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Aliases for DDX5 Gene

Aliases for DDX5 Gene

  • DEAD-Box Helicase 5 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 5 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 5 (RNA Helicase, 68kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 5 2 3
  • DEAD Box Protein 5 3 4
  • RNA Helicase P68 3 4
  • G17P1 3 4
  • HLR1 3 4
  • ATP-Dependent RNA Helicase DDX5 3
  • EC 3.6.4.13 4
  • DEAD Box-5 3
  • EC 3.6.1 63
  • HUMP68 3
  • HELR 4
  • P68 3

External Ids for DDX5 Gene

Previous HGNC Symbols for DDX5 Gene

  • HLR1
  • G17P1

Previous GeneCards Identifiers for DDX5 Gene

  • GC17M065876
  • GC17P068976
  • GC17M062913
  • GC17M063045
  • GC17M059926
  • GC17M062494
  • GC17M057943

Summaries for DDX5 Gene

Entrez Gene Summary for DDX5 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for DDX5 Gene

DDX5 (DEAD-Box Helicase 5) is a Protein Coding gene. Diseases associated with DDX5 include cartilage-hair hypoplasia. Among its related pathways are Proteoglycans in cancer and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and enzyme binding. An important paralog of this gene is DDX53.

UniProtKB/Swiss-Prot for DDX5 Gene

  • Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Gene Wiki entry for DDX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX5 Gene

Genomics for DDX5 Gene

Regulatory Elements for DDX5 Gene

Enhancers for DDX5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX5 on UCSC Golden Path with GeneCards custom track

Promoters for DDX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX5 Gene

Chromosome:
17
Start:
64,498,256 bp from pter
End:
64,508,199 bp from pter
Size:
9,944 bases
Orientation:
Minus strand

Genomic View for DDX5 Gene

Genes around DDX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX5 Gene

Proteins for DDX5 Gene

  • Protein details for DDX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17844-DDX5_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX5
    Protein Accession:
    P17844
    Secondary Accessions:
    • B4DLW8
    • B5BU21
    • D3DU32
    • E7ETL9
    • O75681
    • Q53Y61

    Protein attributes for DDX5 Gene

    Size:
    614 amino acids
    Molecular mass:
    69148 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1; the interaction is enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active).

    Three dimensional structures from OCA and Proteopedia for DDX5 Gene

    Alternative splice isoforms for DDX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX5 Gene

Proteomics data for DDX5 Gene at MOPED

Post-translational modifications for DDX5 Gene

  • Arg-502 is dimethylated, probably to asymmetric dimethylarginine.
  • Polyubiquitinated, leading to proteasomal degradation.
  • Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination.
  • Ubiquitination at Lys 56, Lys 91, Lys 236, Lys 340, Lys 351, Lys 375, Lys 388, Lys 411, Lys 437, Lys 451, and Lys 529
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DDX5 (DDX5)

Domains & Families for DDX5 Gene

Gene Families for DDX5 Gene

Suggested Antigen Peptide Sequences for DDX5 Gene

Graphical View of Domain Structure for InterPro Entry

P17844

UniProtKB/Swiss-Prot:

DDX5_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
genes like me logo Genes that share domains with DDX5: view

Function for DDX5 Gene

Molecular function for DDX5 Gene

GENATLAS Biochemistry:
DEAD/H box protein 5,putative RNA helicase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Enzyme Numbers (IUBMB) for DDX5 Gene

Gene Ontology (GO) - Molecular Function for DDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IEA --
GO:0003713 transcription coactivator activity IDA --
GO:0003724 RNA helicase activity IEA,NAS 1996094
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0030331 estrogen receptor binding IDA --
genes like me logo Genes that share ontologies with DDX5: view
genes like me logo Genes that share phenotypes with DDX5: view

Animal Models for DDX5 Gene

MGI Knock Outs for DDX5:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX5 Gene

Localization for DDX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX5 Gene COMPARTMENTS Subcellular localization image for DDX5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for DDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DDX5: view

Pathways & Interactions for DDX5 Gene

genes like me logo Genes that share pathways with DDX5: view

Pathways by source for DDX5 Gene

2 Cell Signaling Technology pathways for DDX5 Gene
1 BioSystems pathway for DDX5 Gene

SIGNOR curated interactions for DDX5 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 21343338
GO:0008152 metabolic process IEA --
GO:0016049 cell growth NAS 2451786
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP 15660129
GO:0060765 regulation of androgen receptor signaling pathway IMP 18829551
genes like me logo Genes that share ontologies with DDX5: view

Drugs & Compounds for DDX5 Gene

(4) Drugs for DDX5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for DDX5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX5: view

Transcripts for DDX5 Gene

Unigene Clusters for DDX5 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - -
SP2:
SP3: - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - - - - -
SP13: - - - -
SP14: -
SP15: -
SP16:
SP17:
SP18:
SP19:

ExUns: 12d · 12e · 12f ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:

Relevant External Links for DDX5 Gene

GeneLoc Exon Structure for
DDX5
ECgene alternative splicing isoforms for
DDX5

Expression for DDX5 Gene

mRNA expression in normal human tissues for DDX5 Gene

Protein differential expression in normal tissues from HIPED for DDX5 Gene

This gene is overexpressed in Lymph node (13.1) and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX5 Gene



SOURCE GeneReport for Unigene cluster for DDX5 Gene Hs.279806

genes like me logo Genes that share expression patterns with DDX5: view

Protein tissue co-expression partners for DDX5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX5 Gene

Orthologs for DDX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX5 35
  • 95.49 (n)
  • 100 (a)
DDX5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX5 35
  • 96.63 (n)
  • 100 (a)
DDX5 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx5 35
  • 94.08 (n)
  • 98.7 (a)
Ddx5 16
Ddx5 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX5 35
  • 99.57 (n)
  • 99.67 (a)
DDX5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx5 35
  • 94.08 (n)
  • 98.86 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX5 35
  • 83.11 (n)
  • 90.88 (a)
DDX5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx5 35
  • 74.51 (n)
  • 82.3 (a)
MGC76265 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.648 35
zebrafish
(Danio rerio)
Actinopterygii ddx5 35
  • 73.59 (n)
  • 84.63 (a)
Dr.28420 35
ddx5 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10528 35
fruit fly
(Drosophila melanogaster)
Insecta CG10077 37
  • 67 (a)
CG10777 37
  • 58 (a)
CG14443 37
  • 32 (a)
Rm62 37
  • 65 (a)
CG10077 35
  • 59.93 (n)
  • 65.16 (a)
CG10077 36
  • 42 (a)
ManyToMany
CG10777 36
  • 34 (a)
ManyToMany
Rm62 36
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F58E10.3 37
  • 59 (a)
F58G11.2 37
  • 30 (a)
ddx-17 36
  • 50 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL221C 35
  • 58.42 (n)
  • 61.17 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23716g 35
  • 61.02 (n)
  • 61.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 35
  • 57.99 (n)
  • 56.75 (a)
DBP2 36
  • 54 (a)
OneToMany
DBP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G55150 35
  • 60.09 (n)
  • 59.23 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9145 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07839 35
  • 57.72 (n)
  • 61.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp2 35
  • 58.94 (n)
  • 58.54 (a)
Species with no ortholog for DDX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX5 Gene

ENSEMBL:
Gene Tree for DDX5 (if available)
TreeFam:
Gene Tree for DDX5 (if available)

Paralogs for DDX5 Gene

Paralogs for DDX5 Gene

Pseudogenes.org Pseudogenes for DDX5 Gene

genes like me logo Genes that share paralogs with DDX5: view

Variants for DDX5 Gene

Sequence variations from dbSNP and Humsavar for DDX5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_029241 -
rs10186 -- 64,499,848(-) TAGTT(A/G)TTTAA utr-variant-3-prime
rs1050485 -- 64,499,815(-) GACTG(C/T)AGTGC utr-variant-3-prime
rs2229794 -- 64,504,097(-) GTTAT(A/T)GCAAG reference, synonymous-codon
rs2075552 -- 64,504,635(-) CGATC(A/G)TGGAT intron-variant

Variation tolerance for DDX5 Gene

Residual Variation Intolerance Score: 9.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX5 Gene

HapMap Linkage Disequilibrium report
DDX5
Human Gene Mutation Database (HGMD)
DDX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DDX5 Gene

Disorders for DDX5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cartilage-hair hypoplasia
  • mckusick type metaphyseal chondrodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search DDX5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX5

Genetic Association Database (GAD)
DDX5
Human Genome Epidemiology (HuGE) Navigator
DDX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX5
genes like me logo Genes that share disorders with DDX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX5 Gene

Publications for DDX5 Gene

  1. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PMID: 19995069) Mooney S.M. … Janknecht R. (Biochemistry 2010) 3 4 23 67
  2. P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras. (PMID: 18698352) Camats M. … Bach-Elias M. (PLoS ONE 2008) 2 3 23
  3. New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats. (PMID: 22156369) Laurent F.X. … Marie J. (Nucleic Acids Res. 2012) 2 3
  4. A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells. (PMID: 20022962) Guo J. … Friedman S.L. (J. Biol. Chem. 2010) 3 23
  5. Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems. (PMID: 19224332) Chen J.Y. … Wen Y.M. (Arch. Virol. 2009) 3 23

Products for DDX5 Gene

Sources for DDX5 Gene

Content