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Aliases for CYP26A1 Gene

Aliases for CYP26A1 Gene

  • Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily XXVIA, Polypeptide 1 2 3
  • Cytochrome P450 Retinoic Acid-Inactivating 1 3 4
  • Retinoic Acid-Metabolizing Cytochrome 3 4
  • Retinoic Acid 4-Hydroxylase 3 4
  • Cytochrome P450RAI 3 4
  • P450RAI1 3 4
  • HP450RAI 3 4
  • CYP26 3 4
  • P450, Retinoic Acid-Inactivating, 1 3
  • Cytochrome P450 26A1 3
  • EC 1.14.-.- 4
  • P450RAI 3
  • CP26 3

External Ids for CYP26A1 Gene

Previous GeneCards Identifiers for CYP26A1 Gene

  • GC10P093726
  • GC10P094066
  • GC10P094953
  • GC10P094486
  • GC10P094497
  • GC10P094823
  • GC10P088460

Summaries for CYP26A1 Gene

Entrez Gene Summary for CYP26A1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP26A1 Gene

CYP26A1 (Cytochrome P450, Family 26, Subfamily A, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP26A1 include imperforate anus and caudal regression syndrome. Among its related pathways are Metabolism and Vitamin A and carotenoid metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP26C1.

UniProtKB/Swiss-Prot for CYP26A1 Gene

  • Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA

Tocris Summary for CYP26A1 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They are found at high levels in the liver, where they have an important role in metabolism of drugs and endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis, cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP26A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP26A1 Gene

Genomics for CYP26A1 Gene

Regulatory Elements for CYP26A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP26A1 Gene

Start:
93,073,475 bp from pter
End:
93,077,890 bp from pter
Size:
4,416 bases
Orientation:
Plus strand

Genomic View for CYP26A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP26A1 Gene

Proteins for CYP26A1 Gene

  • Protein details for CYP26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43174-CP26A_HUMAN
    Recommended name:
    Cytochrome P450 26A1
    Protein Accession:
    O43174
    Secondary Accessions:
    • B3KNI4
    • Q5VXH9
    • Q5VXI0

    Protein attributes for CYP26A1 Gene

    Size:
    497 amino acids
    Molecular mass:
    56199 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP26A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP26A1 Gene

Proteomics data for CYP26A1 Gene at MOPED

Post-translational modifications for CYP26A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP26A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP26A1 Gene

Domains for CYP26A1 Gene

Gene Families for CYP26A1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP26A1 Gene

Suggested Antigen Peptide Sequences for CYP26A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43174

UniProtKB/Swiss-Prot:

CP26A_HUMAN :
  • O43174
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP26A1: view

Function for CYP26A1 Gene

Molecular function for CYP26A1 Gene

GENATLAS Biochemistry: cytochrome p450,family XXVI,involved in extrahepatic metabolism of retinoic acid
UniProtKB/Swiss-Prot Function: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA
UniProtKB/Swiss-Prot Induction: By retinoic acid

Enzyme Numbers (IUBMB) for CYP26A1 Gene

Gene Ontology (GO) - Molecular Function for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 10823918
GO:0005506 iron ion binding IEA --
GO:0008401 retinoic acid 4-hydroxylase activity IDA 10823918
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0019825 oxygen binding TAS 9228017
genes like me logo Genes that share ontologies with CYP26A1: view
genes like me logo Genes that share phenotypes with CYP26A1: view

Animal Models for CYP26A1 Gene

MGI Knock Outs for CYP26A1:

Animal Model Products

CRISPR Products

miRNA for CYP26A1 Gene

miRTarBase miRNAs that target CYP26A1

No data available for Transcription Factor Targeting and HOMER Transcription for CYP26A1 Gene

Localization for CYP26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP26A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP26A1 Gene COMPARTMENTS Subcellular localization image for CYP26A1 gene
Compartment Confidence
endoplasmic reticulum 5
chloroplast 3
extracellular 2
nucleus 2
golgi apparatus 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with CYP26A1: view

Pathways for CYP26A1 Gene

genes like me logo Genes that share pathways with CYP26A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
    • Notch Signaling Targets in human,mouse,rat

Interacting Proteins for CYP26A1 Gene

Gene Ontology (GO) - Biological Process for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0007417 central nervous system development IEA --
GO:0008152 metabolic process TAS 9228017
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with CYP26A1: view

Compounds for CYP26A1 Gene

(5) Tocris Compounds for CYP26A1 Gene

Compound Action Cas Number
Exemestane Steroidal aromatase (CYP19) inhibitor [107868-30-4]
Ketoconazole Cytochrome P450c17 inhibitor [65277-42-1]
Letrozole Potent, reversible non-steroidal aromatase inhibitor [112809-51-5]
Methoxyresorufin Fluorometric CYP450 substrate [5725-89-3]
Pentoxyresorufin Fluorometric cytochrome P450 substrate [87687-03-4]

(1) HMDB Compounds for CYP26A1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8

(4) Drugbank Compounds for CYP26A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acitretin
55079-83-9 enzyme substrate
Etretinate
54350-48-0 enzyme substrate
Ketoconazole
  • 2%
65277-42-1 enzyme inhibitor
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 enzyme inducer

(10) Novoseek inferred chemical compound relationships for CYP26A1 Gene

Compound -log(P) Hits PubMed IDs
liarozole 89.5 8
retinoic acid 86.8 136
retinoid 84.6 14
am 580 83.4 4
retinaldehyde 77.8 1
genes like me logo Genes that share compounds with CYP26A1: view

Transcripts for CYP26A1 Gene

mRNA/cDNA for CYP26A1 Gene

Unigene Clusters for CYP26A1 Gene

Cytochrome P450, family 26, subfamily A, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP26A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP26A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: -
SP6:

Relevant External Links for CYP26A1 Gene

GeneLoc Exon Structure for
CYP26A1
ECgene alternative splicing isoforms for
CYP26A1

Expression for CYP26A1 Gene

mRNA expression in normal human tissues for CYP26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP26A1 Gene

This gene is overexpressed in Liver (34.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP26A1 Gene

SOURCE GeneReport for Unigene cluster for CYP26A1 Gene Hs.150595

mRNA Expression by UniProt/SwissProt for CYP26A1 Gene

O43174-CP26A_HUMAN
Tissue specificity: Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.
genes like me logo Genes that share expressions with CYP26A1: view

In Situ Assay Products

Orthologs for CYP26A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP26A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP26A1 36
  • 100 (a)
OneToOne
LOC450614 35
  • 99.8 (n)
  • 99.8 (a)
cow
(Bos Taurus)
Mammalia CYP26A1 35
  • 91.95 (n)
  • 94.16 (a)
CYP26A1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP26A1 35
  • 92.42 (n)
  • 94.97 (a)
CYP26C1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp26a1 35
  • 89.81 (n)
  • 93.96 (a)
Cyp26a1 16
Cyp26a1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP26A1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp26a1 35
  • 87.86 (n)
  • 91.95 (a)
chicken
(Gallus gallus)
Aves CYP26A1 35
  • 77.85 (n)
  • 80.28 (a)
CYP26A1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP26A1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398094 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp26a1 35
  • 67.85 (n)
  • 70.23 (a)
zebrafish
(Danio rerio)
Actinopterygii cyp26a1 35
  • 65.85 (n)
  • 69.47 (a)
cyp26a1 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cyp313a1 36
  • 20 (a)
ManyToMany
Cyp313a2 36
  • 20 (a)
ManyToMany
Cyp313a3 36
  • 20 (a)
ManyToMany
Cyp313a4 36
  • 20 (a)
ManyToMany
Cyp313a5 36
  • 20 (a)
ManyToMany
Cyp313b1 36
  • 19 (a)
ManyToMany
Cyp318a1 36
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG11 36
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP716A2 35
  • 44.56 (n)
  • 33.67 (a)
rice
(Oryza sativa)
Liliopsida Os07g0520300 35
  • 45.49 (n)
  • 31.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
CSA.5303 36
  • 33 (a)
ManyToMany
Species with no ortholog for CYP26A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP26A1 Gene

ENSEMBL:
Gene Tree for CYP26A1 (if available)
TreeFam:
Gene Tree for CYP26A1 (if available)

Paralogs for CYP26A1 Gene

Paralogs for CYP26A1 Gene

Selected SIMAP similar genes for CYP26A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP26A1: view

Variants for CYP26A1 Gene

Sequence variations from dbSNP and Humsavar for CYP26A1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2229104 -- 93,077,124(+) GGAGG(C/G)CTTAG reference, synonymous-codon
rs3928850 -- 93,073,019(+) AAGGA(A/C)CCCCT upstream-variant-2KB
rs4411227 -- 93,071,756(+) CCTGC(C/G)GGACG upstream-variant-2KB
rs4917998 -- 93,077,714(+) TTCTA(C/T)AGTCA utr-variant-3-prime
rs4918000 -- 93,077,986(+) ATTGG(C/T)GTGTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CYP26A1 Gene

Variant ID Type Subtype PubMed ID
nsv895899 CNV Loss 21882294

Relevant External Links for CYP26A1 Gene

HapMap Linkage Disequilibrium report
CYP26A1
Human Gene Mutation Database (HGMD)
CYP26A1
Locus Specific Mutation Databases (LSDB)
CYP26A1
The Human Cytochrome P450 Allele Nomenclature Database
CYP26A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP26A1 Gene

Disorders for CYP26A1 Gene

(3) University of Copenhagen DISEASES for CYP26A1 Gene

(9) Novoseek inferred disease relationships for CYP26A1 Gene

Disease -log(P) Hits PubMed IDs
leukemia promyelocytic acute 61.5 2
carcinoma embryonal 45.3 2
vitamin a deficiency 39.1 1
promyelocytic leukemia 34.8 5
hnscc 34.7 2

Relevant External Links for CYP26A1

Genetic Association Database (GAD)
CYP26A1
Human Genome Epidemiology (HuGE) Navigator
CYP26A1
genes like me logo Genes that share disorders with CYP26A1: view

No data available for UniProtKB/Swiss-Prot for CYP26A1 Gene

Publications for CYP26A1 Gene

  1. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. (PMID: 9228017) White J.A. … Petkovich M. (J. Biol. Chem. 1997) 2 3 4 23
  2. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. (PMID: 9716180) Sonneveld E. … van der Saag P.T. (Cell Growth Differ. 1998) 3 4 23
  3. Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues. (PMID: 9826557) Trofimova-Griffin M.E. … Juchau M.R. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  4. Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid. (PMID: 8601734) Duell E.A. … Voorhees J.J. (J. Invest. Dermatol. 1996) 3 23
  5. CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. (PMID: 9228041) Ray W.J. … Gottlieb D.I. (J. Biol. Chem. 1997) 3 23

Products for CYP26A1 Gene

Sources for CYP26A1 Gene

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