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Aliases for STRC Gene

Aliases for STRC Gene

  • Stereocilin 2 3
  • DFNB16 3 6

External Ids for STRC Gene

Previous HGNC Symbols for STRC Gene

  • DFNB16

Previous GeneCards Identifiers for STRC Gene

  • GC15U990014
  • GC15M036787
  • GC15M041470
  • GC15M041607
  • GC15M041679
  • GC15M043892

Summaries for STRC Gene

Entrez Gene Summary for STRC Gene

  • This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]

GeneCards Summary for STRC Gene

STRC (Stereocilin) is a Protein Coding gene. Diseases associated with STRC include deafness, autosomal recessive 16 and deafness-infertility syndrome. An important paralog of this gene is OTOA.

UniProtKB/Swiss-Prot for STRC Gene

  • Essential to the formation of horizontal top connectors between outer hair cell stereocilia.

Gene Wiki entry for STRC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRC Gene

Genomics for STRC Gene

Regulatory Elements for STRC Gene

Genomic Location for STRC Gene

43,599,398 bp from pter
43,618,800 bp from pter
19,403 bases
Minus strand

Genomic View for STRC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRC Gene

Proteins for STRC Gene

  • Protein details for STRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for STRC Gene

    1775 amino acids
    Molecular mass:
    192967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STRC Gene

Proteomics data for STRC Gene at MOPED

Post-translational modifications for STRC Gene

  • Glycosylation at Asn65, Asn202, Asn297, Asn366, Asn427, Asn476, Asn540, Asn565, Asn656, Asn824, Asn916, Asn964, Asn1179, and Asn1274
  • Modification sites at PhosphoSitePlus

Other Protein References for STRC Gene

No data available for DME Specific Peptides for STRC Gene

Domains for STRC Gene

Protein Domains for STRC Gene


Suggested Antigen Peptide Sequences for STRC Gene

Graphical View of Domain Structure for InterPro Entry



  • Q7RTU9
  • Belongs to the stereocilin family.
genes like me logo Genes that share domains with STRC: view

No data available for Gene Families for STRC Gene

Function for STRC Gene

Molecular function for STRC Gene

UniProtKB/Swiss-Prot Function: Essential to the formation of horizontal top connectors between outer hair cell stereocilia.

Phenotypes for STRC Gene

genes like me logo Genes that share phenotypes with STRC: view

Animal Models for STRC Gene

MGI Knock Outs for STRC:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for STRC Gene

Localization for STRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRC Gene

Cell surface. Cell projection, kinocilium. Cell projection, stereocilium.

Subcellular locations from

Jensen Localization Image for STRC Gene COMPARTMENTS Subcellular localization image for STRC gene
Compartment Confidence
extracellular 3
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IEA --
GO:0032420 stereocilium IEA --
GO:0032426 stereocilium bundle tip ISS --
GO:0060091 kinocilium ISS --
genes like me logo Genes that share ontologies with STRC: view

Pathways for STRC Gene

SuperPathways for STRC Gene

No Data Available

Interacting Proteins for STRC Gene

Gene Ontology (GO) - Biological Process for STRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound IEA --
GO:0060088 auditory receptor cell stereocilium organization ISS --
genes like me logo Genes that share ontologies with STRC: view

No data available for Pathways by source for STRC Gene

Transcripts for STRC Gene

Unigene Clusters for STRC Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRC

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for STRC
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRC Gene

No ASD Table

Relevant External Links for STRC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STRC Gene

mRNA expression in normal human tissues for STRC Gene

mRNA differential expression in normal tissues according to GTEx for STRC Gene

This gene is overexpressed in Brain - Cerebellum (15.4) and Brain - Cerebellar Hemisphere (12.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for STRC Gene

SOURCE GeneReport for Unigene cluster for STRC Gene Hs.657395

genes like me logo Genes that share expressions with STRC: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for STRC Gene

Orthologs for STRC Gene

This gene was present in the common ancestor of chordates.

