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Aliases for DLST Gene

Aliases for DLST Gene

  • Dihydrolipoamide S-Succinyltransferase 2 3
  • Dihydrolipoamide S-Succinyltransferase (E2 Component Of 2-Oxo-Glutarate Complex) 2 3 5
  • Dihydrolipoyllysine-Residue Succinyltransferase 2 3
  • EC 2.3.1.61 4 63
  • OGDC-E2 3 4
  • DLTS 3 4
  • E2K 3 4
  • Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex 4
  • 2-Oxoglutarate Dehydrogenase Complex Component E2 4
  • EC 2.3.1 63

External Ids for DLST Gene

Previous HGNC Symbols for DLST Gene

  • DLTS

Previous GeneCards Identifiers for DLST Gene

  • GC14P072875
  • GC14P069166
  • GC14P073338
  • GC14P074418
  • GC14P075348
  • GC14P055516

Summaries for DLST Gene

Entrez Gene Summary for DLST Gene

  • This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for DLST Gene

DLST (Dihydrolipoamide S-Succinyltransferase) is a Protein Coding gene. Diseases associated with DLST include Alpha-Ketoglutarate Dehydrogenase Deficiency and Wernicke-Korsakoff Syndrome. Among its related pathways are Glucose / Energy Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. GO annotations related to this gene include transferase activity and dihydrolipoyllysine-residue succinyltransferase activity.

UniProtKB/Swiss-Prot for DLST Gene

  • The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Gene Wiki entry for DLST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLST Gene

Genomics for DLST Gene

Regulatory Elements for DLST Gene

Enhancers for DLST Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DLST on UCSC Golden Path with GeneCards custom track

Promoters for DLST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLST on UCSC Golden Path with GeneCards custom track

Genomic Location for DLST Gene

Chromosome:
14
Start:
74,881,891 bp from pter
End:
74,903,747 bp from pter
Size:
21,857 bases
Orientation:
Plus strand

Genomic View for DLST Gene

Genes around DLST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLST Gene

Proteins for DLST Gene

  • Protein details for DLST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36957-ODO2_HUMAN
    Recommended name:
    Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
    Protein Accession:
    P36957
    Secondary Accessions:
    • B7Z5W8
    • E7ESY5
    • Q7LDY7
    • Q9BQ32

    Protein attributes for DLST Gene

    Size:
    453 amino acids
    Molecular mass:
    48755 Da
    Cofactor:
    Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
    Quaternary structure:
    • Forms a 24-polypeptide structural core with octahedral symmetry.

    Alternative splice isoforms for DLST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLST Gene

Proteomics data for DLST Gene at MOPED

Post-translational modifications for DLST Gene

  • Ubiquitination at Lys 203 and Lys 217
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DLST (DLST)
  • Santa Cruz Biotechnology (SCBT) Antibodies for DLST

Domains & Families for DLST Gene

Graphical View of Domain Structure for InterPro Entry

P36957

UniProtKB/Swiss-Prot:

ODO2_HUMAN :
  • Contains 1 lipoyl-binding domain.
  • Belongs to the 2-oxoacid dehydrogenase family.
Domain:
  • Contains 1 lipoyl-binding domain.
Family:
  • Belongs to the 2-oxoacid dehydrogenase family.
genes like me logo Genes that share domains with DLST: view

No data available for Gene Families for DLST Gene

Function for DLST Gene

Molecular function for DLST Gene

GENATLAS Biochemistry:
dihydrolipoamide S-succinyltransferase
UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine.
UniProtKB/Swiss-Prot Function:
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Enzyme Numbers (IUBMB) for DLST Gene

Gene Ontology (GO) - Molecular Function for DLST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with DLST: view
genes like me logo Genes that share phenotypes with DLST: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLST Gene

Localization for DLST Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLST Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLST Gene COMPARTMENTS Subcellular localization image for DLST gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DLST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with DLST: view

Pathways & Interactions for DLST Gene

genes like me logo Genes that share pathways with DLST: view

UniProtKB/Swiss-Prot P36957-ODO2_HUMAN

  • Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.

Gene Ontology (GO) - Biological Process for DLST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine IEA --
GO:0044237 cellular metabolic process TAS --
GO:0046487 glyoxylate metabolic process TAS --
genes like me logo Genes that share ontologies with DLST: view

No data available for SIGNOR curated interactions for DLST Gene

Drugs & Compounds for DLST Gene

(3) Drugs for DLST Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(6) Additional Compounds for DLST Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dihydrolipoamide
  • 6,8-Bis-sulfanyloctanamide
  • 6,8-Dimercapto-Octanamide
  • 6,8-Dimercaptooctanamide
  • 6,8-Disulfanyloctanamide
  • Dihydrolipoamide
3884-47-7
(R)-lipoic acid
  • (+)-alpha-Lipoic acid
  • (R)-(+)-lipoic acid
  • (R)-1,2-Dithiolane-3-pentanoic acid
  • (R)-1,2-dithiolane-3-valeric acid
  • (R)-6,8-thioctic acid
1200-22-2
(S)-Succinyldihydrolipoamide
  • S-Succinyl-dihydrolipoamide
  • S-Succinyldihydrolipoamide
Glutaryl-coa
  • Glutaryl-CoA
  • Glutaryl-coenzyme A
103192-48-9
S-Glutaryldihydrolipoamide
genes like me logo Genes that share compounds with DLST: view

Transcripts for DLST Gene

Unigene Clusters for DLST Gene

Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLST Gene

No ASD Table

Relevant External Links for DLST Gene

GeneLoc Exon Structure for
DLST
ECgene alternative splicing isoforms for
DLST

Expression for DLST Gene

mRNA expression in normal human tissues for DLST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DLST Gene

This gene is overexpressed in Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLST Gene



SOURCE GeneReport for Unigene cluster for DLST Gene Hs.525459

genes like me logo Genes that share expression patterns with DLST: view

Protein tissue co-expression partners for DLST Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DLST Gene

Orthologs for DLST Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DLST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLST 35
  • 91.61 (n)
  • 93.6 (a)
DLST 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLST 35
  • 92.94 (n)
  • 94.92 (a)
DLST 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlst 35
  • 88.52 (n)
  • 91.39 (a)
Dlst 16
Dlst 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLST 35
  • 99.48 (n)
  • 99.78 (a)
DLST 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlst 35
  • 88.15 (n)
  • 92.94 (a)
oppossum
(Monodelphis domestica)
Mammalia DLST 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves DLST 35
  • 75.85 (n)
  • 79.65 (a)
DLST 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLST 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlst 35
  • 70.16 (n)
  • 75.06 (a)
Str.124 35
African clawed frog
(Xenopus laevis)
Amphibia dlst-prov 35
zebrafish
(Danio rerio)
Actinopterygii dlst 35
  • 70.05 (n)
  • 71.96 (a)
Dr.3786 35
dlst 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9840 35
fruit fly
(Drosophila melanogaster)
Insecta CG5214 37
  • 72 (a)
CG5214 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004055 35
  • 66.95 (n)
  • 75.64 (a)
worm
(Caenorhabditis elegans)
Secernentea W02F12.5 37
  • 67 (a)
dlst-1 35
  • 64.1 (n)
  • 70.94 (a)
dlst-1 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL200W 35
  • 61.16 (n)
  • 61.3 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16522g 35
  • 58.7 (n)
  • 61.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KGD2 35
  • 57.3 (n)
  • 59.92 (a)
KGD2 36
  • 43 (a)
OneToMany
KGD2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G55070 35
  • 54.69 (n)
  • 49.5 (a)
soybean
(Glycine max)
eudicotyledons Gma.6351 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7649 35
barley
(Hordeum vulgare)
Liliopsida Hv.2268 35
rice
(Oryza sativa)
Liliopsida Os.8748 35
Os04g0394200 35
  • 64.35 (n)
  • 65.65 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28698 35
corn
(Zea mays)
Liliopsida Zm.1058 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6748 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02438 35
  • 53.27 (n)
  • 50.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kgd2 35
  • 57.9 (n)
  • 60.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8110 36
  • 56 (a)
OneToOne
Species with no ortholog for DLST:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DLST Gene

ENSEMBL:
Gene Tree for DLST (if available)
TreeFam:
Gene Tree for DLST (if available)

Paralogs for DLST Gene

Pseudogenes.org Pseudogenes for DLST Gene

genes like me logo Genes that share paralogs with DLST: view

No data available for Paralogs for DLST Gene

Variants for DLST Gene

Sequence variations from dbSNP and Humsavar for DLST Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_004976 -
VAR_004977 -
rs20578 -- 74,901,104(+) GATGG(C/T)GGTAC nc-transcript-variant, reference, synonymous-codon
rs1318501 -- 74,890,872(+) GGGGT(A/T)TCACC intron-variant
rs2537822 -- 74,881,744(+) GCGGA(G/T)GGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DLST Gene

Variant ID Type Subtype PubMed ID
nsv832832 CNV Gain+Loss 17160897

Variation tolerance for DLST Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLST Gene

Human Gene Mutation Database (HGMD)
DLST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLST Gene

Disorders for DLST Gene

MalaCards: The human disease database

(3) MalaCards diseases for DLST Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alpha-ketoglutarate dehydrogenase deficiency
  • 2 alpha ketoglutarate dehydrogenase deficiency
wernicke-korsakoff syndrome
  • korsakoff syndrome
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search DLST in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLST

Genetic Association Database (GAD)
DLST
Human Genome Epidemiology (HuGE) Navigator
DLST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLST
genes like me logo Genes that share disorders with DLST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLST Gene

Publications for DLST Gene

  1. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. (PMID: 8009371) Ali G. … Blass J.P. (Somat. Cell Mol. Genet. 1994) 2 3 23 67
  2. Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association. (PMID: 15038610) Brown A.M. … Blass J.P. (Neurochem. Res. 2004) 3 23
  3. Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. (PMID: 12805207) Kanamori T. … Ohta S. (EMBO J. 2003) 3 23
  4. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PMID: 11436125) Prince J.A. … Brookes A.J. (Eur. J. Hum. Genet. 2001) 3 23
  5. No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (PMID: 11445257) Matsushita S. … Higuchi S. (Neurobiol. Aging 2001) 3 23

Products for DLST Gene

Sources for DLST Gene

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