External Ids for DGUOK Gene
Previous GeneCards Identifiers for DGUOK Gene
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGUOK Gene
DGUOK (Deoxyguanosine Kinase) is a Protein Coding gene. Diseases associated with DGUOK include mitochondrial dna depletion syndrome 3 and mitochondrial dna depletion syndrome, hepatocerebral form due to dguok deficiency. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include nucleoside kinase activity and deoxyguanosine kinase activity. An important paralog of this gene is TK2.
UniProtKB/Swiss-Prot for DGUOK Gene
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.