Orthologs for STRC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100608534 35
  • 99.23 (n)
  • 98.98 (a)
  • 99 (a)
(Bos Taurus)
Mammalia STRC 35
  • 89.36 (n)
  • 91.09 (a)
  • 91 (a)
(Canis familiaris)
Mammalia STRC 35
  • 90.21 (n)
  • 91.87 (a)
  • 91 (a)
(Mus musculus)
Mammalia Strc 35
  • 86.46 (n)
  • 88.16 (a)
Strc 16
Strc 36
  • 86 (a)
(Monodelphis domestica)
Mammalia STRC 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
-- 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Strc 35
  • 86.15 (n)
  • 87.94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia strc 35
  • 49.08 (n)
  • 39.16 (a)
(Danio rerio)
Actinopterygii LOC100004499 35
  • 46.7 (n)
  • 36.87 (a)
  • 34 (a)
Species with no ortholog for STRC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STRC Gene

Gene Tree for STRC (if available)
Gene Tree for STRC (if available)

Paralogs for STRC Gene

Paralogs for STRC Gene

Selected SIMAP similar genes for STRC Gene using alignment to 8 proteins: Pseudogenes for STRC Gene

genes like me logo Genes that share paralogs with STRC: view

Variants for STRC Gene

Sequence variations from dbSNP and Humsavar for STRC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2260105 -- 43,605,003(+) ATGAG(A/C)CCAGA intron-variant
rs2260160 -- 43,603,445(-) TTACT(A/C/G/T)CGCTG intron-variant
rs2442938 -- 43,614,550(+) TTCCA(A/G)CTCCA intron-variant, upstream-variant-2KB
rs2447196 -- 43,601,620(+) TTTAA(A/G)TCTTG intron-variant
rs2447197 -- 43,602,778(+) TAGCT(A/G)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRC Gene

Variant ID Type Subtype PubMed ID
nsv437799 CNV Loss 16327808
nsv832988 CNV Loss 17160897
nsv428304 CNV Loss 18775914
dgv741e1 CNV Complex 17122850
dgv742e1 CNV Complex 17122850
nsv524910 CNV Loss 19592680
dgv2370n71 CNV Gain 21882294
dgv2371n71 CNV Gain 21882294
dgv2372n71 CNV Gain 21882294
nsv509569 CNV Insertion 20534489
nsv904151 CNV Gain 21882294
dgv2373n71 CNV Loss 21882294
nsv904153 CNV Gain+Loss 21882294
esv24113 CNV Gain+Loss 19812545
nsv1514 CNV Loss 18451855
esv2421427 CNV Deletion 20811451
nsv9249 CNV Gain+Loss 18304495
esv33424 CNV Loss 17666407
dgv2374n71 CNV Loss 21882294
dgv743e1 CNV Complex 17122850
esv2749626 CNV Deletion 23290073
nsv442372 CNV CNV 18776908
nsv9250 CNV Loss 18304495
nsv433293 CNV Loss 18776910
nsv904169 CNV Gain 21882294
dgv2375n71 CNV Gain 21882294
nsv9251 CNV Loss 18304495

Relevant External Links for STRC Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRC Gene

Disorders for STRC Gene

(1) OMIM Diseases for STRC Gene (606440)


  • Deafness, autosomal recessive, 16 (DFNB16) [MIM:603720]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:11687802}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Deafness-infertility syndrome (DIS) [MIM:611102]: Characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. {ECO:0000269 PubMed:17098888}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for STRC Gene

genes like me logo Genes that share disorders with STRC: view

Publications for STRC Gene

  1. Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus. (PMID: 11687802) Verpy E. … Petit C. (Nat. Genet. 2001) 2 3 4 23
  2. Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear. (PMID: 12445334) Jovine L. … Wassarman P.M. (BMC Cell Biol. 2002) 3 23
  3. A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22. (PMID: 9429146) Campbell D.A. … Mueller R.F. (J. Med. Genet. 1997) 2 3
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  5. Deafness and Hereditary Hearing Loss Overview (PMID: 20301607) Pagon R.A. … Stephens K. ( 1993) 3

Products for STRC Gene

Sources for STRC Gene

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