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Aliases for DGUOK Gene

Aliases for DGUOK Gene

  • Deoxyguanosine Kinase 2 3
  • DGK 3 4 6
  • MTDPS3 3 6
  • Deoxyguanosine Kinase, Mitochondrial 3
  • EC 4

External Ids for DGUOK Gene

Previous GeneCards Identifiers for DGUOK Gene

  • GC02P074291
  • GC02P074111
  • GC02P074128
  • GC02P074065
  • GC02P074153
  • GC02P073889

Summaries for DGUOK Gene

Entrez Gene Summary for DGUOK Gene

  • In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGUOK Gene

DGUOK (Deoxyguanosine Kinase) is a Protein Coding gene. Diseases associated with DGUOK include mitochondrial dna depletion syndrome 3 and dguok-related mitochondrial dna depletion syndrome, hepatocerebral form. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and deoxyguanosine kinase activity. An important paralog of this gene is TK2.

UniProtKB/Swiss-Prot for DGUOK Gene

  • Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Wiki entry for DGUOK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGUOK Gene

Genomics for DGUOK Gene

Regulatory Elements for DGUOK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DGUOK Gene

73,926,826 bp from pter
73,958,961 bp from pter
32,136 bases
Plus strand

Genomic View for DGUOK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DGUOK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGUOK Gene

Proteins for DGUOK Gene

  • Protein details for DGUOK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxyguanosine kinase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • P78532
    • Q16759
    • Q4ZG09
    • Q7L1W9
    • Q96BC1

    Protein attributes for DGUOK Gene

    277 amino acids
    Molecular mass:
    32056 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DGUOK Gene

    Alternative splice isoforms for DGUOK Gene

neXtProt entry for DGUOK Gene

Proteomics data for DGUOK Gene at MOPED

Post-translational modifications for DGUOK Gene

  • Ubiquitination at Lys129 and Lys275
  • Modification sites at PhosphoSitePlus

Other Protein References for DGUOK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DGUOK Gene

Domains for DGUOK Gene

Protein Domains for DGUOK Gene


Suggested Antigen Peptide Sequences for DGUOK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DCK/DGK family.
  • Belongs to the DCK/DGK family.
genes like me logo Genes that share domains with DGUOK: view

No data available for Gene Families for DGUOK Gene

Function for DGUOK Gene

Molecular function for DGUOK Gene

GENATLAS Biochemistry:
deoxyguanosine kinase,mitochondrial,related to DCK
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + deoxyguanosine = ADP + dGMP.
UniProtKB/Swiss-Prot Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Enzyme Numbers (IUBMB) for DGUOK Gene

Gene Ontology (GO) - Molecular Function for DGUOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004138 deoxyguanosine kinase activity IDA 8706825
GO:0005524 ATP binding IEA --
GO:0019206 nucleoside kinase activity EXP --
genes like me logo Genes that share ontologies with DGUOK: view

Phenotypes for DGUOK Gene

GenomeRNAi human phenotypes for DGUOK:
genes like me logo Genes that share phenotypes with DGUOK: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGUOK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGUOK Gene

Localization for DGUOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGUOK Gene


Subcellular locations from

Jensen Localization Image for DGUOK Gene COMPARTMENTS Subcellular localization image for DGUOK gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DGUOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005739 mitochondrion TAS 8692979
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with DGUOK: view

Pathways for DGUOK Gene

genes like me logo Genes that share pathways with DGUOK: view

Pathways by source for DGUOK Gene

1 BioSystems pathway for DGUOK Gene
2 KEGG pathways for DGUOK Gene

Interacting Proteins for DGUOK Gene

Gene Ontology (GO) - Biological Process for DGUOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006468 protein phosphorylation IEA --
GO:0008617 guanosine metabolic process TAS 8692979
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process TAS 8692979
genes like me logo Genes that share ontologies with DGUOK: view

Drugs for DGUOK Gene

(1) Drugbank Compounds for DGUOK Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine
121032-29-9 3011155 Enzyme substrate approved, investigational

(5) HMDB Compounds for DGUOK Gene

Compound Synonyms Cas Number PubMed IDs
2'-Deoxyguanosine 5'-monophosphate
  • 2'-Deoxy-5'-GMP
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
  • 2'-Deoxy-Guanosine
  • GW-506U78

(29) Novoseek inferred chemical compound relationships for DGUOK Gene

Compound -log(P) Hits PubMed IDs
deoxyguanosine 97.1 138
9-(beta-d-arabinofuranosyl)guanine 94.7 10
deoxycytidine 94.2 60
deoxynucleoside 92 8
2,2-difluorodeoxyguanosine 88.8 5
genes like me logo Genes that share compounds with DGUOK: view

