Aliases for DAB1 Gene
External Ids for DAB1 Gene
Previous GeneCards Identifiers for DAB1 Gene
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for DAB1 Gene
DAB1 (Dab, Reelin Signal Transducer, Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with DAB1 include ciliary dyskinesia, primary, 2. Among its related pathways are Tyrosine Kinases / Adaptors and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include phosphatidylinositol 3-kinase binding. An important paralog of this gene is DAB2.
UniProtKB/Swiss-Prot for DAB1 Gene
Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).