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Aliases for SLC30A8 Gene

Aliases for SLC30A8 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 8 2 3
  • ZNT8 3 4 6
  • ZnT-8 3 4
  • Solute Carrier Family 30 Member 8 4
  • Zinc Transporter ZnT-8 3
  • Zinc Transporter 8 3

External Ids for SLC30A8 Gene

Previous GeneCards Identifiers for SLC30A8 Gene

  • GC08P118024
  • GC08P117632
  • GC08P118104
  • GC08P118032
  • GC08P118216
  • GC08P117963
  • GC08P113288

Summaries for SLC30A8 Gene

Entrez Gene Summary for SLC30A8 Gene

  • The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

GeneCards Summary for SLC30A8 Gene

SLC30A8 (Solute Carrier Family 30 (Zinc Transporter), Member 8) is a Protein Coding gene. Diseases associated with SLC30A8 include diabetes mellitus, noninsulin-dependent. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A4.

UniProtKB/Swiss-Prot for SLC30A8 Gene

  • Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.

Gene Wiki entry for SLC30A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A8 Gene

Genomics for SLC30A8 Gene

Regulatory Elements for SLC30A8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC30A8 Gene

Start:
116,950,273 bp from pter
End:
117,176,714 bp from pter
Size:
226,442 bases
Orientation:
Plus strand

Genomic View for SLC30A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A8 Gene

Proteins for SLC30A8 Gene

  • Protein details for SLC30A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU4-ZNT8_HUMAN
    Recommended name:
    Zinc transporter 8
    Protein Accession:
    Q8IWU4
    Secondary Accessions:
    • A0AVP9
    • A5YM39
    • B4DPE0
    • Q8TCL3

    Protein attributes for SLC30A8 Gene

    Size:
    369 amino acids
    Molecular mass:
    40755 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for SLC30A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC30A8 Gene

Proteomics data for SLC30A8 Gene at MOPED

Post-translational modifications for SLC30A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC30A8 Gene

Domains for SLC30A8 Gene

Gene Families for SLC30A8 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A8 Gene

Suggested Antigen Peptide Sequences for SLC30A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWU4

UniProtKB/Swiss-Prot:

ZNT8_HUMAN :
  • Q8IWU4
Domain:
  • Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A8: view

Function for SLC30A8 Gene

Molecular function for SLC30A8 Gene

UniProtKB/Swiss-Prot Function: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.

Gene Ontology (GO) - Molecular Function for SLC30A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IDA 15331542
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IC 15331542
GO:0008324 cation transmembrane transporter activity --
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with SLC30A8: view
genes like me logo Genes that share phenotypes with SLC30A8: view

Animal Models for SLC30A8 Gene

MGI Knock Outs for SLC30A8:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC30A8 Gene

Localization for SLC30A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A8 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A8 Gene COMPARTMENTS Subcellular localization image for SLC30A8 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC30A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 NOT Golgi apparatus IDA 15331542
GO:0005886 plasma membrane IDA 15331542
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle ISS --
GO:0030141 secretory granule IDA 15331542
genes like me logo Genes that share ontologies with SLC30A8: view

Pathways for SLC30A8 Gene

genes like me logo Genes that share pathways with SLC30A8: view

Interacting Proteins for SLC30A8 Gene

Gene Ontology (GO) - Biological Process for SLC30A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006829 zinc II ion transport IDA 15331542
GO:0006882 cellular zinc ion homeostasis ISS --
GO:0009749 response to glucose IMP 16984975
GO:0030073 insulin secretion IMP 16984975
genes like me logo Genes that share ontologies with SLC30A8: view

Compounds for SLC30A8 Gene

(1) Novoseek inferred chemical compound relationships for SLC30A8 Gene

Compound -log(P) Hits PubMed IDs
zinc 72 20

(1) PharmGKB related drug/compound annotations for SLC30A8 Gene

Drug/compound Annotation
repaglinide CA
genes like me logo Genes that share compounds with SLC30A8: view

Transcripts for SLC30A8 Gene

Unigene Clusters for SLC30A8 Gene

Solute carrier family 30 (zinc transporter), member 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A8 Gene

No ASD Table

Relevant External Links for SLC30A8 Gene

GeneLoc Exon Structure for
SLC30A8
ECgene alternative splicing isoforms for
SLC30A8

Expression for SLC30A8 Gene

mRNA expression in normal human tissues for SLC30A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A8 Gene

This gene is overexpressed in Pancreas (36.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC30A8 Gene

SOURCE GeneReport for Unigene cluster for SLC30A8 Gene Hs.532270

mRNA Expression by UniProt/SwissProt for SLC30A8 Gene

Q8IWU4-ZNT8_HUMAN
Tissue specificity: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
genes like me logo Genes that share expressions with SLC30A8: view

In Situ Assay Products

Orthologs for SLC30A8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A8 35
  • 99.46 (n)
  • 98.92 (a)
SLC30A8 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A8 35
  • 88.35 (n)
  • 86.45 (a)
SLC30A8 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a8 35
  • 82.92 (n)
  • 80.93 (a)
Slc30a8 16
Slc30a8 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc30a8 35
  • 81.52 (n)
  • 79.13 (a)
chicken
(Gallus gallus)
Aves SLC30A8 35
  • 66.03 (n)
  • 61.81 (a)
SLC30A8 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A8 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.27513 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a8 35
  • 63.31 (n)
  • 60.61 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560642 35
  • 62.24 (n)
  • 57.23 (a)
slc30a8 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31860 36
  • 21 (a)
ManyToMany
ZnT35C 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cdf-2 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 36
  • 18 (a)
ManyToMany
ZRC1 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for SLC30A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A8 Gene

ENSEMBL:
Gene Tree for SLC30A8 (if available)
TreeFam:
Gene Tree for SLC30A8 (if available)

Paralogs for SLC30A8 Gene

Paralogs for SLC30A8 Gene

Selected SIMAP similar genes for SLC30A8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A8: view

Variants for SLC30A8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A8 Gene

Q8IWU4-ZNT8_HUMAN
Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) [MIM:125853]

Sequence variations from dbSNP and Humsavar for SLC30A8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs868651 -- 117,062,487(+) CTCAC(A/G)TGAAC intron-variant
rs883906 -- 117,086,759(+) tgttg(A/G)tcaag intron-variant
rs885205 -- 117,087,268(-) TTCTG(A/G)CTCTC intron-variant
rs905904 -- 117,039,065(+) CTGGA(A/T)CTCAA intron-variant
rs924921 -- 117,106,100(+) TTTGT(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A8 Gene

Variant ID Type Subtype PubMed ID
nsv831434 CNV Gain 17160897
nsv891409 CNV Loss 21882294
esv2670074 CNV Deletion 23128226
nsv6360 CNV Loss 18451855
dgv1303e199 CNV Deletion 23128226
esv21665 CNV Loss 19812545
nsv527876 CNV Loss 19592680
nsv819760 CNV Gain 19587683
nsv819890 CNV Loss 19587683

Relevant External Links for SLC30A8 Gene

HapMap Linkage Disequilibrium report
SLC30A8
Human Gene Mutation Database (HGMD)
SLC30A8

Disorders for SLC30A8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC30A8 Gene including...

Search for SLC30A8 Gene in MalaCards »

(1) OMIM Diseases for SLC30A8 Gene (611145)

(1) University of Copenhagen DISEASES for SLC30A8 Gene

(1) Novoseek inferred disease relationships for SLC30A8 Gene

Disease -log(P) Hits PubMed IDs
autoimmunity 46.8 2

Relevant External Links for SLC30A8

Genetic Association Database (GAD)
SLC30A8
Human Genome Epidemiology (HuGE) Navigator
SLC30A8
genes like me logo Genes that share disorders with SLC30A8: view

No data available for UniProtKB/Swiss-Prot for SLC30A8 Gene

Publications for SLC30A8 Gene

  1. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. (PMID: 15331542) Chimienti F. … Seve M. (Diabetes 2004) 3 4 23
  2. ZnT-8, a pancreatic beta-cell-specific zinc transporter. (PMID: 16158222) Chimienti F. … Seve M. (BioMetals 2005) 3 4 23
  3. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. (PMID: 16984975) Chimienti F. … Seve M. (J. Cell Sci. 2006) 3 4 23
  4. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study. (PMID: 18324385) Boesgaard T.W. … Hansen T. (Diabetologia 2008) 3 23 48
  5. SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset. (PMID: 18548167) Gohlke H. … Ziegler A.G. (Rev Diabet Stud 2008) 3 23 48

Products for SLC30A8 Gene

Sources for SLC30A8 Gene

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