Transcripts for DGUOK Gene

Unigene Clusters for DGUOK Gene

Deoxyguanosine kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DGUOK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGUOK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - -
SP16: - - -

Relevant External Links for DGUOK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGUOK Gene

mRNA expression in normal human tissues for DGUOK Gene

Protein differential expression in normal tissues for DGUOK Gene

This gene is overexpressed in Heart (18.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DGUOK Gene

SOURCE GeneReport for Unigene cluster for DGUOK Gene Hs.469022

mRNA Expression by UniProt/SwissProt for DGUOK Gene

Tissue specificity: Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.
genes like me logo Genes that share expressions with DGUOK: view

Expression partners for DGUOK Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DGUOK Gene

Orthologs for DGUOK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGUOK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DGUOK 35
  • 88.21 (n)
  • 84.12 (a)
  • 84 (a)
(Canis familiaris)
Mammalia DGUOK 35
  • 90.13 (n)
  • 84.12 (a)
  • 80 (a)
(Mus musculus)
Mammalia Dguok 35
  • 80.51 (n)
  • 75.09 (a)
Dguok 16
Dguok 36
  • 75 (a)
(Pan troglodytes)
Mammalia DGUOK 35
  • 99.4 (n)
  • 99.28 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dguok 35
  • 80.9 (n)
  • 75.66 (a)
(Monodelphis domestica)
Mammalia DGUOK 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia DGUOK 36
  • 65 (a)
(Gallus gallus)
Aves DGUOK 36
  • 47 (a)
(Anolis carolinensis)
Reptilia DGUOK 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494916 35
  • 62.62 (n)
  • 55.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19838 35
(Danio rerio)
Actinopterygii dguok 35
  • 61.42 (n)
  • 57.45 (a)
dguok 36
  • 49 (a)
dguok 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10372 35
fruit fly
(Drosophila melanogaster)
Insecta dnk 36
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G72040 35
  • 46.88 (n)
  • 40.18 (a)
(Oryza sativa)
Liliopsida Os01g0874100 35
  • 49.9 (n)
  • 40.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for DGUOK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DGUOK Gene

Gene Tree for DGUOK (if available)
Gene Tree for DGUOK (if available)

Paralogs for DGUOK Gene

Paralogs for DGUOK Gene

(2) SIMAP similar genes for DGUOK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DGUOK: view

Variants for DGUOK Gene

Sequence variations from dbSNP and Humsavar for DGUOK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs831525 -- 73,926,204(+) ACCCA(A/G)CCTAC upstream-variant-2KB
rs831546 -- 73,941,914(+) CTTTT(C/T)TTTTT intron-variant
rs940297 -- 73,947,018(+) AAATT(A/G)TCTTC intron-variant
rs940298 -- 73,947,269(+) AATCA(A/G)ATGAT intron-variant
rs940299 -- 73,947,777(+) GAAAT(A/G)GTGCT intron-variant

Relevant External Links for DGUOK Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DGUOK Gene

Disorders for DGUOK Gene

(1) OMIM Diseases for DGUOK Gene (601465)


  • Mitochondrial DNA depletion syndrome 3 (MTDPS3) [MIM:251880]: A disorder due to mitochondrial dysfunction characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in body fluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion. {ECO:0000269 PubMed:12205643, ECO:0000269 PubMed:15639197}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for DGUOK Gene

(15) Novoseek inferred disease relationships for DGUOK Gene

Disease -log(P) Hits PubMed IDs
respiratory chain deficiency 78.4 2
alpers syndrome 68.4 2
mitochondrial diseases 58.5 1
liver failure 55 2
myopathy 49.5 2

Relevant External Links for DGUOK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DGUOK: view

No data available for Genatlas for DGUOK Gene

Publications for DGUOK Gene

  1. Cloning and expression of human deoxyguanosine kinase cDNA. (PMID: 8692979) Johansson M. … Karlsson A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  2. Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes. (PMID: 15639197) Wang L. … Eriksson S. (Mol. Genet. Metab. 2005) 3 4 23
  3. Mitochondrial DNA depletion and dGK gene mutations. (PMID: 12205643) Salviati L. … Vu T.H. (Ann. Neurol. 2002) 3 4 23
  4. Structural basis for substrate specificities of cellular deoxyribonucleoside kinases. (PMID: 11427893) Johansson K. … Eklund H. (Nat. Struct. Biol. 2001) 3 4 23
  5. Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA. (PMID: 8706825) Wang L. … Eriksson S. (FEBS Lett. 1996) 3 4 23

Products for DGUOK Gene

  • Addgene plasmids for DGUOK

Sources for DGUOK Gene

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