Aliases for C11orf65 Gene
External Ids for C11orf65 Gene
- HGNC: 28519
- Entrez Gene: 160140
- Ensembl: ENSG00000166323
- UniProtKB: Q8NCR3
Previous GeneCards Identifiers for C11orf65 Gene
- GC11M107708
- GC11M108179
- GC11M104179
Summaries for C11orf65 Gene
GeneCards Summary for C11orf65 Gene
C11orf65 (Chromosome 11 Open Reading Frame 65) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf65 Gene
Genomics for C11orf65 Gene
Regulatory Elements for C11orf65 Gene
Enhancers for C11orf65 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around C11orf65 on UCSC Golden Path with GeneCards custom track
Promoters for C11orf65 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around C11orf65 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C11orf65 Gene
- Chromosome:
- 11
- Start:
- 108,308,519 bp from pter
- End:
- 108,467,547 bp from pter
- Size:
- 159,029 bases
- Orientation:
- Minus strand
Genomic View for C11orf65 Gene
Genes around C11orf65 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q22.3 by Ensembl
- 11q22.3 by Entrez Gene
- 11q22.3 by HGNC
C11orf65 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C11orf65 Gene
Proteins for C11orf65 Gene
-
Protein details for C11orf65 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NCR3-CK065_HUMAN
- Recommended name:
- Uncharacterized protein C11orf65
- Protein Accession:
- Q8NCR3
- B4DZU4
- Q6PCA8
Protein attributes for C11orf65 Gene
- Size:
- 313 amino acids
- Molecular mass:
- 36720 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for C11orf65 Gene
Other Protein References for C11orf65 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C11orf65
- GeneTex C11orf65 antibody for C11orf65
-
Santa Cruz Biotechnology (SCBT) Antibodies for C11orf65
Protein Products
-
OriGene Purified Proteins for C11orf65
- Search Origene for MassSpec and Protein Over-expression Lysates for C11orf65
- Origene Custom Protein Services for C11orf65
- Novus Biologicals proteins for C11orf65
- Search GeneTex for Proteins for C11orf65
Assay Products
No data available for DME Specific Peptides for C11orf65 Gene
Domains & Families for C11orf65 Gene
Protein Domains for C11orf65 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for C11orf65 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf65 Gene
Function for C11orf65 Gene
Phenotypes for C11orf65 Gene
- GenomeRNAi human phenotypes for C11orf65:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for C11orf65 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
- Search ViGene Biosciences for C11orf65
CRISPR Products
-
OriGene CRISPR knockouts for C11orf65
-
Santa Cruz Biotechnology (SCBT) CRISPR for C11orf65
- GenScript: Design CRISPR guide RNA sequences for C11orf65
miRNA for C11orf65 Gene
- miRTarBase miRNAs that target C11orf65
miRNA Products
- Search ViGene Biosciences for C11orf65
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for C11orf65
- Browse OriGene Inhibitory RNA Products For C11orf65
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
Clone Products
- OriGene clones in human for C11orf65
- OriGene ORF clones in human for C11orf65
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: cDNA clones in your preferred vector
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for C11orf65 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C11orf65 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf65 Gene
Localization for C11orf65 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf65 Gene
Pathways & Interactions for C11orf65 Gene
More details on SuperPathways for C11orf65
No Data Available
Interacting Proteins for C11orf65 Gene
Selected Interacting proteins:
Q8NCR3-CK065_HUMAN
ENSP00000376799
for C11orf65 Gene via
MINT
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for C11orf65 Gene
Drugs & Compounds for C11orf65 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Metformin | Approved | Pharma | AMP-activated protein kinase (AMPK) activator | 1668 |
Transcripts for C11orf65 Gene
mRNA/cDNA for C11orf65 Gene
- (10) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C11orf65 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C11orf65
-
Santa Cruz Biotechnology (SCBT) CRISPR for C11orf65
- GenScript: Design CRISPR guide RNA sequences for C11orf65
miRNA Products
- Search ViGene Biosciences for C11orf65
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for C11orf65
- Browse OriGene Inhibitory RNA Products For C11orf65
-
ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
Clone Products
- OriGene clones in human for C11orf65
- OriGene ORF clones in human for C11orf65
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: cDNA clones in your preferred vector
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for C11orf65 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for C11orf65 Gene
This gene is overexpressed in Testis (x22.8).
SOURCE GeneReport for Unigene cluster for C11orf65 Gene Hs.653180
Primer Products
-
OriGene qPCR primer pairs for C11orf65
No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C11orf65 Gene
Orthologs for C11orf65 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | C15H11orf65 35 |
|
||
| dog (Canis familiaris) |
Mammalia | C5H11orf65 35 |
|
||
| C11orf65 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | 4930550C14Rik 35 |
|
||
| 4930550C14Rik 16 |
|
||||
| 4930550C14Rik 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | C11H11orf65 35 |
|
||
| C11orf65 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | RGD1311251 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C11orf65 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C11orf65 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C11orf65 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490935 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gb:co360592 35 |
|
||
| C24H11orf65 36 |
|
OneToOne | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13913 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3681 36 |
|
OneToOne |
- Species with no ortholog for C11orf65:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C11orf65 Gene
Pseudogenes.org Pseudogenes for C11orf65 Gene
No data available for Paralogs for C11orf65 Gene
Variants for C11orf65 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs573890 | -- | 108,380,636(+) | CCAAG(C/G)GCCCA | intron-variant | |
| rs590972 | -- | 108,373,791(-) | gtgcc(A/G)tctgt | intron-variant | |
| rs596127 | -- | 108,397,319(+) | ttctc(A/C)aaaaa | intron-variant | |
| rs597788 | -- | 108,386,132(+) | AGTAG(C/T)TCACA | intron-variant | |
| rs605394 | -- | 108,372,901(-) | agatg(A/G)ggttt | intron-variant |
Residual Variation Intolerance Score:
76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.52;
44.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C11orf65 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf65 Gene
Disorders for C11orf65 Gene
Relevant External Links for C11orf65
No disorders were found for C11orf65 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf65 Gene
Publications for C11orf65 Gene
- Does metformin work for everyone? A genome-wide association study for metformin response. (PMID: 21845381) Florez J.C. (Curr. Diab. Rep. 2011) 3 48 67
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
- Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. (PMID: 21186350) . … Pearson E.R. (Nat. Genet. 2011) 3
Products for C11orf65 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C11orf65
- Search Origene for MassSpec and Protein Over-expression Lysates for C11orf65
- Origene Custom Protein Services for C11orf65
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for C11orf65
- Browse OriGene Inhibitory RNA Products For C11orf65
- OriGene qPCR primer pairs for C11orf65
- OriGene CRISPR knockouts for C11orf65
- OriGene clones in human for C11orf65
- OriGene ORF clones in human for C11orf65
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for C11orf65
- GenScript Custom Assay Services for C11orf65
- GenScript Custom overexpressing Cell Line Services for C11orf65
- GenScript: Design CRISPR guide RNA sequences for C11orf65
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for C11orf65
- Novus Biologicals Antibodies for C11orf65
- Novus Biologicals proteins for C11orf65
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for C11orf65 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C11orf65 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C11orf65 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C11orf65 gene
- Search ViGene Biosciences for C11orf65
- Search ViGene Biosciences for C11orf65
- Santa Cruz Biotechnology (SCBT) Antibodies for C11orf65
- Search Santa Cruz Biotechnology (SCBT) for C11orf65 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for C11orf65
Sources for C11orf65 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon