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Aliases for DAB1 Gene

Aliases for DAB1 Gene

  • Dab, Reelin Signal Transducer, Homolog 1 (Drosophila) 2 3
  • Disabled (Drosophila) Homolog 1 2
  • Disabled Homolog 1 (Drosophila) 2
  • Dab Reelin Signal Transducer 1 2

External Ids for DAB1 Gene

Summaries for DAB1 Gene

Entrez Gene Summary for DAB1 Gene

  • The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAB1 Gene

DAB1 (Dab, Reelin Signal Transducer, Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with DAB1 include ciliary dyskinesia, primary, 2. Among its related pathways are Tyrosine Kinases / Adaptors and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include phosphatidylinositol 3-kinase binding. An important paralog of this gene is DAB2.

UniProtKB/Swiss-Prot for DAB1 Gene

  • Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).

Gene Wiki entry for DAB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAB1 Gene

Genomics for DAB1 Gene

Genomic Location for DAB1 Gene

Start:
56,994,778 bp from pter
End:
58,546,734 bp from pter
Size:
1,551,957 bases
Orientation:
Minus strand

Genomic View for DAB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAB1 Gene

Regulatory Elements for DAB1 Gene

Proteins for DAB1 Gene

  • Protein details for DAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75553-DAB1_HUMAN
    Recommended name:
    Disabled homolog 1
    Protein Accession:
    O75553
    Secondary Accessions:
    • A4FU90
    • B3KTG3
    • Q4LE59
    • Q5T6M6
    • Q5T6M9
    • Q5T835
    • Q5T836
    • Q5T837
    • Q6NWS9
    • Q6NWT0
    • Q6NWT1
    • Q9NYA8

    Protein attributes for DAB1 Gene

    Size:
    588 amino acids
    Molecular mass:
    63775 Da
    Quaternary structure:
    • Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain). Interacts with DAB2IP, SIAH1, LRP1, LRP8 and VLDLR.
    SequenceCaution:
    • Sequence=BAE06094.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAB1 Gene

neXtProt entry for DAB1 Gene

Proteomics data for DAB1 Gene at MOPED

Post-translational modifications for DAB1 Gene

  • Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAB1 Gene

No data available for DME Specific Peptides for DAB1 Gene

Domains for DAB1 Gene

Protein Domains for DAB1 Gene

UniProtKB/Swiss-Prot:

DAB1_HUMAN
Domain:
  • The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins:
    • O75553
  • Contains 1 PID domain.:
    • O75553
genes like me logo Genes that share domains with DAB1: view

No data available for Gene Families for DAB1 Gene

Function for DAB1 Gene

Molecular function for DAB1 Gene

GENATLAS Biochemistry: murine disabled-1 homolog,expressed in brain and likely involved in brain development
UniProtKB/Swiss-Prot Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).

Gene Ontology (GO) - Molecular Function for DAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043548 phosphatidylinositol 3-kinase binding IEA --
genes like me logo Genes that share ontologies with DAB1: view
genes like me logo Genes that share phenotypes with DAB1: view

Animal Models for DAB1 Gene

MGI Knock Outs for DAB1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DAB1 Gene

Localization for DAB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAB1 Gene COMPARTMENTS Subcellular localization image for DAB1 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for DAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005903 brush border IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with DAB1: view

Pathways for DAB1 Gene

genes like me logo Genes that share pathways with DAB1: view

Pathways by source for DAB1 Gene

Gene Ontology (GO) - Biological Process for DAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007420 brain development --
GO:0007494 midgut development IEA --
genes like me logo Genes that share ontologies with DAB1: view

Compounds for DAB1 Gene

(6) Novoseek inferred chemical compound relationships for DAB1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 57.9 35
phosphotyrosine 54.6 6
phosphoinositide 39.5 4
calcium 0 1
glutamate 0 1
genes like me logo Genes that share compounds with DAB1: view

Transcripts for DAB1 Gene

Unigene Clusters for DAB1 Gene

Dab, reelin signal transducer, homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAB1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - -
SP6:

Relevant External Links for DAB1 Gene

GeneLoc Exon Structure for
DAB1
ECgene alternative splicing isoforms for
DAB1

Expression for DAB1 Gene

mRNA expression in normal human tissues for DAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAB1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.1) and Brain - Cerebellum (6.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DAB1 Gene

SOURCE GeneReport for Unigene cluster for DAB1 Gene Hs.477370

genes like me logo Genes that share expressions with DAB1: view

Orthologs for DAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAB1 36
  • 99.76 (n)
  • 99.82 (a)
DAB1 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAB1 36
  • 95.5 (n)
  • 97.66 (a)
DAB1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAB1 36
  • 96.35 (n)
  • 98.65 (a)
DAB1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dab1 36
  • 92.91 (n)
  • 96.58 (a)
Dab1 16
Dab1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAB1 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAB1 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dab1 36
  • 93.15 (n)
  • 96.76 (a)
chicken
(Gallus gallus)
Aves DAB1 36
  • 85.54 (n)
  • 91.11 (a)
DAB1 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dab1 36
  • 78.98 (n)
  • 84.65 (a)
zebrafish
(Danio rerio)
Actinopterygii dab1a 36
  • 66.36 (n)
  • 70.34 (a)
dab1a 37
  • 63 (a)
OneToMany
dab1b 37
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dab 37
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dab-1 37
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 4 (a)
OneToMany
Species with no ortholog for DAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAB1 Gene

ENSEMBL:
Gene Tree for DAB1 (if available)
TreeFam:
Gene Tree for DAB1 (if available)

Paralogs for DAB1 Gene

Paralogs for DAB1 Gene

genes like me logo Genes that share paralogs with DAB1: view

Variants for DAB1 Gene

Sequence variations from dbSNP and Humsavar for DAB1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1053 -- 57,205,990(-) ATGCT(C/T)ATTGA intron-variant
rs3558 -- 57,988,129(-) GGTCA(A/G)GACCT intron-variant
rs23705 -- 57,185,819(-) TGTCC(G/T)GGTAC intron-variant
rs77510 -- 57,329,846(-) ATTGA(C/T)TGACC intron-variant
rs77511 -- 57,329,799(-) CAGAA(A/G)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAB1 Gene

Variant ID Type Subtype PubMed ID
nsv483162 CNV Complex 15286789
nsv10195 CNV Gain 18304495
nsv10206 CNV Gain+Loss 18304495
nsv526087 CNV Loss 19592680
nsv943 CNV Insertion 18451855
esv25746 CNV Loss 19812545
dgv231n71 CNV Loss 21882294
nsv954 CNV Loss 18451855
esv2748697 CNV Deletion 23290073
esv2031864 CNV Deletion 18987734
nsv870908 CNV Loss 21882294
nsv966 CNV Insertion 18451855
esv26685 CNV Loss 19812545
nsv508013 CNV Loss 20534489
nsv870802 CNV Loss 21882294
nsv523574 CNV Loss 19592680
nsv871684 CNV Loss 21882294
esv272319 CNV Insertion 20981092
esv2748708 CNV Deletion 23290073
esv2748719 CNV Deletion 23290073
esv2748730 CNV Deletion 23290073
nsv871620 CNV Loss 21882294
esv2748741 CNV Deletion 23290073
esv6090 CNV Gain 19470904
nsv829937 CNV Gain 17160897
esv2663515 CNV Deletion 23128226
nsv977 CNV Insertion 18451855
esv2641726 CNV Deletion 19546169
esv2277330 CNV Deletion 18987734
esv2748752 CNV Deletion 23290073
esv4838 CNV Deletion 18987735
esv1002928 CNV Deletion 20482838
esv1095459 CNV Deletion 17803354
esv7642 CNV Loss 19470904
esv275018 CNV Loss 21479260
nsv527673 CNV Loss 19592680
esv2748763 CNV Deletion 23290073
esv268153 CNV Insertion 20981092
nsv525581 CNV Loss 19592680
esv994666 CNV Deletion 20482838
esv2676025 CNV Deletion 23128226
esv29351 CNV Loss 19812545
esv2748774 CNV Deletion 23290073
esv2748785 CNV Deletion 23290073

Relevant External Links for DAB1 Gene

HapMap Linkage Disequilibrium report
DAB1
Human Gene Mutation Database (HGMD)
DAB1

Disorders for DAB1 Gene

(1) Novoseek inferred disease relationships for DAB1 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 0 1

Relevant External Links for DAB1

Genetic Association Database (GAD)
DAB1
Human Genome Epidemiology (HuGE) Navigator
DAB1
genes like me logo Genes that share disorders with DAB1: view

No data available for UniProtKB/Swiss-Prot for DAB1 Gene

Publications for DAB1 Gene

  1. Cloning of human DAB1 and mapping to chromosome 1p31-p32. (PMID: 9790777) Lambert de Rouvroit C. … Goffinet A.M. (Genomics 1998) 2 3 4
  2. Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors. (PMID: 17548821) Yasui N. … Takagi J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  3. Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. (PMID: 17974915) Feng L. … Cooper J.A. (Genes Dev. 2007) 3 23
  4. Disabled-1 is a large common fragile site gene, inactivated in multiple cancers. (PMID: 18008369) McAvoy S. … Smith D.I. (Genes Chromosomes Cancer 2008) 3 23
  5. Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5. (PMID: 18076569) Sato Y. … Hisanaga S. (Genes Cells 2007) 3 23

Products for DAB1 Gene

Sources for DAB1 Gene

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