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Aliases for IFNLR1 Gene

Aliases for IFNLR1 Gene

  • Interferon Lambda Receptor 1 2 3
  • Interferon, Lambda Receptor 1 2 3 5
  • Interleukin 28 Receptor, Alpha (Interferon, Lambda Receptor) 2 3
  • Likely Interleukin Or Cytokine Receptor 2 3 4
  • Interleukin-28 Receptor Subunit Alpha 3 4
  • Cytokine Receptor Class-II Member 12 3 4
  • Cytokine Receptor Family 2 Member 12 3 4
  • IL-28 Receptor Subunit Alpha 3 4
  • IFN-Lambda Receptor 1 3 4
  • IFN-Lambda-R1 3 4
  • IL-28R-Alpha 3 4
  • CRF2-12 3 4
  • IL-28RA 3 4
  • IL28RA 3 4
  • LICR2 3 4
  • Class II Cytokine Receptor CRF2/12 3
  • Interleukin Or Cytokine Receptor 2 3
  • Interleukin 28 Receptor, Alpha 2
  • Interferon Lambda, Receptor 1 3
  • Interleukin 28 Alpha Receptor 3
  • Interleukin 28 Receptor A 3
  • CRF2/12 3
  • IL-28R1 3
  • IFNLR 3

External Ids for IFNLR1 Gene

Previous HGNC Symbols for IFNLR1 Gene

  • IL28RA

Previous GeneCards Identifiers for IFNLR1 Gene

  • GC01M024481

Summaries for IFNLR1 Gene

Entrez Gene Summary for IFNLR1 Gene

  • The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNLR1 Gene

IFNLR1 (Interferon Lambda Receptor 1) is a Protein Coding gene. Among its related pathways are Jak-STAT signaling pathway and Immune System. GO annotations related to this gene include cytokine receptor activity.

UniProtKB/Swiss-Prot for IFNLR1 Gene

  • The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Gene Wiki entry for IFNLR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNLR1 Gene

Genomics for IFNLR1 Gene

Regulatory Elements for IFNLR1 Gene

Enhancers for IFNLR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNLR1 on UCSC Golden Path with GeneCards custom track

Promoters for IFNLR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFNLR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNLR1 Gene

Chromosome:
1
Start:
24,154,157 bp from pter
End:
24,187,959 bp from pter
Size:
33,803 bases
Orientation:
Minus strand

Genomic View for IFNLR1 Gene

Genes around IFNLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNLR1 Gene

Proteins for IFNLR1 Gene

  • Protein details for IFNLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU57-INLR1_HUMAN
    Recommended name:
    Interferon lambda receptor 1
    Protein Accession:
    Q8IU57
    Secondary Accessions:
    • Q5VTX5
    • Q5VTX7
    • Q5VTX8
    • Q6ZML8
    • Q8IV66
    • Q8IZI7
    • Q8IZI8

    Protein attributes for IFNLR1 Gene

    Size:
    520 amino acids
    Molecular mass:
    57653 Da
    Quaternary structure:
    • Heterodimer with IL10RB.
    SequenceCaution:
    • Sequence=BAD18707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFNLR1 Gene

    Alternative splice isoforms for IFNLR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNLR1 Gene

Proteomics data for IFNLR1 Gene at MOPED

Post-translational modifications for IFNLR1 Gene

  • Glycosylation at Asn 29, Asn 36, Asn 142, and Asn 169
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNLR1 Gene

Antibody Products

  • R&D Systems Antibodies for IFNLR1 (IL-28 R alpha/IFN-lambda R1)

No data available for DME Specific Peptides for IFNLR1 Gene

Domains & Families for IFNLR1 Gene

Gene Families for IFNLR1 Gene

Protein Domains for IFNLR1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IU57

UniProtKB/Swiss-Prot:

INLR1_HUMAN :
  • Contains 1 fibronectin type-III domain.
  • Belongs to the type II cytokine receptor family.
Domain:
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IFNLR1: view

Function for IFNLR1 Gene

Molecular function for IFNLR1 Gene

UniProtKB/Swiss-Prot Function:
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
genes like me logo Genes that share phenotypes with IFNLR1: view

Animal Models for IFNLR1 Gene

MGI Knock Outs for IFNLR1:

Animal Model Products

miRNA for IFNLR1 Gene

miRTarBase miRNAs that target IFNLR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNLR1 Gene

Localization for IFNLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNLR1 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for IFNLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032002 interleukin-28 receptor complex IDA 12469119
genes like me logo Genes that share ontologies with IFNLR1: view

No data available for Subcellular locations from COMPARTMENTS for IFNLR1 Gene

Pathways & Interactions for IFNLR1 Gene

genes like me logo Genes that share pathways with IFNLR1: view

Pathways by source for IFNLR1 Gene

SIGNOR curated interactions for IFNLR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IFNLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034342 response to type III interferon ISS --
GO:0050691 regulation of defense response to virus by host IDA 12469119
genes like me logo Genes that share ontologies with IFNLR1: view

Drugs & Compounds for IFNLR1 Gene

(1) Drugs for IFNLR1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PEG-INTERFERON LAMBA Pharma 0
genes like me logo Genes that share compounds with IFNLR1: view

Transcripts for IFNLR1 Gene

Unigene Clusters for IFNLR1 Gene

Interferon, lambda receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNLR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -
SP7:

Relevant External Links for IFNLR1 Gene

GeneLoc Exon Structure for
IFNLR1
ECgene alternative splicing isoforms for
IFNLR1

Expression for IFNLR1 Gene

mRNA expression in normal human tissues for IFNLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for IFNLR1 Gene Hs.221375

mRNA Expression by UniProt/SwissProt for IFNLR1 Gene

Q8IU57-INLR1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with IFNLR1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IFNLR1 Gene

Orthologs for IFNLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNLR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL28RA 35
  • 80.8 (n)
  • 70.69 (a)
IFNLR1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFNLR1 35
  • 79.51 (n)
  • 70.23 (a)
IFNLR1 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifnlr1 35
  • 72.83 (n)
  • 60.89 (a)
Ifnlr1 16
Ifnlr1 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL28RA 35
  • 99.23 (n)
  • 98.65 (a)
IFNLR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifnlr1 35
  • 73.62 (n)
  • 63.22 (a)
oppossum
(Monodelphis domestica)
Mammalia IFNLR1 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFNLR1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFNLR1 36
  • 32 (a)
OneToOne
Species with no ortholog for IFNLR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNLR1 Gene

ENSEMBL:
Gene Tree for IFNLR1 (if available)
TreeFam:
Gene Tree for IFNLR1 (if available)

Paralogs for IFNLR1 Gene

(1) SIMAP similar genes for IFNLR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFNLR1: view

No data available for Paralogs for IFNLR1 Gene

Variants for IFNLR1 Gene

Sequence variations from dbSNP and Humsavar for IFNLR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs946671 -- 24,157,951(+) TTATC(A/G)TCATC intron-variant
rs1416834 -- 24,160,170(+) ACTTC(A/G)AGGAG intron-variant
rs1416835 -- 24,160,465(+) TTACC(C/T)GTCTC intron-variant
rs1538632 -- 24,158,257(+) GGGCA(A/G)TGTGG intron-variant
rs2153334 -- 24,156,258(-) ACTTA(A/C)CATTC utr-variant-3-prime

Variation tolerance for IFNLR1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for IFNLR1 Gene

Disorders for IFNLR1 Gene

Relevant External Links for IFNLR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNLR1

No disorders were found for IFNLR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNLR1 Gene

Publications for IFNLR1 Gene

  1. Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1. (PMID: 20934432) Miknis Z.J. … Wlodawer A. (J. Mol. Biol. 2010) 3 4 67
  2. Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth. (PMID: 24409098) Ding S. … Robek M.D. (PLoS Biol. 2014) 3
  3. IL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV-coinfected patients. (PMID: 24438680) JimAcnez-Sousa M.A. … Resino S. (J. Viral Hepat. 2014) 3
  4. Interferon lambda 1 expression in cervical cells differs between low-risk and high-risk human papillomavirus-positive women. (PMID: 24510368) Cannella F. … Pierangeli A. (Med. Microbiol. Immunol. 2014) 3
  5. IFN-I> receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-I>3 genotype and with nonresponsiveness to IFN-I+ therapies. (PMID: 24752298) Duong F.H. … Heim M.H. (J. Exp. Med. 2014) 3

Products for IFNLR1 Gene

Sources for IFNLR1 Gene

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