Aliases for DLG3 Gene
External Ids for DLG3 Gene
Previous GeneCards Identifiers for DLG3 Gene
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
GeneCards Summary for DLG3 Gene
DLG3 (Discs Large Homolog 3) is a Protein Coding gene. Diseases associated with DLG3 include non-syndromic x-linked intellectual disability and partington syndrome. Among its related pathways are Hippo signaling pathway and Neuroscience. GO annotations related to this gene include ubiquitin protein ligase binding and protein C-terminus binding. An important paralog of this gene is MPP6.
UniProtKB/Swiss-Prot for DLG3 Gene
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.