Aliases for DHX9 Gene
External Ids for DHX9 Gene
Previous HGNC Symbols for DHX9 Gene
Previous GeneCards Identifiers for DHX9 Gene
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]
GeneCards Summary for DHX9 Gene
DHX9 (DEAH-Box Helicase 9) is a Protein Coding gene. Diseases associated with DHX9 include pseudopterygium and conjunctival degeneration. Among its related pathways are MyD88 cascade initiated on plasma membrane and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX29.
UniProtKB/Swiss-Prot for DHX9 Gene
Unwinds double-stranded DNA and RNA in a 3 to 5 direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression.