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Aliases for AP1B1 Gene

Aliases for AP1B1 Gene

  • Adaptor-Related Protein Complex 1, Beta 1 Subunit 2 3
  • CLAPB2 3 4 6
  • ADTB1 3 4 6
  • BAM22 3 4 6
  • Clathrin Assembly Protein Complex 1 Beta Large Chain 3 4
  • Adaptor-Related Protein Complex 1 Subunit Beta-1 3 4
  • Adaptor Protein Complex AP-1 Subunit Beta-1 3 4
  • Golgi Adaptor HA1/AP1 Adaptin Beta Subunit 3 4
  • Beta-Adaptin 1 3 4
  • Beta-1-Adaptin 3 4
  • Plasma Membrane Adaptor HA2/AP2 Adaptor Beta Subunit 3
  • Adapter-Related Protein Complex 1 Subunit Beta-1 3
  • AP-1 Complex Subunit Beta-1 3
  • Beta-Prime-Adaptin 3
  • Beta1-Adaptin 3
  • AP105A 3

External Ids for AP1B1 Gene

Previous HGNC Symbols for AP1B1 Gene

  • ADTB1
  • CLAPB2

Previous GeneCards Identifiers for AP1B1 Gene

  • GC22M026419
  • GC22M028048
  • GC22M029723
  • GC22M012687

Summaries for AP1B1 Gene

Entrez Gene Summary for AP1B1 Gene

  • Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for AP1B1 Gene

AP1B1 (Adaptor-Related Protein Complex 1, Beta 1 Subunit) is a Protein Coding gene. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include transporter activity and protein transporter activity. An important paralog of this gene is AP4B1.

UniProtKB/Swiss-Prot for AP1B1 Gene

  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1B1 Gene

Genomics for AP1B1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AP1B1 Gene

Start:
29,327,680 bp from pter
End:
29,423,179 bp from pter
Size:
95,500 bases
Orientation:
Minus strand

Genomic View for AP1B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1B1 Gene

Proteins for AP1B1 Gene

  • Protein details for AP1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10567-AP1B1_HUMAN
    Recommended name:
    AP-1 complex subunit beta-1
    Protein Accession:
    Q10567
    Secondary Accessions:
    • C9JRD1
    • F8WDL0
    • P78436
    • Q20WL3
    • Q86X54

    Protein attributes for AP1B1 Gene

    Size:
    949 amino acids
    Molecular mass:
    104637 Da
    Quaternary structure:
    • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3)

    Three dimensional structures from OCA and Proteopedia for AP1B1 Gene

    Alternative splice isoforms for AP1B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1B1 Gene

Proteomics data for AP1B1 Gene at MOPED

Post-translational modifications for AP1B1 Gene

  • Ubiquitination at Lys887
  • Modification sites at PhosphoSitePlus

Other Protein References for AP1B1 Gene

No data available for DME Specific Peptides for AP1B1 Gene

Domains for AP1B1 Gene

Suggested Antigen Peptide Sequences for AP1B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q10567

UniProtKB/Swiss-Prot:

AP1B1_HUMAN :
  • Q10567
Family:
  • Belongs to the adaptor complexes large subunit family.
genes like me logo Genes that share domains with AP1B1: view

No data available for Gene Families for AP1B1 Gene

Function for AP1B1 Gene

Molecular function for AP1B1 Gene

UniProtKB/Swiss-Prot Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Ontology (GO) - Molecular Function for AP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 7987321
GO:0005488 binding --
GO:0005515 protein binding IPI 23415225
GO:0008565 protein transporter activity IEA --
GO:0019901 protein kinase binding ISS --
genes like me logo Genes that share ontologies with AP1B1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AP1B1 Gene

Localization for AP1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1B1 Gene

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1B1 Gene COMPARTMENTS Subcellular localization image for AP1B1 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
lysosome 4
vacuole 4
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for AP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005829 cytosol TAS --
GO:0030117 membrane coat --
GO:0030131 clathrin adaptor complex IEA --
genes like me logo Genes that share ontologies with AP1B1: view

Pathways for AP1B1 Gene

genes like me logo Genes that share pathways with AP1B1: view

Pathways by source for AP1B1 Gene

1 Qiagen pathway for AP1B1 Gene
1 BioSystems pathway for AP1B1 Gene
1 KEGG pathway for AP1B1 Gene
1 GeneGo (Thomson Reuters) pathway for AP1B1 Gene

Gene Ontology (GO) - Biological Process for AP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0015031 protein transport --
GO:0016032 viral process TAS --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with AP1B1: view

Transcripts for AP1B1 Gene

Unigene Clusters for AP1B1 Gene

Adaptor-related protein complex 1, beta 1 subunit:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AP1B1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AP1B1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1B1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ^
SP1: - - - - -
SP2: -
SP3: -
SP4: -
SP5: -

