Aliases for DGKB Gene
External Ids for DGKB Gene
Previous HGNC Symbols for DGKB Gene
Previous GeneCards Identifiers for DGKB Gene
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGKB Gene
DGKB (Diacylglycerol Kinase Beta) is a Protein Coding gene. Diseases associated with DGKB include Mitochondrial Dna Depletion Syndrome 3. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKI.
UniProtKB/Swiss-Prot for DGKB Gene
Exhibits high phosphorylation activity for long-chain diacylglycerols.
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.