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Aliases for DCN Gene

Aliases for DCN Gene

  • Decorin 2 3 5
  • Bone Proteoglycan II 3 4
  • SLRR1B 3 4
  • PG40 3 4
  • Dermatan Sulphate Proteoglycans II 3
  • Small Leucine-Rich Protein 1B 3
  • Proteoglycan Core Protein 3
  • Decorin Proteoglycan 2
  • DSPG2 3
  • PG-S2 4
  • CSCD 3
  • PGII 3
  • PGS2 3

External Ids for DCN Gene

Previous GeneCards Identifiers for DCN Gene

  • GC12M090861
  • GC12M091986
  • GC12M091472
  • GC12M090041
  • GC12M088606

Summaries for DCN Gene

Entrez Gene Summary for DCN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for DCN Gene

DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Stromal Dystrophy. Among its related pathways are Glycosaminoglycan metabolism and Defective B3GAT3 causes JDSSDHD. GO annotations related to this gene include poly(A) RNA binding and collagen binding. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for DCN Gene

  • May affect the rate of fibrils formation.

Gene Wiki entry for DCN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCN Gene

Genomics for DCN Gene

Regulatory Elements for DCN Gene

Enhancers for DCN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCN on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DCN gene promoter:

Genomic Location for DCN Gene

91,140,484 bp from pter
91,183,123 bp from pter
42,640 bases
Minus strand

Genomic View for DCN Gene

Genes around DCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCN Gene

Proteins for DCN Gene

  • Protein details for DCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9P0Z0
    • Q9P0Z1
    • Q9Y5N8
    • Q9Y5N9

    Protein attributes for DCN Gene

    359 amino acids
    Molecular mass:
    39747 Da
    Quaternary structure:
    • Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).

    Alternative splice isoforms for DCN Gene


neXtProt entry for DCN Gene

Proteomics data for DCN Gene at MOPED

Post-translational modifications for DCN Gene

  • The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
  • Glycosylation at Ser 34, Asn 211, Asn 262, and Asn 303
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCN Gene

Domains & Families for DCN Gene

Gene Families for DCN Gene

Suggested Antigen Peptide Sequences for DCN Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
  • Contains 12 LRR (leucine-rich) repeats.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with DCN: view

Function for DCN Gene

Molecular function for DCN Gene

GENATLAS Biochemistry:
decorin,small collagen-binding proteoglycan of the extracellular matrix,leucine-rich repeats (LRR) family,involved in the differentiation of retinal glanglion cells
UniProtKB/Swiss-Prot Function:
May affect the rate of fibrils formation.

Gene Ontology (GO) - Molecular Function for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with DCN: view
genes like me logo Genes that share phenotypes with DCN: view

Human Phenotype Ontology for DCN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DCN Gene

MGI Knock Outs for DCN:

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for DCN Gene

Localization for DCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for DCN Gene COMPARTMENTS Subcellular localization image for DCN gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 4
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with DCN: view

Pathways & Interactions for DCN Gene

genes like me logo Genes that share pathways with DCN: view

Gene Ontology (GO) - Biological Process for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007519 skeletal muscle tissue development IEA --
GO:0007568 aging IEA --
GO:0009887 organ morphogenesis TAS 7961765
genes like me logo Genes that share ontologies with DCN: view

No data available for SIGNOR curated interactions for DCN Gene

Drugs & Compounds for DCN Gene

(25) Drugs for DCN Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tris(Hydroxymethyl)Aminomethane Experimental Pharma Target 0

(46) Additional Compounds for DCN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DCN: view

Transcripts for DCN Gene

Unigene Clusters for DCN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: -
SP17: - -

ExUns: 12d · 12e ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d · 16e
SP5: - - - -
SP7: - - - -
SP12: - - - - - -

Relevant External Links for DCN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCN Gene

mRNA expression in normal human tissues for DCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCN Gene

This gene is overexpressed in Urinary Bladder (8.0) and Nasopharynx (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCN Gene

SOURCE GeneReport for Unigene cluster for DCN Gene Hs.156316

genes like me logo Genes that share expression patterns with DCN: view

Protein tissue co-expression partners for DCN Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCN Gene

Orthologs for DCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCN 35
  • 88.83 (n)
  • 90.78 (a)
DCN 36
  • 90 (a)
(Canis familiaris)
Mammalia DCN 35
  • 90.41 (n)
  • 93.58 (a)
DCN 36
  • 93 (a)
(Mus musculus)
Mammalia Dcn 35
  • 80.7 (n)
  • 81.64 (a)
Dcn 16
Dcn 36
  • 82 (a)
(Pan troglodytes)
Mammalia DCN 35
  • 99.81 (n)
  • 100 (a)
DCN 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dcn 35
  • 78.91 (n)
  • 79.1 (a)
(Monodelphis domestica)
Mammalia DCN 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia DCN 36
  • 86 (a)
(Gallus gallus)
Aves DCN 35
  • 75.35 (n)
  • 78.15 (a)
DCN 36
  • 78 (a)
(Anolis carolinensis)
Reptilia DCN 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcn 35
  • 70.76 (n)
  • 75.7 (a)
Str.8982 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24505 35
(Danio rerio)
Actinopterygii -- 35
dcn 35
  • 66.85 (n)
  • 67.69 (a)
dcn 36
  • 65 (a)
Species with no ortholog for DCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCN Gene

Gene Tree for DCN (if available)
Gene Tree for DCN (if available)

Paralogs for DCN Gene

Paralogs for DCN Gene

genes like me logo Genes that share paralogs with DCN: view

Variants for DCN Gene

Sequence variations from dbSNP and Humsavar for DCN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1803344 - 91,151,722(-) TGAGG(C/G)AGCTT intron-variant, reference, missense
rs3138268 - 91,151,736(-) CAACA(C/T)GCCTC intron-variant, reference, missense
rs3343 -- 91,145,685(-) TTAGC(C/T)CATTT utr-variant-3-prime
rs7441 -- 91,145,898(-) AATTG(C/T)CTACA utr-variant-3-prime
rs12310 -- 91,146,212(-) TGGAT(C/T)AAGTG reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCN Gene

Variant ID Type Subtype PubMed ID
nsv899425 CNV Gain 21882294
nsv899429 CNV Loss 21882294
dgv210n27 CNV Loss 19166990
nsv832484 CNV Gain+Loss 17160897
nsv899430 CNV Gain 21882294

Variation tolerance for DCN Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCN Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCN Gene

Disorders for DCN Gene

MalaCards: The human disease database

(25) MalaCards diseases for DCN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
corneal dystrophy, congenital stromal
  • congenital stromal corneal dystrophy
stromal dystrophy
localized scleroderma
  • circumscribed scleroderma
neonatal marfan syndrome
  • neonatal mfs
corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search DCN in MalaCards View complete list of genes associated with diseases


  • Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. {ECO:0000269 PubMed:15671264}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DCN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DCN: view

No data available for Genatlas for DCN Gene

Publications for DCN Gene

  1. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. (PMID: 8432526) Danielson K.G. … Iozzo R.V. (Genomics 1993) 2 3 4 23 67
  2. Decorin is a novel antagonistic ligand of the Met receptor. (PMID: 19433454) Goldoni S. … Iozzo R.V. (J. Cell Biol. 2009) 3 23
  3. Decorin suppresses bone metastasis in a breast cancer cell line. (PMID: 19590249) Araki K. … Uchida A. (Oncology 2009) 3 23
  4. Effects of decorin on the expression of alpha-smooth muscle actin in a human myofibroblast cell line. (PMID: 17952560) Nakatani T. … Munakata H. (Mol. Cell. Biochem. 2008) 3 23
  5. Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity. (PMID: 18413316) Fiedler L.R. … Eble J.A. (J. Biol. Chem. 2008) 3 23

Products for DCN Gene

Sources for DCN Gene