Aliases for DEFA3 Gene
External Ids for DEFA3 Gene
Previous Symbols for DEFA3 Gene
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFA3 Gene
DEFA3 (Defensin, Alpha 3, Neutrophil-Specific) is a Protein Coding gene. Diseases associated with DEFA3 include multidrug-resistant tuberculosis and bells palsy. Among its related pathways are Defensins and Defensins. An important paralog of this gene is DEFA1B.
UniProtKB/Swiss-Prot for DEFA3 Gene
Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.