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Aliases for DDX6 Gene

Aliases for DDX6 Gene

  • DEAD-Box Helicase 6 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 6 2 3
  • ATP-Dependent RNA Helicase P54 3 4
  • DEAD Box Protein 6 3 4
  • Oncogene RCK 3 4
  • HLR2 3 4
  • RCK 3 4
  • Probable ATP-Dependent RNA Helicase DDX6 3
  • EC 3.6.4.13 4
  • DEAD Box-6 3
  • EC 3.6.1 61
  • P54 3

External Ids for DDX6 Gene

Previous HGNC Symbols for DDX6 Gene

  • HLR2

Previous GeneCards Identifiers for DDX6 Gene

  • GC11M120959
  • GC11M120132
  • GC11M118654
  • GC11M118160
  • GC11M118162
  • GC11M118125
  • GC11M114556
  • GC11M118619

Summaries for DDX6 Gene

Entrez Gene Summary for DDX6 Gene

  • This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX6 Gene

DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include B-Cell Lymphomas. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. GO annotations related to this gene include nucleic acid binding and protein domain specific binding. An important paralog of this gene is DDX20.

UniProtKB/Swiss-Prot for DDX6 Gene

  • In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Gene Wiki entry for DDX6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX6 Gene

Genomics for DDX6 Gene

Regulatory Elements for DDX6 Gene

Enhancers for DDX6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G118868 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26.3 -78.5 -78542 3.5 FOXA2 ATF1 PKNOX1 WRNIP1 SIN3A RAD21 ZBTB40 YY1 CREM ZEB2 DDX6 CCDC84 TREHP1 UPK2 FOXR1 ENSG00000222529 BCL9L RN7SL688P ENSG00000255176 ENSG00000255121
GH11G119167 1.1 ENCODE 20.9 -377.7 -377666 2.8 PKNOX1 ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 BCL9L IFT46 ENSG00000254909 UBE4A RPL23AP64 ARCN1 HINFP DDX6 ENSG00000254428 ENSG00000272186
GH11G118699 1.4 FANTOM5 Ensembl ENCODE 13.7 +91.1 91144 2.0 ZNF146 ZFP64 ZNF140 ZNF697 ZNF316 NR2F6 ZNF584 ZNF433 NR2F1 ZBTB11 LOC105369519 IFT46 DDX6 BCL9L ENSG00000272186 CD3E CD3G CCDC84 KMT2A MPZL3
GH11G119090 1.7 Ensembl ENCODE dbSUPER 11.2 -302.4 -302409 5.9 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 HINFP ARCN1 RNF26 ENSG00000254909 C2CD2L BCL9L RPL23AP64 UBE4A RPS25 IFT46
GH11G118874 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -86.1 -86083 5.0 HDGF PKNOX1 ZBTB7B YY1 ZNF766 GATA2 ZNF207 PAF1 TBX21 PPARG TREHP1 UPK2 BCL9L RN7SL688P DDX6 PHLDB1 LOC105369519 TREH CXCR5 CCDC84
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX6 on UCSC Golden Path with GeneCards custom track

Promoters for DDX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045682 263 4001 HDGF PKNOX1 CREB3L1 AGO1 SIN3A ARID4B ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for DDX6 Gene

Chromosome:
11
Start:
118,747,763 bp from pter
End:
118,791,263 bp from pter
Size:
43,501 bases
Orientation:
Minus strand

Genomic View for DDX6 Gene

Genes around DDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX6 Gene

Proteins for DDX6 Gene

  • Protein details for DDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26196-DDX6_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX6
    Protein Accession:
    P26196
    Secondary Accessions:
    • Q5D048

    Protein attributes for DDX6 Gene

    Size:
    483 amino acids
    Molecular mass:
    54417 Da
    Quaternary structure:
    • Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657). Interacts with MCRIP1 (PubMed:26184334). Interacts with MCRIP2 (PubMed:26184334). Interacts with NUFIP2 (PubMed:26184334).

    Three dimensional structures from OCA and Proteopedia for DDX6 Gene

neXtProt entry for DDX6 Gene

Selected DME Specific Peptides for DDX6 Gene

P26196:
  • LLMGIFE
  • PSPIQEE
  • RNRVFHDFRNG
  • PYEINLM
  • GVTQYYA
  • IDKSLYV
  • LGYSCFYIHAKM
  • GAYLIPLLERLDLKKD
  • GRDILARAKNGTGK
  • TKGNEFEDY
  • DEADKLLS
  • QAVNVVINFDFP
  • HRIGRSGRFG
  • VPTRELA
  • GPGGGGTQ
  • NQSIIFCNS
  • VIATPGR
  • RVELLAKKI
  • YLHRIGR
  • TPGRILDL
  • TLPKNRQILLYSATFPLSVQKFM
  • EKPSPIQ
  • HCLNTLF
  • AETYLHR
  • LGTEIKPIP
  • TTGGTNLR
  • LYVAEYHSE
  • LRDDIMRL
  • GHLGLAINLI
  • SSQNGQLRGP
  • PTRELALQ

Post-translational modifications for DDX6 Gene

Domains & Families for DDX6 Gene

Gene Families for DDX6 Gene

Suggested Antigen Peptide Sequences for DDX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26196

UniProtKB/Swiss-Prot:

DDX6_HUMAN :
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
genes like me logo Genes that share domains with DDX6: view

Function for DDX6 Gene

Molecular function for DDX6 Gene

GENATLAS Biochemistry:
DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific helicase ME31,overexpressed in colorectal adenocarcinomas
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Enzyme Numbers (IUBMB) for DDX6 Gene

Gene Ontology (GO) - Molecular Function for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003724 RNA helicase activity TAS 1579499
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 1394235
genes like me logo Genes that share ontologies with DDX6: view
genes like me logo Genes that share phenotypes with DDX6: view

Animal Model Products

CRISPR Products

miRNA for DDX6 Gene

miRTarBase miRNAs that target DDX6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX6 Gene

Localization for DDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX6 Gene

Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules (PubMed:26184334). {ECO:0000269 PubMed:26184334}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0000932 P-body IMP,IDA 22022269
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IEA,IDA 26184334
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with DDX6: view

Pathways & Interactions for DDX6 Gene

genes like me logo Genes that share pathways with DDX6: view

Pathways by source for DDX6 Gene

1 Cell Signaling Technology pathway for DDX6 Gene
1 KEGG pathway for DDX6 Gene

SIGNOR curated interactions for DDX6 Gene

Other effect:

Gene Ontology (GO) - Biological Process for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IBA --
GO:0007283 spermatogenesis IEA --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0019074 viral RNA genome packaging IMP 22022269
GO:0019827 stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with DDX6: view

Drugs & Compounds for DDX6 Gene

(4) Drugs for DDX6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
D-tartaric acid Experimental Pharma Target 0

(1) Additional Compounds for DDX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX6: view

Transcripts for DDX6 Gene

Unigene Clusters for DDX6 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for DDX6 Gene

GeneLoc Exon Structure for
DDX6
ECgene alternative splicing isoforms for
DDX6

Expression for DDX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX6 Gene

Protein differential expression in normal tissues from HIPED for DDX6 Gene

This gene is overexpressed in Lymph node (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX6 Gene



Protein tissue co-expression partners for DDX6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX6 Gene:

DDX6

SOURCE GeneReport for Unigene cluster for DDX6 Gene:

Hs.408461

mRNA Expression by UniProt/SwissProt for DDX6 Gene:

P26196-DDX6_HUMAN
Tissue specificity: Abundantly expressed in most tissues.

Evidence on tissue expression from TISSUES for DDX6 Gene

  • Lung(4.3)
  • Skin(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DDX6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX6 Gene

Orthologs for DDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX6 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX6 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX6 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX6 34 35
  • 98 (n)
cow
(Bos Taurus)
Mammalia DDX6 34 35
  • 97.99 (n)
rat
(Rattus norvegicus)
Mammalia Ddx6 34
  • 94.48 (n)
mouse
(Mus musculus)
Mammalia Ddx6 34 16 35
  • 93.58 (n)
chicken
(Gallus gallus)
Aves DDX6 34 35
  • 91.22 (n)
lizard
(Anolis carolinensis)
Reptilia DDX6 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx6 34
  • 85.21 (n)
Str.1861 34
African clawed frog
(Xenopus laevis)
Amphibia P54H 34
zebrafish
(Danio rerio)
Actinopterygii ddx6 34 35
  • 76.9 (n)
wufk48d07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9736 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009135 34
  • 67.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta me31B 36 34 35
  • 67.08 (n)
Dhh1 36
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea cgh-1 34 35
  • 64.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DHH1 34 35
  • 64.09 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR197W 34
  • 62.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16599g 34
  • 60.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH8 34
  • 67.08 (n)
soybean
(Glycine max)
eudicotyledons Gma.10855 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12384 34
rice
(Oryza sativa)
Liliopsida Os04g0533000 34
  • 65.91 (n)
Os.2594 34
barley
(Hordeum vulgare)
Liliopsida Hv.6031 34
wheat
(Triticum aestivum)
Liliopsida Ta.7626 34
corn
(Zea mays)
Liliopsida Zm.12922 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ste13 34
  • 65.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06149 34
  • 63.43 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11700 34
Species where no ortholog for DDX6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX6 Gene

ENSEMBL:
Gene Tree for DDX6 (if available)
TreeFam:
Gene Tree for DDX6 (if available)

Paralogs for DDX6 Gene

Paralogs for DDX6 Gene

(21) SIMAP similar genes for DDX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDX6: view

Variants for DDX6 Gene

Sequence variations from dbSNP and Humsavar for DDX6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000024449 -- 118,771,907(+) TTACC(A/G)TATGA intron-variant
rs1000110169 -- 118,752,803(+) GATGA(C/T)AGAGG intron-variant
rs1000138908 -- 118,783,362(+) GCCTT(C/T)ATTAT intron-variant
rs1000190010 -- 118,774,452(+) CCTAA(G/T)TCTCT intron-variant
rs1000284713 -- 118,774,727(+) CCAAT(A/T)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX6 Gene

Variant ID Type Subtype PubMed ID
esv2673492 CNV deletion 23128226
esv2762946 CNV gain 21179565
nsv1134179 CNV deletion 24896259
nsv832283 CNV loss 17160897

Variation tolerance for DDX6 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX6 Gene

Human Gene Mutation Database (HGMD)
DDX6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX6 Gene

Disorders for DDX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphomas
  • b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search DDX6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DDX6_HUMAN
  • Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Relevant External Links for DDX6

Genetic Association Database (GAD)
DDX6
Human Genome Epidemiology (HuGE) Navigator
DDX6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX6
genes like me logo Genes that share disorders with DDX6: view

No data available for Genatlas for DDX6 Gene

Publications for DDX6 Gene

  1. Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PMID: 14684915) Matsui T. … Tanaka N. (Acta Crystallogr. D 2004) 3 4 22 64
  2. RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PMID: 11839790) Smillie D.A. … Sommerville J. (J. Cell. Sci. 2002) 2 3 22 64
  3. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PMID: 1579499) Lu D. … Yunis J.J. (Nucleic Acids Res. 1992) 2 3 4 64
  4. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R. … Vogel C. (Biomolecules 2015) 3 4 64
  5. HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PMID: 22915799) Phalora P.K. … Malim M.H. (J. Virol. 2012) 3 4 64

Products for DDX6 Gene

Sources for DDX6 Gene

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