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Aliases for GADD45A Gene

Aliases for GADD45A Gene

  • Growth Arrest And DNA-Damage-Inducible, Alpha 2 3
  • DNA Damage-Inducible Transcript 1 Protein 3 4
  • DDIT-1 3 4
  • GADD45 3 4
  • DDIT1 3 4
  • Growth Arrest And DNA-Damage-Inducible 45 Alpha 3
  • DNA Damage-Inducible Transcript-1 3
  • DNA-Damage-Inducible Transcript 1 3

External Ids for GADD45A Gene

Previous HGNC Symbols for GADD45A Gene

  • DDIT1

Previous GeneCards Identifiers for GADD45A Gene

  • GC01P068111
  • GC01P067082
  • GC01P067508
  • GC01P067520
  • GC01P067862
  • GC01P067923
  • GC01P066261

Summaries for GADD45A Gene

Entrez Gene Summary for GADD45A Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

GeneCards Summary for GADD45A Gene

GADD45A (Growth Arrest And DNA-Damage-Inducible, Alpha) is a Protein Coding gene. Diseases associated with GADD45A include prostate disease and ataxia-telangiectasia. Among its related pathways are MAPK signaling pathway and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include core promoter binding. An important paralog of this gene is GADD45G.

UniProtKB/Swiss-Prot for GADD45A Gene

  • In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.

Gene Wiki entry for GADD45A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45A Gene

Genomics for GADD45A Gene

Regulatory Elements for GADD45A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GADD45A Gene

Chromosome:
1
Start:
67,685,061 bp from pter
End:
67,688,338 bp from pter
Size:
3,278 bases
Orientation:
Plus strand

Genomic View for GADD45A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GADD45A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45A Gene

Proteins for GADD45A Gene

  • Protein details for GADD45A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24522-GA45A_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 alpha
    Protein Accession:
    P24522
    Secondary Accessions:
    • Q5TCA7
    • Q5TCA8

    Protein attributes for GADD45A Gene

    Size:
    165 amino acids
    Molecular mass:
    18336 Da
    Quaternary structure:
    • Interacts with MAPK14 (By similarity). Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization.

    Three dimensional structures from OCA and Proteopedia for GADD45A Gene

    Alternative splice isoforms for GADD45A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GADD45A Gene

Proteomics data for GADD45A Gene at MOPED

Post-translational modifications for GADD45A Gene

  • Ubiquitination at Lys 29
  • Modification sites at PhosphoSitePlus

Other Protein References for GADD45A Gene

Antibody Products

  • R&D Systems Antibodies for GADD45A (GADD45 alpha)
  • Cell Signaling Technology (CST) Antibodies for GADD45A (GADD45A)

No data available for DME Specific Peptides for GADD45A Gene

Domains & Families for GADD45A Gene

Protein Domains for GADD45A Gene

Graphical View of Domain Structure for InterPro Entry

P24522

UniProtKB/Swiss-Prot:

GA45A_HUMAN :
  • Belongs to the GADD45 family.
Family:
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45A: view

No data available for Gene Families for GADD45A Gene

Function for GADD45A Gene

Molecular function for GADD45A Gene

GENATLAS Biochemistry:
growth arrest and DNA-damage-inducible transcript alpha,involved in UV- and methyl methanisulfonate (MMS)-induced G2 arrest,p53-responsive stress protein activating MEKK4,interacting with the four core histones,mediating G2/M checkpoint,down-regulated by cyclin B1 and Cdc25C expression,inactivating (M phase promoting factor) MPF through interaction with CDC2 but not cyclin B1,putative downregulated c-Myc target gene,modifying DNA accessibility on damaged chromatin
UniProtKB/Swiss-Prot Function:
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
UniProtKB/Swiss-Prot Induction:
By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediated by some kinase(s) other than PKC

Gene Ontology (GO) - Molecular Function for GADD45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IEA --
GO:0005515 protein binding IPI 12052864
genes like me logo Genes that share ontologies with GADD45A: view
genes like me logo Genes that share phenotypes with GADD45A: view

Animal Models for GADD45A Gene

MGI Knock Outs for GADD45A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GADD45A Gene

Localization for GADD45A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GADD45A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GADD45A Gene COMPARTMENTS Subcellular localization image for GADD45A gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GADD45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9827804
GO:0005737 cytoplasm IDA 9827804
genes like me logo Genes that share ontologies with GADD45A: view

Pathways & Interactions for GADD45A Gene

genes like me logo Genes that share pathways with GADD45A: view

Pathways by source for GADD45A Gene

1 Sino Biological pathway for GADD45A Gene
1 Cell Signaling Technology pathway for GADD45A Gene
1 GeneGo (Thomson Reuters) pathway for GADD45A Gene

PCR Array Products

SIGNOR curated interactions for GADD45A Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for GADD45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 10747892
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0006281 DNA repair TAS 7973727
GO:0006469 negative regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with GADD45A: view

Drugs & Compounds for GADD45A Gene

(24) Drugs for GADD45A Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorambucil Approved Pharma 52
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Deferoxamine Approved, Investigational Pharma 44
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127

(17) Additional Compounds for GADD45A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
5fluorouracil
Actinomycin D
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
Cd 437
125316-60-1
genes like me logo Genes that share compounds with GADD45A: view

Transcripts for GADD45A Gene

Unigene Clusters for GADD45A Gene

Growth arrest and DNA-damage-inducible, alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GADD45A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for GADD45A Gene

GeneLoc Exon Structure for
GADD45A
ECgene alternative splicing isoforms for
GADD45A

Expression for GADD45A Gene

mRNA expression in normal human tissues for GADD45A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GADD45A Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

SOURCE GeneReport for Unigene cluster for GADD45A Gene Hs.80409

genes like me logo Genes that share expression patterns with GADD45A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GADD45A Gene

Orthologs for GADD45A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GADD45A 35
  • 94.14 (n)
  • 99.39 (a)
GADD45A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GADD45A 35
  • 92.48 (n)
  • 96.95 (a)
GADD45A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gadd45a 35
  • 90.51 (n)
  • 94.55 (a)
Gadd45a 16
Gadd45a 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GADD45A 35
  • 100 (n)
  • 100 (a)
GADD45A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadd45a 35
  • 87.88 (n)
  • 92.73 (a)
oppossum
(Monodelphis domestica)
Mammalia GADD45A 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GADD45A 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves GADD45A 35
  • 77.71 (n)
  • 82.17 (a)
GADD45 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GADD45A 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45a 35
  • 70.06 (n)
  • 71.34 (a)
Str.1971 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14374 35
gadd45ab 35
  • 68.8 (n)
  • 75 (a)
gadd45aa 36
  • 69 (a)
OneToMany
gadd45ab 36
  • 67 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4328 35
Species with no ortholog for GADD45A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45A Gene

ENSEMBL:
Gene Tree for GADD45A (if available)
TreeFam:
Gene Tree for GADD45A (if available)

Paralogs for GADD45A Gene

Paralogs for GADD45A Gene

(3) SIMAP similar genes for GADD45A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GADD45A: view

Variants for GADD45A Gene

Sequence variations from dbSNP and Humsavar for GADD45A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs828 -- 67,687,895(+) AGGGG(C/G)TGAGT utr-variant-3-prime
rs829 -- 67,687,835(+) TTGTA(A/G)TTACT utr-variant-3-prime
rs830 -- 67,687,864(+) ACTGA(C/T)GCAAG utr-variant-3-prime
rs2620 -- 67,687,846(+) CAAGC(A/C)GTTAC utr-variant-3-prime
rs2621 -- 67,688,052(+) GTATT(A/G)ATTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GADD45A Gene

Variant ID Type Subtype PubMed ID
nsv1276 CNV Loss 18451855

Variation tolerance for GADD45A Gene

Residual Variation Intolerance Score: 38.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GADD45A Gene

HapMap Linkage Disequilibrium report
GADD45A
Human Gene Mutation Database (HGMD)
GADD45A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45A Gene

Disorders for GADD45A Gene

MalaCards: The human disease database

(5) MalaCards diseases for GADD45A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
prostate disease
  • prostate diseases
ataxia-telangiectasia
  • ataxia telangiectasia
esophageal cancer
  • esophageal cancer, somatic
pancreatic cancer
  • pancreatic carcinoma, somatic
breast cancer
  • breast cancer, invasive ductal
- elite association

Relevant External Links for GADD45A

Genetic Association Database (GAD)
GADD45A
Human Genome Epidemiology (HuGE) Navigator
GADD45A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GADD45A
genes like me logo Genes that share disorders with GADD45A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45A Gene

Publications for GADD45A Gene

  1. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. (PMID: 1990262) Papathanasiou M.A. … Fornace A.J. Jr. (Mol. Cell. Biol. 1991) 2 23 67
  2. Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells. (PMID: 20131288) Li Y. … Lu Q. (Arthritis Rheum. 2010) 23 67
  3. Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production. (PMID: 18849615) Sasaki Y. … Aiba S. (Int. Arch. Allergy Immunol. 2009) 23 67
  4. NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway. (PMID: 19305429) Jinawath N. … Shih I.M. (Oncogene 2009) 23 67
  5. Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells. (PMID: 19714865) Satomi Y. … Nishino H. (Biochim. Biophys. Acta 2009) 23 67

Products for GADD45A Gene

Sources for GADD45A Gene

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