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Aliases for DCP2 Gene

Aliases for DCP2 Gene

  • Decapping MRNA 2 2 3
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 20 2 3
  • MRNA-Decapping Enzyme 2 3 4
  • NUDT20 3 4
  • HDpc 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 20 4
  • DCP2 Decapping Enzyme Homolog (S. Cerevisiae) 2
  • DCP2 Decapping Enzyme Homolog 3
  • M(7)GpppN-MRNA Hydrolase 2
  • M7GpppN-MRNA Hydrolase 3
  • Nudix Motif 20 4
  • EC 3.6.1.62 4

External Ids for DCP2 Gene

Previous GeneCards Identifiers for DCP2 Gene

  • GC05P112759
  • GC05P112343
  • GC05P112388
  • GC05P112340
  • GC05P107492
  • GC05P112313

Summaries for DCP2 Gene

Entrez Gene Summary for DCP2 Gene

  • The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for DCP2 Gene

DCP2 (Decapping MRNA 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include RNA binding and m7G(5)pppN diphosphatase activity.

UniProtKB/Swiss-Prot for DCP2 Gene

  • Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.

Gene Wiki entry for DCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP2 Gene

Genomics for DCP2 Gene

Regulatory Elements for DCP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCP2 Gene

Start:
112,976,702 bp from pter
End:
113,022,195 bp from pter
Size:
45,494 bases
Orientation:
Plus strand

Genomic View for DCP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP2 Gene

Proteins for DCP2 Gene

  • Protein details for DCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU60-DCP2_HUMAN
    Recommended name:
    m7GpppN-mRNA hydrolase
    Protein Accession:
    Q8IU60
    Secondary Accessions:
    • C9J778
    • Q6P2D4
    • Q7Z5W5
    • Q8NBG5

    Protein attributes for DCP2 Gene

    Size:
    420 amino acids
    Molecular mass:
    48457 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Mn(2+) ion is required for highest activity. Can also utilize magnesium ions.;
    Quaternary structure:
    • Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2 and UPF3B. Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC4/HEDLS. Interacts with DPC1B, UPF1, UPF2 and UPF3B. Interacts (via N-terminus and C-terminus) with TRIM21 (via N-terminus and C-terminus). Associates with polysomes. Interacts with LIMD1, WTIP and AJUBA. Interacts with DDX17 in an RNA-dependent manner. Interacts with ZC3HAV1. Interacts with APOBEC3G in an RNA-dependent manner.

    Alternative splice isoforms for DCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP2 Gene

Proteomics data for DCP2 Gene at MOPED

Post-translational modifications for DCP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DCP2 Gene

Domains for DCP2 Gene

Gene Families for DCP2 Gene

HGNC:
  • NUDT :Nudix motif containing

Suggested Antigen Peptide Sequences for DCP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IU60

UniProtKB/Swiss-Prot:

DCP2_HUMAN :
  • Q8IU60
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. DCP2 subfamily.
genes like me logo Genes that share domains with DCP2: view

Function for DCP2 Gene

Molecular function for DCP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 5-(N(7)-methylguanosine 5-triphospho)-(mRNA) + H(2)O = N(7)-methylguanosine 5-diphosphate + 5-phospho-(mRNA).
UniProtKB/Swiss-Prot Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.

Enzyme Numbers (IUBMB) for DCP2 Gene

Gene Ontology (GO) - Molecular Function for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 12417715
GO:0016787 hydrolase activity --
GO:0016896 exoribonuclease activity, producing 5-phosphomonoesters TAS --
GO:0030145 manganese ion binding IEA --
genes like me logo Genes that share ontologies with DCP2: view

Phenotypes for DCP2 Gene

MGI mutant phenotypes for DCP2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with DCP2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCP2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DCP2 Gene

Localization for DCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP2 Gene

Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCP2 Gene COMPARTMENTS Subcellular localization image for DCP2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 20616046
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016442 RISC complex IDA 20616046
genes like me logo Genes that share ontologies with DCP2: view

Pathways for DCP2 Gene

genes like me logo Genes that share pathways with DCP2: view

Pathways by source for DCP2 Gene

Gene Ontology (GO) - Biological Process for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 22890540
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0006402 mRNA catabolic process IDA 21070968
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
genes like me logo Genes that share ontologies with DCP2: view

