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Aliases for DCK Gene

Aliases for DCK Gene

  • Deoxycytidine Kinase 2 3 5
  • EC 2.7.1.74 4 61
  • EC 2.7.1 61
  • DCK 4

External Ids for DCK Gene

Previous GeneCards Identifiers for DCK Gene

  • GC04P071816
  • GC04P072099
  • GC04P072259
  • GC04P072325
  • GC04P072224
  • GC04P072078
  • GC04P067664

Summaries for DCK Gene

Entrez Gene Summary for DCK Gene

  • Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCK Gene

DCK (Deoxycytidine Kinase) is a Protein Coding gene. Diseases associated with DCK include Periampullary Adenocarcinoma and Neurofibrosarcoma. Among its related pathways are Purine metabolism (REACTOME) and Pyrimidine metabolism. GO annotations related to this gene include protein homodimerization activity and nucleoside kinase activity. An important paralog of this gene is DGUOK.

UniProtKB/Swiss-Prot for DCK Gene

  • Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Wiki entry for DCK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCK Gene

Genomics for DCK Gene

Regulatory Elements for DCK Gene

Enhancers for DCK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G070969 1 ENCODE dbSUPER 19.4 -21.6 -21619 2.2 SOX5 SOX13 GATAD2A TFE3 FOXA2 FOXA3 CEBPB HMG20A THRB ATF2 DCK RUFY3 GRSF1 JCHAIN UTP3 MOB1B
GH04G070901 1.5 FANTOM5 ENCODE 11.9 -89.5 -89505 3.0 HNRNPUL1 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 MOB1B DCK GRSF1 UTP3 JCHAIN
GH04G070992 1.7 FANTOM5 ENCODE dbSUPER 9 +2.7 2702 6.2 PKNOX1 MLX ARNT AGO1 ARID4B SIN3A FEZF1 ZBTB7B SLC30A9 ZNF766 DCK RUFY3 MOB1B JCHAIN GC04M071034
GH04G070894 0.9 Ensembl ENCODE 7.5 -96.7 -96746 3.1 RFX1 HLF ZNF316 ZNF585B IKZF1 FOXJ2 MAFK EMSY DCK GC04P070898 GC04P070862
GH04G070836 1.1 ENCODE 6 -153.8 -153805 3.8 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UTP3 JCHAIN RUFY3 DCK GC04P070840 PIR34937
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCK on UCSC Golden Path with GeneCards custom track

Promoters for DCK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169045 1562 2201 PKNOX1 MLX ARNT AGO1 ARID4B SIN3A ZBTB7B SLC30A9 ZNF766 ZNF207

Genomic Location for DCK Gene

Chromosome:
4
Start:
70,992,538 bp from pter
End:
71,030,914 bp from pter
Size:
38,377 bases
Orientation:
Plus strand

Genomic View for DCK Gene

Genes around DCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCK Gene

Proteins for DCK Gene

  • Protein details for DCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27707-DCK_HUMAN
    Recommended name:
    Deoxycytidine kinase
    Protein Accession:
    P27707
    Secondary Accessions:
    • B2R8V6
    • Q5TZY7
    • Q6FI11

    Protein attributes for DCK Gene

    Size:
    260 amino acids
    Molecular mass:
    30519 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DCK Gene

neXtProt entry for DCK Gene

Selected DME Specific Peptides for DCK Gene

P27707:
  • KKISIEGNI
  • FERSVYSDRYIFA
  • EDWEVVPEPVARWCNVQSTQ

Post-translational modifications for DCK Gene

  • Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
  • Ubiquitination at isoforms=34, Lys88, Lys117, Lys211, and isoforms=254
  • Modification sites at PhosphoSitePlus

Other Protein References for DCK Gene

Domains & Families for DCK Gene

Protein Domains for DCK Gene

Suggested Antigen Peptide Sequences for DCK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27707

UniProtKB/Swiss-Prot:

DCK_HUMAN :
  • Belongs to the DCK/DGK family.
Family:
  • Belongs to the DCK/DGK family.
genes like me logo Genes that share domains with DCK: view

No data available for Gene Families for DCK Gene

Function for DCK Gene

Molecular function for DCK Gene

GENATLAS Biochemistry:
deoxycytidine kinase,pyrimidine salvage pathway
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.2 uM for deoxycytidine (dC) {ECO:0000269 PubMed:12808445}; KM=15.5 uM for cytarabine (araC) {ECO:0000269 PubMed:12808445}; KM=22 uM for gemcitabine (dC) {ECO:0000269 PubMed:12808445};
UniProtKB/Swiss-Prot CatalyticActivity:
NTP + deoxycytidine = NDP + dCMP.
UniProtKB/Swiss-Prot Function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Enzyme Numbers (IUBMB) for DCK Gene

Gene Ontology (GO) - Molecular Function for DCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004137 deoxycytidine kinase activity IDA,TAS 12808445
GO:0005524 ATP binding IEA --
GO:0008144 drug binding IDA 12808445
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DCK: view
genes like me logo Genes that share phenotypes with DCK: view

Animal Models for DCK Gene

MGI Knock Outs for DCK:
  • Dck tm1.1Radu

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCK

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCK Gene

Localization for DCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCK Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCK gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
extracellular 1

Gene Ontology (GO) - Cellular Components for DCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCK: view

Pathways & Interactions for DCK Gene

genes like me logo Genes that share pathways with DCK: view

Gene Ontology (GO) - Biological Process for DCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IDA,TAS 12808445
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process IEA --
GO:0009165 nucleotide biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DCK: view

No data available for SIGNOR curated interactions for DCK Gene

Drugs & Compounds for DCK Gene

(61) Drugs for DCK Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma Enzyme, substrate 1117
Fludarabine Approved Pharma inhibitor, Target, agonist DNA synthsis inhibitor 1154,1154
Gemcitabine Approved Pharma Enzyme, substrate Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2018
Clofarabine Approved, Investigational Pharma Enzyme, substrate Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 159
Emtricitabine Approved, Investigational Pharma Enzyme, substrate 457

(51) Additional Compounds for DCK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
NTP
genes like me logo Genes that share compounds with DCK: view

Transcripts for DCK Gene

Unigene Clusters for DCK Gene

Deoxycytidine kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for DCK Gene

GeneLoc Exon Structure for
DCK
ECgene alternative splicing isoforms for
DCK

Expression for DCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCK Gene

This gene is overexpressed in Bone (49.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCK Gene



Protein tissue co-expression partners for DCK Gene

NURSA nuclear receptor signaling pathways regulating expression of DCK Gene:

DCK

SOURCE GeneReport for Unigene cluster for DCK Gene:

Hs.709

Evidence on tissue expression from TISSUES for DCK Gene

  • Nervous system(3.5)
  • Blood(2.4)
  • Bone marrow(2.2)
  • Intestine(2.1)
  • Lymph node(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with DCK: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCK Gene

Orthologs for DCK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCK 34 35
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia DCK 34 35
  • 92.82 (n)
dog
(Canis familiaris)
Mammalia DCK 34 35
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Dck 34
  • 89.45 (n)
mouse
(Mus musculus)
Mammalia Dck 34 16 35
  • 88.33 (n)
oppossum
(Monodelphis domestica)
Mammalia DCK 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCK 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCK 34 35
  • 78.39 (n)
lizard
(Anolis carolinensis)
Reptilia DCK 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dck.1 34
  • 72.69 (n)
Str.15187 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6839 34
zebrafish
(Danio rerio)
Actinopterygii dck 34 35
  • 66.67 (n)
Dr.24858 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10686 34
fruit fly
(Drosophila melanogaster)
Insecta dnk 35
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os05g0430200 34
  • 54.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for DCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCK Gene

ENSEMBL:
Gene Tree for DCK (if available)
TreeFam:
Gene Tree for DCK (if available)

Paralogs for DCK Gene

Paralogs for DCK Gene

(7) SIMAP similar genes for DCK Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DCK: view

Variants for DCK Gene

Sequence variations from dbSNP and Humsavar for DCK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000052491 -- 71,021,321(+) CCACC(C/T)GCCTC intron-variant
rs1000102088 -- 71,014,480(+) AGCAC(C/G)ACATC intron-variant
rs1000265479 -- 70,993,074(+) CCACT(A/G)GCAGG upstream-variant-2KB
rs1000277305 -- 70,999,081(+) TTGTT(A/G)TGTAG intron-variant
rs1000322168 -- 71,012,213(+) GAGGC(A/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCK Gene

Variant ID Type Subtype PubMed ID
esv3325241 CNV insertion 20981092
nsv594652 CNV loss 21841781

Variation tolerance for DCK Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCK Gene

Human Gene Mutation Database (HGMD)
DCK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCK Gene

Disorders for DCK Gene

MalaCards: The human disease database

(8) MalaCards diseases for DCK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
periampullary adenocarcinoma
neurofibrosarcoma
  • neurosarcoma [obs]
uterine sarcoma
  • sarcoma of the uterus
chronic lymphocytic leukemia
  • cll
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search DCK in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCK

Genetic Association Database (GAD)
DCK
Human Genome Epidemiology (HuGE) Navigator
DCK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCK
genes like me logo Genes that share disorders with DCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCK Gene

Publications for DCK Gene

  1. [Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia]. (PMID: 20137114) Yao L. … Li J.Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 22 25 64
  2. Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. (PMID: 19159229) Hazra S. … Lavie A. (Biochemistry 2009) 3 4 22 64
  3. Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK). (PMID: 18974616) Kim S.R. … Sawada J. (Drug Metab. Pharmacokinet. 2008) 3 22 46 64
  4. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. (PMID: 17602053) Rha S.Y. … Chung H.C. (Oncologist 2007) 3 22 46 64
  5. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. (PMID: 16421443) Zhang Y. … Ealick S.E. (Acta Crystallogr. D 2006) 4 22 25 64

Products for DCK Gene

Sources for DCK Gene

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