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Aliases for HTR3C Gene

Aliases for HTR3C Gene

  • 5-Hydroxytryptamine Receptor 3C 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member C 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3C, Ionotropic 2 3
  • Serotonin Receptor 3C 3 4
  • 5-HT3-C 3 4
  • 5-HT3C 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit C 3

External Ids for HTR3C Gene

Previous GeneCards Identifiers for HTR3C Gene

  • GC00U991163
  • GC03P184765
  • GC03P185172
  • GC03P185092
  • GC03P185093
  • GC03P185253
  • GC03P183770
  • GC03P181178

Summaries for HTR3C Gene

Entrez Gene Summary for HTR3C Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR3C Gene

HTR3C (5-Hydroxytryptamine Receptor 3C) is a Protein Coding gene. Diseases associated with HTR3C include Primary Angle-Closure Glaucoma and Esophagus Adenocarcinoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include extracellular ligand-gated ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot for HTR3C Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3C Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3C Gene

Additional gene information for HTR3C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3C Gene

Genomics for HTR3C Gene

Regulatory Elements for HTR3C Gene

Enhancers for HTR3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H184015 1.4 Ensembl ENCODE 10.6 -36.0 -36045 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF207 YEATS2 HTR3D ENSG00000271682 ABCC5 RPS3P3 HTR3C EIF2B5 AP2M1 ALG3 CAMK2N2
GH03H184154 1.3 ENCODE dbSUPER 10.2 +103.4 103350 4 HDGF ARID4B SIN3A DMAP1 ZNF121 SLC30A9 GLIS2 ELK1 ZNF143 KLF7 EIF2B5 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 ALG3 ABCF3 CAMK2N2 PSMD2 VWA5B2 MIR1224
GH03H184110 1.2 Ensembl ENCODE 10.3 +57.5 57474 0 HDAC1 ARID4B ZBTB40 FOS ATF7 MIXL1 THAP11 ZEB2 MAFF MTA1 EIF2B5 HTR3C CAMK2N2 ABCC5 PSMD2 VWA5B2 HSP90AA5P HTR3E-AS1
GH03H184005 1.2 Ensembl ENCODE 10.1 -46.7 -46661 1 PKNOX1 ARNT SIN3A FOS ATF7 DEK JUNB ZNF592 MAFF SMARCA4 ABCC5 EEF1A1P8 HTR3D HTR3C RPSAP31 PARL EIF2B5 CAMK2N2 MAP6D1 ABCC5-AS1
GH03H184022 1 FANTOM5 Ensembl ENCODE 12.1 -30.5 -30524 0 JUN GABPA ABCC5 HTR3C PARL RPSAP31 EIF2B5 CAMK2N2 ALG3 ECE2 EEF1AKMT4-ECE2 EEF1AKMT4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTR3C on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR3C Gene

Chromosome:
3
Start:
184,053,047 bp from pter
End:
184,060,673 bp from pter
Size:
7,627 bases
Orientation:
Plus strand

Genomic View for HTR3C Gene

Genes around HTR3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3C Gene

Proteins for HTR3C Gene

  • Protein details for HTR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXA8-5HT3C_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3C
    Protein Accession:
    Q8WXA8
    Secondary Accessions:
    • A2RRR5

    Protein attributes for HTR3C Gene

    Size:
    447 amino acids
    Molecular mass:
    50220 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

neXtProt entry for HTR3C Gene

Post-translational modifications for HTR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR3C Gene

Domains & Families for HTR3C Gene

Gene Families for HTR3C Gene

Suggested Antigen Peptide Sequences for HTR3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXA8

UniProtKB/Swiss-Prot:

5HT3C_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
genes like me logo Genes that share domains with HTR3C: view

Function for HTR3C Gene

Molecular function for HTR3C Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Phenotypes From GWAS Catalog for HTR3C Gene

Gene Ontology (GO) - Molecular Function for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005515 protein binding IPI 17392525
GO:0022850 serotonin-gated cation channel activity IDA 17392525
genes like me logo Genes that share ontologies with HTR3C: view
genes like me logo Genes that share phenotypes with HTR3C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HTR3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTR3C Gene

Localization for HTR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3C Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR3C gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR3C Gene

Pathways & Interactions for HTR3C Gene

genes like me logo Genes that share pathways with HTR3C: view

Pathways by source for HTR3C Gene

Gene Ontology (GO) - Biological Process for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with HTR3C: view

No data available for SIGNOR curated interactions for HTR3C Gene

Drugs & Compounds for HTR3C Gene

(27) Drugs for HTR3C Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 2226
Granisetron Approved, Investigational Pharma antagonist Serotonin 5-HT3 receptor antagonist 73
Ergoloid mesylate Approved Pharma Target, antagonist 0
Setiptiline Approved Pharma Target, antagonist Serotonin receptor antagonist 0
Tiapride Approved, Investigational Pharma Target, antagonist 0

(1) Additional Compounds for HTR3C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ondansetron hydrochloride
99614-01-4

(5) Tocris Compounds for HTR3C Gene

Compound Action Cas Number
Dihydroergotamine mesylate Partial alpha agonist. Non-selective 6190-39-2
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
Ondansetron hydrochloride Selective 5-HT3 antagonist 99614-01-4
SR 57227 hydrochloride Potent, selective 5-HT3 agonist 77145-61-0
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(18) ApexBio Compounds for HTR3C Gene

Compound Action Cas Number
1-Phenylbiguanide hydrochloride 55-57-2
2-[1-(4-Piperonyl)piperazinyl]benzothiazole 155106-73-3
3-AQC 201216-42-4
Alosetron Hydrochloride 5-HT3 receptor antagonist,potent and highly selective 122852-69-1
Azasetron HCl 5-HT3 receptor antagonist 123040-16-4
EMD 386088 hydrochloride 1171123-46-8
Granisetron Serotonin 5-HT3 receptor antagonist 109889-09-0
Granisetron HCl 5-HT3 receptor antagonist 107007-99-8
m-Chlorophenylbiguanide hydrochloride 2113-05-5
N-Methylquipazine dimaleate 171205-17-7
Ondansetron HCl 5-HT3 receptor antagonist 99614-01-4
Palonosetron 5-HT3 antagonist 135729-61-2
Quipazine dimaleate 150323-78-7
RS 56812 hydrochloride 143339-12-2
SDZ 205-557 hydrochloride 1197334-02-3
SR 57227 hydrochloride 77145-61-0
Tianeptine 5-HT facilitator 66981-73-5
Zacopride hydrochloride 101303-98-4
genes like me logo Genes that share compounds with HTR3C: view

Drug Products

Transcripts for HTR3C Gene

mRNA/cDNA for HTR3C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR3C Gene

5-hydroxytryptamine (serotonin) receptor 3C, ionotropic:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HTR3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3C Gene

No ASD Table

Relevant External Links for HTR3C Gene

GeneLoc Exon Structure for
HTR3C
ECgene alternative splicing isoforms for
HTR3C

Expression for HTR3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR3C Gene

mRNA differential expression in normal tissues according to GTEx for HTR3C Gene

This gene is overexpressed in Lung (x33.6).

NURSA nuclear receptor signaling pathways regulating expression of HTR3C Gene:

HTR3C

SOURCE GeneReport for Unigene cluster for HTR3C Gene:

Hs.632579

mRNA Expression by UniProt/SwissProt for HTR3C Gene:

Q8WXA8-5HT3C_HUMAN
Tissue specificity: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.

Evidence on tissue expression from TISSUES for HTR3C Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with HTR3C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR3C Gene

Orthologs for HTR3C Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR3C 33 34
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia HTR3C 33 34
  • 85.98 (n)
cow
(Bos Taurus)
Mammalia HTR3C 34
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU207281.1 34
  • 46 (a)
ManyToMany
CABZ01016332.1 34
  • 32 (a)
ManyToMany
CU207281.2 34
  • 31 (a)
ManyToMany
Species where no ortholog for HTR3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3C Gene

ENSEMBL:
Gene Tree for HTR3C (if available)
TreeFam:
Gene Tree for HTR3C (if available)

Paralogs for HTR3C Gene

Paralogs for HTR3C Gene

(4) SIMAP similar genes for HTR3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR3C: view

Variants for HTR3C Gene

Sequence variations from dbSNP and Humsavar for HTR3C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs142791028 A colorectal cancer sample 184,056,279(+) TCATC(A/G)TGGAA reference, missense
rs1000307042 -- 184,056,401(+) AACGA(A/G)CTGAC intron-variant
rs1000624634 -- 184,056,140(+) GCTCA(C/T)CGTCA intron-variant
rs1000639516 -- 184,056,029(+) TTGTT(A/G)AATCA intron-variant
rs1000699950 -- 184,055,559(+) AAATA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR3C Gene

Variant ID Type Subtype PubMed ID
nsv4145 CNV insertion 18451855

Variation tolerance for HTR3C Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.68; 94.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3C Gene

Human Gene Mutation Database (HGMD)
HTR3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3C Gene

Disorders for HTR3C Gene

MalaCards: The human disease database

(2) MalaCards diseases for HTR3C Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
primary angle-closure glaucoma
  • primary angle closure glaucoma
esophagus adenocarcinoma
  • adenocarcinoma of esophagus
- elite association - COSMIC cancer census association via MalaCards
Search HTR3C in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR3C

Genetic Association Database (GAD)
HTR3C
Human Genome Epidemiology (HuGE) Navigator
HTR3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3C
genes like me logo Genes that share disorders with HTR3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3C Gene

Publications for HTR3C Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B … Rappold GA (Gene 2003) 2 3 4 60
  2. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PMID: 20538960) Larkin EK … Redline S (American journal of respiratory and critical care medicine 2010) 3 45 60
  3. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (PMID: 20021265) Goecke TW … Fasching PA (Acta obstetricia et gynecologica Scandinavica 2010) 3 45 60
  4. Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. (PMID: 19794330) Schuhmacher A … Maier W (Pharmacogenetics and genomics 2009) 3 45 60
  5. Allelic variants in HTR3C show association with autism. (PMID: 19035560) Rehnström K … Peltonen L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 45 60

Products for HTR3C Gene

Sources for HTR3C Gene

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