EIEE31) [MIM:616346]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. {ECO:0000269 PubMed:25262651, ECO:0000269 PubMed:25533962, ECO:0000269 PubMed:27476654}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DNM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNM1: view

No data available for Genatlas for DNM1 Gene

Publications for DNM1 Gene

  1. Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans. (PMID: 18987626) Xu Q … Li MD (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009) 3 22 45 60
  2. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. (PMID: 15703209) Soulet F … Schmid SL (Molecular biology of the cell 2005) 3 4 22 60
  3. Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PMID: 9143509) Newman-Smith ED … van der Bliek AM (Genomics 1997) 2 3 22 60
  4. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. (PMID: 25262651) EuroEPINOMICS-RES Consortium … Epi4K Consortium (American journal of human genetics 2014) 3 4 60
  5. A possible effector role for the pleckstrin homology (PH) domain of dynamin. (PMID: 19666604) Bethoney KA … Lemmon MA (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 60

Products for DNM1 Gene

Sources for DNM1 Gene

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