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Aliases for DDX6 Gene

Aliases for DDX6 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 6 2 3
  • HLR2 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 2 3
  • ATP-Dependent RNA Helicase P54 3 4
  • DEAD Box Protein 6 3 4
  • Oncogene RCK 3 4
  • RCK 3 4
  • Probable ATP-Dependent RNA Helicase DDX6 3
  • EC 3.6.4.13 4
  • DEAD Box-6 3
  • EC 3.6.1 64
  • P54 3

External Ids for DDX6 Gene

Previous Symbols for DDX6 Gene

  • HLR2

Summaries for DDX6 Gene

Entrez Gene Summary for DDX6 Gene

  • This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX6 Gene

DDX6 (DEAD (Asp-Glu-Ala-Asp) Box Helicase 6) is a Protein Coding gene. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA binding and helicase activity.

UniProtKB/Swiss-Prot for DDX6 Gene

  • In the process of mRNA degradation, may play a role in mRNA decapping

Gene Wiki entry for DDX6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX6 Gene

Genomics for DDX6 Gene

Genomic Location for DDX6 Gene

Start:
118,747,763 bp from pter
End:
118,791,263 bp from pter
Size:
43,501 bases
Orientation:
Minus strand

Genomic View for DDX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX6 Gene

Regulatory Elements for DDX6 Gene

Proteins for DDX6 Gene

  • Protein details for DDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26196-DDX6_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX6
    Protein Accession:
    P26196
    Secondary Accessions:
    • Q5D048

    Protein attributes for DDX6 Gene

    Size:
    483 amino acids
    Molecular mass:
    54417 Da
    Quaternary structure:
    • Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with RC3H1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DDX6 Gene

neXtProt entry for DDX6 Gene

Proteomics data for DDX6 Gene at MOPED

Post-translational modifications for DDX6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys104

Other Protein References for DDX6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DDX6 Gene

Gene Families for DDX6 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX6_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • P26196
  • Contains 1 helicase C-terminal domain.:
    • P26196
Family:
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.:
    • P26196
genes like me logo Genes that share domains with DDX6: view

Function for DDX6 Gene

Molecular function for DDX6 Gene

GENATLAS Biochemistry: DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific helicase ME31,overexpressed in colorectal adenocarcinomas
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: In the process of mRNA degradation, may play a role in mRNA decapping

Enzyme Numbers (IUBMB) for DDX6 Gene

Gene Ontology (GO) - Molecular Function for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003724 RNA helicase activity TAS 1579499
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 1394235
GO:0005515 protein binding IPI 16364915
genes like me logo Genes that share ontologies with DDX6: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX6 Gene

Localization for DDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX6 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX6 Gene COMPARTMENTS Subcellular localization image for DDX6 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IMP 22022269
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0010494 cytoplasmic stress granule IDA 17392519
genes like me logo Genes that share ontologies with DDX6: view

Pathways for DDX6 Gene

genes like me logo Genes that share pathways with DDX6: view

Pathways by source for DDX6 Gene

1 Cell Signaling Technology pathway for DDX6 Gene
1 KEGG pathway for DDX6 Gene

Gene Ontology (GO) - Biological Process for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006417 regulation of translation IBA --
GO:0010467 gene expression TAS --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX6: view

Compounds for DDX6 Gene

(1) Drugbank Compounds for DDX6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
D-tartaric acid
  • (-)-Tartaric acid
147-71-7 target
genes like me logo Genes that share compounds with DDX6: view

Transcripts for DDX6 Gene

Unigene Clusters for DDX6 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for DDX6 Gene

GeneLoc Exon Structure for
DDX6
ECgene alternative splicing isoforms for
DDX6

Expression for DDX6 Gene

mRNA expression in normal human tissues for DDX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DDX6 Gene

SOURCE GeneReport for Unigene cluster for DDX6 Gene Hs.408461

mRNA Expression by UniProt/SwissProt for DDX6 Gene

P26196-DDX6_HUMAN
Tissue specificity: Abundantly expressed in most tissues
genes like me logo Genes that share expressions with DDX6: view

Orthologs for DDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX6 36
  • 100 (n)
  • 100 (a)
DDX6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX6 36
  • 97.99 (n)
  • 99.79 (a)
DDX6 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX6 36
  • 98 (n)
  • 99.79 (a)
DDX6 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx6 36
  • 93.58 (n)
  • 97.72 (a)
Ddx6 16
Ddx6 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX6 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX6 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx6 36
  • 94.48 (n)
  • 98.14 (a)
chicken
(Gallus gallus)
Aves DDX6 36
  • 91.22 (n)
  • 99.17 (a)
DDX6 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX6 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia P54H 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx6 36
  • 85.21 (n)
  • 95.42 (a)
Str.1861 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9736 36
zebrafish
(Danio rerio)
Actinopterygii ddx6 36
  • 76.9 (n)
  • 89.42 (a)
ddx6 37
  • 89 (a)
OneToOne
wufk48d07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009135 36
  • 67.49 (n)
  • 76.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta me31B 36
  • 67.08 (n)
  • 75.19 (a)
me31B 37
  • 68 (a)
OneToOne
Dhh1 38
  • 33 (a)
me31B 38
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea cgh-1 36
  • 64.48 (n)
  • 72.02 (a)
cgh-1 37
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR197W 36
  • 62.2 (n)
  • 68.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DHH1 36
  • 64.09 (n)
  • 68.83 (a)
DHH1 37
  • 56 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16599g 36
  • 60.68 (n)
  • 65.05 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12384 36
soybean
(Glycine max)
eudicotyledons Gma.10855 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RH8 36
  • 67.08 (n)
  • 71.68 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6031 36
corn
(Zea mays)
Liliopsida Zm.12922 36
rice
(Oryza sativa)
Liliopsida Os.2594 36
Os04g0533000 36
  • 65.91 (n)
  • 71.93 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7626 36
bread mold
(Neurospora crassa)
Ascomycetes NCU06149 36
  • 63.43 (n)
  • 67.96 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ste13 36
  • 65.67 (n)
  • 72.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11700 36
Species with no ortholog for DDX6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX6 Gene

ENSEMBL:
Gene Tree for DDX6 (if available)
TreeFam:
Gene Tree for DDX6 (if available)

Paralogs for DDX6 Gene

Selected SIMAP similar genes for DDX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDX6: view

No data available for Paralogs for DDX6 Gene

Variants for DDX6 Gene

Sequence variations from dbSNP and Humsavar for DDX6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs475946 -- 118,758,434(+) aatgg(C/T)gcaat intron-variant
rs480227 -- 118,751,589(-) TCAAC(A/C)ATAGT utr-variant-3-prime
rs484916 -- 118,751,427(+) TCCCC(A/C)AAAAG utr-variant-3-prime
rs485901 -- 118,751,536(+) AATAA(A/G)AAGAC utr-variant-3-prime
rs486651 -- 118,779,150(+) GACCC(A/T)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX6 Gene

Variant ID Type Subtype PubMed ID
nsv832283 CNV Loss 17160897
esv2673492 CNV Deletion 23128226

Relevant External Links for DDX6 Gene

HapMap Linkage Disequilibrium report
DDX6

Disorders for DDX6 Gene

UniProtKB/Swiss-Prot

DDX6_HUMAN
  • Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

(1) Novoseek inferred disease relationships for DDX6 Gene

Disease -log(P) Hits PubMed IDs
lymphoma b-cell 70.2 7

Relevant External Links for DDX6

Genetic Association Database (GAD)
DDX6
Human Genome Epidemiology (HuGE) Navigator
DDX6
genes like me logo Genes that share disorders with DDX6: view

Publications for DDX6 Gene

  1. RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PMID: 11839790) Smillie D.A. … Sommerville J. (J. Cell. Sci. 2002) 2 3 23
  2. Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PMID: 14684915) Matsui T. … Tanaka N. (Acta Crystallogr. D 2004) 3 4 23
  3. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PMID: 1579499) Lu D. … Yunis J.J. (Nucleic Acids Res. 1992) 2 3 4
  4. Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly. (PMID: 19297524) Minshall N. … Standart N. (Mol. Biol. Cell 2009) 3 23
  5. The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. (PMID: 1394235) Akao Y. … Ueda R. (Cancer Res. 1992) 3 4

Products for DDX6 Gene

  • Addgene plasmids for DDX6

Sources for DDX6 Gene

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