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Aliases for DDX5 Gene

Aliases for DDX5 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 5 2 3
  • G17P1 3 4 6
  • HLR1 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 5 (RNA Helicase, 68kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 5 2 3
  • DEAD Box Protein 5 3 4
  • RNA Helicase P68 3 4
  • Probable ATP-Dependent RNA Helicase DDX5 3
  • ATP-Dependent RNA Helicase DDX5 3
  • EC 3.6.4.13 4
  • DEAD Box-5 3
  • EC 3.6.1 64
  • HUMP68 3
  • HELR 4
  • P68 3

External Ids for DDX5 Gene

Previous Symbols for DDX5 Gene

  • HLR1
  • G17P1

Summaries for DDX5 Gene

Entrez Gene Summary for DDX5 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX5 Gene

DDX5 (DEAD (Asp-Glu-Ala-Asp) Box Helicase 5) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer and Translational Control. GO annotations related to this gene include enzyme binding and calmodulin binding. An important paralog of this gene is DDX53.

UniProtKB/Swiss-Prot for DDX5 Gene

  • Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Gene Wiki entry for DDX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX5 Gene

Genomics for DDX5 Gene

Genomic Location for DDX5 Gene

Start:
64,498,254 bp from pter
End:
64,508,199 bp from pter
Size:
9,946 bases
Orientation:
Minus strand

Genomic View for DDX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX5 Gene

Regulatory Elements for DDX5 Gene

Proteins for DDX5 Gene

  • Protein details for DDX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17844-DDX5_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX5
    Protein Accession:
    P17844
    Secondary Accessions:
    • B4DLW8
    • B5BU21
    • D3DU32
    • E7ETL9
    • O75681
    • Q53Y61

    Protein attributes for DDX5 Gene

    Size:
    614 amino acids
    Molecular mass:
    69148 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1; the interaction is enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active).

    Three dimensional structures from OCA and Proteopedia for DDX5 Gene

    Alternative splice isoforms for DDX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX5 Gene

Proteomics data for DDX5 Gene at MOPED

Post-translational modifications for DDX5 Gene

  • Arg-502 is dimethylated, probably to asymmetric dimethylarginine
  • Polyubiquitinated, leading to proteasomal degradation.
  • Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys56, Lys91, Lys197, Lys207, Lys236, Lys284, Lys340, Lys351, Lys375, Lys388, Lys411, Lys437, Lys451, Lys470, and Lys529

Domains for DDX5 Gene

Gene Families for DDX5 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX5_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • P17844
  • Contains 1 helicase C-terminal domain.:
    • P17844
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.:
    • P17844
genes like me logo Genes that share domains with DDX5: view

Function for DDX5 Gene

Molecular function for DDX5 Gene

GENATLAS Biochemistry: DEAD/H box protein 5,putative RNA helicase
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Enzyme Numbers (IUBMB) for DDX5 Gene

Gene Ontology (GO) - Molecular Function for DDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003712 transcription cofactor activity --
GO:0003713 transcription coactivator activity IDA --
GO:0003724 RNA helicase activity NAS 1996094
GO:0004004 ATP-dependent RNA helicase activity IBA --
genes like me logo Genes that share ontologies with DDX5: view
genes like me logo Genes that share phenotypes with DDX5: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX5 Gene

Localization for DDX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX5 Gene COMPARTMENTS Subcellular localization image for DDX5 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for DDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 2451786
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 10837141
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX5: view

Pathways for DDX5 Gene

genes like me logo Genes that share pathways with DDX5: view

Pathways by source for DDX5 Gene

2 Cell Signaling Technology pathways for DDX5 Gene
1 BioSystems pathway for DDX5 Gene

Gene Ontology (GO) - Biological Process for DDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15298701
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 21343338
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0001701 in utero embryonic development IEA --
GO:0006200 obsolete ATP catabolic process --
genes like me logo Genes that share ontologies with DDX5: view

Compounds for DDX5 Gene

(4) Novoseek inferred chemical compound relationships for DDX5 Gene

Compound -log(P) Hits PubMed IDs
11beta-hydroxysteroid 38.2 2
tyrosine 7.38 4
threonine 4.58 2
serine 1.26 1
genes like me logo Genes that share compounds with DDX5: view

Transcripts for DDX5 Gene

Unigene Clusters for DDX5 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - -
SP2:
SP3: - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - - - - -
SP13: - - - -
SP14: -
SP15: -
SP16:
SP17:
SP18:
SP19:

ExUns: 12d · 12e · 12f ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:

Relevant External Links for DDX5 Gene

GeneLoc Exon Structure for
DDX5
ECgene alternative splicing isoforms for
DDX5

Expression for DDX5 Gene

mRNA expression in normal human tissues for DDX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX5 Gene

