Aliases for DLX3 Gene
External Ids for DLX3 Gene
Previous GeneCards Identifiers for DLX3 Gene
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLX3 Gene
DLX3 (Distal-Less Homeobox 3) is a Protein Coding gene. Diseases associated with DLX3 include amelogenesis imperfecta, type iv and trichodontoosseous syndrome. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is DLX5.
UniProtKB/Swiss-Prot for DLX3 Gene
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis