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Aliases for DCT Gene

Aliases for DCT Gene

  • Dopachrome Tautomerase 2 3
  • Tyrosinase-Related Protein 2 3 4
  • L-Dopachrome Delta-Isomerase 3 4
  • Dopachrome Delta-Isomerase 2 3
  • Tyrosine-Related Protein 2 2 3
  • EC 5.3.3.12 4 63
  • TYRP2 3 4
  • TRP-2 3 4
  • TRP2 3 4
  • DT 3 4
  • Dopachrome Tautomerase (Dopachrome Delta-Isomerase, Tyrosine-Related Protein 2) 3
  • Tyrosinase Related Protein-2 3

External Ids for DCT Gene

Previous HGNC Symbols for DCT Gene

  • TYRP2

Previous GeneCards Identifiers for DCT Gene

  • GC13M093451
  • GC13M089476
  • GC13M093926
  • GC13M092789
  • GC13M093889
  • GC13M095091
  • GC13M075688

Summaries for DCT Gene

GeneCards Summary for DCT Gene

DCT (Dopachrome Tautomerase) is a Protein Coding gene. Diseases associated with DCT include amelanotic melanoma and vitiligo-associated multiple autoimmune disease susceptibility 1. Among its related pathways are Neural Crest Differentiation and Metabolism. GO annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.

UniProtKB/Swiss-Prot for DCT Gene

  • Involved in regulating eumelanin and phaeomelanin levels

Gene Wiki entry for DCT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCT Gene

Genomics for DCT Gene

Regulatory Elements for DCT Gene

Genomic Location for DCT Gene

Chromosome:
13
Start:
94,436,808 bp from pter
End:
94,550,265 bp from pter
Size:
113,458 bases
Orientation:
Minus strand

Genomic View for DCT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCT Gene

Proteins for DCT Gene

  • Protein details for DCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40126-TYRP2_HUMAN
    Recommended name:
    L-dopachrome tautomerase
    Protein Accession:
    P40126
    Secondary Accessions:
    • Q09GT4

    Protein attributes for DCT Gene

    Size:
    519 amino acids
    Molecular mass:
    59145 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.

    Three dimensional structures from OCA and Proteopedia for DCT Gene

    Alternative splice isoforms for DCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCT Gene

Proteomics data for DCT Gene at MOPED

Post-translational modifications for DCT Gene

  • Glycosylation at Asn 170, Asn 178, Asn 237, Asn 300, Asn 342, and Asn 377
  • Modification sites at PhosphoSitePlus

Other Protein References for DCT Gene

Antibody Products

Domains & Families for DCT Gene

Protein Domains for DCT Gene

Graphical View of Domain Structure for InterPro Entry

P40126

UniProtKB/Swiss-Prot:

TYRP2_HUMAN :
  • Belongs to the tyrosinase family.
Family:
  • Belongs to the tyrosinase family.
genes like me logo Genes that share domains with DCT: view

No data available for Gene Families for DCT Gene

Function for DCT Gene

Molecular function for DCT Gene

GENATLAS Biochemistry:
DOPAchrome tautomerase
UniProtKB/Swiss-Prot CatalyticActivity:
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
UniProtKB/Swiss-Prot Function:
Involved in regulating eumelanin and phaeomelanin levels

Enzyme Numbers (IUBMB) for DCT Gene

Gene Ontology (GO) - Molecular Function for DCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004167 dopachrome isomerase activity ISS --
GO:0005507 copper ion binding TAS 8206391
GO:0016491 oxidoreductase activity TAS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DCT: view
genes like me logo Genes that share phenotypes with DCT: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCT

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCT Gene

Localization for DCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCT Gene

Melanosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCT Gene COMPARTMENTS Subcellular localization image for DCT gene
Compartment Confidence
cytosol 4
nucleus 2
endosome 1
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol ISS --
GO:0016021 integral component of membrane IEA --
GO:0033162 melanosome membrane TAS --
GO:0042470 melanosome ISS --
genes like me logo Genes that share ontologies with DCT: view

Pathways & Interactions for DCT Gene

genes like me logo Genes that share pathways with DCT: view

Pathways by source for DCT Gene

1 BioSystems pathway for DCT Gene

UniProtKB/Swiss-Prot P40126-TYRP2_HUMAN

  • Pathway: Pigment biosynthesis; melanin biosynthesis

Interacting Proteins for DCT Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000392762%0d%0a9606.ENSP00000373570%0d%0a
Selected Interacting proteins: P40126-TYRP2_HUMAN ENSP00000392762 for DCT Gene via I2D STRING

Gene Ontology (GO) - Biological Process for DCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0006583 melanin biosynthetic process from tyrosine ISS --
GO:0008152 metabolic process --
GO:0008544 epidermis development TAS 8206391
GO:0021847 ventricular zone neuroblast division IEA --
genes like me logo Genes that share ontologies with DCT: view

No data available for SIGNOR curated interactions for DCT Gene

Drugs & Compounds for DCT Gene

(14) Drugs for DCT Gene - From: NovoSeek, HMDB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 1820
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Levodopa Approved Pharma Agonist 339
Zinc Approved Pharma 1404

(16) Additional Compounds for DCT Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
l-dopachrome
  • 2-L-Carboxy-2,3-dihydroindole-5,6-quinone
  • L-Dopachrome
89762-39-0
5,6-Dihydroxyindole-2-carboxylic acid
  • 5,6-Dhica
  • 5,6-Dihydroxy-1H-indole-2-carboxylate
  • 5,6-Dihydroxy-1H-indole-2-carboxylic acid
  • 5,6-Dihydroxy-2-indolecarboxylate
  • 5,6-Dihydroxy-2-indolecarboxylic acid
4790-08-3
-, methyl ester
12-O-Tetradecanoylphorbol 13-acetate
adenylate
genes like me logo Genes that share compounds with DCT: view

Transcripts for DCT Gene

Unigene Clusters for DCT Gene

Dopachrome tautomerase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for DCT Gene

GeneLoc Exon Structure for
DCT
ECgene alternative splicing isoforms for
DCT

Expression for DCT Gene

mRNA expression in normal human tissues for DCT Gene

mRNA differential expression in normal tissues according to GTEx for DCT Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.8) and Skin - Sun Exposed (Lower leg) (x14.8).

Protein differential expression in normal tissues from HIPED for DCT Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCT Gene



SOURCE GeneReport for Unigene cluster for DCT Gene Hs.301865

genes like me logo Genes that share expression patterns with DCT: view

Protein tissue co-expression partners for DCT Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DCT Gene

Orthologs for DCT Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCT 35
  • 85.94 (n)
  • 85.54 (a)
DCT 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCT 35
  • 85.43 (n)
  • 84.91 (a)
DCT 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dct 35
  • 82.66 (n)
  • 83.56 (a)
Dct 16
Dct 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCT 35
  • 96.52 (n)
  • 95.36 (a)
DCT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dct 35
  • 83.08 (n)
  • 84.53 (a)
oppossum
(Monodelphis domestica)
Mammalia DCT 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCT 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCT 35
  • 70.91 (n)
  • 69.88 (a)
DCT 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCT 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dct 35
  • 68.64 (n)
  • 70.95 (a)
Str.15440 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12540 35
zebrafish
(Danio rerio)
Actinopterygii dct 35
  • 63.3 (n)
  • 64.55 (a)
dct 36
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.236 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
CSA.6982 36
  • 49 (a)
OneToMany
Species with no ortholog for DCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCT Gene

ENSEMBL:
Gene Tree for DCT (if available)
TreeFam:
Gene Tree for DCT (if available)

Paralogs for DCT Gene

Paralogs for DCT Gene

(3) SIMAP similar genes for DCT Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCT: view

Variants for DCT Gene

Structural Variations from Database of Genomic Variants (DGV) for DCT Gene

Variant ID Type Subtype PubMed ID
esv34004 CNV Loss 18971310
nsv1133 CNV Insertion 18451855

Variation tolerance for DCT Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCT Gene

HapMap Linkage Disequilibrium report
DCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DCT Gene

Disorders for DCT Gene

MalaCards: The human disease database

(4) MalaCards diseases for DCT Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
amelanotic melanoma
  • melanoma amelanotic
vitiligo-associated multiple autoimmune disease susceptibility 1
  • vitiligo
hermansky-pudlak syndrome
  • platelet storage pool deficiency
cell type cancer
- elite association
Search DCT in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCT

Genetic Association Database (GAD)
DCT
Human Genome Epidemiology (HuGE) Navigator
DCT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCT
genes like me logo Genes that share disorders with DCT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCT Gene

Publications for DCT Gene

  1. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. (PMID: 8306979) Bouchard B. … Dubertret L. (Eur. J. Biochem. 1994) 2 23 67
  2. Human eyelash characterization. (PMID: 19804590) Thibaut S. … Bernard B.A. (Br. J. Dermatol. 2010) 23 67
  3. Transcriptome analysis and molecular signature of human retinal pigment epithelium. (PMID: 20360305) Strunnikova N.V. … Miller S.S. (Hum. Mol. Genet. 2010) 23 67
  4. Purification and N-glycosylation analysis of melanoma antigen dopachrome tautomerase. (PMID: 20386969) Vavricka C.J. … Li J. (Protein J. 2010) 23 67
  5. Gpnmb is a melanoblast-expressed, MITF-dependent gene. (PMID: 18983539) Loftus S.K. … Pavan W.J. (Pigment Cell Melanoma Res 2009) 23 67

Products for DCT Gene

Sources for DCT Gene

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