Aliases for AGA Gene
External Ids for AGA Gene
Previous GeneCards Identifiers for AGA Gene
Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010]
GeneCards Summary for AGA Gene
AGA (Aspartylglucosaminidase) is a Protein Coding gene. Diseases associated with AGA include aspartylglucosaminuria and lysosomal storage disease. Among its related pathways are Integrated Pancreatic Cancer Pathway and Lysosome. GO annotations related to this gene include peptidase activity and N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. An important paralog of this gene is TASP1.
UniProtKB/Swiss-Prot for AGA Gene
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins