Aliases for C11orf65 Gene
External Ids for C11orf65 Gene
- HGNC: 28519
- Entrez Gene: 160140
- Ensembl: ENSG00000166323
- UniProtKB: Q8NCR3
Previous GeneCards Identifiers for C11orf65 Gene
- GC11M107708
- GC11M108179
- GC11M104179
Summaries for C11orf65 Gene
GeneCards Summary for C11orf65 Gene
C11orf65 (Chromosome 11 Open Reading Frame 65) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf65 Gene
Genomics for C11orf65 Gene
Regulatory Elements for C11orf65 Gene
Enhancers for C11orf65 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G108233 | 1.4 | Ensembl ENCODE dbSUPER | 7.9 | +228.9 | 228942 | 11.1 | FOXA2 ZNF48 ZBTB40 RARA YY1 EGR1 CBX5 SCRT2 FOS ETV6 | ACAT1 ATM ENSG00000255467 DDX10 C11orf65 KDELC2 ENSG00000206967 GC11M108232 PIR35860 |
| GH11G108219 | 1.4 | ENCODE dbSUPER | 4.9 | +241.7 | 241686 | 12.2 | HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 | ACAT1 KDELC2 ENSG00000255467 DDX10 C11orf65 ENSG00000206967 GC11M108232 NPAT |
| GH11G108246 | 0.7 | dbSUPER | 4.9 | +220.5 | 220454 | 1.5 | PAF1 CTCF ZNF654 MAFG CEBPB CEBPG REST RAD21 MAFF ZNF316 | ACAT1 NPAT ATM ENSG00000255467 DDX10 C11orf65 ENSG00000206967 GC11M108232 PIR35860 |
| GH11G108215 | 0.6 | dbSUPER | 5.1 | +251.1 | 251122 | 2.2 | ZNF263 EGR1 POLR2A SCRT2 CEBPB CEBPG | ACAT1 ENSG00000255467 C11orf65 ATM |
| GH11G108432 | 0.4 | ENCODE | 4.7 | +34.5 | 34544 | 1.8 | MTA2 | KDELC2 ACAT1 C11orf65 PIR35860 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C11orf65 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C11orf65 Gene
- Chromosome:
- 11
- Start:
- 108,308,519 bp from pter
- End:
- 108,467,547 bp from pter
- Size:
- 159,029 bases
- Orientation:
- Minus strand
Genomic View for C11orf65 Gene
Genes around C11orf65 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q22.3 by Ensembl
- 11q22.3 by Entrez Gene
- 11q22.3 by HGNC
C11orf65 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C11orf65 Gene
Proteins for C11orf65 Gene
-
Protein details for C11orf65 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NCR3-CK065_HUMAN
- Recommended name:
- Uncharacterized protein C11orf65
- Protein Accession:
- Q8NCR3
- B4DZU4
- Q6PCA8
Protein attributes for C11orf65 Gene
- Size:
- 313 amino acids
- Molecular mass:
- 36720 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for C11orf65 Gene
Other Protein References for C11orf65 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C11orf65
-
Abcam antibodies for C11orf65
- GeneTex C11orf65 antibody for C11orf65
Protein Products
-
OriGene Purified Proteins for C11orf65
- Search Origene for MassSpec and Protein Over-expression Lysates for C11orf65
- Origene Custom Protein Services for C11orf65
- Search GeneTex for Proteins for C11orf65
No data available for DME Specific Peptides for C11orf65 Gene
Domains & Families for C11orf65 Gene
Protein Domains for C11orf65 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for C11orf65 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf65 Gene
Function for C11orf65 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for C11orf65 Gene
- GenomeRNAi human phenotypes for C11orf65:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C11orf65
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C11orf65 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
- Search ViGene Biosciences for C11orf65
CRISPR Products
-
OriGene CRISPR knockouts for C11orf65
-
Santa Cruz Biotechnology (SCBT) CRISPR for C11orf65
- GenScript: Design CRISPR guide RNA sequences for C11orf65
miRNA for C11orf65 Gene
- miRTarBase miRNAs that target C11orf65
miRNA Products
- Search ViGene Biosciences for C11orf65
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C11orf65
- Browse OriGene Inhibitory RNA Products For C11orf65
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
Clone Products
-
OriGene ORF clones in human for C11orf65
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C11orf65
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C11orf65
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C11orf65
-
ViGene Biosciences adenoviral particle packaged cDNA for C11orf65 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C11orf65 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf65 Gene
Localization for C11orf65 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf65 Gene
Pathways & Interactions for C11orf65 Gene
No Data Available
Interacting Proteins for C11orf65 Gene
Selected Interacting proteins:
ENSP00000376799
Q8NCR3-CK065_HUMAN
for C11orf65 Gene via
STRING
IID
UniProtKB
No data available for Pathways by source and SIGNOR curated interactions for C11orf65 Gene
Drugs & Compounds for C11orf65 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Metformin | Approved | Pharma | AMP-activated protein kinase (AMPK) activator | 1803 |
Transcripts for C11orf65 Gene
mRNA/cDNA for C11orf65 Gene
- (17) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C11orf65 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C11orf65
-
Santa Cruz Biotechnology (SCBT) CRISPR for C11orf65
- GenScript: Design CRISPR guide RNA sequences for C11orf65
miRNA Products
- Search ViGene Biosciences for C11orf65
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C11orf65
- Browse OriGene Inhibitory RNA Products For C11orf65
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
Clone Products
-
OriGene ORF clones in human for C11orf65
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C11orf65
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C11orf65
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for C11orf65 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for C11orf65 Gene
This gene is overexpressed in Testis (x22.8).
NURSA nuclear receptor signaling pathways regulating expression of C11orf65 Gene:
C11orf65SOURCE GeneReport for Unigene cluster for C11orf65 Gene:
Hs.653180Primer Products
-
OriGene qPCR primer pairs for C11orf65
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf65 Gene
Orthologs for C11orf65 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C11orf65 35 |
|
OneToOne | |
| C11H11orf65 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | C5H11orf65 34 |
|
||
| C11orf65 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C15H11orf65 34 |
|
||
| mouse (Mus musculus) |
Mammalia | 4930550C14Rik 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1311251 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | C11orf65 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C11orf65 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C11orf65 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490935 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gb:co360592 34 |
|
||
| C24H11orf65 35 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3681 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13913 34 |
|
- Species where no ortholog for C11orf65 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C11orf65 Gene
Pseudogenes.org Pseudogenes for C11orf65 Gene
No data available for Paralogs for C11orf65 Gene
Variants for C11orf65 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11212617 | drug-response | 108,412,434(+) | agaga(A/C)tgtca | intron-variant | |
| rs1057519029 | Pathogenic | 108,335,894(+) | CCAGA(NNNNNN/TGTGTAATACA)TTACT | intron-variant | |
| rs121434216 | Pathogenic | 108,345,804(+) | AAATT(G/T)TCAAC | intron-variant, reference, missense | |
| rs121434218 | Pathogenic | 108,333,925(+) | TAAAC(C/T)TAAGA | intron-variant, reference, missense | |
| rs121434219 | Pathogenic | 108,365,476(+) | TCAGC(C/T)GACTT | intron-variant, reference, stop-gained |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2182n54 | CNV | gain | 21841781 |
| esv1612880 | CNV | insertion | 17803354 |
| esv21753 | CNV | gain | 19812545 |
| esv3627675 | CNV | gain | 21293372 |
| esv3627676 | CNV | loss | 21293372 |
| esv3627677 | CNV | loss | 21293372 |
| esv3892100 | CNV | loss | 25118596 |
| nsv832262 | CNV | loss | 17160897 |
| nsv832263 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.52;
44.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C11orf65 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf65 Gene
Disorders for C11orf65 Gene
Relevant External Links for C11orf65
No disorders were found for C11orf65 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf65 Gene
Publications for C11orf65 Gene
- Does metformin work for everyone? A genome-wide association study for metformin response. (PMID: 21845381) Florez J.C. (Curr. Diab. Rep. 2011) 3 46 64
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for C11orf65 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- OriGene Purified Proteins for C11orf65
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- OriGene qPCR primer pairs for C11orf65
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for C11orf65 in any vector
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- GenScript: Design CRISPR guide RNA sequences for C11orf65
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- Novus Biologicals Antibodies for C11orf65
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- Abcam antibodies for C11orf65
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- GeneTex C11orf65 antibody for C11orf65
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- ViGene Biosciences adenoviral particle packaged cDNA for C11orf65 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C11orf65 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
- Search ViGene Biosciences for C11orf65
- Horizon Cell Lines for C11orf65
- Cyagen custom Knockout/knockin (KOKI) mouse models for C11orf65
- VectorBuilder custom plasmid, inducible vectors for C11orf65
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C11orf65
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C11orf65 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer