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Aliases for DCP2 Gene

Aliases for DCP2 Gene

  • Decapping MRNA 2 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 20 2 3
  • MRNA-Decapping Enzyme 2 3 4
  • NUDT20 3 4
  • HDpc 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 20 4
  • DCP2 Decapping Enzyme Homolog (S. Cerevisiae) 2
  • DCP2 Decapping Enzyme Homolog 3
  • M(7)GpppN-MRNA Hydrolase 2
  • Nudix Motif 20 4
  • EC 3.6.1.62 4

External Ids for DCP2 Gene

Previous GeneCards Identifiers for DCP2 Gene

  • GC05P112759
  • GC05P112343
  • GC05P112388
  • GC05P112340
  • GC05P107492
  • GC05P112313

Summaries for DCP2 Gene

Entrez Gene Summary for DCP2 Gene

  • The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for DCP2 Gene

DCP2 (Decapping MRNA 2) is a Protein Coding gene. Diseases associated with DCP2 include non-syndromic x-linked intellectual disability. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include RNA binding and manganese ion binding.

UniProtKB/Swiss-Prot for DCP2 Gene

  • Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Gene Wiki entry for DCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP2 Gene

Genomics for DCP2 Gene

Regulatory Elements for DCP2 Gene

Promoters for DCP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCP2 Gene

Chromosome:
5
Start:
112,976,702 bp from pter
End:
113,022,195 bp from pter
Size:
45,494 bases
Orientation:
Plus strand

Genomic View for DCP2 Gene

Genes around DCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP2 Gene

Proteins for DCP2 Gene

  • Protein details for DCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU60-DCP2_HUMAN
    Recommended name:
    m7GpppN-mRNA hydrolase
    Protein Accession:
    Q8IU60
    Secondary Accessions:
    • C9J778
    • Q6P2D4
    • Q7Z5W5
    • Q8NBG5

    Protein attributes for DCP2 Gene

    Size:
    420 amino acids
    Molecular mass:
    48457 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2 and UPF3B (PubMed:12417715, PubMed:12515382, PubMed:14527413). Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC4/HEDLS (PubMed:15231747, PubMed:15067023, PubMed:16364915). Interacts with DPC1B (PubMed:15231747). Interacts (via N-terminus and C-terminus) with TRIM21 (via N-terminus and C-terminus) (PubMed:18361920). Associates with polysomes (PubMed:12218187). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with DDX17 in an RNA-dependent manner (PubMed:21876179). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599).

    Alternative splice isoforms for DCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP2 Gene

Proteomics data for DCP2 Gene at MOPED

Post-translational modifications for DCP2 Gene

  • Phosphorylated at ser-249 in a MTOR-dependent manner (PubMed:26098573).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCP2 Gene

Antibody Products

No data available for DME Specific Peptides for DCP2 Gene

Domains & Families for DCP2 Gene

Gene Families for DCP2 Gene

Suggested Antigen Peptide Sequences for DCP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IU60

UniProtKB/Swiss-Prot:

DCP2_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family. DCP2 subfamily.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. DCP2 subfamily.
genes like me logo Genes that share domains with DCP2: view

Function for DCP2 Gene

Molecular function for DCP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
5-(N(7)-methylguanosine 5-triphospho)-[mRNA] + H(2)O = N(7)-methylguanosine 5-diphosphate + 5-phospho-[mRNA].
UniProtKB/Swiss-Prot Function:
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Enzyme Numbers (IUBMB) for DCP2 Gene

Gene Ontology (GO) - Molecular Function for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DCP2: view
genes like me logo Genes that share phenotypes with DCP2: view

Animal Models for DCP2 Gene

MGI Knock Outs for DCP2:
  • Dcp2 tm1b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for DCP2

miRNA for DCP2 Gene

miRTarBase miRNAs that target DCP2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCP2 Gene

Localization for DCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP2 Gene

Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322). {ECO:0000269 PubMed:15273322, ECO:0000269 PubMed:16364915, ECO:0000269 PubMed:20616046}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCP2 Gene COMPARTMENTS Subcellular localization image for DCP2 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCP2: view

Pathways & Interactions for DCP2 Gene

genes like me logo Genes that share pathways with DCP2: view

Gene Ontology (GO) - Biological Process for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 22890540
GO:0043488 regulation of mRNA stability TAS --
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS --
genes like me logo Genes that share ontologies with DCP2: view

No data available for SIGNOR curated interactions for DCP2 Gene

Drugs & Compounds for DCP2 Gene

(2) Drugs for DCP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
Magnesium Nutra 0

(1) Additional Compounds for DCP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DCP2: view

Transcripts for DCP2 Gene

Unigene Clusters for DCP2 Gene

DCP2 decapping enzyme homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6: - -
SP7: - -

Relevant External Links for DCP2 Gene

GeneLoc Exon Structure for
DCP2
ECgene alternative splicing isoforms for
DCP2

Expression for DCP2 Gene

mRNA expression in normal human tissues for DCP2 Gene

mRNA differential expression in normal tissues according to GTEx for DCP2 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for DCP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.2), Placenta (16.4), and Monocytes (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCP2 Gene



SOURCE GeneReport for Unigene cluster for DCP2 Gene Hs.443875

mRNA Expression by UniProt/SwissProt for DCP2 Gene

Q8IU60-DCP2_HUMAN
Tissue specificity: Expressed in brain and testis. Not detected in heart (at protein level).
genes like me logo Genes that share expression patterns with DCP2: view

Protein tissue co-expression partners for DCP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DCP2 Gene

Orthologs for DCP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP2 35
  • 98.75 (n)
  • 98.39 (a)
DCP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCP2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCP2 36
  • 93 (a)
OneToOne
DCP2 35
  • 96.03 (n)
  • 97.38 (a)
mouse
(Mus musculus)
Mammalia Dcp2 36
  • 92 (a)
OneToOne
Dcp2 35
  • 89.21 (n)
  • 92.86 (a)
Dcp2 16
oppossum
(Monodelphis domestica)
Mammalia DCP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCP2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcp2 35
  • 89.18 (n)
  • 93.32 (a)
chicken
(Gallus gallus)
Aves DCP2 36
  • 84 (a)
OneToOne
DCP2 35
  • 82.16 (n)
  • 85.47 (a)
lizard
(Anolis carolinensis)
Reptilia DCP2 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8706 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp2 35
  • 71.3 (n)
  • 74.34 (a)
Str.18589 35
zebrafish
(Danio rerio)
Actinopterygii dcp2 36
  • 71 (a)
OneToMany
dcp2 36
  • 71 (a)
OneToMany
LOC100534849 35
  • 69.06 (n)
  • 72.82 (a)
zgc55938 35
fruit fly
(Drosophila melanogaster)
Insecta Dcp2 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dcap-2 36
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCP2 36
  • 10 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11885 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9654 36
  • 49 (a)
OneToOne
Species with no ortholog for DCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCP2 Gene

ENSEMBL:
Gene Tree for DCP2 (if available)
TreeFam:
Gene Tree for DCP2 (if available)

Paralogs for DCP2 Gene

No data available for Paralogs for DCP2 Gene

Variants for DCP2 Gene

Sequence variations from dbSNP and Humsavar for DCP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_059528 -
rs7670 -- 113,020,952(-) AAAAC(C/T)GCCCA nc-transcript-variant, utr-variant-3-prime
rs13445 -- 113,020,211(+) AAACC(A/G)GACTT nc-transcript-variant, utr-variant-3-prime
rs33543 -- 112,985,791(+) TCGTT(A/G)TAGTT intron-variant
rs33544 -- 112,985,373(-) CCAAA(A/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCP2 Gene

Variant ID Type Subtype PubMed ID
nsv882717 CNV Loss 21882294

Variation tolerance for DCP2 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCP2 Gene

HapMap Linkage Disequilibrium report
DCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP2 Gene

Disorders for DCP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • mrx
- elite association - COSMIC cancer census association via MalaCards
Search DCP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCP2
genes like me logo Genes that share disorders with DCP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCP2 Gene

Publications for DCP2 Gene

  1. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J. (Mol. Cell. Biol. 2002) 2 3 4 67
  2. Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein. (PMID: 18039849) Li Y. … Kiledjian M. (Mol. Cell. Biol. 2008) 3 23
  3. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PMID: 16699599) Wichroski M.J. … Rana T.M. (PLoS Pathog. 2006) 3 23
  4. The hDcp2 protein is a mammalian mRNA decapping enzyme. (PMID: 12218187) Wang Z. … Kiledjian M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity. (PMID: 25870104) Erickson S.L. … Lykke-Andersen J. (Mol. Cell. Biol. 2015) 3

Products for DCP2 Gene

Sources for DCP2 Gene

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