Aliases for AFP Gene
External Ids for AFP Gene
Previous HGNC Symbols for AFP Gene
Previous GeneCards Identifiers for AFP Gene
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
GeneCards Summary for AFP Gene
AFP (Alpha Fetoprotein) is a Protein Coding gene. Diseases associated with AFP include alpha-fetoprotein deficiency and hereditary persistence of alpha-fetoprotein. Among its related pathways are FOXA2 and FOXA3 transcription factor networks and Hippo signaling pathway. An important paralog of this gene is AFM.
UniProtKB/Swiss-Prot for AFP Gene
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.