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Aliases for DLX4 Gene

Aliases for DLX4 Gene

  • Distal-Less Homeobox 4 2 3
  • DLX7 3 4 6
  • DLX8 3 4 6
  • Homeobox Protein DLX-7 3 4
  • Homeobox Protein DLX-8 3 4
  • Beta Protein 1 3 4
  • DLX9 3 4
  • BP1 3 4
  • Distal-Less Homeo Box 7 3
  • Distal-Less Homeo Box 9 3
  • Homeobox Protein DLX-4 3

External Ids for DLX4 Gene

Previous HGNC Symbols for DLX4 Gene

  • DLX7
  • DLX9

Previous GeneCards Identifiers for DLX4 Gene

  • GC17P047757
  • GC17P050526
  • GC17P048388
  • GC17P048521
  • GC17P045401
  • GC17P048046
  • GC17P043411

Summaries for DLX4 Gene

Entrez Gene Summary for DLX4 Gene

  • Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLX4 Gene

DLX4 (Distal-Less Homeobox 4) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for DLX4 Gene

  • May play a role in determining the production of hemoglobin S. May act as a repressor.

Gene Wiki entry for DLX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLX4 Gene

Genomics for DLX4 Gene

Regulatory Elements for DLX4 Gene

Genomic Location for DLX4 Gene

Start:
49,968,970 bp from pter
End:
49,974,959 bp from pter
Size:
5,990 bases
Orientation:
Plus strand

Genomic View for DLX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLX4 Gene

Proteins for DLX4 Gene

  • Protein details for DLX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92988-DLX4_HUMAN
    Recommended name:
    Homeobox protein DLX-4
    Protein Accession:
    Q92988
    Secondary Accessions:
    • D3DTX2
    • D3DTX3
    • O60480
    • Q13265
    • Q6PJK0
    • Q9HBE0

    Protein attributes for DLX4 Gene

    Size:
    240 amino acids
    Molecular mass:
    26263 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLX4 Gene

Proteomics data for DLX4 Gene at MOPED

Post-translational modifications for DLX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLX4 Gene

No data available for DME Specific Peptides for DLX4 Gene

Domains for DLX4 Gene

Gene Families for DLX4 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Suggested Antigen Peptide Sequences for DLX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92988

UniProtKB/Swiss-Prot:

DLX4_HUMAN :
  • Q92988
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the distal-less homeobox family.
genes like me logo Genes that share domains with DLX4: view

Function for DLX4 Gene

Molecular function for DLX4 Gene

GENATLAS Biochemistry: Drosophila distal less homolog Dlx4,homeo domain encoding gene,expressed in extra-embryonic tissues such as placenta,clustering with DLX3 (? and seven)
UniProtKB/Swiss-Prot Function: May play a role in determining the production of hemoglobin S. May act as a repressor.

Gene Ontology (GO) - Molecular Function for DLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 11909945
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 11909945
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11069021
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with DLX4: view

miRNA for DLX4 Gene

miRTarBase miRNAs that target DLX4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DLX4 Gene

Localization for DLX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLX4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLX4 Gene COMPARTMENTS Subcellular localization image for DLX4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11069021
genes like me logo Genes that share ontologies with DLX4: view

Pathways for DLX4 Gene

SuperPathways for DLX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11909945
GO:0006355 regulation of transcription, DNA-templated NAS 11069021
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with DLX4: view

No data available for Pathways by source for DLX4 Gene

Transcripts for DLX4 Gene

Unigene Clusters for DLX4 Gene

Distal-less homeobox 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLX4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:

Relevant External Links for DLX4 Gene

GeneLoc Exon Structure for
DLX4
ECgene alternative splicing isoforms for
DLX4

Expression for DLX4 Gene

mRNA expression in normal human tissues for DLX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLX4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (10.3) and Skin - Sun Exposed (Lower leg) (7.9).

SOURCE GeneReport for Unigene cluster for DLX4 Gene Hs.591167

mRNA Expression by UniProt/SwissProt for DLX4 Gene

Q92988-DLX4_HUMAN
Tissue specificity: Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.
genes like me logo Genes that share expressions with DLX4: view

No data available for Protein expression for DLX4 Gene

Orthologs for DLX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLX4 35
  • 99.31 (n)
  • 99.17 (a)
DLX4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLX4 35
  • 88.18 (n)
  • 85.9 (a)
DLX4 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLX4 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlx4 35
  • 80.81 (n)
  • 76.47 (a)
Dlx4 16
Dlx4 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLX4 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLX4 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlx4 35
  • 83.12 (n)
  • 77.64 (a)
chicken
(Gallus gallus)
Aves DLX4 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLX4 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dlx4a 36
  • 46 (a)
OneToMany
dlx4b 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dll 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-43 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
Species with no ortholog for DLX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DLX4 Gene

ENSEMBL:
Gene Tree for DLX4 (if available)
TreeFam:
Gene Tree for DLX4 (if available)

Paralogs for DLX4 Gene

Selected SIMAP similar genes for DLX4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLX4: view

Variants for DLX4 Gene

Sequence variations from dbSNP and Humsavar for DLX4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs750522 -- 49,971,350(-) CTCTC(C/G)ATCAC upstream-variant-2KB, intron-variant
rs919089 -- 49,970,057(-) TTTTC(C/T)GTTAC intron-variant
rs919091 -- 49,967,498(+) TTAAC(A/C)TCCAG upstream-variant-2KB
rs1058559 -- 49,973,890(+) TTGGA(C/G)CCTGG missense, reference
rs1058560 -- 49,974,083(+) GAAAA(A/G)GGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DLX4 Gene

Variant ID Type Subtype PubMed ID
nsv833474 CNV Loss 17160897
nsv908588 CNV Loss 21882294
nsv908589 CNV Loss 21882294
esv24299 CNV Gain 19812545

Relevant External Links for DLX4 Gene

HapMap Linkage Disequilibrium report
DLX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLX4 Gene

Disorders for DLX4 Gene

(9) Novoseek inferred disease relationships for DLX4 Gene

Disease -log(P) Hits PubMed IDs
charcot-marie-tooth disease 68.4 1
choriocarcinoma 51.9 4
sickle cell disease 29.2 1
cancer lung 11.8 4
leukemia 9.28 2

Relevant External Links for DLX4

Genetic Association Database (GAD)
DLX4
Human Genome Epidemiology (HuGE) Navigator
DLX4
genes like me logo Genes that share disorders with DLX4: view

No data available for UniProtKB/Swiss-Prot for DLX4 Gene

Publications for DLX4 Gene

  1. BP1, a homeodomain-containing isoform of DLX4, represses the beta- globin gene. (PMID: 11909945) Chase M.B. … Berg P.E. (Mol. Cell. Biol. 2002) 3 4 23
  2. Genomic analysis of a new mammalian distal-less gene: Dlx7. (PMID: 8975708) Nakamura S. … Ruddle F.H. (Genomics 1996) 3 4 23
  3. Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. (PMID: 9073066) Quinn L.M. … Kalionis B. (Gene 1997) 3 4 23
  4. Identification of a mutation in DLX3 associated with tricho-dento- osseous (TDO) syndrome. (PMID: 9467018) Price J.A. … Hart T.C. (Hum. Mol. Genet. 1998) 3 4
  5. Genomic structure and functional control of the Dlx3-7 bigene cluster. (PMID: 11792834) Sumiyama K. … Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4

Products for DLX4 Gene

Sources for DLX4 Gene

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