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Aliases for AFM Gene

Aliases for AFM Gene

  • Afamin 2 3 5
  • Alpha-Albumin 3 4
  • Alpha-Alb 3 4
  • ALB2 3 4
  • ALBA 3 4
  • ALF 3

External Ids for AFM Gene

Previous GeneCards Identifiers for AFM Gene

  • GC04P074336
  • GC04P074587
  • GC04P074748
  • GC04P074813
  • GC04P074712
  • GC04P074566
  • GC04P070158

Summaries for AFM Gene

Entrez Gene Summary for AFM Gene

  • This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. [provided by RefSeq, Jul 2008]

GeneCards Summary for AFM Gene

AFM (Afamin) is a Protein Coding gene. Diseases associated with AFM include Trigonitis and Squamous Papillomatosis. GO annotations related to this gene include vitamin E binding. An important paralog of this gene is GC.

UniProtKB/Swiss-Prot for AFM Gene

  • Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier.

Gene Wiki entry for AFM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AFM Gene

Genomics for AFM Gene

Regulatory Elements for AFM Gene

Enhancers for AFM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AFM on UCSC Golden Path with GeneCards custom track

Genomic Location for AFM Gene

73,481,683 bp from pter
73,504,001 bp from pter
22,319 bases
Plus strand

Genomic View for AFM Gene

Genes around AFM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AFM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AFM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AFM Gene

Proteins for AFM Gene

  • Protein details for AFM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K3E1
    • Q32MR3
    • Q4W5C5

    Protein attributes for AFM Gene

    599 amino acids
    Molecular mass:
    69069 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AFM Gene

Proteomics data for AFM Gene at MOPED

Post-translational modifications for AFM Gene

  • N-glycosylated; more than 90% of the glycans are sialylated.
  • Glycosylation at Asn 33, Asn 109, Asn 383, Asn 402, and Asn 488
  • Modification sites at PhosphoSitePlus

Other Protein References for AFM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AFM Gene

Domains & Families for AFM Gene

Suggested Antigen Peptide Sequences for AFM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 albumin domains.
  • Belongs to the ALB/AFP/VDB family.
  • Contains 3 albumin domains.
  • Belongs to the ALB/AFP/VDB family.
genes like me logo Genes that share domains with AFM: view

No data available for Gene Families for AFM Gene

Function for AFM Gene

Molecular function for AFM Gene

GENATLAS Biochemistry:
afamin,87kDa,albumin superfamily
UniProtKB/Swiss-Prot Function:
Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier.
genes like me logo Genes that share phenotypes with AFM: view

Animal Models for AFM Gene

MGI Knock Outs for AFM:
  • Afm tm1a(KOMP)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AFM Gene

Localization for AFM Gene

Subcellular locations from UniProtKB/Swiss-Prot for AFM Gene


Subcellular locations from

Jensen Localization Image for AFM Gene COMPARTMENTS Subcellular localization image for AFM gene
Compartment Confidence
extracellular 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for AFM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IDA 12463752
genes like me logo Genes that share ontologies with AFM: view

Pathways & Interactions for AFM Gene

SuperPathways for AFM Gene

No Data Available

Interacting Proteins for AFM Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000226355 for AFM Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for AFM Gene


No data available for Pathways by source and SIGNOR curated interactions for AFM Gene

Drugs & Compounds for AFM Gene

(1) Drugs for AFM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for AFM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AFM: view

Transcripts for AFM Gene

mRNA/cDNA for AFM Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AFM Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AFM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - -
SP4: -

Relevant External Links for AFM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AFM Gene

mRNA expression in normal human tissues for AFM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AFM Gene

This gene is overexpressed in Liver (x50.8).

Protein differential expression in normal tissues from HIPED for AFM Gene

This gene is overexpressed in Serum (21.2), Plasma (15.8), and Synovial fluid (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AFM Gene

SOURCE GeneReport for Unigene cluster for AFM Gene Hs.168718

mRNA Expression by UniProt/SwissProt for AFM Gene

Tissue specificity: High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level).
genes like me logo Genes that share expression patterns with AFM: view

Protein tissue co-expression partners for AFM Gene

- Elite partner

Primer Products

Orthologs for AFM Gene

This gene was present in the common ancestor of chordates.

Orthologs for AFM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AFM 35
  • 83.89 (n)
  • 75.59 (a)
AFM 36
  • 75 (a)
(Canis familiaris)
Mammalia AFM 35
  • 82.75 (n)
  • 75.21 (a)
AFM 36
  • 74 (a)
(Mus musculus)
Mammalia Afm 35
  • 76.96 (n)
  • 67.78 (a)
Afm 16
Afm 36
  • 67 (a)
(Pan troglodytes)
Mammalia AFM 35
  • 99.44 (n)
  • 99 (a)
AFM 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Afm 35
  • 76.74 (n)
  • 67.95 (a)
(Monodelphis domestica)
Mammalia AFM 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
-- 36
  • 38 (a)
(Gallus gallus)
Aves -- 36
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
-- 36
  • 33 (a)
Species with no ortholog for AFM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AFM Gene

Gene Tree for AFM (if available)
Gene Tree for AFM (if available)

Paralogs for AFM Gene

Paralogs for AFM Gene

(2) SIMAP similar genes for AFM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AFM: view

Variants for AFM Gene

Sequence variations from dbSNP and Humsavar for AFM Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2276444 - 73,497,670(+) ATGAG(A/T)CAACT reference, missense
rs41265665 - 73,495,425(+) TTACC(A/G)TTACG reference, missense
rs1158101 -- 73,497,565(+) AGAAA(C/T)AAGAA intron-variant
rs1159624 -- 73,501,989(+) CCCTG(C/T)AGGAC intron-variant
rs2071097 -- 73,503,581(+) TTTAC(A/G)TGAAC intron-variant

Variation tolerance for AFM Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for AFM Gene

Disorders for AFM Gene

MalaCards: The human disease database

(2) MalaCards diseases for AFM Gene - From: DISEASES

Disorder Aliases PubMed IDs
squamous papillomatosis
- elite association - COSMIC cancer census association via MalaCards
Search AFM in MalaCards View complete list of genes associated with diseases

Relevant External Links for AFM

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AFM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AFM Gene

Publications for AFM Gene

  1. Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family. (PMID: 7517938) Lichenstein H.S. … Zukowski M.M. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier. (PMID: 19046407) Kratzer I. … Sattler W. (J. Neurochem. 2009) 3 23
  3. Afamin and apolipoprotein A-IV: novel protein markers for ovarian cancer. (PMID: 19336561) Dieplinger H. … Stieber P. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23
  4. Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression. (PMID: 15952736) Jerkovic L. … Dieplinger H. (J. Proteome Res. 2005) 3 23
  5. Characterization of the vitamin E-binding properties of human plasma afamin. (PMID: 12463752) Voegele A.F. … Dieplinger H. (Biochemistry 2002) 3 23

Products for AFM Gene

Sources for AFM Gene