Compounds for DCP2 Gene

(2) HMDB Compounds for DCP2 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with DCP2: view

Transcripts for DCP2 Gene

Unigene Clusters for DCP2 Gene

DCP2 decapping enzyme homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6: - -
SP7: - -

Relevant External Links for DCP2 Gene

GeneLoc Exon Structure for
DCP2
ECgene alternative splicing isoforms for
DCP2

Expression for DCP2 Gene

mRNA expression in normal human tissues for DCP2 Gene

mRNA differential expression in normal tissues according to GTEx for DCP2 Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCP2 Gene

SOURCE GeneReport for Unigene cluster for DCP2 Gene Hs.443875

mRNA Expression by UniProt/SwissProt for DCP2 Gene

Q8IU60-DCP2_HUMAN
Tissue specificity: Expressed in brain and testis. Not detected in heart (at protein level).
genes like me logo Genes that share expressions with DCP2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DCP2 Gene

Orthologs for DCP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP2 35
  • 98.75 (n)
  • 98.39 (a)
DCP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCP2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCP2 35
  • 96.03 (n)
  • 97.38 (a)
DCP2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcp2 35
  • 89.21 (n)
  • 92.86 (a)
Dcp2 16
Dcp2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCP2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcp2 35
  • 89.18 (n)
  • 93.32 (a)
chicken
(Gallus gallus)
Aves DCP2 35
  • 82.16 (n)
  • 85.47 (a)
DCP2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCP2 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8706 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp2 35
  • 71.3 (n)
  • 74.34 (a)
Str.18589 35
zebrafish
(Danio rerio)
Actinopterygii dcp2 36
  • 71 (a)
OneToMany
dcp2 36
  • 71 (a)
OneToMany
LOC100534849 35
  • 69.06 (n)
  • 72.82 (a)
zgc55938 35
fruit fly
(Drosophila melanogaster)
Insecta Dcp2 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dcap-2 36
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCP2 36
  • 10 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11885 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9654 36
  • 49 (a)
OneToOne
Species with no ortholog for DCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCP2 Gene

ENSEMBL:
Gene Tree for DCP2 (if available)
TreeFam:
Gene Tree for DCP2 (if available)

Paralogs for DCP2 Gene

No data available for Paralogs for DCP2 Gene

Variants for DCP2 Gene

Sequence variations from dbSNP and Humsavar for DCP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4778 -- 113,019,971(+) CTTGA(C/G)TTTTT utr-variant-3-prime, nc-transcript-variant
rs7670 -- 113,020,952(-) AAAAC(C/T)GCCCA utr-variant-3-prime, nc-transcript-variant
rs13445 -- 113,020,211(+) AAACC(A/G)GACTT utr-variant-3-prime, nc-transcript-variant
rs33543 -- 112,985,791(+) TCGTT(A/G)TAGTT intron-variant
rs33544 -- 112,985,373(-) CCAAA(A/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCP2 Gene

Variant ID Type Subtype PubMed ID
nsv882717 CNV Loss 21882294

Relevant External Links for DCP2 Gene

HapMap Linkage Disequilibrium report
DCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP2 Gene

Disorders for DCP2 Gene

(1) University of Copenhagen DISEASES for DCP2 Gene

genes like me logo Genes that share disorders with DCP2: view

No data available for UniProtKB/Swiss-Prot for DCP2 Gene

Publications for DCP2 Gene

  1. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PMID: 16699599) Wichroski M.J. … Rana T.M. (PLoS Pathog. 2006) 3 4 23
  2. The hDcp2 protein is a mammalian mRNA decapping enzyme. (PMID: 12218187) Wang Z. … Kiledjian M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4
  3. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J. (Mol. Cell. Biol. 2002) 2 3 4
  4. Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein. (PMID: 18039849) Li Y. … Kiledjian M. (Mol. Cell. Biol. 2008) 3 23
  5. Functional characterization of the mammalian mRNA decapping enzyme hDcp2. (PMID: 12923261) Piccirillo C. … Kiledjian M. (RNA 2003) 3 4

Products for DCP2 Gene

  • Addgene plasmids for DCP2

Sources for DCP2 Gene

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