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Aliases for DCN Gene

Aliases for DCN Gene

  • Decorin 2 3
  • Decorin Proteoglycan 2 3
  • Bone Proteoglycan II 3 4
  • SLRR1B 3 4
  • PG-S2 3 4
  • CSCD 3 6
  • PG40 3 4
  • Dermatan Sulphate Proteoglycans II 3
  • Small Leucine-Rich Protein 1B 3
  • Proteoglycan Core Protein 3
  • DSPG2 3
  • PGII 3
  • PGS2 3

External Ids for DCN Gene

Summaries for DCN Gene

Entrez Gene Summary for DCN Gene

  • The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCN Gene

DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include corneal dystrophy, congenital stromal and burn scar. Among its related pathways are Proteoglycans in cancer and Disease. GO annotations related to this gene include protein N-terminus binding and glycosaminoglycan binding. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for DCN Gene

  • May affect the rate of fibrils formation

Gene Wiki entry for DCN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCN Gene

Genomics for DCN Gene

Genomic Location for DCN Gene

Start:
91,140,484 bp from pter
End:
91,183,123 bp from pter
Size:
42,640 bases
Orientation:
Minus strand

Genomic View for DCN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCN Gene

Regulatory Elements for DCN Gene

Transcription factor binding sites by QIAGEN in the DCN gene promoter:

Proteins for DCN Gene

  • Protein details for DCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07585-PGS2_HUMAN
    Recommended name:
    Decorin
    Protein Accession:
    P07585
    Secondary Accessions:
    • Q9P0Z0
    • Q9P0Z1
    • Q9Y5N8
    • Q9Y5N9

    Protein attributes for DCN Gene

    Size:
    359 amino acids
    Molecular mass:
    39747 Da
    Quaternary structure:
    • Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).

    Alternative splice isoforms for DCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCN Gene

Proteomics data for DCN Gene at MOPED

Post-translational modifications for DCN Gene

  • The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser34, Asn211, Asn262, and Asn303

No data available for DME Specific Peptides for DCN Gene

Domains for DCN Gene

Gene Families for DCN Gene

HGNC:
  • SLRR :Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

UniProtKB/Swiss-Prot:

PGS2_HUMAN
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.:
    • P07585
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.:
    • P07585
genes like me logo Genes that share domains with DCN: view

Function for DCN Gene

Molecular function for DCN Gene

GENATLAS Biochemistry: decorin,small collagen-binding proteoglycan of the extracellular matrix,leucine-rich repeats (LRR) family,involved in the differentiation of retinal glanglion cells
UniProtKB/Swiss-Prot Function: May affect the rate of fibrils formation

Gene Ontology (GO) - Molecular Function for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005518 collagen binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with DCN: view
genes like me logo Genes that share phenotypes with DCN: view

Animal Models for DCN Gene

MGI Knock Outs for DCN:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DCN Gene

Localization for DCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCN Gene COMPARTMENTS Subcellular localization image for DCN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 2
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005589 collagen type VI trimer IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with DCN: view

Pathways for DCN Gene

genes like me logo Genes that share pathways with DCN: view

Pathways by source for DCN Gene

Gene Ontology (GO) - Biological Process for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0001890 placenta development IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007519 skeletal muscle tissue development IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with DCN: view

Compounds for DCN Gene

(1) Drugbank Compounds for DCN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tris(Hydroxymethyl)Aminomethane
target

(70) Novoseek inferred chemical compound relationships for DCN Gene

Compound -log(P) Hits PubMed IDs
glycosaminoglycan 90.2 91
dermatan sulfate 89.5 69
chondroitin 89.3 53
chondroitin sulfate 86.1 65
dermatan 83.7 13
genes like me logo Genes that share compounds with DCN: view

Transcripts for DCN Gene

Unigene Clusters for DCN Gene

Decorin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: -
SP17: - -

ExUns: 12d · 12e ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DCN Gene

GeneLoc Exon Structure for
DCN
ECgene alternative splicing isoforms for
DCN

Expression for DCN Gene

mRNA expression in normal human tissues for DCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DCN Gene

SOURCE GeneReport for Unigene cluster for DCN Gene Hs.156316

genes like me logo Genes that share expressions with DCN: view

Orthologs for DCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCN 36
  • 99.81 (n)
  • 100 (a)
DCN 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCN 36
  • 88.83 (n)
  • 90.78 (a)
DCN 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCN 36
  • 90.41 (n)
  • 93.58 (a)
DCN 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcn 36
  • 80.7 (n)
  • 81.64 (a)
Dcn 16
Dcn 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCN 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCN 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcn 36
  • 78.91 (n)
  • 79.1 (a)
chicken
(Gallus gallus)
Aves DCN 36
  • 75.35 (n)
  • 78.15 (a)
DCN 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCN 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24505 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dcn 36
  • 70.76 (n)
  • 75.7 (a)
Str.8982 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
dcn 36
  • 66.85 (n)
  • 67.69 (a)
dcn 37
  • 65 (a)
OneToOne
Species with no ortholog for DCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCN Gene

ENSEMBL:
Gene Tree for DCN (if available)
TreeFam:
Gene Tree for DCN (if available)

Paralogs for DCN Gene

Paralogs for DCN Gene

genes like me logo Genes that share paralogs with DCN: view

Variants for DCN Gene

Sequence variations from dbSNP and Humsavar for DCN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3343 -- 91,145,685(-) TTAGC(C/T)CATTT utr-variant-3-prime
rs7441 -- 91,145,898(-) AATTG(C/T)CTACA utr-variant-3-prime
rs12310 -- 91,146,212(-) TGGAT(C/T)AAGTG reference, missense, utr-variant-3-prime
rs491181 -- 91,170,575(-) GAGCA(C/G)TTTTT intron-variant
rs491237 -- 91,152,736(-) GAATT(A/T)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCN Gene

Variant ID Type Subtype PubMed ID
nsv899425 CNV Gain 21882294
nsv899429 CNV Loss 21882294
dgv210n27 CNV Loss 19166990
nsv832484 CNV Gain+Loss 17160897
nsv899430 CNV Gain 21882294

Relevant External Links for DCN Gene

HapMap Linkage Disequilibrium report
DCN
Human Gene Mutation Database (HGMD)
DCN

Disorders for DCN Gene

(1) OMIM Diseases for DCN Gene (125255)

UniProtKB/Swiss-Prot

PGS2_HUMAN
  • Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for DCN Gene

(89) Novoseek inferred disease relationships for DCN Gene

Disease -log(P) Hits PubMed IDs
collagen fibril 82.8 62
scars hypertrophic 61.1 20
osteoarthritis 42.2 4
scar 41.2 23
ehlers-danlos syndrome 39 4

Relevant External Links for DCN

GeneTests
DCN
GeneReviews
DCN
Genetic Association Database (GAD)
DCN
Human Genome Epidemiology (HuGE) Navigator
DCN
genes like me logo Genes that share disorders with DCN: view

Publications for DCN Gene

  1. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. (PMID: 8432526) Danielson K.G. … Iozzo R.V. (Genomics 1993) 2 3 4 23
  2. Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene. (PMID: 15671264) Bredrup C. … Boman H. (Invest. Ophthalmol. Vis. Sci. 2005) 3 4 23
  3. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PMID: 16902402) Wang I.J. … Lin L.L. (Mol. Vis. 2006) 3 23 49
  4. The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. (PMID: 19616852) Chen Z.T. … Lin L.L. (Ophthalmology 2009) 3 23 49
  5. [Effects and mechanism of decorin on the proliferation of HuH7 hepatoma carcinoma cells in vitro]. (PMID: 19737460) Shangguan J.Y. … Ti Z.Y. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009) 3 23

Products for DCN Gene

Sources for DCN Gene

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