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Aliases for DGKB Gene

Aliases for DGKB Gene

  • Diacylglycerol Kinase Beta 2 3 5
  • Diacylglycerol Kinase, Beta 90kDa 2 3
  • 90 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Beta 3 4
  • DAG Kinase Beta 3 4
  • EC 2.7.1.107 4 63
  • DGK-BETA 3 4
  • DAGK2 3 4
  • Diacylglycerol Kinase, Beta (90kD) 2
  • KIAA0718 4
  • EC 2.7.1 63
  • DGK 3

External Ids for DGKB Gene

Previous HGNC Symbols for DGKB Gene

  • DAGK2

Previous GeneCards Identifiers for DGKB Gene

  • GC07M013831
  • GC07M013931
  • GC07M013960
  • GC07M014153
  • GC07M014066

Summaries for DGKB Gene

Entrez Gene Summary for DGKB Gene

  • Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKB Gene

DGKB (Diacylglycerol Kinase Beta) is a Protein Coding gene. Diseases associated with DGKB include mitochondrial dna depletion syndrome 3. Among its related pathways are Phospholipase D signaling pathway and triacylglycerol biosynthesis. GO annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKB Gene

  • Exhibits high phosphorylation activity for long-chain diacylglycerols.

Tocris Summary for DGKB Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKB Gene

Genomics for DGKB Gene

Regulatory Elements for DGKB Gene

Enhancers for DGKB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DGKB on UCSC Golden Path with GeneCards custom track

Genomic Location for DGKB Gene

Chromosome:
7
Start:
14,145,049 bp from pter
End:
14,974,777 bp from pter
Size:
829,729 bases
Orientation:
Minus strand

Genomic View for DGKB Gene

Genes around DGKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKB Gene

Proteins for DGKB Gene

  • Protein details for DGKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6T7-DGKB_HUMAN
    Recommended name:
    Diacylglycerol kinase beta
    Protein Accession:
    Q9Y6T7
    Secondary Accessions:
    • A4D116
    • A4D117
    • A8MXU2
    • O75241
    • Q2M377
    • Q75MF9
    • Q75MU7
    • Q86UI5
    • Q86UM9
    • Q9UQ29

    Protein attributes for DGKB Gene

    Size:
    804 amino acids
    Molecular mass:
    90595 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAS07533.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DGKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKB Gene

Proteomics data for DGKB Gene at MOPED

Post-translational modifications for DGKB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGKB Gene

Antibody Products

Domains & Families for DGKB Gene

Suggested Antigen Peptide Sequences for DGKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6T7

UniProtKB/Swiss-Prot:

DGKB_HUMAN :
  • Contains 1 DAGKc domain.
  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 DAGKc domain.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with DGKB: view

Function for DGKB Gene

Molecular function for DGKB Gene

GENATLAS Biochemistry:
diacylglycerol kinase,beta,homolog to rat diacylglycerol
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by phosphatidylserine.
UniProtKB/Swiss-Prot Function:
Exhibits high phosphorylation activity for long-chain diacylglycerols.

Enzyme Numbers (IUBMB) for DGKB Gene

Gene Ontology (GO) - Molecular Function for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DGKB: view
genes like me logo Genes that share phenotypes with DGKB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKB

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGKB Gene

Localization for DGKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DGKB Gene COMPARTMENTS Subcellular localization image for DGKB gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for DGKB Gene

Pathways & Interactions for DGKB Gene

genes like me logo Genes that share pathways with DGKB: view

Gene Ontology (GO) - Biological Process for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DGKB: view

No data available for SIGNOR curated interactions for DGKB Gene

Drugs & Compounds for DGKB Gene

(6) Drugs for DGKB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(154) Additional Compounds for DGKB Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKB Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKB: view

Transcripts for DGKB Gene

Unigene Clusters for DGKB Gene

Diacylglycerol kinase, beta 90kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGKB Gene

No ASD Table

Relevant External Links for DGKB Gene

GeneLoc Exon Structure for
DGKB
ECgene alternative splicing isoforms for
DGKB

Expression for DGKB Gene

mRNA expression in normal human tissues for DGKB Gene

mRNA differential expression in normal tissues according to GTEx for DGKB Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.0), Brain - Caudate (basal ganglia) (x9.3), Brain - Nucleus accumbens (basal ganglia) (x8.3), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Frontal Cortex (BA9) (x4.4).

Protein differential expression in normal tissues from HIPED for DGKB Gene

This gene is overexpressed in Lymph node (32.0) and CD4 Tcells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DGKB Gene



SOURCE GeneReport for Unigene cluster for DGKB Gene Hs.567255

genes like me logo Genes that share expression patterns with DGKB: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DGKB Gene

Orthologs for DGKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DGKB 35
  • 94.02 (n)
  • 97.63 (a)
DGKB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DGKB 35
  • 94.56 (n)
  • 98.63 (a)
DGKB 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgkb 35
  • 90.02 (n)
  • 96.73 (a)
Dgkb 16
Dgkb 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DGKB 35
  • 99.67 (n)
  • 99.88 (a)
DGKB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgkb 35
  • 90.18 (n)
  • 96.5 (a)
oppossum
(Monodelphis domestica)
Mammalia DGKB 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves DGKB 35
  • 83 (n)
  • 90.65 (a)
DGKB 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKB 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkb 35
  • 76.65 (n)
  • 87.26 (a)
zebrafish
(Danio rerio)
Actinopterygii dgkb 35
  • 68.97 (n)
  • 75.63 (a)
Dr.19975 35
dgkb 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dgk 37
  • 57 (a)
Dgk 35
  • 58.44 (n)
  • 59.25 (a)
Dgk 36
  • 36 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006762 35
  • 59.83 (n)
  • 61.67 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-3 37
  • 51 (a)
dgk-3 35
  • 58.04 (n)
  • 56.06 (a)
dgk-3 36
  • 50 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.20201 35
corn
(Zea mays)
Liliopsida Zm.4984 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12076 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10986 36
  • 55 (a)
OneToMany
Species with no ortholog for DGKB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKB Gene

ENSEMBL:
Gene Tree for DGKB (if available)
TreeFam:
Gene Tree for DGKB (if available)

Paralogs for DGKB Gene

Paralogs for DGKB Gene

(6) SIMAP similar genes for DGKB Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DGKB: view

Variants for DGKB Gene

Sequence variations from dbSNP and Humsavar for DGKB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs34616903 - 14,149,181(+) TAAAC(C/T)GGTTT reference, missense
rs879692 -- 14,602,362(-) TACAT(A/G)CAGAT intron-variant
rs879693 -- 14,602,300(-) accaa(C/G)tcaaa intron-variant
rs885438 -- 14,683,269(+) TTATG(C/T)TATTT intron-variant
rs891808 -- 14,413,436(-) atctc(C/T)tcttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DGKB Gene

Variant ID Type Subtype PubMed ID
nsv821652 CNV Loss 15273396
nsv8052 CNV Loss 18304495
esv2734011 CNV Deletion 23290073
nsv8053 CNV Gain+Loss 18304495
esv27782 CNV Gain+Loss 19812545
nsv821255 CNV Deletion 20802225
esv2734012 CNV Deletion 23290073
esv2589671 CNV Deletion 19546169
esv2734013 CNV Deletion 23290073
esv2367407 CNV Deletion 18987734
esv2665678 CNV Deletion 23128226
esv2734014 CNV Deletion 23290073
nsv8054 CNV Gain 18304495
esv270222 CNV Insertion 20981092
esv274346 CNV Insertion 20981092
esv2734015 CNV Deletion 23290073
esv1008785 CNV Deletion 20482838
esv1543610 CNV Deletion 17803354
esv2648403 CNV Deletion 19546169
nsv511949 CNV Loss 21212237
esv2009841 CNV Deletion 18987734
esv4153 CNV Deletion 18987735
esv2734016 CNV Deletion 23290073
esv7200 CNV Loss 19470904
esv1770636 CNV Deletion 17803354
esv2372428 CNV Deletion 18987734
esv3711 CNV Deletion 18987735
esv2734018 CNV Deletion 23290073
esv2673931 CNV Deletion 23128226
nsv887707 CNV Loss 21882294
nsv887708 CNV Loss 21882294
esv2676590 CNV Deletion 23128226
esv1248437 CNV Insertion 17803354
esv2657075 CNV Deletion 23128226
nsv887709 CNV Loss 21882294
nsv887710 CNV Loss 21882294
nsv518783 CNV Loss 19592680
nsv887711 CNV Loss 21882294
esv2516570 CNV Insertion 19546169
esv2734019 CNV Deletion 23290073
esv2734020 CNV Deletion 23290073
esv2035361 CNV Deletion 18987734
esv1008799 CNV Deletion 20482838
esv1572679 CNV Deletion 17803354
esv2734021 CNV Deletion 23290073
esv2734022 CNV Deletion 23290073
esv2609849 CNV Insertion 19546169
esv268947 CNV Insertion 20981092
nsv887712 CNV Loss 21882294
esv2734023 CNV Deletion 23290073
esv2144200 CNV Deletion 18987734
esv2227136 CNV Deletion 18987734
esv2734024 CNV Deletion 23290073
esv26569 CNV Loss 19812545
esv22096 CNV Loss 19812545
esv2590385 CNV Deletion 19546169

Variation tolerance for DGKB Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DGKB Gene

HapMap Linkage Disequilibrium report
DGKB
Human Gene Mutation Database (HGMD)
DGKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKB Gene

Disorders for DGKB Gene

MalaCards: The human disease database

(1) MalaCards diseases for DGKB Gene - From: OMIM

Disorder Aliases PubMed IDs
mitochondrial dna depletion syndrome 3
  • hepatocerebral mitochondrial dna deletions syndrome autosomal recessive
- elite association - COSMIC cancer census association via MalaCards
Search DGKB in MalaCards View complete list of genes associated with diseases

Relevant External Links for DGKB

Genetic Association Database (GAD)
DGKB
Human Genome Epidemiology (HuGE) Navigator
DGKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DGKB
genes like me logo Genes that share disorders with DGKB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGKB Gene

Publications for DGKB Gene

  1. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 48 67
  2. Diacylglycerol kinases: at the hub of cell signalling. (PMID: 18062770) MAcrida I. … Merino E. (Biochem. J. 2008) 3 23
  3. Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. (PMID: 11719522) Caricasole A. … Terstappen G.C. (J. Biol. Chem. 2002) 3 23
  4. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons. (PMID: 7689223) Goto K. … Kondo H. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3
  5. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. (PMID: 25187374) Hwang J.Y. … Kim B.J. (Diabetes 2015) 3

Products for DGKB Gene

Sources for DGKB Gene

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