Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HTR3C Gene

Aliases for HTR3C Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 3C, Ionotropic 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member C 2 3
  • Serotonin Receptor 3C 3 4
  • 5-HT3-C 3 4
  • 5-HT3C 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit C 3

External Ids for HTR3C Gene

Previous GeneCards Identifiers for HTR3C Gene

  • GC00U991163
  • GC03P184765
  • GC03P185172
  • GC03P185092
  • GC03P185093
  • GC03P185253
  • GC03P183770
  • GC03P181178

Summaries for HTR3C Gene

Entrez Gene Summary for HTR3C Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR3C Gene

HTR3C (5-Hydroxytryptamine (Serotonin) Receptor 3C, Ionotropic) is a Protein Coding gene. Among its related pathways are CREB Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include extracellular ligand-gated ion channel activity and serotonin receptor activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3C Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Tocris Summary for HTR3C Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3C Gene

Genomics for HTR3C Gene

Regulatory Elements for HTR3C Gene

Genomic Location for HTR3C Gene

Chromosome:
3
Start:
184,053,047 bp from pter
End:
184,060,673 bp from pter
Size:
7,627 bases
Orientation:
Plus strand

Genomic View for HTR3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3C Gene

Proteins for HTR3C Gene

  • Protein details for HTR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXA8-5HT3C_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3C
    Protein Accession:
    Q8WXA8
    Secondary Accessions:
    • A2RRR5

    Protein attributes for HTR3C Gene

    Size:
    447 amino acids
    Molecular mass:
    50220 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

neXtProt entry for HTR3C Gene

Proteomics data for HTR3C Gene at MOPED

Post-translational modifications for HTR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR3C Gene

Domains & Families for HTR3C Gene

Gene Families for HTR3C Gene

Suggested Antigen Peptide Sequences for HTR3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXA8

UniProtKB/Swiss-Prot:

5HT3C_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
genes like me logo Genes that share domains with HTR3C: view

Function for HTR3C Gene

Molecular function for HTR3C Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Gene Ontology (GO) - Molecular Function for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 NOT contributes_to acetylcholine-activated cation-selective channel activity IBA --
GO:0004993 serotonin receptor activity IDA 17392525
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005232 serotonin-activated cation-selective channel activity IBA --
GO:0015464 NOT contributes_to acetylcholine receptor activity IBA --
genes like me logo Genes that share ontologies with HTR3C: view

Phenotypes for HTR3C Gene

GenomeRNAi human phenotypes for HTR3C:
genes like me logo Genes that share phenotypes with HTR3C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTR3C Gene

Localization for HTR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3C Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR3C Gene COMPARTMENTS Subcellular localization image for HTR3C gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 NOT acetylcholine-gated channel complex IBA --
GO:0016020 membrane --
GO:0043005 neuron projection IBA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with HTR3C: view

Pathways & Interactions for HTR3C Gene

genes like me logo Genes that share pathways with HTR3C: view

Pathways by source for HTR3C Gene

1 KEGG pathway for HTR3C Gene

Interacting Proteins for HTR3C Gene

Gene Ontology (GO) - Biological Process for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007210 serotonin receptor signaling pathway IDA 17392525
GO:0007271 NOT synaptic transmission, cholinergic IBA --
GO:0007274 NOT neuromuscular synaptic transmission IBA --
genes like me logo Genes that share ontologies with HTR3C: view

No data available for SIGNOR curated interactions for HTR3C Gene

Drugs & Compounds for HTR3C Gene

(10) Drugs for HTR3C Gene - From: ApexBio, DGIdb, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 1708
Ergoloid mesylate Approved Pharma Target, antagonist 0
Dolasetron Approved Pharma antagonist 7
Granisetron Approved, Investigational Pharma antagonist 69
Azasetron HCl Pharma 5-HT3 receptor antagonist 0

(5) Additional Compounds for HTR3C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methyl-5-hydroxytryptamine hydrochloride
845861-49-6
Dexfenfluramine hydrochloride
3239-45-0
m-Chlorophenylbiguanide hydrochloride
2113-05-5
N-Methylquipazine dimaleate
171205-17-7
Quipazine dimaleate
150323-78-7
genes like me logo Genes that share compounds with HTR3C: view

Transcripts for HTR3C Gene

mRNA/cDNA for HTR3C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR3C Gene

5-hydroxytryptamine (serotonin) receptor 3C, ionotropic:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3C Gene

No ASD Table

Relevant External Links for HTR3C Gene

GeneLoc Exon Structure for
HTR3C
ECgene alternative splicing isoforms for
HTR3C

Expression for HTR3C Gene

mRNA expression in normal human tissues for HTR3C Gene

mRNA differential expression in normal tissues according to GTEx for HTR3C Gene

This gene is overexpressed in Lung (x33.6).

SOURCE GeneReport for Unigene cluster for HTR3C Gene Hs.632579

mRNA Expression by UniProt/SwissProt for HTR3C Gene

Q8WXA8-5HT3C_HUMAN
Tissue specificity: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.
genes like me logo Genes that share expression patterns with HTR3C: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HTR3C Gene

Orthologs for HTR3C Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HTR3C 35
  • 85.98 (n)
  • 81.21 (a)
HTR3C 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR3C 35
  • 98.88 (n)
  • 98.66 (a)
HTR3C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTR3C 36
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01016332.1 36
  • 32 (a)
ManyToMany
CU207281.1 36
  • 46 (a)
ManyToMany
CU207281.2 36
  • 31 (a)
ManyToMany
Species with no ortholog for HTR3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3C Gene

ENSEMBL:
Gene Tree for HTR3C (if available)
TreeFam:
Gene Tree for HTR3C (if available)

Paralogs for HTR3C Gene

Paralogs for HTR3C Gene

(4) SIMAP similar genes for HTR3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR3C: view

Variants for HTR3C Gene

Sequence variations from dbSNP and Humsavar for HTR3C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6443932 -- 184,051,895(+) AGTTT(C/T)TTTTG upstream-variant-2KB
rs6762938 -- 184,055,983(+) ATCTG(C/T)CTGCC intron-variant
rs6766182 -- 184,053,598(+) AAATA(C/T)TATGG intron-variant
rs6766410 - 184,056,974(+) TGTAA(A/C)CTGGA missense, reference
rs6794223 -- 184,058,045(+) CTAAA(A/G)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR3C Gene

Variant ID Type Subtype PubMed ID
nsv4145 CNV Insertion 18451855

Variation tolerance for HTR3C Gene

Residual Variation Intolerance Score: 83.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.68; 94.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3C Gene

HapMap Linkage Disequilibrium report
HTR3C
Human Gene Mutation Database (HGMD)
HTR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3C Gene

Disorders for HTR3C Gene

Relevant External Links for HTR3C

Genetic Association Database (GAD)
HTR3C
Human Genome Epidemiology (HuGE) Navigator
HTR3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3C
genes like me logo Genes that share disorders with HTR3C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HTR3C Gene

Publications for HTR3C Gene

  1. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. (PMID: 15157181) Peters J.A. … Lambert J.J. (Biochem. Soc. Trans. 2004) 2 67
  2. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B. … Rappold G.A. (Gene 2003) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. 5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option. (PMID: 23928294) Lennertz L. … MAPssner R. (Eur Neuropsychopharmacol 2014) 67
  5. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. (PMID: 24603532) Nongpiur M.E. … Aung T. (PLoS Genet. 2014) 67

Products for HTR3C Gene

Sources for HTR3C Gene

Back to Top

Content