SOURCE GeneReport for Unigene cluster for DDX5 Gene Hs.279806

genes like me logo Genes that share expressions with DDX5: view

Orthologs for DDX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX5 36
  • 99.57 (n)
  • 99.67 (a)
DDX5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX5 36
  • 95.49 (n)
  • 100 (a)
DDX5 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX5 36
  • 96.63 (n)
  • 100 (a)
DDX5 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx5 36
  • 94.08 (n)
  • 98.7 (a)
Ddx5 16
Ddx5 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX5 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 94 (a)
OneToMany
-- 37
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddx5 36
  • 94.08 (n)
  • 98.86 (a)
chicken
(Gallus gallus)
Aves DDX5 36
  • 83.11 (n)
  • 90.88 (a)
DDX5 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 89 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.648 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx5 36
  • 74.51 (n)
  • 82.3 (a)
MGC76265 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10528 36
zebrafish
(Danio rerio)
Actinopterygii ddx5 36
  • 73.59 (n)
  • 84.63 (a)
ddx5 37
  • 76 (a)
OneToOne
Dr.28420 36
fruit fly
(Drosophila melanogaster)
Insecta CG10077 36
  • 59.93 (n)
  • 65.16 (a)
CG10077 37
  • 42 (a)
ManyToMany
CG10777 37
  • 34 (a)
ManyToMany
Rm62 37
  • 45 (a)
ManyToMany
Rm62 38
  • 65 (a)
CG14443 38
  • 32 (a)
CG10077 38
  • 67 (a)
CG10777 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea ddx-17 37
  • 50 (a)
OneToMany
F58E10.3 38
  • 59 (a)
F58G11.2 38
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL221C 36
  • 58.42 (n)
  • 61.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 36
  • 57.99 (n)
  • 56.75 (a)
DBP2 37
  • 54 (a)
OneToMany
DBP2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23716g 36
  • 61.02 (n)
  • 61.72 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G55150 36
  • 60.09 (n)
  • 59.23 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9145 36
bread mold
(Neurospora crassa)
Ascomycetes NCU07839 36
  • 57.72 (n)
  • 61.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp2 36
  • 58.94 (n)
  • 58.54 (a)
Species with no ortholog for DDX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX5 Gene

ENSEMBL:
Gene Tree for DDX5 (if available)
TreeFam:
Gene Tree for DDX5 (if available)

Paralogs for DDX5 Gene

Paralogs for DDX5 Gene

Pseudogenes.org Pseudogenes for DDX5 Gene

genes like me logo Genes that share paralogs with DDX5: view

Variants for DDX5 Gene

Sequence variations from dbSNP and Humsavar for DDX5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10186 -- 64,499,848(-) TAGTT(A/G)TTTAA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs1050485 -- 64,499,815(-) GACTG(C/T)AGTGC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs2075552 -- 64,504,635(-) CGATC(A/G)TGGAT intron-variant
rs2229794 -- 64,504,097(-) GTTAT(A/T)GCAAG synonymous-codon, reference, nc-transcript-variant
rs2734254 -- 64,504,480(-) AACAA(G/T)AAATT intron-variant

Relevant External Links for DDX5 Gene

HapMap Linkage Disequilibrium report
DDX5
Human Gene Mutation Database (HGMD)
DDX5

No data available for Structural Variations from Database of Genomic Variants (DGV) for DDX5 Gene

Disorders for DDX5 Gene

(3) Novoseek inferred disease relationships for DDX5 Gene

Disease -log(P) Hits PubMed IDs
tumors 4.17 5
necrosis 0 1
cancer 0 3

Relevant External Links for DDX5

Genetic Association Database (GAD)
DDX5
Human Genome Epidemiology (HuGE) Navigator
DDX5
genes like me logo Genes that share disorders with DDX5: view

No data available for UniProtKB/Swiss-Prot for DDX5 Gene

Publications for DDX5 Gene

  1. Structure and expression of the human p68 RNA helicase gene. (PMID: 10648785) Roessler O.G. … Stahl H. (Nucleic Acids Res. 2000) 3 4 23
  2. p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts. (PMID: 1996094) Iggo R.D. … Lane D.P. (Mol. Cell. Biol. 1991) 3 4 23
  3. Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. (PMID: 12527917) Rossow K.L. … Janknecht R. (Oncogene 2003) 3 4 23
  4. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. (PMID: 15298701) Wilson B.J. … Fuller-Pace F.V. (BMC Mol. Biol. 2004) 3 4 23
  5. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. (PMID: 15660129) Bates G.J. … Fuller-Pace F.V. (EMBO J. 2005) 3 4 23

Products for DDX5 Gene

Sources for DDX5 Gene

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