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Aliases for DAXX Gene

Aliases for DAXX Gene

  • Death-Domain Associated Protein 2 3 5
  • Fas Death Domain-Associated Protein 3 4
  • Death-Associated Protein 6 2 3
  • ETS1-Associated Protein 1 3 4
  • BING2 3 4
  • DAP6 3 4
  • EAP1 3 4
  • CENP-C Binding Protein 3
  • Fas-Binding Protein 3
  • HDaxx 4
  • Daxx 4

External Ids for DAXX Gene

Previous GeneCards Identifiers for DAXX Gene

  • GC06M033298
  • GC06M033334
  • GC06M033336
  • GC06M033394
  • GC06M033286
  • GC06M033027

Summaries for DAXX Gene

Entrez Gene Summary for DAXX Gene

  • This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

GeneCards Summary for DAXX Gene

DAXX (Death-Domain Associated Protein) is a Protein Coding gene. Diseases associated with DAXX include Thalassemias, Alpha-. Among its related pathways are TWEAK Pathway and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for DAXX Gene

  • Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV).

Gene Wiki entry for DAXX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAXX Gene

Genomics for DAXX Gene

Regulatory Elements for DAXX Gene

Enhancers for DAXX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DAXX on UCSC Golden Path with GeneCards custom track

Genomic Location for DAXX Gene

Chromosome:
6
Start:
33,318,558 bp from pter
End:
33,329,269 bp from pter
Size:
10,712 bases
Orientation:
Minus strand

Genomic View for DAXX Gene

Genes around DAXX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAXX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAXX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for DAXX Gene

  • Protein details for DAXX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UER7-DAXX_HUMAN
    Recommended name:
    Death domain-associated protein 6
    Protein Accession:
    Q9UER7
    Secondary Accessions:
    • B4E1I3
    • F5ANJ6
    • F5ANJ7
    • F5H082
    • O14747
    • O15141
    • O15208
    • Q5STK9
    • Q9BWI3

    Protein attributes for DAXX Gene

    Size:
    740 amino acids
    Molecular mass:
    81373 Da
    Quaternary structure:
    • Homomultimer. Interacts (via C-terminus) with TNFRSF6 (via death domain). Interacts with PAX5, SLC2A4/GLUT4, MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC, ETS1, sumoylated PML, UBE2I, MCRS1 and TP53. Interacts (via N-terminus) with HIPK2 and HIPK3. Interacts with HIPK1, which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1. Interacts (non-phosphorylated) with PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and histones H2A, H2B, H3, H3.3 and H4. Interacts with SPOP; mediating CUL3-dependent proteosomal degradation. Interacts with CBP; the interaction is dependent the sumoylation of CBP and suppresses CBP transcriptional activity via recruitment of HDAC2 directly in the complex with TP53 and HIPK2. Interacts with AXIN1; the interaction stimulates the interaction of DAXX with TP53, stimulates Ser-46 phosphorylation of TP53 on and induces cell death on UV irradiation. Interacts with MDM2; the interaction is direct. Interacts with USP7; the interaction is direct and independent of MDM2 and TP53. Part of a complex with DAXX, MDM2 and USP7 under non-stress conditions. Interacts (via N-terminus) with RASSF1 (via C-terminus); the interaction is independent of MDM2 and TP53; RASSF1 isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. Interacts with ATRX to form the chromatin remodeling complex ATRX:DAXX. Interacts with human cytomegalovirus/HHV-5 tegument phosphoprotein pp71 and protein UL123. Interacts with Epstein-Barr virus protein BNRF1. Interacts with human adenovirus 5 E1B-55K protein; this interaction might alterate the normal interactions of DAXX, PML, and TP53, which may contribute to cell transformation (PubMed:14557665).