ExUns: 20 ^ 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for AP1B1 Gene

GeneLoc Exon Structure for
AP1B1
ECgene alternative splicing isoforms for
AP1B1

Expression for AP1B1 Gene

mRNA expression in normal human tissues for AP1B1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP1B1 Gene

SOURCE GeneReport for Unigene cluster for AP1B1 Gene Hs.368794

mRNA Expression by UniProt/SwissProt for AP1B1 Gene

Q10567-AP1B1_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with AP1B1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AP1B1 Gene

Orthologs for AP1B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP1B1 35
  • 99.78 (n)
  • 99.89 (a)
AP1B1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AP1B1 35
  • 91.33 (n)
  • 97.25 (a)
AP1B1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP1B1 35
  • 92.03 (n)
  • 98.52 (a)
AP1B1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1b1 35
  • 89.36 (n)
  • 96.72 (a)
Ap1b1 16
Ap1b1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AP1B1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AP1B1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap1b1 35
  • 89.82 (n)
  • 96.62 (a)
chicken
(Gallus gallus)
Aves AP1B1 35
  • 86.6 (n)
  • 95.25 (a)
AP1B1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP1B1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1b1 35
  • 76.02 (n)
  • 90.04 (a)
zebrafish
(Danio rerio)
Actinopterygii ap1b1 35
  • 78.34 (n)
  • 88.32 (a)
ap1b1 36
  • 87 (a)
OneToOne
wufa16e07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001267 35
  • 70.35 (n)
  • 75.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bap 35
  • 72.96 (n)
  • 76.88 (a)
Bap 36
  • 75 (a)
OneToMany
Bap 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea apb-1 35
  • 61.8 (n)
  • 67.38 (a)
apb-1 36
  • 64 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APL2 36
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23460 35
  • 59.51 (n)
  • 63.28 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10635 35
corn
(Zea mays)
Liliopsida Zm.12502 35
rice
(Oryza sativa)
Liliopsida Os03g0355600 35
  • 59.18 (n)
  • 61.17 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27318 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4537 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 75 (a)
ManyToMany
CSA.9795 36
  • 51 (a)
ManyToMany
Species with no ortholog for AP1B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AP1B1 Gene

ENSEMBL:
Gene Tree for AP1B1 (if available)
TreeFam:
Gene Tree for AP1B1 (if available)

Paralogs for AP1B1 Gene

Paralogs for AP1B1 Gene

Selected SIMAP similar genes for AP1B1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AP1B1 Gene

genes like me logo Genes that share paralogs with AP1B1: view

Variants for AP1B1 Gene

Sequence variations from dbSNP and Humsavar for AP1B1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs174765 -- 29,331,877(+) AGTGG(C/T)GCGTG synonymous-codon, reference
rs174766 -- 29,338,707(+) GGCCG(G/T)GGTCT intron-variant
rs174767 -- 29,344,739(+) gtctc(A/G)gactc intron-variant
rs174768 -- 29,346,852(+) tgttt(C/T)tgctc intron-variant
rs174769 -- 29,363,455(+) CCATC(C/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AP1B1 Gene

Variant ID Type Subtype PubMed ID
nsv829154 CNV Gain 20364138
nsv834171 CNV Loss 17160897
nsv829155 CNV Loss 20364138
esv2724124 CNV Deletion 23290073
esv2724125 CNV Deletion 23290073
dgv4952n71 CNV Gain 21882294
esv2580719 CNV Deletion 19546169
nsv436866 CNV Insertion 17901297
dgv579n27 CNV Gain 19166990
nsv821257 CNV Duplication 20802225
esv23708 CNV Loss 19812545
dgv759n67 CNV Loss 20364138

Relevant External Links for AP1B1 Gene

HapMap Linkage Disequilibrium report
AP1B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP1B1 Gene

Disorders for AP1B1 Gene

(2) Novoseek inferred disease relationships for AP1B1 Gene

Disease -log(P) Hits PubMed IDs
meningioma 63.7 5
tumors 0 3

Relevant External Links for AP1B1

Genetic Association Database (GAD)
AP1B1
Human Genome Epidemiology (HuGE) Navigator
AP1B1
genes like me logo Genes that share disorders with AP1B1: view

No data available for UniProtKB/Swiss-Prot for AP1B1 Gene

Publications for AP1B1 Gene

  1. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. (PMID: 7987321) Peyrard M. … Dumanski J.P. (Hum. Mol. Genet. 1994) 2 3 4 23
  2. Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12. (PMID: 8812422) Peyrard M. … Dumanski J.P. (Genomics 1996) 2 3 4 23
  3. Genetic variations in humans associated with differences in the course of hepatitis C. (PMID: 15063762) Saito T. … Kawata S. (Biochem. Biophys. Res. Commun. 2004) 3 48
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. (PMID: 11106728) Nakagawa T. … Hirokawa N. (Cell 2000) 3 23

Products for AP1B1 Gene

Sources for AP1B1 Gene

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