    Three dimensional structures from OCA and Proteopedia for DAXX Gene

    Alternative splice isoforms for DAXX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAXX Gene

Proteomics data for DAXX Gene at MOPED

Post-translational modifications for DAXX Gene

  • Phosphorylated by HIPK1 upon glucose deprivation.
  • Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation. Ubiquitinated by MDM2; inducing its degradation. Deubiquitinated by USP7; leading to stabilize it.
  • Sumoylated with SUMO1 on multiple lysine residues.
  • Ubiquitination at Lys 243, Lys 277, Lys 378, and Lys 385
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAXX (DAXX)

No data available for DME Specific Peptides for DAXX Gene

Domains & Families for DAXX Gene

Protein Domains for DAXX Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UER7

UniProtKB/Swiss-Prot:

DAXX_HUMAN :
  • The Sumo interaction motif mediates Sumo binding, and is required both for sumoylation and binding to sumoylated targets.
  • Belongs to the DAXX family.
Domain:
  • The Sumo interaction motif mediates Sumo binding, and is required both for sumoylation and binding to sumoylated targets.
Family:
  • Belongs to the DAXX family.
genes like me logo Genes that share domains with DAXX: view

No data available for Gene Families for DAXX Gene

Function for DAXX Gene

Molecular function for DAXX Gene

GENATLAS Biochemistry:
murine Daxx homolog,120kDa,with a dominant transcript ubiquitously expressed,a truncated transcript in placenta and pancreas,and an extended transcript in heart and skeletal muscle,binding to FAS (APT1),enhancing Fas-mediated apoptosis through the JNK signal transduction pathway,alternatively,potential regulator of FAS-induced apoptosis from nuclear oncogenic domains PODs in which it colocalizes with PML.
UniProtKB/Swiss-Prot Function:
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV).
UniProtKB/Swiss-Prot Induction:
Upon mitogenic stimulation by concanavalin-A.

Gene Ontology (GO) - Molecular Function for DAXX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 12140263
GO:0005057 receptor signaling protein activity TAS 9215629
GO:0008134 transcription factor binding IEA,IDA --
GO:0019899 enzyme binding IPI 16845383
GO:0042803 protein homodimerization activity IDA 10698492
genes like me logo Genes that share ontologies with DAXX: view
genes like me logo Genes that share phenotypes with DAXX: view

Animal Models for DAXX Gene

MGI Knock Outs for DAXX:

Animal Model Products

miRNA for DAXX Gene

miRTarBase miRNAs that target DAXX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAXX Gene

Localization for DAXX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAXX Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body. Nucleus, nucleolus. Chromosome, centromere. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli (Probable). Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies (PubMed:12953102, PubMed:14990586, PubMed:23222847, PubMed:24200965). Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres (PubMed:9645950). Detected in cytoplasmic punctate structures (PubMed:11842083). Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress (PubMed:12968034). Colocalizes with RASSF1 in the nucleus (PubMed:18566590). Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures (PubMed:16845383). {ECO:0000269 PubMed:11842083, ECO:0000269 PubMed:12953102, ECO:0000269 PubMed:12968034, ECO:0000269 PubMed:14990586, ECO:0000269 PubMed:16845383, ECO:0000269 PubMed:18566590, ECO:0000269 PubMed:23222847, ECO:0000269 PubMed:24200965, ECO:0000269 PubMed:9645950, ECO:0000305 PubMed:10669754}.
Isoform beta: Nucleus. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269 PubMed:21482821}.
Isoform gamma: Nucleus. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269 PubMed:21482821}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAXX Gene COMPARTMENTS Subcellular localization image for DAXX gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for DAXX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 10504293
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 15572661
GO:0005938 cell cortex IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with DAXX: view

Pathways & Interactions for DAXX Gene

genes like me logo Genes that share pathways with DAXX: view

SIGNOR curated interactions for DAXX Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DAXX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006334 nucleosome assembly IDA 20504901
GO:0006338 chromatin remodeling IDA 20651253
GO:0006355 regulation of transcription, DNA-templated IDA 15878163
GO:0007257 activation of JUN kinase activity TAS 9215629
genes like me logo Genes that share ontologies with DAXX: view

Drugs & Compounds for DAXX Gene

(4) Drugs for DAXX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for DAXX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DAXX: view

Transcripts for DAXX Gene

Unigene Clusters for DAXX Gene

Death-domain associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAXX Gene

No ASD Table

Relevant External Links for DAXX Gene

GeneLoc Exon Structure for
DAXX
ECgene alternative splicing isoforms for
DAXX

Expression for DAXX Gene

mRNA expression in normal human tissues for DAXX Gene

Protein differential expression in normal tissues from HIPED for DAXX Gene

This gene is overexpressed in Cerebrospinal fluid (19.0), Blymphocyte (15.0), Peripheral blood mononuclear cells (11.9), and CD8 Tcells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAXX Gene



SOURCE GeneReport for Unigene cluster for DAXX Gene Hs.336916

mRNA Expression by UniProt/SwissProt for DAXX Gene

Q9UER7-DAXX_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DAXX: view

Protein tissue co-expression partners for DAXX Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DAXX Gene

Orthologs for DAXX Gene

This gene was present in the common ancestor of animals.

Orthologs for DAXX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAXX 35
  • 87.98 (n)
  • 85.38 (a)
DAXX 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAXX 35
  • 90.27 (n)
  • 90.18 (a)
DAXX 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daxx 35
  • 78.4 (n)
  • 72.9 (a)
Daxx 16
Daxx 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAXX 35
  • 99.32 (n)
  • 98.78 (a)
DAXX 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Daxx 35
  • 77.75 (n)
  • 73.9 (a)
oppossum
(Monodelphis domestica)
Mammalia DAXX 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10894 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24796 35
zebrafish
(Danio rerio)
Actinopterygii daxx 36
  • 36 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009432 35
  • 43.96 (n)
  • 29.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta DLP 36
  • 8 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for DAXX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAXX Gene

ENSEMBL:
Gene Tree for DAXX (if available)
TreeFam:
Gene Tree for DAXX (if available)

Paralogs for DAXX Gene

No data available for Paralogs for DAXX Gene

Variants for DAXX Gene

Sequence variations from dbSNP and Humsavar for DAXX Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1059231 -- 33,320,494(-) AAATA(C/T)GCAAT reference, synonymous-codon
rs6902291 -- 33,322,494(+) CCATA(G/T)TTCAC intron-variant
rs9500940 -- 33,324,002(+) GACTC(G/T)TGGAG upstream-variant-2KB
rs6935247 -- 33,324,878(+) agatt(A/T)tctca upstream-variant-2KB
rs2073524 -- 33,322,770(+) ACAGC(A/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAXX Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv830635 CNV Loss 17160897
esv22635 CNV Loss 19812545

Variation tolerance for DAXX Gene

Residual Variation Intolerance Score: 6.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DAXX Gene

Disorders for DAXX Gene

MalaCards: The human disease database

(1) MalaCards diseases for DAXX Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
thalassemias, alpha-
  • thalassemia, alpha-
- elite association - COSMIC cancer census association via MalaCards
Search DAXX in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAXX

Genetic Association Database (GAD)
DAXX
Human Genome Epidemiology (HuGE) Navigator
DAXX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAXX
genes like me logo Genes that share disorders with DAXX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAXX Gene

Publications for DAXX Gene

  1. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. (PMID: 9215629) Yang X. … Baltimore D. (Cell 1997) 2 3 4 23 67
  2. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. (PMID: 9407001) Kiriakidou M. … Strauss J.F. III (DNA Cell Biol. 1997) 2 3 23
  3. Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations. (PMID: 20097304) Ho C.L. … Huang S.M. (Int. J. Biochem. Cell Biol. 2010) 3 23
  4. Daxx is reciprocally regulated by Mdm2 and Hausp. (PMID: 20153724) Tang J. … Yang X. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. (PMID: 18932217) Lalioti V.S. … Sandoval I.V. (J. Cell. Physiol. 2009) 3 23

Products for DAXX Gene

Sources for DAXX Gene

Content